|
US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
US9393315B2
(en)
|
2011-06-08 |
2016-07-19 |
Nitto Denko Corporation |
Compounds for targeting drug delivery and enhancing siRNA activity
|
|
JP5777846B2
(ja)
|
2005-06-15 |
2015-09-09 |
マサチューセッツ インスティテュート オブ テクノロジー |
アミン含有脂質およびその使用
|
|
AU2009307677C1
(en)
|
2008-10-20 |
2022-09-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin
|
|
CA3006395C
(en)
*
|
2008-11-07 |
2022-05-31 |
Massachusetts Institute Of Technology |
Aminoalcohol lipidoids and uses thereof
|
|
AU2010245933B2
(en)
*
|
2009-05-05 |
2016-06-16 |
Arbutus Biopharma Corporation |
Methods of delivering oligonucleotides to immune cells
|
|
KR20180094137A
(ko)
*
|
2009-05-05 |
2018-08-22 |
알닐람 파마슈티칼스 인코포레이티드 |
지질 조성물
|
|
WO2011056883A1
(en)
*
|
2009-11-03 |
2011-05-12 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of transthyretin (ttr)
|
|
AU2010326132B9
(en)
|
2009-12-01 |
2014-10-02 |
Translate Bio, Inc. |
Delivery of mRNA for the augmentation of proteins and enzymes in human genetic diseases
|
|
CN103153284B
(zh)
|
2010-07-06 |
2015-11-25 |
诺华股份有限公司 |
含有其pKa值有利于RNA递送的脂质的脂质体
|
|
DK2591114T3
(en)
|
2010-07-06 |
2016-08-29 |
Glaxosmithkline Biologicals Sa |
Immunization of large mammals with low doses of RNA
|
|
SI3243526T1
(sl)
|
2010-07-06 |
2020-02-28 |
Glaxosmithkline Biologicals S.A. |
Dostava RNA za sprožitev večih imunskih poti
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2012027675A2
(en)
*
|
2010-08-26 |
2012-03-01 |
Massachusetts Institute Of Technology |
Poly(beta-amino alcohols), their preparation, and uses thereof
|
|
WO2012027727A2
(en)
*
|
2010-08-26 |
2012-03-01 |
Kunyuan Cui |
Lipomacrocycles and uses thereof
|
|
LT4226941T
(lt)
|
2010-08-31 |
2025-01-10 |
Glaxosmithkline Biologicals Sa |
Pegilintos liposomos, skirtos imunogeną koduojančios rnr pristatymui
|
|
US9549901B2
(en)
|
2010-09-03 |
2017-01-24 |
The Brigham And Women's Hospital, Inc. |
Lipid-polymer hybrid particles
|
|
PL3590949T3
(pl)
|
2010-10-01 |
2022-08-29 |
Modernatx, Inc. |
Kwasy rybonukleinowe zawierające n1-metylo-pseudouracyle i ich zastosowania
|
|
BR112013008700B8
(pt)
|
2010-10-11 |
2022-10-04 |
Novartis Ag |
Molécula de rna auto-replicante, partícula de replicon de alfavírus, composição, molécula de dna recombinante, uso da molécula de rna auto-replicante
|
|
US20120136073A1
(en)
|
2010-11-15 |
2012-05-31 |
Life Technologies Corporation |
Amine-Containing Transfection Reagents and methods for making and using same
|
|
PL2691443T3
(pl)
|
2011-03-28 |
2021-08-30 |
Massachusetts Institute Of Technology |
Sprzężone lipomery i ich zastosowania
|
|
DE12722942T1
(de)
|
2011-03-31 |
2021-09-30 |
Modernatx, Inc. |
Freisetzung und formulierung von manipulierten nukleinsäuren
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
ES2663360T3
(es)
|
2011-06-08 |
2018-04-12 |
Translate Bio, Inc. |
Lípidos escindibles
|
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
|
EP4043025A1
(en)
|
2011-06-08 |
2022-08-17 |
Translate Bio, Inc. |
Lipid nanoparticle compositions and methods for mrna delivery
|
|
EP3854413A1
(en)
|
2011-07-06 |
2021-07-28 |
GlaxoSmithKline Biologicals SA |
Immunogenic combination compositions and uses thereof
|
|
KR20130024079A
(ko)
|
2011-08-30 |
2013-03-08 |
현대자동차주식회사 |
고체 scr 시스템 및 이를 이용한 고체상의 환원제 가열 방법
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
RS62993B1
(sr)
|
2011-10-03 |
2022-03-31 |
Modernatx Inc |
Modifikovani nukleozidi, nukleotidi, i nukleinske kiseline, i njihove upotrebe
|
|
KR101329702B1
(ko)
|
2011-10-06 |
2013-11-14 |
연세대학교 산학협력단 |
siRNA 전달을 위한 폴리아민 기반의 전달체
|
|
JP6151707B2
(ja)
|
2011-10-27 |
2017-06-21 |
マサチューセッツ インスティテュート オブ テクノロジー |
薬物内包微小球の形成が可能なn−末端で官能基化されたアミノ酸誘導体
|
|
PE20142362A1
(es)
|
2011-11-18 |
2015-01-30 |
Alnylam Pharmaceuticals Inc |
Agentes de iarn, composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr)
|
|
PT2791160T
(pt)
|
2011-12-16 |
2022-07-04 |
Modernatx Inc |
Composições arnm modificado
|
|
EP2791210A1
(en)
|
2011-12-16 |
2014-10-22 |
Massachusetts Institute of Technology |
Alpha-aminoamidine polymers and uses thereof
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
AU2013243955B2
(en)
|
2012-04-02 |
2018-02-22 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
CA2876155C
(en)
|
2012-06-08 |
2022-12-13 |
Ethris Gmbh |
Pulmonary delivery of mrna to non-lung target cells
|
|
EP3536787A1
(en)
|
2012-06-08 |
2019-09-11 |
Translate Bio, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
|
CA2884870C
(en)
*
|
2012-08-13 |
2022-03-29 |
Massachusetts Institute Of Technology |
Amine-containing lipidoids and uses thereof
|
|
CA2892529C
(en)
|
2012-11-26 |
2023-04-25 |
Moderna Therapeutics, Inc. |
Terminally modified rna
|
|
WO2014089486A1
(en)
|
2012-12-07 |
2014-06-12 |
Shire Human Genetic Therapies, Inc. |
Lipidic nanoparticles for mrna delivering
|
|
SG11201504523UA
(en)
|
2012-12-12 |
2015-07-30 |
Broad Inst Inc |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
CN103087012B
(zh)
*
|
2012-12-28 |
2014-10-22 |
四川大学 |
环氧化合物与阳离子聚合物及它们的制备方法
|
|
US9765022B2
(en)
|
2013-02-28 |
2017-09-19 |
Tufts University |
Disulfide compounds for delivery of pharmaceutical agents
|
|
EP2971010B1
(en)
|
2013-03-14 |
2020-06-10 |
ModernaTX, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
LT2968586T
(lt)
|
2013-03-14 |
2018-11-26 |
Translate Bio, Inc. |
Cft mrnr kompozicijos bei su jomis susiję būdai ir panaudojimai
|
|
ES2692363T3
(es)
|
2013-03-14 |
2018-12-03 |
Translate Bio, Inc. |
Composiciones terapéuticas de ARNm y su uso para tratar enfermedades y trastornos
|
|
KR20150127582A
(ko)
|
2013-03-14 |
2015-11-17 |
샤이어 휴먼 지네틱 테라피즈 인크. |
4''-티오 개질된 뉴클레오티드를 갖는 리보핵산 및 관련 방법
|
|
TR201901310T4
(tr)
|
2013-03-14 |
2019-02-21 |
Translate Bio Inc |
Mesajcı RNA'nın saflaştırılması yöntemleri.
|
|
ES2882110T3
(es)
|
2013-03-14 |
2021-12-01 |
Translate Bio Inc |
Métodos y composiciones para administrar anticuerpos codificados con ARNm
|
|
WO2014144767A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Ion exchange purification of mrna
|
|
EP2971161B1
(en)
|
2013-03-15 |
2018-12-26 |
ModernaTX, Inc. |
Ribonucleic acid purification
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
PT2972360T
(pt)
|
2013-03-15 |
2018-05-25 |
Translate Bio Inc |
Intensificação sinérgica da entrega de ácidos nucleicos via formulações combinadas
|
|
US9315472B2
(en)
|
2013-05-01 |
2016-04-19 |
Massachusetts Institute Of Technology |
1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
|
|
US20160082126A1
(en)
|
2013-05-13 |
2016-03-24 |
Tufts University |
Nanocomplexes for delivery of saporin
|
|
WO2014186348A2
(en)
*
|
2013-05-14 |
2014-11-20 |
Tufts University |
Nanocomplexes of modified peptides or proteins
|
|
EP3011029B1
(en)
|
2013-06-17 |
2019-12-11 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
BR112015031611A2
(pt)
|
2013-06-17 |
2017-12-12 |
Massachusetts Inst Technology |
aplicação, manipulação e otimização de sistemas, métodos e composições para direcionamento e modelação de doenças e distúrbios de células pós-mitóticas
|
|
WO2014204729A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
EP3011031B1
(en)
|
2013-06-17 |
2020-09-30 |
The Broad Institute Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたCRISPR−Cas二重ニッカーゼ系、方法および組成物
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2014210356A1
(en)
*
|
2013-06-26 |
2014-12-31 |
Massachusetts Institute Of Technology |
Multi-tailed lipids and uses thereof
|
|
EA036400B1
(ru)
*
|
2013-06-28 |
2020-11-06 |
Этрис Гмбх |
Композиции для введения рнк в клетки
|
|
HUE056760T2
(hu)
|
2013-07-11 |
2022-03-28 |
Modernatx Inc |
A CRISPR-hez kapcsolódó fehérjéket és a szintetikus SGRNS-ket kódoló szintetikus polinukleotidokat tartalmazó készítmények és felhasználási módjaik
|
|
EP3041938A1
(en)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
US20160194625A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
EP3052106A4
(en)
|
2013-09-30 |
2017-07-19 |
ModernaTX, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
WO2015051169A2
(en)
|
2013-10-02 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
EP3052521A1
(en)
|
2013-10-03 |
2016-08-10 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
|
ES2865699T3
(es)
|
2013-10-22 |
2021-10-15 |
Translate Bio Inc |
Formulaciones de lípidos para la administración de ARN mensajero
|
|
JP6506749B2
(ja)
|
2013-10-22 |
2019-04-24 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
フェニルケトン尿症のためのmRNA療法
|
|
JP6608815B2
(ja)
|
2013-10-22 |
2019-11-20 |
トランスレイト バイオ, インコーポレイテッド |
アルギニノコハク酸合成酵素欠損症のmRNA治療
|
|
JP6893785B2
(ja)
|
2013-10-22 |
2021-06-23 |
トランスレイト バイオ, インコーポレイテッド |
mRNAのCNS送達及びその使用方法
|
|
EP4219699A1
(en)
|
2013-12-12 |
2023-08-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
BR112016013213A2
(pt)
|
2013-12-12 |
2017-12-05 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas
|
|
EP3080261B1
(en)
|
2013-12-12 |
2019-05-22 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders
|
|
EP3079725B1
(en)
|
2013-12-12 |
2019-10-16 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
|
RU2016138020A
(ru)
|
2014-02-26 |
2018-03-29 |
Этрис Гмбх |
Композиции для введения phk в желудочно-кишечный тракт
|
|
LT3116900T
(lt)
|
2014-03-09 |
2020-12-10 |
The Trustees Of The University Of Pennsylvania |
Kompozicijos, naudotinos ornitino transkarbamilazės (otc) nepakankamumo gydymui
|
|
TR201900649T4
(tr)
|
2014-03-24 |
2019-02-21 |
Translate Bio Inc |
Oküler hastalıkların tedavisi için mrna tedavisi.
|
|
US9624191B2
(en)
|
2014-03-24 |
2017-04-18 |
International Business Machines Corporation |
Cyclic carbonate monomers and ring opened polycarbonates therefrom
|
|
US9215876B2
(en)
|
2014-03-24 |
2015-12-22 |
International Business Machines Corporation |
1,3,6-dioxazocan-2-ones and antimicrobial cationic polycarbonates therefrom
|
|
CA3177878A1
(en)
|
2014-04-23 |
2015-10-29 |
Modernatx, Inc. |
Nucleic acid vaccines
|
|
CN106164248B
(zh)
|
2014-04-25 |
2019-10-15 |
川斯勒佰尔公司 |
信使rna的纯化方法
|
|
ES2936810T3
(es)
|
2014-05-16 |
2023-03-22 |
Pfizer |
Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería
|
|
MA48050A
(fr)
|
2014-05-30 |
2020-02-12 |
Translate Bio Inc |
Lipides biodégradables pour l'administration d'acides nucléiques
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
CN116059170A
(zh)
|
2014-06-24 |
2023-05-05 |
川斯勒佰尔公司 |
用于递送核酸的立体化学富集组合物
|
|
CN106456547B
(zh)
|
2014-07-02 |
2021-11-12 |
川斯勒佰尔公司 |
信使rna的包封
|
|
US9840479B2
(en)
|
2014-07-02 |
2017-12-12 |
Massachusetts Institute Of Technology |
Polyamine-fatty acid derived lipidoids and uses thereof
|
|
EP3169693B1
(en)
|
2014-07-16 |
2022-03-09 |
ModernaTX, Inc. |
Chimeric polynucleotides
|
|
WO2016014846A1
(en)
|
2014-07-23 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of intrabodies
|
|
US10736966B2
(en)
|
2014-08-12 |
2020-08-11 |
Massachusetts Institute Of Technology |
Brush-poly (glycoamidoamine)-lipids and uses thereof
|
|
GB201414464D0
(en)
|
2014-08-14 |
2014-10-01 |
Technion Res & Dev Foundation |
Compositions and methods for therapeutics prescreening
|
|
ES2780904T3
(es)
|
2014-08-17 |
2020-08-27 |
Broad Inst Inc |
Edición genómica usando nickasas Cas9
|
|
US10060921B2
(en)
|
2014-08-29 |
2018-08-28 |
Alnylam Pharmaceuticals, Inc. |
Methods of treating transthyretin (TTR) mediated amyloidosis
|
|
US9339029B2
(en)
|
2014-09-04 |
2016-05-17 |
Preceres Inc. |
Hydrazinyl lipidoids and uses thereof
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
US12263229B2
(en)
|
2014-11-10 |
2025-04-01 |
Ethris Gmbh |
Induction of osteogenesis by delivering BMP encoding RNA
|
|
AU2015357562B2
(en)
|
2014-12-05 |
2021-10-21 |
Translate Bio, Inc. |
Messenger RNA therapy for treatment of articular disease
|
|
WO2016094342A1
(en)
|
2014-12-08 |
2016-06-16 |
The Board Of Regents Of The University Of Texas System |
Lipocationic polymers and uses thereof
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3985115A1
(en)
|
2014-12-12 |
2022-04-20 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
EP3034539A1
(en)
|
2014-12-19 |
2016-06-22 |
Ethris GmbH |
Compositions for introducing nucleic acid into cells
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
WO2016118724A1
(en)
*
|
2015-01-21 |
2016-07-28 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
AU2016233135B2
(en)
|
2015-03-19 |
2021-07-08 |
Translate Bio, Inc. |
mRNA therapy for pompe disease
|
|
WO2016168469A1
(en)
*
|
2015-04-17 |
2016-10-20 |
The Regents Of The University Of California |
Fatty acid analogs and methods of use thereof
|
|
EP4026568A1
(en)
|
2015-04-17 |
2022-07-13 |
CureVac Real Estate GmbH |
Lyophilization of rna
|
|
US20180110877A1
(en)
|
2015-04-27 |
2018-04-26 |
The Trustees Of The University Of Pennsylvania |
DUAL AAV VECTOR SYSTEM FOR CRISPR/Cas9 MEDIATED CORRECTION OF HUMAN DISEASE
|
|
EP3916091A3
(en)
|
2015-05-20 |
2022-03-30 |
CureVac AG |
Dry powder composition comprising long-chain rna
|
|
WO2016184576A2
(en)
|
2015-05-20 |
2016-11-24 |
Curevac Ag |
Dry powder composition comprising long-chain rna
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
RU2752834C2
(ru)
|
2015-06-18 |
2021-08-09 |
Те Брод Инститьют, Инк. |
Мутации фермента crispr, уменьшающие нецелевые эффекты
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
FI3430134T3
(fi)
|
2015-06-18 |
2023-01-13 |
|
Uusia CRISPR-entsyymejä ja järjestelmiä
|
|
CA3012607A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Crispr enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
FI3310764T3
(fi)
|
2015-06-19 |
2023-07-18 |
Massachusetts Inst Technology |
Alkenyylillä substituoidut 2,5-piperatsiinidionit ja niiden käyttö koostumuksissa agenssin kuljettamiseksi subjektille tai soluun
|
|
AU2016286364B2
(en)
|
2015-06-30 |
2022-07-28 |
Ethris Gmbh |
ATP-binding cassette family coding polyribonucleotides and formulations thereof
|
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
KR20240074895A
(ko)
|
2015-07-31 |
2024-05-28 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴(TTR) iRNA 조성물 및 TTR-관련 질병을 치료하거나, 예방하기 위한 그의 사용 방법
|
|
EP3337908A4
(en)
|
2015-08-18 |
2019-01-23 |
The Broad Institute, Inc. |
METHOD AND COMPOSITIONS FOR CHANGING THE FUNCTION AND STRUCTURE OF CHROMATIN GRINDING AND / OR DOMAINS
|
|
CN108351350B
(zh)
|
2015-08-25 |
2022-02-18 |
杜克大学 |
使用rna指导型内切核酸酶改善基因组工程特异性的组合物和方法
|
|
US10881682B2
(en)
*
|
2015-08-26 |
2021-01-05 |
International Business Machines Corporation |
Therapeutic compositions comprising n-alkyl-hydroxy polymers
|
|
US11247968B2
(en)
|
2015-09-14 |
2022-02-15 |
The Board Of Regents Of The University Of Texas System |
Lipocationic dendrimers and uses thereof
|
|
US11434486B2
(en)
|
2015-09-17 |
2022-09-06 |
Modernatx, Inc. |
Polynucleotides containing a morpholino linker
|
|
WO2017049275A2
(en)
|
2015-09-17 |
2017-03-23 |
Moderna Therapeutics, Inc. |
Polynucleotides containing a stabilizing tail region
|
|
AU2016324310B2
(en)
|
2015-09-17 |
2021-04-08 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
EP3362571A4
(en)
|
2015-10-13 |
2019-07-10 |
Duke University |
GENOM ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS
|
|
CA3002922A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
|
EP3365441A1
(en)
|
2015-10-22 |
2018-08-29 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
|
WO2017074788A1
(en)
|
2015-10-27 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
DK3386484T3
(da)
|
2015-12-10 |
2022-07-04 |
Modernatx Inc |
Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler
|
|
WO2017100744A1
(en)
*
|
2015-12-11 |
2017-06-15 |
Preceres Inc. |
Aminolipidoids and uses thereof
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
EP4036079B1
(en)
|
2015-12-22 |
2025-11-19 |
ModernaTX, Inc. |
Compounds and compositions for intracellular delivery of agents
|
|
WO2017112852A1
(en)
*
|
2015-12-23 |
2017-06-29 |
Preceres Inc. |
Modified polyethyleneimines and uses thereof
|
|
SMT202200310T1
(it)
|
2015-12-23 |
2022-09-14 |
Modernatx Inc |
Metodi di utilizzo dei polinucleotidi codificanti il ligando di ox40
|
|
WO2017120612A1
(en)
|
2016-01-10 |
2017-07-13 |
Modernatx, Inc. |
Therapeutic mrnas encoding anti ctla-4 antibodies
|
|
AU2017248189B2
(en)
|
2016-04-08 |
2021-04-29 |
Translate Bio, Inc. |
Multimeric coding nucleic acid and uses thereof
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
AU2017253089B2
(en)
|
2016-04-19 |
2023-07-20 |
Massachusetts Institute Of Technology |
Novel CRISPR enzymes and systems
|
|
US11286478B2
(en)
|
2016-04-19 |
2022-03-29 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
WO2017189308A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
JP7080826B2
(ja)
|
2016-05-16 |
2022-06-06 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質
|
|
PT3458074T
(pt)
|
2016-05-16 |
2024-08-21 |
Univ Texas |
Composições para a entrega de trna na forma de nanopartículas e métodos de utilização com os mesmos
|
|
CN115837014A
(zh)
|
2016-05-18 |
2023-03-24 |
摩登纳特斯有限公司 |
编码松弛素的多核苷酸
|
|
US12123030B2
(en)
|
2016-05-18 |
2024-10-22 |
Modernatx, Inc. |
Polynucleotides encoding lipoprotein lipase for the treatment of hyperlipidemia
|
|
AU2017271665B2
(en)
|
2016-05-27 |
2023-11-23 |
Transcriptx, Inc. |
Treatment of primary ciliary dyskinesia with synthetic messenger RNA
|
|
US20190336608A1
(en)
|
2016-06-09 |
2019-11-07 |
Curevac Ag |
Cationic carriers for nucleic acid delivery
|
|
CA3023174A1
(en)
*
|
2016-06-09 |
2017-12-14 |
Curevac Ag |
Hybrid carriers for nucleic acid cargo
|
|
EP3842530A1
(en)
|
2016-06-13 |
2021-06-30 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of ornithine transcarbamylase deficiency
|
|
AU2017283713B2
(en)
|
2016-06-17 |
2021-04-08 |
Massachusetts Institute Of Technology |
Type VI CRISPR orthologs and systems
|
|
IL246378A0
(en)
|
2016-06-21 |
2016-11-30 |
Technion Res & Dev Foundation |
A hybrid matrix of polymers that adhere to the mucosa and a lipidic drug release system for the treatment of oral cancer
|
|
WO2018005873A1
(en)
|
2016-06-29 |
2018-01-04 |
The Broad Institute Inc. |
Crispr-cas systems having destabilization domain
|
|
KR101816795B1
(ko)
|
2016-06-30 |
2018-01-10 |
한국화학연구원 |
신규한 3차 아민계 폴리올 및 자가촉매를 이용한 폴리우레탄 합성
|
|
US12214056B2
(en)
|
2016-07-19 |
2025-02-04 |
Duke University |
Therapeutic applications of CPF1-based genome editing
|
|
US20200283743A1
(en)
|
2016-08-17 |
2020-09-10 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
EP4485466A3
(en)
|
2016-08-17 |
2025-04-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
EP3500270A1
(en)
|
2016-08-19 |
2019-06-26 |
Fundación Para La Investigación Biomédica Del Hospital Universitario Ramón Y Cajal |
Mir-127 agents for use in the treatment of renal fibrosis
|
|
JP6778380B2
(ja)
*
|
2016-08-23 |
2020-11-04 |
昭和電工マテリアルズ株式会社 |
吸着材
|
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
WO2018064208A1
(en)
|
2016-09-28 |
2018-04-05 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
EP3528821A4
(en)
|
2016-10-21 |
2020-07-01 |
ModernaTX, Inc. |
HUMAN CYTOMEGALOVIRUS VACCINE
|
|
EP3538067A1
(en)
|
2016-11-08 |
2019-09-18 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
|
CA3041345A1
(en)
|
2016-11-10 |
2018-05-17 |
Shrirang KARVE |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
US11400109B2
(en)
|
2016-11-10 |
2022-08-02 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger RNA
|
|
WO2018104540A1
(en)
|
2016-12-08 |
2018-06-14 |
Curevac Ag |
Rnas for wound healing
|
|
US11464836B2
(en)
|
2016-12-08 |
2022-10-11 |
Curevac Ag |
RNA for treatment or prophylaxis of a liver disease
|
|
US11524066B2
(en)
|
2016-12-23 |
2022-12-13 |
CureVac SE |
Henipavirus vaccine
|
|
WO2018115527A2
(en)
|
2016-12-23 |
2018-06-28 |
Curevac Ag |
Mers coronavirus vaccine
|
|
US11464847B2
(en)
|
2016-12-23 |
2022-10-11 |
Curevac Ag |
Lassa virus vaccine
|
|
US11873496B2
(en)
|
2017-01-09 |
2024-01-16 |
Whitehead Institute For Biomedical Research |
Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops
|
|
DK3585892T3
(da)
|
2017-02-27 |
2022-08-22 |
Translate Bio Inc |
Fremgangsmåder til oprensning af messenger-rna
|
|
AU2018224843B2
(en)
|
2017-02-27 |
2024-08-15 |
Translate Bio, Inc. |
Methods for purification of messenger RNA
|
|
AU2018224326B2
(en)
|
2017-02-27 |
2024-01-04 |
Translate Bio, Inc. |
Novel codon-optimized CFTR mRNA
|
|
JOP20190200A1
(ar)
|
2017-02-28 |
2019-08-27 |
Univ Pennsylvania |
تركيبات نافعة في معالجة ضمور العضل النخاعي
|
|
LT3589730T
(lt)
|
2017-02-28 |
2024-03-12 |
The Trustees Of The University Of Pennsylvania |
Adenoasocijuoto viruso (aav) monofiletinės grupės f vektorius, ir jo panaudojimo būdai
|
|
RU2019130004A
(ru)
|
2017-03-01 |
2021-04-01 |
Зе Трастис Оф Зе Юниверсити Оф Пеннсильвания |
Генная терапия при глазных заболеваниях
|
|
US10961184B2
(en)
|
2017-03-07 |
2021-03-30 |
Translate Bio, Inc. |
Polyanionic delivery of nucleic acids
|
|
SI3596041T1
(sl)
|
2017-03-15 |
2023-02-28 |
Modernatx, Inc. |
Spojina in sestavki za intracelično dostavljanje terapevtskih sredstev
|
|
JP7332478B2
(ja)
|
2017-03-15 |
2023-08-23 |
モデルナティエックス インコーポレイテッド |
脂質ナノ粒子製剤
|
|
SI3596042T1
(sl)
|
2017-03-15 |
2022-04-29 |
Modernatx, Inc. |
Kristalne oblike amino lipidov
|
|
KR102454284B1
(ko)
|
2017-03-15 |
2022-10-12 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규 cas13b 오르소로그 crispr 효소 및 시스템
|
|
WO2018167320A1
(en)
|
2017-03-17 |
2018-09-20 |
Curevac Ag |
Rna vaccine and immune checkpoint inhibitors for combined anticancer therapy
|
|
MX2019011215A
(es)
|
2017-03-24 |
2020-02-12 |
Curevac Ag |
Ácidos nucleicos que codifican proteínas asociadas a crispr y usos de los mismos.
|
|
BR112019021378A2
(pt)
|
2017-04-12 |
2020-05-05 |
Massachusetts Inst Technology |
ortólogos de crispr tipo vi inovadores e sistemas
|
|
US12350368B2
(en)
|
2017-04-14 |
2025-07-08 |
The Broad Institute, Inc. |
Delivery of large payloads
|
|
EP3634986A4
(en)
|
2017-04-24 |
2021-09-08 |
The Trustees of The University of Pennsylvania |
GENE THERAPY FOR EYE DISORDERS
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
CA3061655A1
(en)
|
2017-05-11 |
2018-11-15 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for neuronal ceroid lipofuscinoses
|
|
CA3063531A1
(en)
|
2017-05-16 |
2018-11-22 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
|
|
EP3625345B1
(en)
|
2017-05-18 |
2023-05-24 |
ModernaTX, Inc. |
Modified messenger rna comprising functional rna elements
|
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11421011B2
(en)
|
2017-05-18 |
2022-08-23 |
Modernatx, Inc. |
Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof
|
|
EP3630986A4
(en)
|
2017-05-31 |
2021-08-11 |
The Trustees of The University of Pennsylvania |
GENE THERAPY FOR TREATMENT OF PEROXISOMAL DISEASES
|
|
EP3638678B1
(en)
|
2017-06-14 |
2025-12-03 |
ModernaTX, Inc. |
Compounds and compositions for intracellular delivery of agents
|
|
EP3638292A1
(en)
|
2017-06-14 |
2020-04-22 |
ModernaTX, Inc. |
Polynucleotides encoding coagulation factor viii
|
|
WO2018232357A1
(en)
|
2017-06-15 |
2018-12-20 |
Modernatx, Inc. |
Rna formulations
|
|
US10780183B2
(en)
|
2017-06-19 |
2020-09-22 |
Translate Bio, Inc. |
Messenger RNA therapy for the treatment of Friedreich's ataxia
|
|
EP4494652A3
(en)
|
2017-07-04 |
2025-05-14 |
CureVac SE |
Cancer rna-vaccine
|
|
US11602557B2
(en)
|
2017-08-22 |
2023-03-14 |
Cure Vac SE |
Bunyavirales vaccine
|
|
MX2020002348A
(es)
|
2017-08-31 |
2020-10-08 |
Modernatx Inc |
Métodos de elaboración de nanopartículas lipídicas.
|
|
GB201714430D0
(en)
|
2017-09-07 |
2017-10-25 |
Micol Romain |
Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue
|
|
KR20250046363A
(ko)
|
2017-09-19 |
2025-04-02 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법
|
|
AU2018338318B2
(en)
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
EP3697912A1
(en)
|
2017-10-19 |
2020-08-26 |
CureVac AG |
Novel artificial nucleic acid molecules
|
|
US12227742B2
(en)
|
2017-10-23 |
2025-02-18 |
The Broad Institute, Inc. |
Nucleic acid modifiers
|
|
US11547614B2
(en)
|
2017-10-31 |
2023-01-10 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
US12018080B2
(en)
|
2017-11-13 |
2024-06-25 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway
|
|
EP3710583A1
(en)
|
2017-11-16 |
2020-09-23 |
Astrazeneca AB |
Compositions and methods for improving the efficacy of cas9-based knock-in strategies
|
|
JP7423521B2
(ja)
|
2017-11-22 |
2024-01-29 |
モダーナティエックス・インコーポレイテッド |
フェニルケトン尿症の治療用のフェニルアラニンヒドロキシラーゼをコードするポリヌクレオチド
|
|
US11859215B2
(en)
|
2017-11-22 |
2024-01-02 |
Modernatx, Inc. |
Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
|
|
JP7424976B2
(ja)
|
2017-11-22 |
2024-01-30 |
モダーナティエックス・インコーポレイテッド |
プロピオン酸血症の治療用のプロピオニルCoAカルボキシラーゼアルファ及びベータサブユニットをコードするポリヌクレオチド
|
|
BR112020010735A2
(pt)
|
2017-11-30 |
2020-11-10 |
The Trustees Of The University Of Pennsylvania |
terapia genética para mucopolissacaridose iii a
|
|
KR20200104864A
(ko)
|
2017-11-30 |
2020-09-04 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
뮤코다당류증 iiib형에 대한 유전자 요법
|
|
WO2019110067A1
(en)
*
|
2017-12-07 |
2019-06-13 |
Aarhus Universitet |
Hybrid nanoparticle
|
|
US11931406B2
(en)
|
2017-12-13 |
2024-03-19 |
CureVac SE |
Flavivirus vaccine
|
|
US11167043B2
(en)
|
2017-12-20 |
2021-11-09 |
Translate Bio, Inc. |
Composition and methods for treatment of ornithine transcarbamylase deficiency
|
|
EP3728575A4
(en)
|
2017-12-22 |
2021-11-24 |
The Broad Institute, Inc. |
CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF DNA BASES
|
|
WO2019136241A1
(en)
|
2018-01-05 |
2019-07-11 |
Modernatx, Inc. |
Polynucleotides encoding anti-chikungunya virus antibodies
|
|
WO2019152802A1
(en)
|
2018-02-02 |
2019-08-08 |
Translate Bio, Inc. |
Cationic polymers
|
|
CA3091543A1
(en)
|
2018-02-19 |
2019-08-22 |
Combined Therapeutics, Inc. |
Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids
|
|
JP6887020B2
(ja)
|
2018-03-16 |
2021-06-16 |
株式会社東芝 |
生分解性化合物、脂質粒子、脂質粒子を含む組成物、およびキット
|
|
US10968257B2
(en)
|
2018-04-03 |
2021-04-06 |
The Broad Institute, Inc. |
Target recognition motifs and uses thereof
|
|
US20210361761A1
(en)
|
2018-04-05 |
2021-11-25 |
Curevac Ag |
Novel yellow fever nucleic acid molecules for vaccination
|
|
EP3773745A1
(en)
|
2018-04-11 |
2021-02-17 |
ModernaTX, Inc. |
Messenger rna comprising functional rna elements
|
|
KR20210003811A
(ko)
|
2018-04-17 |
2021-01-14 |
큐어백 아게 |
백신 접종을 위한 신규 rsv rna 분자 및 조성물
|
|
CN112153986B
(zh)
|
2018-04-25 |
2024-02-09 |
埃泽瑞斯公司 |
用于递送rna的脂质基制剂
|
|
EP3793689A1
(en)
|
2018-05-15 |
2021-03-24 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger rna
|
|
CN112384523B
(zh)
|
2018-05-16 |
2025-03-14 |
川斯勒佰尔公司 |
核糖阳离子脂质
|
|
WO2019226650A1
(en)
|
2018-05-23 |
2019-11-28 |
Modernatx, Inc. |
Delivery of dna
|
|
AU2019275068B2
(en)
|
2018-05-24 |
2024-09-26 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
MA52766A
(fr)
|
2018-05-30 |
2021-04-14 |
Translate Bio Inc |
Lipides cationiques vitaminiques
|
|
US20200016274A1
(en)
|
2018-05-30 |
2020-01-16 |
Translate Bio, Inc. |
Messenger rna vaccines and uses thereof
|
|
WO2019232097A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Phosphoester cationic lipids
|
|
EP4442831A3
(en)
|
2018-05-30 |
2024-10-30 |
Translate Bio, Inc. |
Cationic lipids comprising a steroidal moiety
|
|
US12357580B2
(en)
|
2018-06-19 |
2025-07-15 |
The Board Of Regents Of The University Of Texas System |
Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
|
|
EP3813874A1
(en)
|
2018-06-27 |
2021-05-05 |
CureVac AG |
Novel lassa virus rna molecules and compositions for vaccination
|
|
CA3107055A1
(en)
|
2018-07-23 |
2020-01-30 |
Translate Bio, Inc. |
Dry powder formulations for messenger rna
|
|
US20220184185A1
(en)
|
2018-07-25 |
2022-06-16 |
Modernatx, Inc. |
Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
|
|
WO2020028729A1
(en)
|
2018-08-01 |
2020-02-06 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
|
JP2021532815A
(ja)
|
2018-08-07 |
2021-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新規Cas12b酵素およびシステム
|
|
US20210317461A1
(en)
|
2018-08-09 |
2021-10-14 |
Verseau Therapeutics, Inc. |
Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
|
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
|
EP3841205A4
(en)
|
2018-08-22 |
2022-08-17 |
The Regents of The University of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
CA3108544A1
(en)
|
2018-08-24 |
2020-02-27 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
US20210317527A1
(en)
|
2018-08-27 |
2021-10-14 |
The Regents Of The University Of California |
Reporter nucleic acids for type v crispr-mediated detection
|
|
EP3843709A1
(en)
|
2018-08-29 |
2021-07-07 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
CA3110686C
(en)
|
2018-08-29 |
2025-11-04 |
Ecolab Usa Inc. |
IONIC COMPOUNDS WITH MULTIPLE CHARGES DERIVED FROM POLYAMINES AND COMPOSITIONS BASED ON THESE COMPOUNDS AND ASSOCIATED PREPARATION PROCESSES
|
|
WO2020047467A2
(en)
|
2018-08-30 |
2020-03-05 |
Tenaya Therapeutics, Inc. |
Cardiac cell reprogramming with myocardin and ascl1
|
|
EP3846776A1
(en)
|
2018-09-02 |
2021-07-14 |
ModernaTX, Inc. |
Polynucleotides encoding very long-chain acyl-coa dehydrogenase for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
|
EP3846857A4
(en)
|
2018-09-04 |
2022-10-12 |
The Board Of Regents Of The University Of Texas System |
COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS
|
|
EP3846822A4
(en)
|
2018-09-04 |
2022-07-06 |
The Board Of Regents Of The University Of Texas System |
COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS
|
|
CN112654702B
(zh)
|
2018-09-07 |
2025-05-13 |
阿斯利康(瑞典)有限公司 |
改进的核酸酶的组合物和方法
|
|
US20230009009A1
(en)
|
2018-09-13 |
2023-01-12 |
Modernatx, Inc. |
Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease
|
|
EP3849594A2
(en)
|
2018-09-13 |
2021-07-21 |
Modernatx, Inc. |
Polynucleotides encoding branched-chain alpha-ketoacid dehydrogenase complex e1-alpha, e1-beta, and e2 subunits for the treatment of maple syrup urine disease
|
|
EP3849617A1
(en)
|
2018-09-14 |
2021-07-21 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
|
AU2019339430A1
(en)
|
2018-09-14 |
2021-04-29 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide A1 for the treatment of Crigler-Najjar Syndrome
|
|
EP3852813A4
(en)
|
2018-09-18 |
2022-06-22 |
VNV Newco Inc. |
ARC-BASED CAPSIDS AND THEIR USES
|
|
JP7410135B2
(ja)
|
2018-09-19 |
2024-01-09 |
モデルナティエックス インコーポレイテッド |
治療薬の細胞内送達のための化合物及び組成物
|
|
EP4509118A3
(en)
|
2018-09-19 |
2025-05-14 |
ModernaTX, Inc. |
High-purity peg lipids and uses thereof
|
|
WO2020061284A1
(en)
|
2018-09-19 |
2020-03-26 |
Modernatx, Inc. |
Peg lipids and uses thereof
|
|
JP2022501367A
(ja)
|
2018-09-20 |
2022-01-06 |
モデルナティエックス インコーポレイテッドModernaTX, Inc. |
脂質ナノ粒子の調製及びその投与方法
|
|
WO2020069169A1
(en)
|
2018-09-27 |
2020-04-02 |
Modernatx, Inc. |
Polynucleotides encoding arginase 1 for the treatment of arginase deficiency
|
|
US20210378962A1
(en)
|
2018-10-19 |
2021-12-09 |
Translate Bio, Inc. |
Pumpless encapsulation of messenger rna
|
|
US20220001026A1
(en)
|
2018-11-08 |
2022-01-06 |
Modernatx, Inc. |
Use of mrna encoding ox40l to treat cancer in human patients
|
|
CA3115119A1
(en)
|
2018-11-08 |
2020-05-14 |
Translate Bio, Inc. |
Methods and compositions for messenger rna purification
|
|
AU2019377525B2
(en)
|
2018-11-09 |
2025-10-16 |
Translate Bio, Inc. |
Multi-PEG lipid compounds
|
|
US12460189B2
(en)
|
2018-11-09 |
2025-11-04 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
EP3877368A1
(en)
|
2018-11-09 |
2021-09-15 |
Translate Bio, Inc. |
2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities
|
|
WO2020097511A2
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
|
WO2020097379A2
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
|
WO2020102172A2
(en)
|
2018-11-12 |
2020-05-22 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
|
AU2019384557B2
(en)
|
2018-11-21 |
2025-07-17 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR
|
|
CA3119976A1
(en)
|
2018-11-21 |
2020-05-28 |
Translate Bio, Inc. |
Cationic lipid compounds
|
|
TW202039534A
(zh)
|
2018-12-14 |
2020-11-01 |
美商美國禮來大藥廠 |
KRAS變體mRNA分子
|
|
BR112021009422A2
(pt)
|
2018-12-21 |
2021-10-26 |
Curevac Ag |
Rna para vacinas contra malária
|
|
WO2020142754A2
(en)
|
2019-01-04 |
2020-07-09 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
|
EP3908597A1
(en)
|
2019-01-07 |
2021-11-17 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
CA3125511A1
(en)
|
2019-02-08 |
2020-08-13 |
Curevac Ag |
Coding rna administered into the suprachoroidal space in the treatment of ophthalmic diseases
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
WO2020181101A1
(en)
|
2019-03-07 |
2020-09-10 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
WO2020186213A1
(en)
|
2019-03-14 |
2020-09-17 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US20220177863A1
(en)
|
2019-03-18 |
2022-06-09 |
The Broad Institute, Inc. |
Type vii crispr proteins and systems
|
|
CA3136427C
(en)
|
2019-04-16 |
2023-10-24 |
Ecolab Usa Inc. |
Use of multiple charged cationic compounds derived from polyamines and compositions thereof for corrosion inhibition in a water system
|
|
US20220177423A1
(en)
|
2019-04-18 |
2022-06-09 |
Translate Bio, Inc. |
Cystine cationic lipids
|
|
US20220233444A1
(en)
|
2019-04-22 |
2022-07-28 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
WO2020227085A1
(en)
|
2019-05-03 |
2020-11-12 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
|
CN114375190A
(zh)
|
2019-05-08 |
2022-04-19 |
阿斯利康(瑞典)有限公司 |
用于皮肤和伤口的组合物及其使用方法
|
|
WO2020232276A1
(en)
|
2019-05-14 |
2020-11-19 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
US20220220469A1
(en)
|
2019-05-20 |
2022-07-14 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
WO2020237227A1
(en)
|
2019-05-22 |
2020-11-26 |
Massachusetts Institute Of Technology |
Circular rna compositions and methods
|
|
US20220226244A1
(en)
|
2019-05-31 |
2022-07-21 |
Translate Bio, Inc. |
Macrocyclic lipids
|
|
US20220313813A1
(en)
|
2019-06-18 |
2022-10-06 |
Curevac Ag |
Rotavirus mrna vaccine
|
|
EP3986858A1
(en)
|
2019-06-21 |
2022-04-27 |
Translate Bio, Inc. |
Tricine and citric acid lipids
|
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
|
WO2020263883A1
(en)
|
2019-06-24 |
2020-12-30 |
Modernatx, Inc. |
Endonuclease-resistant messenger rna and uses thereof
|
|
MA56517A
(fr)
|
2019-06-24 |
2022-04-27 |
Modernatx Inc |
Arn messager comprenant des éléments d'arn fonctionnels et leurs utilisations
|
|
ES2992127T3
(es)
|
2019-07-08 |
2024-12-09 |
Translate Bio Inc |
Nanopartículas lipídicas cargadas de ARNm mejoradas y sus procesos de fabricación
|
|
US20230137971A1
(en)
|
2019-07-11 |
2023-05-04 |
Tenaya Therapeutics Inc. |
Cardiac cell reprogramming with micrornas and other factors
|
|
JP7764363B2
(ja)
|
2019-07-23 |
2025-11-05 |
トランスレイト バイオ, インコーポレイテッド |
mRNA担持脂質ナノ粒子の安定性組成物および作製のプロセス
|
|
CA3148819A1
(en)
|
2019-07-30 |
2021-02-04 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
|
|
WO2021028439A1
(en)
|
2019-08-14 |
2021-02-18 |
Curevac Ag |
Rna combinations and compositions with decreased immunostimulatory properties
|
|
CN115023499A
(zh)
|
2019-08-16 |
2022-09-06 |
麻省理工学院 |
使用CRISPR/Cas13的靶向反式剪接
|
|
AU2020350759A1
(en)
|
2019-09-19 |
2022-03-31 |
Modernatx, Inc. |
Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
|
|
US20240197825A1
(en)
|
2019-09-20 |
2024-06-20 |
Translate Bio, Inc. |
mRNA Encoding Engineered CFTR
|
|
AU2020348872A1
(en)
|
2019-09-20 |
2022-04-14 |
Massachusetts Institute Of Technology |
Compositions and methods for delivering cargo to a target cell
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
CN114728176A
(zh)
|
2019-10-09 |
2022-07-08 |
川斯勒佰尔公司 |
信使rna的组合物、方法和使用
|
|
WO2021077066A1
(en)
*
|
2019-10-18 |
2021-04-22 |
The Trustees Of The University Of Pennsylvania |
Lipid and lipid nanoparticle formulation for drug delivery
|
|
EP4045021A4
(en)
*
|
2019-10-18 |
2024-02-21 |
The Trustees of the University of Pennsylvania |
LIPID NANOPARTICLES AND FORMULATIONS THEREOF FOR DELIVERY OF CAR MRNA
|
|
CN115279418A
(zh)
|
2019-10-21 |
2022-11-01 |
川斯勒佰尔公司 |
信使rna的组合物、方法和用途
|
|
CA3160739A1
(en)
|
2019-12-04 |
2021-06-10 |
Brian Goodman |
Circular rna compositions and methods
|
|
BR112022012085A2
(pt)
|
2019-12-20 |
2022-08-30 |
Translate Bio Inc |
Adminstração retal de rna mensageiro
|
|
EP4076400A1
(en)
|
2019-12-20 |
2022-10-26 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
|
KR102198736B1
(ko)
*
|
2020-01-15 |
2021-01-05 |
이화여자대학교 산학협력단 |
생체 내 약물 전달을 위한 지질 나노입자 및 이의 용도
|
|
US20230285297A1
(en)
*
|
2020-01-31 |
2023-09-14 |
Modernatx, Inc. |
Methods of preparing lipid nanoparticles
|
|
DE112021000012C9
(de)
|
2020-02-04 |
2025-02-06 |
CureVac SE |
Coronavirus-Vakzine
|
|
EP4110296A1
(en)
|
2020-02-25 |
2023-01-04 |
Translate Bio, Inc. |
Improved processes of preparing mrna-loaded lipid nanoparticles
|
|
AU2021230476A1
(en)
|
2020-03-02 |
2022-10-20 |
Tenaya Therapeutics, Inc. |
Gene vector control by cardiomyocyte-expressed microRNAs
|
|
US11773391B2
(en)
|
2020-04-01 |
2023-10-03 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Therapeutic and diagnostic target for SARS-CoV-2 and COVID-19
|
|
EP4133069A2
(en)
|
2020-04-08 |
2023-02-15 |
Astrazeneca AB |
Compositions and methods for improved site-specific modification
|
|
EP4146342A1
(en)
|
2020-05-07 |
2023-03-15 |
Translate Bio, Inc. |
Improved compositions for cftr mrna therapy
|
|
JP2023524767A
(ja)
|
2020-05-07 |
2023-06-13 |
トランスレイト バイオ, インコーポレイテッド |
SARS-CoV-2抗原をコードする最適化されたヌクレオチド配列
|
|
EP4146680A1
(en)
|
2020-05-07 |
2023-03-15 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
CN115803064A
(zh)
|
2020-05-12 |
2023-03-14 |
宾夕法尼亚州大学信托人 |
用于drg特异性降低转基因表达的组合物
|
|
EP4149556B1
(en)
|
2020-05-14 |
2026-01-07 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
|
EP4149425A1
(en)
|
2020-05-15 |
2023-03-22 |
Translate Bio, Inc. |
Lipid nanoparticle formulations for mrna delivery
|
|
US20240042015A1
(en)
|
2020-05-19 |
2024-02-08 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
CN116322760A
(zh)
|
2020-05-20 |
2023-06-23 |
旗舰创业创新第六有限责任公司 |
冠状病毒抗原组合物及其用途
|
|
US20230193311A1
(en)
|
2020-05-20 |
2023-06-22 |
Flagship Pioneering Innovations Vi, Llc |
Immunogenic compositions and uses thereof
|
|
US20230203510A1
(en)
|
2020-05-29 |
2023-06-29 |
Flagship Pioneering Innovations Vi, Llc |
Trem compositions and methods relating thereto
|
|
WO2021243301A2
(en)
|
2020-05-29 |
2021-12-02 |
Flagship Pioneering Innovations Vi, Llc. |
Trem compositions and methods relating thereto
|
|
AU2021279312A1
(en)
|
2020-05-29 |
2022-12-15 |
CureVac SE |
Nucleic acid based combination vaccines
|
|
WO2021247507A1
(en)
|
2020-06-01 |
2021-12-09 |
Modernatx, Inc. |
Phenylalanine hydroxylase variants and uses thereof
|
|
AU2021292200A1
(en)
|
2020-06-17 |
2023-02-02 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of gene therapy patients
|
|
WO2025056938A1
(en)
|
2023-09-11 |
2025-03-20 |
BioNTech SE |
Rna compositions for delivery of incretin agents
|
|
WO2022006527A1
(en)
|
2020-07-02 |
2022-01-06 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
|
KR20230038503A
(ko)
|
2020-07-13 |
2023-03-20 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
샤르코-마리-투스 질환의 치료에 유용한 조성물
|
|
EP4172194A1
(en)
|
2020-07-31 |
2023-05-03 |
CureVac SE |
Nucleic acid encoded antibody mixtures
|
|
US11406703B2
(en)
|
2020-08-25 |
2022-08-09 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
|
US20240066114A1
(en)
|
2020-08-31 |
2024-02-29 |
CureVac SE |
Multivalent nucleic acid based coronavirus vaccines
|
|
MX2023002439A
(es)
|
2020-09-03 |
2023-05-09 |
Flagship Pioneering Innovations Vi Llc |
Composiciones immunogénicas y usos de las mismas.
|
|
WO2022076562A1
(en)
|
2020-10-06 |
2022-04-14 |
Translate Bio, Inc. |
Improved process and formulation of lipid nanoparticles
|
|
WO2022076582A1
(en)
|
2020-10-07 |
2022-04-14 |
Regenxbio Inc. |
Gene therapy for ocular manifestations of cln2 disease
|
|
WO2022076669A1
(en)
|
2020-10-09 |
2022-04-14 |
Board Of Regents, The University Of Texas System |
Prefusion-stabilized hmpv f proteins
|
|
TW202229560A
(zh)
|
2020-10-09 |
2022-08-01 |
賓州大學委員會 |
治療法布瑞氏症之組成物及方法
|
|
US20220133631A1
(en)
|
2020-10-12 |
2022-05-05 |
Translate Bio, Inc. |
Process of preparing ice-based lipid nanoparticles
|
|
CN116490166A
(zh)
|
2020-10-12 |
2023-07-25 |
翻译生物公司 |
制备加载mRNA的脂质纳米颗粒的改进方法
|
|
US20220160633A1
(en)
|
2020-11-09 |
2022-05-26 |
Translate Bio, Inc. |
Compositions for delivery of codon-optimized mrna
|
|
CA3199784A1
(en)
|
2020-11-13 |
2022-05-19 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
|
WO2022115547A1
(en)
|
2020-11-25 |
2022-06-02 |
Translate Bio, Inc. |
Stable liquid lipid nanoparticle formulations
|
|
EP4255500A1
(en)
|
2020-12-01 |
2023-10-11 |
The Trustees of The University of Pennsylvania |
Compositions and uses thereof for treatment of angelman syndrome
|
|
JP2023551903A
(ja)
|
2020-12-01 |
2023-12-13 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組織特異的標的化モチーフを有する新規組成物及びそれを含有する組成物
|
|
IL303434A
(en)
*
|
2020-12-07 |
2023-08-01 |
Tufts College |
Lipidoid preparations and methods of using them
|
|
CA3171051A1
(en)
|
2020-12-22 |
2022-06-30 |
Curevac Ag |
Pharmaceutical composition comprising lipid-based carriers encapsulating rna for multidose administration
|
|
WO2022137133A1
(en)
|
2020-12-22 |
2022-06-30 |
Curevac Ag |
Rna vaccine against sars-cov-2 variants
|
|
IL303886A
(en)
|
2020-12-23 |
2023-08-01 |
Flagship Pioneering Inc |
Compositions of modified trems and uses thereof
|
|
CA3196789A1
(en)
*
|
2020-12-23 |
2022-06-30 |
Ashish Dhawan |
Non-cationic softeners and methods of use
|
|
CA3205397A1
(en)
*
|
2020-12-24 |
2022-06-30 |
EnhancedBio Inc. |
Composition for preventing or treating cancer, containing lipid nanoparticles
|
|
CN116981692A
(zh)
|
2021-01-14 |
2023-10-31 |
翻译生物公司 |
递送mRNA编码的抗体的方法和组合物
|
|
AU2022208435A1
(en)
|
2021-01-18 |
2023-08-10 |
Conserv Bioscience Limited |
Coronavirus immunogenic compositions, methods and uses thereof
|
|
EP4087938A2
(en)
|
2021-01-27 |
2022-11-16 |
CureVac AG |
Method of reducing the immunostimulatory properties of in vitro transcribed rna
|
|
EP4284335A1
(en)
|
2021-02-01 |
2023-12-06 |
RegenxBio Inc. |
Gene therapy for neuronal ceroid lipofuscinoses
|
|
AU2021425941A1
(en)
|
2021-02-08 |
2023-08-17 |
The Board Of Regents Of The University Of Texas System |
Unsaturated dendrimers compositions,related formulations, and methods of use thereof
|
|
US11524023B2
(en)
|
2021-02-19 |
2022-12-13 |
Modernatx, Inc. |
Lipid nanoparticle compositions and methods of formulating the same
|
|
US20240189446A1
(en)
|
2021-02-23 |
2024-06-13 |
Poseida Therapeutics, Inc. |
Compositions and methods for delivery of nucleic acids
|
|
CA3209032A1
(en)
|
2021-02-26 |
2022-09-01 |
Ethris Gmbh |
Formulations for aerosol formation and aerosols for the delivery of nucleic acid
|
|
WO2022204219A1
(en)
|
2021-03-22 |
2022-09-29 |
Recode Therapeutics, Inc. |
Compositions and methods for targeted delivery to cells
|
|
KR20230175196A
(ko)
|
2021-03-23 |
2023-12-29 |
리코드 테라퓨틱스, 인크. |
폴리뉴클레오티드 조성물, 관련된 제제, 및 이의 사용 방법
|
|
WO2022204390A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
|
|
WO2022204371A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
|
|
US20240216288A1
(en)
|
2021-03-24 |
2024-07-04 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
|
|
JP2024512026A
(ja)
|
2021-03-24 |
2024-03-18 |
モデルナティエックス インコーポレイテッド |
オルニチントランスカルバミラーゼ欠損症の治療を目的とした脂質ナノ粒子及びオルニチントランスカルバミラーゼをコードするポリヌクレオチド
|
|
US20240226025A1
(en)
|
2021-03-24 |
2024-07-11 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
|
|
WO2022204549A1
(en)
|
2021-03-25 |
2022-09-29 |
Translate Bio, Inc. |
Optimized nucleotide sequences encoding the extracellular domain of human ace2 protein or a portion thereof
|
|
CN117377491A
(zh)
|
2021-03-26 |
2024-01-09 |
葛兰素史克生物有限公司 |
免疫原性组合物
|
|
US20220325287A1
(en)
|
2021-03-31 |
2022-10-13 |
Flagship Pioneering Innovations V, Inc. |
Thanotransmission polypeptides and their use in treating cancer
|
|
WO2022207862A2
(en)
|
2021-03-31 |
2022-10-06 |
Curevac Ag |
Syringes containing pharmaceutical compositions comprising rna
|
|
EP4320234A2
(en)
|
2021-04-07 |
2024-02-14 |
Astrazeneca AB |
Compositions and methods for site-specific modification
|
|
KR20230170022A
(ko)
|
2021-04-12 |
2023-12-18 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
척수 및 연수 근위축증(sbma) 치료에 유용한 조성물
|
|
AU2022261865A1
(en)
|
2021-04-19 |
2023-11-30 |
Translate Bio, Inc. |
Improved compositions for delivery of mrna
|
|
EP4326886A4
(en)
|
2021-04-22 |
2025-04-30 |
The Board Of Regents Of The University Of Texas System |
All-in-one dendrimer-based lipid nanoparticulates for precise HDR-mediated gene editing in vivo
|
|
MX2023012513A
(es)
|
2021-04-23 |
2023-12-15 |
Univ Pennsylvania |
Nuevas composiciones con motivos selectivos para el cerebro y composiciones que las contienen.
|
|
EP4083227A1
(en)
|
2021-04-29 |
2022-11-02 |
4basebio, S.L.U. |
Linear dna with enhanced resistance against exonucleases
|
|
CA3171589A1
(en)
|
2021-05-03 |
2022-11-03 |
Moritz THRAN |
Improved nucleic acid sequence for cell type specific expression
|
|
WO2022247755A1
(en)
|
2021-05-24 |
2022-12-01 |
Suzhou Abogen Biosciences Co., Ltd. |
Lipid compounds and lipid nanoparticle compositions
|
|
WO2022248645A1
(en)
|
2021-05-27 |
2022-12-01 |
Astrazeneca Ab |
Cas9 effector proteins with enhanced stability
|
|
CA3215963A1
(en)
|
2021-05-28 |
2022-12-01 |
Yaoxin LIN |
Lipid compound and use thereof in delivery of nucleic acid
|
|
IL309247A
(en)
*
|
2021-06-14 |
2024-02-01 |
Flagship Pioneering Innovations Vi Llc |
Modification of plant messenger packs
|
|
EP4355882A2
(en)
|
2021-06-15 |
2024-04-24 |
Modernatx, Inc. |
Engineered polynucleotides for cell-type or microenvironment-specific expression
|
|
WO2022271776A1
(en)
|
2021-06-22 |
2022-12-29 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
|
|
JP2024527541A
(ja)
|
2021-07-01 |
2024-07-25 |
トランスレイト バイオ, インコーポレイテッド |
Mrnaの送達のための組成物
|
|
US20240336945A1
(en)
|
2021-07-26 |
2024-10-10 |
Flagship Pioneering Innovations Vi, Llc |
Trem compositions and uses thereof
|
|
WO2023006999A2
(en)
|
2021-07-30 |
2023-02-02 |
CureVac SE |
Mrnas for treatment or prophylaxis of liver diseases
|
|
EP4381067A1
(en)
|
2021-08-03 |
2024-06-12 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof
|
|
CN115724806B
(zh)
*
|
2021-08-25 |
2025-07-01 |
广州谷森制药有限公司 |
阳离子脂质化合物
|
|
US20240398940A1
(en)
|
2021-09-03 |
2024-12-05 |
CureVac SE |
Novel lipid nanoparticles for delivery of nucleic acids
|
|
US20240398933A1
(en)
|
2021-09-03 |
2024-12-05 |
CureVac SE |
Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine
|
|
CA3229889A1
(en)
|
2021-09-03 |
2023-03-09 |
Glaxosmithkline Biologicals Sa |
Substitution of nucleotide bases in self-amplifying messenger ribonucleic acids
|
|
EP4464783A3
(en)
|
2021-09-17 |
2025-01-22 |
Flagship Pioneering Innovations VI, LLC |
Compositions and methods for producing circular polyribonucleotides
|
|
EP4408436A1
(en)
*
|
2021-09-28 |
2024-08-07 |
The Trustees of The University of Pennsylvania |
Compositions and methods for t cell targeted delivery of therapeutic agents
|
|
US20240392272A1
(en)
|
2021-09-28 |
2024-11-28 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
EP4408996A2
(en)
|
2021-09-30 |
2024-08-07 |
Astrazeneca AB |
Use of inhibitors to increase efficiency of crispr/cas insertions
|
|
EP4408437A4
(en)
*
|
2021-10-01 |
2025-08-27 |
Univ Pennsylvania |
LIPID NANOPARTICLE (LNP) COMPOSITIONS AND METHODS OF USE THEREOF
|
|
EP4408871A1
(en)
|
2021-10-01 |
2024-08-07 |
ModernaTX, Inc. |
Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease
|
|
WO2023059806A1
(en)
|
2021-10-06 |
2023-04-13 |
Massachusetts Institute Of Technology |
Lipid nanoparticles for drug delivery to microglia in the brain
|
|
AR127312A1
(es)
|
2021-10-08 |
2024-01-10 |
Suzhou Abogen Biosciences Co Ltd |
Compuestos lipídicos ycomposiciones de nanopartículas lipídicas
|
|
CN115957187B
(zh)
*
|
2021-10-09 |
2025-08-22 |
北京启辰生生物科技有限公司 |
一种脂质纳米颗粒组合物以及由其制备的药物递送系统
|
|
TW202322826A
(zh)
|
2021-10-18 |
2023-06-16 |
美商旗艦先鋒創新有限責任公司 |
用於純化多核糖核苷酸之組成物及方法
|
|
WO2023073228A1
(en)
|
2021-10-29 |
2023-05-04 |
CureVac SE |
Improved circular rna for expressing therapeutic proteins
|
|
TW202334080A
(zh)
|
2021-11-08 |
2023-09-01 |
美商歐納醫療公司 |
用於遞送環狀聚核苷酸之脂質奈米粒子組合物
|
|
JP2024545572A
(ja)
|
2021-11-10 |
2024-12-10 |
トランスレイト バイオ, インコーポレイテッド |
原発性線毛機能不全の治療のための組成物及び方法
|
|
WO2023087019A2
(en)
|
2021-11-15 |
2023-05-19 |
The Trustees Of The University Of Pennsylvania |
Compositions for drg-specific reduction of transgene expression
|
|
KR20240122785A
(ko)
|
2021-11-24 |
2024-08-13 |
플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 |
면역원성 조성물 및 이의 용도
|
|
AU2022398478A1
(en)
|
2021-11-24 |
2024-06-13 |
Flagship Pioneering Innovations Vi, Llc |
Coronavirus immunogen compositions and their uses
|
|
EP4436983A1
(en)
|
2021-11-24 |
2024-10-02 |
Flagship Pioneering Innovations VI, LLC |
Varicella-zoster virus immunogen compositions and their uses
|
|
US11510975B1
(en)
*
|
2021-11-29 |
2022-11-29 |
Replicate Bioscience, Inc. |
Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses
|
|
WO2023102517A1
(en)
|
2021-12-02 |
2023-06-08 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of fabry disease
|
|
AR128002A1
(es)
|
2021-12-17 |
2024-03-20 |
Flagship Pioneering Innovations Vi Llc |
Métodos de enriquecimiento de rna circular en condiciones desnaturalizantes
|
|
KR20240117149A
(ko)
|
2021-12-22 |
2024-07-31 |
플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 |
폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법
|
|
MX2024007870A
(es)
|
2021-12-23 |
2024-08-15 |
Flagship Pioneering Innovations Vi Llc |
Polirribonucleotidos circulares que codifican polipeptidos antifusogenicos.
|
|
TW202340467A
(zh)
|
2022-01-10 |
2023-10-16 |
賓州大學委員會 |
有用於治療c9orf72介導之病症之組成物及方法
|
|
CN114507195B
(zh)
*
|
2022-01-14 |
2024-02-13 |
华南理工大学 |
一种脂质化合物、包含其的组合物及应用
|
|
WO2023144193A1
(en)
|
2022-01-25 |
2023-08-03 |
CureVac SE |
Mrnas for treatment of hereditary tyrosinemia type i
|
|
IL314324A
(en)
|
2022-01-27 |
2024-09-01 |
BioNTech SE |
Pharmaceutical preparations for administration of herpes simplex virus antigens and related methods
|
|
EP4469091A1
(en)
|
2022-01-28 |
2024-12-04 |
CureVac SE |
Nucleic acid encoded transcription factor inhibitors
|
|
WO2023143601A1
(zh)
*
|
2022-01-30 |
2023-08-03 |
康希诺生物股份公司 |
一种用于核酸递送的新型可电离脂质及其lnp组合物和疫苗
|
|
CN116554042A
(zh)
*
|
2022-01-30 |
2023-08-08 |
康希诺生物股份公司 |
一种用于核酸递送的新型可电离脂质及其lnp组合物和疫苗
|
|
US20250327041A1
(en)
|
2022-02-24 |
2025-10-23 |
Io Biotech Aps |
Nucleotide delivery of cancer therapy
|
|
WO2023183909A2
(en)
|
2022-03-25 |
2023-09-28 |
Modernatx, Inc. |
Polynucleotides encoding fanconi anemia, complementation group proteins for the treatment of fanconi anemia
|
|
KR20240166554A
(ko)
|
2022-03-25 |
2024-11-26 |
세일 바이오메디슨스, 인크. |
신규한 이온화 가능 지질 및 지질 나노입자, 및 이를 사용하는 방법
|
|
AU2023250649A1
(en)
|
2022-04-04 |
2024-11-14 |
The Regents Of The University Of California |
Genetic complementation compositions and methods
|
|
WO2023196634A2
(en)
|
2022-04-08 |
2023-10-12 |
Flagship Pioneering Innovations Vii, Llc |
Vaccines and related methods
|
|
EP4507719A1
(en)
|
2022-04-13 |
2025-02-19 |
Universitat Autònoma de Barcelona |
Treatment of neuromuscular diseases via gene therapy that expresses klotho protein
|
|
WO2023214405A1
(en)
|
2022-05-01 |
2023-11-09 |
Yeda Research And Development Co. Ltd. |
Reexpression of hnf4a to alleviate cancer-associated cachexia
|
|
WO2023220083A1
(en)
|
2022-05-09 |
2023-11-16 |
Flagship Pioneering Innovations Vi, Llc |
Trem compositions and methods of use for treating proliferative disorders
|
|
JP2025516638A
(ja)
|
2022-05-13 |
2025-05-30 |
フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー |
二本鎖dna組成物及び関連する方法
|
|
US20250345407A1
(en)
|
2022-05-25 |
2025-11-13 |
CureVac SE |
Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide
|
|
WO2023242817A2
(en)
|
2022-06-18 |
2023-12-21 |
Glaxosmithkline Biologicals Sa |
Recombinant rna molecules comprising untranslated regions or segments encoding spike protein from the omicron strain of severe acute respiratory coronavirus-2
|
|
EP4544043A1
(en)
|
2022-06-22 |
2025-04-30 |
Flagship Pioneering Innovations VI, LLC |
Compositions of modified trems and uses thereof
|
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
|
US12297285B2
(en)
|
2022-06-24 |
2025-05-13 |
Orna Therapeutics, Inc. |
Circular RNA encoding chimeric antigen receptors targeting BCMA
|
|
WO2024026254A1
(en)
|
2022-07-26 |
2024-02-01 |
Modernatx, Inc. |
Engineered polynucleotides for temporal control of expression
|
|
AU2023320333A1
(en)
|
2022-08-01 |
2025-01-16 |
Flagship Pioneering Innovations Vii, Llc |
Immunomodulatory proteins and related methods
|
|
WO2024035952A1
(en)
|
2022-08-12 |
2024-02-15 |
Remix Therapeutics Inc. |
Methods and compositions for modulating splicing at alternative splice sites
|
|
JP2025529925A
(ja)
|
2022-08-26 |
2025-09-09 |
エスリス ゲーエムベーハー |
安定な脂質またはリピドイドナノ粒子懸濁液
|
|
EP4327829A1
(en)
|
2022-08-26 |
2024-02-28 |
Ethris GmbH |
Stabilization of lipid or lipidoid nanoparticle suspensions
|
|
WO2024049979A2
(en)
|
2022-08-31 |
2024-03-07 |
Senda Biosciences, Inc. |
Novel ionizable lipids and lipid nanoparticles and methods of using the same
|
|
JP2025533541A
(ja)
|
2022-09-23 |
2025-10-07 |
ビオンテック・ソシエタス・エウロパエア |
肝病期抗原の送達のための組成物及び関連方法
|
|
WO2024063788A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of malaria antigens and related methods
|
|
WO2024063789A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of malaria antigens and related methods
|
|
WO2024064934A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of plasmodium csp antigens and related methods
|
|
WO2024068545A1
(en)
|
2022-09-26 |
2024-04-04 |
Glaxosmithkline Biologicals Sa |
Influenza virus vaccines
|
|
EP4598946A1
(en)
|
2022-10-05 |
2025-08-13 |
Flagship Pioneering Innovations V, Inc. |
Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
|
|
WO2024089638A1
(en)
|
2022-10-28 |
2024-05-02 |
Glaxosmithkline Biologicals Sa |
Nucleic acid based vaccine
|
|
WO2024097664A1
(en)
|
2022-10-31 |
2024-05-10 |
Flagship Pioneering Innovations Vi, Llc |
Compositions and methods for purifying polyribonucleotides
|
|
TW202425959A
(zh)
|
2022-11-08 |
2024-07-01 |
美商歐納醫療公司 |
遞送多核苷酸的脂質及奈米顆粒組合物
|
|
TW202434728A
(zh)
|
2022-11-08 |
2024-09-01 |
美商旗艦先鋒創新有限責任公司 |
用於產生環狀多核糖核苷酸的組成物和方法
|
|
WO2024102677A1
(en)
|
2022-11-08 |
2024-05-16 |
Orna Therapeutics, Inc. |
Circular rna compositions
|
|
WO2024102762A1
(en)
|
2022-11-08 |
2024-05-16 |
Orna Therapeutics, Inc. |
Lipids and lipid nanoparticle compositions for delivering polynucleotides
|
|
WO2024102954A1
(en)
|
2022-11-10 |
2024-05-16 |
Massachusetts Institute Of Technology |
Activation induced clipping system (aics)
|
|
EP4622630A1
(en)
|
2022-11-21 |
2025-10-01 |
Translate Bio, Inc. |
Compositions of dry powder formulations of messenger rna and methods of use thereof
|
|
IL321026A
(en)
|
2022-12-08 |
2025-07-01 |
Recode Therapeutics Inc |
Nanoparticle formulations and their uses
|
|
TW202430215A
(zh)
|
2022-12-14 |
2024-08-01 |
美商旗艦先鋒創新有限責任(Vii)公司 |
用於將治療劑遞送至骨之組成物和方法
|
|
EP4633673A1
(en)
|
2022-12-15 |
2025-10-22 |
Sanofi Pasteur Inc. |
Mrna encoding influenza virus-like particle
|
|
AU2023398825A1
(en)
|
2022-12-15 |
2025-06-26 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
AU2023398931A1
(en)
|
2022-12-17 |
2025-07-10 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav mutant vectors with cardiac and skeletal muscle-specific targeting motifs and compositions containing same
|
|
WO2024130070A2
(en)
|
2022-12-17 |
2024-06-20 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof
|
|
CN120456919A
(zh)
|
2022-12-19 |
2025-08-08 |
葛兰素史克生物有限公司 |
乙型肝炎组合物
|
|
AR131438A1
(es)
|
2022-12-20 |
2025-03-19 |
Sanofi Sa |
VACUNA DE ARNm DE RINOVIRUS
|
|
EP4638766A1
(en)
|
2022-12-20 |
2025-10-29 |
NanoCell Therapeutics Holdings B.V. |
Integrating and self-inactivating viral vectors and constructs and uses thereof
|
|
US20240238473A1
(en)
|
2023-01-09 |
2024-07-18 |
Beth Israel Deaconess Medical Center, Inc. |
Recombinant nucleic acid molecules and their use in wound healing
|
|
US20240252520A1
(en)
|
2023-01-09 |
2024-08-01 |
Beth Israel Deaconess Medical Center, Inc. |
Therapeutic agents and their use for treating chronic wounds
|
|
WO2024151586A2
(en)
|
2023-01-09 |
2024-07-18 |
Board Of Regents, The University Of Texas System |
Prefusion-stabilized human parainfluenza virus 3 f proteins
|
|
TW202438673A
(zh)
|
2023-01-09 |
2024-10-01 |
美商旗艦先鋒創新有限責任(Vii)公司 |
疫苗及相關方法
|
|
WO2024151687A1
(en)
|
2023-01-09 |
2024-07-18 |
Flagship Pioneering Innovations V, Inc. |
Genetic switches and their use in treating cancer
|
|
IL322050A
(en)
|
2023-01-27 |
2025-09-01 |
BioNTech SE |
Pharmaceutical compositions for administering herpes simplex virus antigens glycoprotein c, glycoprotein d and glycoprotein e and related methods
|
|
WO2024160936A1
(en)
|
2023-02-03 |
2024-08-08 |
Glaxosmithkline Biologicals Sa |
Rna formulation
|
|
WO2024167885A1
(en)
|
2023-02-06 |
2024-08-15 |
Flagship Pioneering Innovations Vii, Llc |
Immunomodulatory compositions and related methods
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
CN121263425A
(zh)
|
2023-02-13 |
2026-01-02 |
旗舰创业创新第七有限责任公司 |
含可裂解接头的可电离脂质和用于治疗性组合物的脂质载体
|
|
GB202302092D0
(en)
|
2023-02-14 |
2023-03-29 |
Glaxosmithkline Biologicals Sa |
Analytical method
|
|
WO2024173836A2
(en)
|
2023-02-17 |
2024-08-22 |
Flagship Pioneering Innovations Vii, Llc |
Dna compositions comprising modified cytosine
|
|
EP4665405A1
(en)
|
2023-02-17 |
2025-12-24 |
Flagship Pioneering Innovations VII, LLC |
Dna compositions comprising modified uracil
|
|
KR20250153298A
(ko)
|
2023-03-08 |
2025-10-24 |
큐어백 에스이 |
핵산 전달을 위한 신규의 지질 나노입자 제형
|
|
KR20250166967A
(ko)
*
|
2023-03-09 |
2025-11-28 |
맥시알엔에이 (상하이) 파마슈티컬 씨오., 엘티디. |
이온화 가능 지질 분자 및 그 제조 방법과 용도
|
|
AU2024235803A1
(en)
|
2023-03-15 |
2025-09-25 |
Flagship Pioneering Innovations Vi, Llc |
Compositions comprising polyribonucleotides and uses thereof
|
|
WO2024192422A1
(en)
|
2023-03-15 |
2024-09-19 |
Flagship Pioneering Innovations Vi, Llc |
Immunogenic compositions and uses thereof
|
|
WO2024197033A1
(en)
|
2023-03-21 |
2024-09-26 |
Modernatx, Inc. |
Polynucleotides encoding relaxin for the treatment of heart failure
|
|
WO2024205657A2
(en)
|
2023-03-29 |
2024-10-03 |
Orna Therapeutics, Inc. |
Lipids and lipid nanoparticle compositions for delivering polynucleotides
|
|
CN121127605A
(zh)
|
2023-03-29 |
2025-12-12 |
阿斯利康(瑞典)有限公司 |
使用抑制剂来提高CRISPR/Cas插入的效率
|
|
AU2024255972A1
(en)
|
2023-04-12 |
2025-10-23 |
Flagship Pioneering Innovations Vi, Llc |
Modified trems, compositions, and related methods thereof
|
|
WO2024216128A1
(en)
|
2023-04-12 |
2024-10-17 |
Flagship Pioneering Innovations Vi, Llc |
Trems for use in correction of missense mutations
|
|
CN120957707A
(zh)
|
2023-04-17 |
2025-11-14 |
赛诺菲巴斯德有限公司 |
可复溶干粉配制品及其使用方法
|
|
WO2024220746A2
(en)
|
2023-04-21 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting fatty acid synthase and related methods
|
|
WO2024223728A1
(en)
|
2023-04-27 |
2024-10-31 |
Glaxosmithkline Biologicals Sa |
Influenza virus vaccines
|
|
WO2024223724A1
(en)
|
2023-04-27 |
2024-10-31 |
Glaxosmithkline Biologicals Sa |
Influenza virus vaccines
|
|
WO2024229321A1
(en)
|
2023-05-03 |
2024-11-07 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
|
WO2024228150A1
(en)
|
2023-05-03 |
2024-11-07 |
BioNTech SE |
Optimized csp variants and related methods
|
|
WO2024228044A1
(en)
|
2023-05-03 |
2024-11-07 |
BioNTech SE |
Optimized csp variants and related methods
|
|
WO2024233308A2
(en)
|
2023-05-05 |
2024-11-14 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
WO2024230934A1
(en)
|
2023-05-11 |
2024-11-14 |
CureVac SE |
Therapeutic nucleic acid for the treatment of ophthalmic diseases
|
|
CN116803995B
(zh)
*
|
2023-05-16 |
2025-06-06 |
河北大学 |
一类氨基酰胺类脂质化合物及其制备方法和应用
|
|
WO2024240962A1
(en)
|
2023-05-25 |
2024-11-28 |
Ethris Gmbh |
Gm-csf-encoding nucleic acids, pharmaceutical compositions, methods and uses thereof
|
|
WO2024258829A1
(en)
|
2023-06-12 |
2024-12-19 |
Flagship Pioneering Innovations Vii, Llc |
Sars-cov-2 vaccine compositions and related methods
|
|
WO2024258961A1
(en)
|
2023-06-12 |
2024-12-19 |
The Trustees Of The University Of Pennsylvania |
Aav gene therapy for mucopolysaccharidosis iiib
|
|
WO2025006684A1
(en)
|
2023-06-28 |
2025-01-02 |
Flagship Pioneering Innovations Vi, Llc |
Circular polyribonucleotides encoding antifusogenic polypeptides
|
|
AR133098A1
(es)
|
2023-06-29 |
2025-08-27 |
Univ Pennsylvania |
Aav mutante con motivos dirigidos al sistema nervioso central y composiciones que lo contienen
|
|
WO2025012671A1
(en)
|
2023-07-07 |
2025-01-16 |
Institute National De La Sante Et De La Recherche Medicale (Inserm) |
Sars-cov-2 5'utr sequences and linkage thereof to coding sequences
|
|
WO2025011529A2
(en)
|
2023-07-07 |
2025-01-16 |
Shanghai Circode Biomed Co., Ltd. |
Circular rna vaccines for seasonal flu and methods of uses
|
|
AU2024301077A1
(en)
|
2023-07-21 |
2026-01-08 |
BioNTech SE |
Compositions for delivery of plasmodium antigens and related methods
|
|
WO2025024324A1
(en)
|
2023-07-21 |
2025-01-30 |
BioNTech SE |
Compositions for delivery of plasmodium antigens and related methods
|
|
AU2024299365A1
(en)
|
2023-07-24 |
2026-01-08 |
BioNTech SE |
Compositions for delivery of plasmodium antigens and related methods
|
|
TW202516001A
(zh)
|
2023-07-25 |
2025-04-16 |
美商旗艦先鋒創新有限責任(Vii)公司 |
Cas內切酶及相關方法
|
|
WO2025030097A2
(en)
|
2023-08-03 |
2025-02-06 |
BioNTech SE |
Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
|
|
WO2025030154A1
(en)
|
2023-08-03 |
2025-02-06 |
The Trustees Of The University Of Pennsylvania |
Pharmaceutical compositions for delivery of herpes simplex virus glycoprotein b antigens and related methods
|
|
WO2025035143A1
(en)
|
2023-08-10 |
2025-02-13 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of spinal muscular atrophy
|
|
WO2025042786A1
(en)
|
2023-08-18 |
2025-02-27 |
Flagship Pioneering Innovations Vi, Llc |
Compositions comprising circular polyribonucleotides and uses thereof
|
|
WO2025045767A1
(en)
|
2023-08-25 |
2025-03-06 |
Ethris Gmbh |
Stabilized lipid and lipidoid nanoparticle formulations with specific surfactant properties for enhanced pharmaceutical applications
|
|
WO2025045142A1
(en)
|
2023-08-29 |
2025-03-06 |
Shanghai Circode Biomed Co., Ltd. |
Circular rna encoding vegf polypeptides, formulations, and methods of uses
|
|
EP4520345A1
(en)
|
2023-09-06 |
2025-03-12 |
Myneo Nv |
Product
|
|
WO2025054236A2
(en)
|
2023-09-06 |
2025-03-13 |
Flagship Pioneering Innovations Vii, Llc |
Sars-cov-2 vaccine compositions and related methods
|
|
WO2025054556A1
(en)
|
2023-09-07 |
2025-03-13 |
BioNTech SE |
Rna compositions for delivery of mpox antigens and related methods
|
|
WO2025059107A1
(en)
*
|
2023-09-11 |
2025-03-20 |
The Trustees Of The University Of Pennsylvania |
Degradable, branched lipid compounds, methods of preparation thereof, lipid nanoparticles (lnps) comprising the same, and methods of use thereof
|
|
TW202540154A
(zh)
|
2023-09-11 |
2025-10-16 |
德商拜恩技術股份公司 |
用於遞送腸促胰島素劑之rna組合物
|
|
WO2025059215A1
(en)
|
2023-09-12 |
2025-03-20 |
Aadigen, Llc |
Methods and compositions for treating or preventing cancer
|
|
US20250268826A1
(en)
|
2023-09-18 |
2025-08-28 |
Flagship Pioneering Innovations Vii, Llc |
Ionizable lipidoid compositions and therapeutic uses thereof
|
|
WO2025072383A1
(en)
|
2023-09-25 |
2025-04-03 |
The Broad Institute, Inc. |
Viral open reading frames, uses thereof, and methods of detecting the same
|
|
WO2025072331A1
(en)
|
2023-09-26 |
2025-04-03 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
WO2025072482A1
(en)
|
2023-09-27 |
2025-04-03 |
Modernatx, Inc. |
Immunoglobulin a protease polypeptides, polynucleotides, and uses thereof
|
|
CN117164468B
(zh)
*
|
2023-10-26 |
2024-01-30 |
南京澄实生物医药科技有限公司 |
一种可电离脂质化合物及其应用
|
|
WO2025088192A1
(en)
|
2023-10-27 |
2025-05-01 |
Xl-Protein Gmbh |
Methods for the coupling of di(alkyl)amines to polypeptides
|
|
WO2025096807A2
(en)
|
2023-10-31 |
2025-05-08 |
Flagship Pioneering Innovations Vii, Llc |
Novel therapeutic dna forms
|
|
WO2025097055A2
(en)
|
2023-11-02 |
2025-05-08 |
The Broad Institute, Inc. |
Compositions and methods of use of t cells in immunotherapy
|
|
WO2025101501A1
(en)
|
2023-11-07 |
2025-05-15 |
Orna Therapeutics, Inc. |
Circular rna compositions
|
|
WO2025102034A1
(en)
|
2023-11-10 |
2025-05-15 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for barth syndrome
|
|
WO2025106661A1
(en)
|
2023-11-14 |
2025-05-22 |
The Trustees Of The University Of Pennsylvania |
Compositions with cardiac and skeletal musclespecific targeting motifs and uses thereof
|
|
US20250162981A1
(en)
|
2023-11-14 |
2025-05-22 |
Flagship Pioneering Innovations Vii, Llc |
Ionizable lipidoid compositions and therapeutic uses thereof
|
|
WO2025111526A1
(en)
|
2023-11-22 |
2025-05-30 |
Flagship Pioneering Innovations Vii, Llc |
Methods and compositions for treating non-alcoholic fatty liver disease
|
|
WO2025117877A2
(en)
|
2023-12-01 |
2025-06-05 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
US12364773B2
(en)
|
2023-12-01 |
2025-07-22 |
Recode Therapeutics, Inc. |
Lipid nanoparticle compositions and uses thereof
|
|
WO2025129158A1
(en)
|
2023-12-15 |
2025-06-19 |
The Broad Institute, Inc. |
Engineered arc delivery vesicles and uses thereof
|
|
WO2025132839A1
(en)
|
2023-12-21 |
2025-06-26 |
Glaxosmithkline Biologicals Sa |
Influenza virus vaccines
|
|
WO2025137646A1
(en)
|
2023-12-22 |
2025-06-26 |
Recode Therapeutics, Inc. |
Gene editing methods and compositions for treating cystic fibrosis
|
|
US20250375499A1
(en)
|
2024-01-26 |
2025-12-11 |
Flagship Pioneering Innovations Vii, Llc |
Immunoreceptor inhibitory proteins and related methods
|
|
WO2025172421A1
(en)
|
2024-02-14 |
2025-08-21 |
Astrazeneca Ab |
Compositions and methods for treatment of huntington's disease
|
|
WO2025184172A1
(en)
|
2024-02-27 |
2025-09-04 |
Overt Bio, Inc. |
Cancer reactive t cell receptors
|
|
WO2025184170A1
(en)
|
2024-02-27 |
2025-09-04 |
Overt Bio, Inc. |
Methods and compositions for improving t cell function in an immunosuppressive environment
|
|
WO2025193628A2
(en)
|
2024-03-09 |
2025-09-18 |
Aadigen, Llc |
Compositions for treating cancer with kras mutations and uses thereof
|
|
WO2025194019A1
(en)
|
2024-03-14 |
2025-09-18 |
Flagship Pioneering Innovations Vii, Llc |
Methods for treating liver fibrosis and non-alcoholic fatty liver disease
|
|
WO2025196065A1
(en)
|
2024-03-20 |
2025-09-25 |
Sanofi |
Novel homocysteine based lipids and their use for delivery of nucleic acids
|
|
WO2025202937A1
(en)
|
2024-03-26 |
2025-10-02 |
BioNTech SE |
Cancer vaccines
|
|
GB202404607D0
(en)
|
2024-03-29 |
2024-05-15 |
Glaxosmithkline Biologicals Sa |
RNA formulation
|
|
WO2025213131A1
(en)
|
2024-04-05 |
2025-10-09 |
BioNTech SE |
Rna compositions for delivery of orthopox antigens and related methods
|
|
WO2025217275A2
(en)
|
2024-04-10 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Immune cell targeted compositions and related methods
|
|
WO2025229572A1
(en)
|
2024-05-01 |
2025-11-06 |
Glaxosmithkline Biologicals Sa |
Epstein-barr virus antigen-encoding messenger ribonucleic acid and antigen protein vaccines
|
|
WO2025235862A1
(en)
|
2024-05-10 |
2025-11-13 |
Inndura Therapeutics Inc. |
A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a
|
|
US20250353881A1
(en)
|
2024-05-16 |
2025-11-20 |
Flagship Pioneering Innovations Vii, Llc |
Immunoreceptor inhibitory proteins and related methods
|
|
WO2025245188A2
(en)
|
2024-05-21 |
2025-11-27 |
Flagship Pioneering Innovations Vii, Llc |
Methods of treating liver steatosis and non-alcoholic fatty liver disease
|
|
WO2025245111A1
(en)
|
2024-05-22 |
2025-11-27 |
Flagship Pioneering Innovations Vii, Llc |
Immunoreceptor targeting proteins and related methods
|
|
WO2025250808A1
(en)
|
2024-05-29 |
2025-12-04 |
The Brigham And Women’S Hospital, Inc. |
Anti-crispr delivery compositions and methods
|
|
WO2025250751A1
(en)
|
2024-05-31 |
2025-12-04 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
WO2025252759A1
(en)
|
2024-06-03 |
2025-12-11 |
Bio-Sourcing |
Transient expression by lipid nanoparticle formulations
|
|
WO2025255199A1
(en)
|
2024-06-05 |
2025-12-11 |
Modernatx, Inc. |
Argininosuccinate synthase 1 and argininosuccinate lyase polypeptides and polynucleotides and uses thereof
|
|
WO2026006577A1
(en)
|
2024-06-26 |
2026-01-02 |
Flagship Pioneering Innovations Vii, Llc |
Therapeutic circular dna forms
|