|
US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
US9393315B2
(en)
|
2011-06-08 |
2016-07-19 |
Nitto Denko Corporation |
Compounds for targeting drug delivery and enhancing siRNA activity
|
|
EP1912679A4
(en)
|
2005-06-15 |
2009-07-29 |
Massachusetts Inst Technology |
AMINOUS LIPIDS AND ITS USES
|
|
SG10201809460SA
(en)
|
2008-10-20 |
2018-11-29 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of transthyretin
|
|
WO2010053572A2
(en)
|
2008-11-07 |
2010-05-14 |
Massachusetts Institute Of Technology |
Aminoalcohol lipidoids and uses thereof
|
|
CA2760776C
(en)
*
|
2009-05-05 |
2019-07-09 |
Alnylam Pharmaceuticals, Inc. |
Lipid compositions for the delivery of therapeutic agents
|
|
CA3045126A1
(en)
*
|
2009-05-05 |
2010-11-11 |
Arbutus Biopharma Corporation |
Methods of delivering oligonucleotides to immune cells
|
|
WO2011056883A1
(en)
*
|
2009-11-03 |
2011-05-12 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of transthyretin (ttr)
|
|
ME03091B
(me)
|
2009-12-01 |
2019-01-20 |
Translate Bio Inc |
Isporuka irnk za povećanje ekspresije proteina i enzima u humanim genetskim oboljenjima
|
|
RS54489B1
(sr)
|
2010-07-06 |
2016-06-30 |
Glaxosmithkline Biologicals Sa |
Lipozomi sa lipidima koji imaju poboljšanu pka vrednost za oslobađanje rnk
|
|
HUE047796T2
(hu)
|
2010-07-06 |
2020-05-28 |
Glaxosmithkline Biologicals Sa |
RNS bevitele több immunútvonal bekapcsolására
|
|
JP5940064B2
(ja)
|
2010-07-06 |
2016-06-29 |
ノバルティス アーゲー |
低用量のｒｎａを用いた大型哺乳動物の免疫化
|
|
US8822663B2
(en)
|
2010-08-06 |
2014-09-02 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
JP6124078B2
(ja)
*
|
2010-08-26 |
2017-05-10 |
ツイ，クンユァン |
巨大環状脂肪族化合物及びその応用
|
|
US9193827B2
(en)
|
2010-08-26 |
2015-11-24 |
Massachusetts Institute Of Technology |
Poly(beta-amino alcohols), their preparation, and uses thereof
|
|
SMT202200311T1
(it)
|
2010-08-31 |
2022-09-14 |
Glaxosmithkline Biologicals Sa |
Liposomi pegilati per somministrare rna codificante un immunogene
|
|
WO2012031205A2
(en)
|
2010-09-03 |
2012-03-08 |
The Brigham And Women's Hospital, Inc. |
Lipid-polymer hybrid particles
|
|
DK4108671T3
(da)
|
2010-10-01 |
2025-01-06 |
Modernatx Inc |
Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf
|
|
EP3520813B1
(en)
|
2010-10-11 |
2023-04-19 |
GlaxoSmithKline Biologicals S.A. |
Antigen delivery platforms
|
|
BR122022001262B1
(pt)
*
|
2010-11-15 |
2022-09-27 |
Life Technologies Corporation |
Compostos de transfecção contendo amina e complexo de transfecção
|
|
US9238716B2
(en)
|
2011-03-28 |
2016-01-19 |
Massachusetts Institute Of Technology |
Conjugated lipomers and uses thereof
|
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
PT2717893T
(pt)
|
2011-06-08 |
2019-08-20 |
Translate Bio Inc |
Composições de nanopartículas lipídicas e métodos para transferência de arnm
|
|
EP3998064A1
(en)
|
2011-06-08 |
2022-05-18 |
Translate Bio, Inc. |
Cleavable lipids
|
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
|
EP3854413A1
(en)
|
2011-07-06 |
2021-07-28 |
GlaxoSmithKline Biologicals SA |
Immunogenic combination compositions and uses thereof
|
|
KR20130024079A
(ko)
|
2011-08-30 |
2013-03-08 |
현대자동차주식회사 |
고체 ｓｃｒ 시스템 및 이를 이용한 고체상의 환원제 가열 방법
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
JP6113737B2
(ja)
|
2011-10-03 |
2017-04-12 |
モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． |
修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法
|
|
KR101329702B1
(ko)
|
2011-10-06 |
2013-11-14 |
연세대학교 산학협력단 |
ｓｉＲＮＡ 전달을 위한 폴리아민 기반의 전달체
|
|
MX363734B
(es)
|
2011-10-27 |
2019-03-29 |
Massachusetts Inst Technology |
Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco.
|
|
WO2013075035A1
(en)
|
2011-11-18 |
2013-05-23 |
Alnylam Pharmaceuticals |
Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases
|
|
KR20140102759A
(ko)
|
2011-12-16 |
2014-08-22 |
모더나 세라퓨틱스, 인코포레이티드 |
변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
|
|
EA201491185A1
(ru)
|
2011-12-16 |
2015-05-29 |
Массачусетс Инститьют Оф Текнолоджи |
Полимеры альфа-аминоамидинов и их применение
|
|
EP2834259A4
(en)
|
2012-04-02 |
2016-08-24 |
Moderna Therapeutics Inc |
MODIFIED POLYNUCLEOTIDES
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US20150267192A1
(en)
|
2012-06-08 |
2015-09-24 |
Shire Human Genetic Therapies, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
|
BR112014030677A2
(pt)
|
2012-06-08 |
2022-07-19 |
Shire Human Genetic Therapies |
distribuição pulmonar de mrna para células-alvo não-pulmonares
|
|
CA2884870C
(en)
|
2012-08-13 |
2022-03-29 |
Massachusetts Institute Of Technology |
Amine-containing lipidoids and uses thereof
|
|
US9597380B2
(en)
|
2012-11-26 |
2017-03-21 |
Modernatx, Inc. |
Terminally modified RNA
|
|
WO2014089486A1
(en)
|
2012-12-07 |
2014-06-12 |
Shire Human Genetic Therapies, Inc. |
Lipidic nanoparticles for mrna delivering
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
WO2014093622A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
CN103087012B
(zh)
*
|
2012-12-28 |
2014-10-22 |
四川大学 |
环氧化合物与阳离子聚合物及它们的制备方法
|
|
ES2859923T3
(es)
|
2013-02-28 |
2021-10-04 |
Univ Tufts |
Compuestos de disulfuro para el suministro de agentes farmacéuticos
|
|
US20160184458A1
(en)
|
2013-03-14 |
2016-06-30 |
Shire Human Genetic Therapies, Inc. |
Mrna therapeutic compositions and use to treat diseases and disorders
|
|
HUE055044T2
(hu)
|
2013-03-14 |
2021-10-28 |
Translate Bio Inc |
MRNS-kódolt ellenanyagok bejuttatására szolgáló eljárások és készítmények
|
|
CA2904151C
(en)
|
2013-03-14 |
2023-09-12 |
Shire Human Genetic Therapies, Inc. |
Cftr mrna compositions and related methods and uses
|
|
KR20150127582A
(ko)
|
2013-03-14 |
2015-11-17 |
샤이어 휴먼 지네틱 테라피즈 인크. |
4''-티오 개질된 뉴클레오티드를 갖는 리보핵산 및 관련 방법
|
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
KR20150128687A
(ko)
|
2013-03-14 |
2015-11-18 |
샤이어 휴먼 지네틱 테라피즈 인크. |
메신저 rna의 정제 방법
|
|
US11377470B2
(en)
|
2013-03-15 |
2022-07-05 |
Modernatx, Inc. |
Ribonucleic acid purification
|
|
ES3032013T3
(en)
|
2013-03-15 |
2025-07-14 |
Translate Bio Inc |
Synergistic enhancement of the delivery of nucleic acids via blended formulations
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
WO2014144767A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Ion exchange purification of mrna
|
|
WO2014179562A1
(en)
|
2013-05-01 |
2014-11-06 |
Massachusetts Institute Of Technology |
1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
|
|
WO2014186366A1
(en)
|
2013-05-13 |
2014-11-20 |
Tufts University |
Nanocomplexes for delivery of saporin
|
|
US10888622B2
(en)
|
2013-05-14 |
2021-01-12 |
Trustees Of Tufts College |
Nanocomplexes of modified peptides or proteins
|
|
CA2915837A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
SG11201510327TA
(en)
|
2013-06-17 |
2016-01-28 |
Broad Inst Inc |
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
|
|
EP3597755A1
(en)
|
2013-06-17 |
2020-01-22 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
KR20240172759A
(ko)
|
2013-06-17 |
2024-12-10 |
더 브로드 인스티튜트, 인코퍼레이티드 |
간의 표적화 및 치료를 위한 ＣＲＩＳＰＲＣａｓ 시스템, 벡터 및 조성물의 전달 및 용도
|
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
WO2014210356A1
(en)
*
|
2013-06-26 |
2014-12-31 |
Massachusetts Institute Of Technology |
Multi-tailed lipids and uses thereof
|
|
KR102285326B1
(ko)
*
|
2013-06-28 |
2021-08-04 |
에트리스 게엠베하 |
Rna를 세포에 도입하기 위한 조성물
|
|
DK3019619T3
(da)
|
2013-07-11 |
2021-10-11 |
Modernatx Inc |
Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder
|
|
EP3041938A1
(en)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
AU2014315287A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
EP3052521A1
(en)
|
2013-10-03 |
2016-08-10 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
|
WO2015061467A1
(en)
|
2013-10-22 |
2015-04-30 |
Shire Human Genetic Therapies, Inc. |
Lipid formulations for delivery of messenger rna
|
|
BR112016009014B1
(pt)
|
2013-10-22 |
2024-02-06 |
Translate Bio, Inc |
USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE
|
|
CN105658800A
(zh)
|
2013-10-22 |
2016-06-08 |
夏尔人类遗传性治疗公司 |
Mrna的cns递送及其用途
|
|
EA201992208A1
(ru)
|
2013-10-22 |
2020-07-31 |
Транслейт Био, Инк. |
ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
|
|
WO2015089354A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
JP2017501149A
(ja)
|
2013-12-12 |
2017-01-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
粒子送達構成成分を用いた障害及び疾患の標的化のためのｃｒｉｓｐｒ−ｃａｓ系及び組成物の送達、使用及び治療適用
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
CN105899658B
(zh)
|
2013-12-12 |
2020-02-18 |
布罗德研究所有限公司 |
针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
EP3653229A1
(en)
|
2013-12-12 |
2020-05-20 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
|
CA2940199A1
(en)
|
2014-02-26 |
2015-09-03 |
Ethris Gmbh |
Compositions for gastrointestinal administration of rna
|
|
WO2015138357A2
(en)
|
2014-03-09 |
2015-09-17 |
The Trustees Of The University Of Pennsylvania |
Compositions useful in treatment of otc deficency
|
|
US9624191B2
(en)
|
2014-03-24 |
2017-04-18 |
International Business Machines Corporation |
Cyclic carbonate monomers and ring opened polycarbonates therefrom
|
|
US9215876B2
(en)
|
2014-03-24 |
2015-12-22 |
International Business Machines Corporation |
1,3,6-dioxazocan-2-ones and antimicrobial cationic polycarbonates therefrom
|
|
ES2774552T3
(es)
|
2014-03-24 |
2020-07-21 |
Translate Bio Inc |
Terapia de ARNm para el tratamiento de enfermedades oculares
|
|
RU2021109685A
(ru)
|
2014-04-23 |
2021-04-13 |
МОДЕРНАТиЭкс, ИНК. |
Вакцины на основе нуклеиновых кислот
|
|
KR102739894B1
(ko)
|
2014-04-25 |
2024-12-05 |
샤이어 휴먼 지네틱 테라피즈 인크. |
메신저 rna 의 정제 방법
|
|
JP6868394B2
(ja)
|
2014-05-16 |
2021-05-12 |
ファイザー・インク |
二重特異性抗体
|
|
US10022455B2
(en)
|
2014-05-30 |
2018-07-17 |
Translate Bio, Inc. |
Biodegradable lipids for delivery of nucleic acids
|
|
CA2951707A1
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
AU2015279968B2
(en)
|
2014-06-24 |
2019-11-14 |
Translate Bio, Inc. |
Stereochemically enriched compositions for delivery of nucleic acids
|
|
CN106456547B
(zh)
|
2014-07-02 |
2021-11-12 |
川斯勒佰尔公司 |
信使rna的包封
|
|
WO2016004202A1
(en)
|
2014-07-02 |
2016-01-07 |
Massachusetts Institute Of Technology |
Polyamine-fatty acid derived lipidoids and uses thereof
|
|
EP3169693B1
(en)
|
2014-07-16 |
2022-03-09 |
ModernaTX, Inc. |
Chimeric polynucleotides
|
|
EP3171895A1
(en)
|
2014-07-23 |
2017-05-31 |
Modernatx, Inc. |
Modified polynucleotides for the production of intrabodies
|
|
WO2016025643A1
(en)
|
2014-08-12 |
2016-02-18 |
Massachusetts Institute Of Technology |
Brush-poly(glycoamidoamine)-lipids and uses thereof
|
|
GB201414464D0
(en)
|
2014-08-14 |
2014-10-01 |
Technion Res & Dev Foundation |
Compositions and methods for therapeutics prescreening
|
|
EP3686279B1
(en)
|
2014-08-17 |
2023-01-04 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
LT3185957T
(lt)
|
2014-08-29 |
2022-09-26 |
Alnylam Pharmaceuticals, Inc. |
Patisiranas, skirtas naudoti transtiretino amiloidozei gydyti
|
|
US9339029B2
(en)
|
2014-09-04 |
2016-05-17 |
Preceres Inc. |
Hydrazinyl lipidoids and uses thereof
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
KR102647743B1
(ko)
|
2014-11-10 |
2024-03-14 |
에트리스 게엠베하 |
Bmp 인코딩 rna의 전달에 의한 골형성 유도
|
|
WO2016090262A1
(en)
|
2014-12-05 |
2016-06-09 |
Shire Human Genetic Therapies, Inc. |
Messenger rna therapy for treatment of articular disease
|
|
AU2015360794B2
(en)
|
2014-12-08 |
2021-07-08 |
The Board Of Regents Of The University Of Texas System |
Lipocationic polymers and uses thereof
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3230452B1
(en)
|
2014-12-12 |
2025-06-11 |
The Broad Institute, Inc. |
Dead guides for crispr transcription factors
|
|
EP3034539A1
(en)
|
2014-12-19 |
2016-06-22 |
Ethris GmbH |
Compositions for introducing nucleic acid into cells
|
|
WO2016100974A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
US20180000953A1
(en)
*
|
2015-01-21 |
2018-01-04 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
|
US10172924B2
(en)
|
2015-03-19 |
2019-01-08 |
Translate Bio, Inc. |
MRNA therapy for pompe disease
|
|
WO2016168469A1
(en)
*
|
2015-04-17 |
2016-10-20 |
The Regents Of The University Of California |
Fatty acid analogs and methods of use thereof
|
|
CN107567497A
(zh)
|
2015-04-17 |
2018-01-09 |
库瑞瓦格股份公司 |
Rna的冻干
|
|
EP3288594B1
(en)
|
2015-04-27 |
2022-06-29 |
The Trustees of The University of Pennsylvania |
Dual aav vector system for crispr/cas9 mediated correction of human disease
|
|
EP3297682B1
(en)
|
2015-05-20 |
2021-07-14 |
CureVac AG |
Dry powder composition comprising long-chain rna
|
|
WO2016184575A1
(en)
|
2015-05-20 |
2016-11-24 |
Curevac Ag |
Dry powder composition comprising long-chain rna
|
|
MX392008B
(es)
|
2015-06-18 |
2025-03-21 |
Broad Inst Inc |
Mutaciones de la enzima crispr que reducen los efectos fuera del blanco
|
|
EP4159856A1
(en)
|
2015-06-18 |
2023-04-05 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
CA2990172A1
(en)
|
2015-06-19 |
2016-12-22 |
Massachusetts Institute Of Technology |
Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
|
|
DE112016002962T5
(de)
|
2015-06-30 |
2018-05-24 |
Ethris Gmbh |
Familie der ATP-bindenden Kassetten-codierende Polyribonucleotide und Formulierungen derselben
|
|
US10676735B2
(en)
|
2015-07-22 |
2020-06-09 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
PL3329002T3
(pl)
|
2015-07-31 |
2021-04-19 |
Alnylam Pharmaceuticals, Inc. |
Kompozycje irna transtyretyny (ttr) i sposoby ich zastosowania do leczenia lub zapobiegania chorobom związanym z ttr
|
|
AU2016308339A1
(en)
|
2015-08-18 |
2018-04-12 |
Baylor College Of Medicine |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
CN108351350B
(zh)
|
2015-08-25 |
2022-02-18 |
杜克大学 |
使用rna指导型内切核酸酶改善基因组工程特异性的组合物和方法
|
|
US10881682B2
(en)
*
|
2015-08-26 |
2021-01-05 |
International Business Machines Corporation |
Therapeutic compositions comprising n-alkyl-hydroxy polymers
|
|
US11247968B2
(en)
|
2015-09-14 |
2022-02-15 |
The Board Of Regents Of The University Of Texas System |
Lipocationic dendrimers and uses thereof
|
|
PL3350333T3
(pl)
|
2015-09-17 |
2022-03-07 |
Modernatx, Inc. |
Polinukleotydy zawierające region stabilizujący ogon
|
|
WO2017049286A1
(en)
|
2015-09-17 |
2017-03-23 |
Moderna Therapeutics, Inc. |
Polynucleotides containing a morpholino linker
|
|
EP3350157B1
(en)
|
2015-09-17 |
2022-01-05 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
|
WO2017070605A1
(en)
|
2015-10-22 |
2017-04-27 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
|
CA3002922A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
|
WO2017074788A1
(en)
|
2015-10-27 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
ES2924407T3
(es)
|
2015-12-10 |
2022-10-06 |
Modernatx Inc |
Composiciones y procedimientos para el suministro de agentes terapéuticos
|
|
WO2017100744A1
(en)
*
|
2015-12-11 |
2017-06-15 |
Preceres Inc. |
Aminolipidoids and uses thereof
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
SI3394030T1
(sl)
|
2015-12-22 |
2022-04-29 |
Modernatx, Inc. |
Sestave za doziranje sredstev v celice
|
|
LT3394093T
(lt)
|
2015-12-23 |
2022-04-25 |
Modernatx, Inc. |
Ox40 ligandus koduojančių polinukleotidų naudojimo būdai
|
|
WO2017112852A1
(en)
*
|
2015-12-23 |
2017-06-29 |
Preceres Inc. |
Modified polyethyleneimines and uses thereof
|
|
EP3400023A1
(en)
|
2016-01-10 |
2018-11-14 |
ModernaTX, Inc. |
Therapeutic mrnas encoding anti ctla-4 antibodies
|
|
CN109072223B
(zh)
|
2016-04-08 |
2022-10-21 |
川斯勒佰尔公司 |
多聚体编码核酸及其用途
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
WO2017189308A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
KR20260004568A
(ko)
|
2016-04-19 |
2026-01-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
WO2017201091A1
(en)
|
2016-05-16 |
2017-11-23 |
The Board Of Regents Of The University Of Texas System |
COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH
|
|
EP3458032A4
(en)
|
2016-05-16 |
2019-12-25 |
The Board of Regents of The University of Texas System |
CATIONIC SULFONAMIDE AMINOLIPIDS AND AMPHIPHILE ZWITTERIONIC AMINOLIPIDS
|
|
KR102533456B1
(ko)
|
2016-05-18 |
2023-05-17 |
모더나티엑스, 인크. |
릴랙신을 인코딩하는 폴리뉴클레오타이드
|
|
EP3458106A4
(en)
*
|
2016-05-18 |
2020-03-18 |
Modernatx, Inc. |
POLYNUCLEOTIDS FOR CODING LIPOPROTEIN LIPASE FOR TREATING HYPERLIPIDEMIA
|
|
CA3025626A1
(en)
|
2016-05-27 |
2017-11-30 |
Transcriptx, Inc. |
Treatment of primary ciliary dyskinesia with synthetic messenger rna
|
|
US20190336608A1
(en)
|
2016-06-09 |
2019-11-07 |
Curevac Ag |
Cationic carriers for nucleic acid delivery
|
|
CA3023174A1
(en)
|
2016-06-09 |
2017-12-14 |
Curevac Ag |
Hybrid carriers for nucleic acid cargo
|
|
EP3469074B1
(en)
|
2016-06-13 |
2020-12-09 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of ornithine transcarbamylase deficiency
|
|
KR20190019168A
(ko)
|
2016-06-17 |
2019-02-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
제vi형 crispr 오솔로그 및 시스템
|
|
IL246378A0
(en)
|
2016-06-21 |
2016-11-30 |
Technion Res & Dev Foundation |
A hybrid matrix of polymers that adhere to the mucosa and a lipidic drug release system for the treatment of oral cancer
|
|
US20210222164A1
(en)
|
2016-06-29 |
2021-07-22 |
The Broad Institute, Inc. |
Crispr-cas systems having destabilization domain
|
|
KR101816795B1
(ko)
|
2016-06-30 |
2018-01-10 |
한국화학연구원 |
신규한 3차 아민계 폴리올 및 자가촉매를 이용한 폴리우레탄 합성
|
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
CN110312799A
(zh)
|
2016-08-17 |
2019-10-08 |
博德研究所 |
新型crispr酶和系统
|
|
EP3500270A1
(en)
|
2016-08-19 |
2019-06-26 |
Fundación Para La Investigación Biomédica Del Hospital Universitario Ramón Y Cajal |
Mir-127 agents for use in the treatment of renal fibrosis
|
|
JP6778380B2
(ja)
*
|
2016-08-23 |
2020-11-04 |
昭和電工マテリアルズ株式会社 |
吸着材
|
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
WO2018064208A1
(en)
|
2016-09-28 |
2018-04-05 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
CA3041307A1
(en)
|
2016-10-21 |
2018-04-26 |
Giuseppe Ciaramella |
Human cytomegalovirus vaccine
|
|
US11583504B2
(en)
|
2016-11-08 |
2023-02-21 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
|
JP7738979B2
(ja)
|
2016-11-10 |
2025-09-16 |
トランスレイト バイオ， インコーポレイテッド |
Ｍｒｎａ担持脂質ナノ粒子を調製する改善されたプロセス
|
|
US11400109B2
(en)
|
2016-11-10 |
2022-08-02 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger RNA
|
|
WO2018104540A1
(en)
|
2016-12-08 |
2018-06-14 |
Curevac Ag |
Rnas for wound healing
|
|
JP2020501545A
(ja)
|
2016-12-08 |
2020-01-23 |
キュアバック アーゲー |
肝疾患の処置または予防のためのｒｎａ
|
|
US11524066B2
(en)
|
2016-12-23 |
2022-12-13 |
CureVac SE |
Henipavirus vaccine
|
|
US11141476B2
(en)
|
2016-12-23 |
2021-10-12 |
Curevac Ag |
MERS coronavirus vaccine
|
|
WO2018115525A1
(en)
|
2016-12-23 |
2018-06-28 |
Curevac Ag |
Lassa virus vaccine
|
|
FI3565891T3
(fi)
|
2017-01-09 |
2023-07-04 |
Whitehead Inst Biomedical Res |
Menetelmiä geeniekspression muuttamiseksi häiritsemällä säätelysilmukoita muodostavia transkriptiotekijämultimeerejä
|
|
WO2018157133A1
(en)
|
2017-02-27 |
2018-08-30 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
DK3585892T3
(da)
|
2017-02-27 |
2022-08-22 |
Translate Bio Inc |
Fremgangsmåder til oprensning af messenger-rna
|
|
MX2019010155A
(es)
|
2017-02-27 |
2020-12-10 |
Translate Bio Inc |
Arnm de cftr optimizado por codón novedoso.
|
|
JOP20190200A1
(ar)
|
2017-02-28 |
2019-08-27 |
Univ Pennsylvania |
تركيبات نافعة في معالجة ضمور العضل النخاعي
|
|
SI3589730T1
(sl)
|
2017-02-28 |
2024-04-30 |
The Trustees Of The University Of Pennsylvania |
Adeno-povezan virus (AAV) clade F vektor in njihova uporaba
|
|
CN119752819A
(zh)
|
2017-03-01 |
2025-04-04 |
宾夕法尼亚州立大学托管会 |
用于眼部病症的基因疗法
|
|
EP3592728A1
(en)
|
2017-03-07 |
2020-01-15 |
Translate Bio, Inc. |
Polyanionic delivery of nucleic acids
|
|
ES2911186T3
(es)
|
2017-03-15 |
2022-05-18 |
Modernatx Inc |
Formas cristalinas de aminolípidos
|
|
JP7332478B2
(ja)
|
2017-03-15 |
2023-08-23 |
モデルナティエックス インコーポレイテッド |
脂質ナノ粒子製剤
|
|
CN120330163A
(zh)
|
2017-03-15 |
2025-07-18 |
博德研究所 |
新型cas13b直向同源物crispr酶和系统
|
|
FI3596041T3
(fi)
|
2017-03-15 |
2023-01-31 |
|
Yhdiste ja koostumuksia terapeuttisten aineiden antamiseen solun sisään
|
|
JP2020514370A
(ja)
|
2017-03-17 |
2020-05-21 |
キュアバック アーゲー |
組合せ抗癌療法のためのｒｎａワクチン及び免疫チェックポイント阻害剤
|
|
KR102842382B1
(ko)
|
2017-03-24 |
2025-08-04 |
큐어백 에스이 |
Crispr-연관 단백질을 암호화하는 핵산 및 이의 용도
|
|
CA3059757A1
(en)
|
2017-04-12 |
2018-10-18 |
Massachusetts Institute Of Technology |
Novel type vi crispr orthologs and systems
|
|
WO2018191750A2
(en)
|
2017-04-14 |
2018-10-18 |
The Broad Institute Inc. |
Novel delivery of large payloads
|
|
US11879133B2
(en)
|
2017-04-24 |
2024-01-23 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for ocular disorders
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
IL316926A
(en)
|
2017-05-11 |
2025-01-01 |
Univ Pennsylvania |
Gene therapy for neuronal ceroid lipofuscinosis
|
|
WO2018213476A1
(en)
|
2017-05-16 |
2018-11-22 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
|
|
US11485972B2
(en)
|
2017-05-18 |
2022-11-01 |
Modernatx, Inc. |
Modified messenger RNA comprising functional RNA elements
|
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11421011B2
(en)
|
2017-05-18 |
2022-08-23 |
Modernatx, Inc. |
Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof
|
|
CA3098592A1
(en)
|
2017-05-31 |
2018-12-06 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for treating peroxisomal disorders
|
|
EP3638292A1
(en)
|
2017-06-14 |
2020-04-22 |
ModernaTX, Inc. |
Polynucleotides encoding coagulation factor viii
|
|
EP3638678B1
(en)
|
2017-06-14 |
2025-12-03 |
ModernaTX, Inc. |
Compounds and compositions for intracellular delivery of agents
|
|
US11786607B2
(en)
|
2017-06-15 |
2023-10-17 |
Modernatx, Inc. |
RNA formulations
|
|
EP3641834B1
(en)
|
2017-06-19 |
2023-10-04 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of friedreich's ataxia
|
|
BR112019028280A2
(pt)
|
2017-07-04 |
2020-07-14 |
Curevac Ag |
moléculas de ácido nucleico
|
|
EP3673069A1
(en)
|
2017-08-22 |
2020-07-01 |
CureVac AG |
Bunyavirales vaccine
|
|
AU2018326799A1
(en)
|
2017-08-31 |
2020-02-27 |
Modernatx, Inc. |
Methods of making lipid nanoparticles
|
|
GB201714430D0
(en)
|
2017-09-07 |
2017-10-25 |
Micol Romain |
Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue
|
|
BR112020005230A2
(pt)
|
2017-09-19 |
2020-09-24 |
Alnylam Pharmaceuticals, Inc. |
composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
|
|
KR20200066616A
(ko)
|
2017-09-21 |
2020-06-10 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 시스템, 방법 및 조성물
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
US20220233568A1
(en)
|
2017-10-19 |
2022-07-28 |
Curevac Ag |
Novel artificial nucleic acid molecules
|
|
US12227742B2
(en)
|
2017-10-23 |
2025-02-18 |
The Broad Institute, Inc. |
Nucleic acid modifiers
|
|
US11547614B2
(en)
|
2017-10-31 |
2023-01-10 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
EP3710039A4
(en)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
|
|
JP7423520B2
(ja)
|
2017-11-16 |
2024-01-29 |
アストラゼネカ・アクチエボラーグ |
Ｃａｓ９ベースノックイン方針の効力を改善するための組成物及び方法
|
|
JP7423522B2
(ja)
|
2017-11-22 |
2024-01-29 |
モダーナティエックス・インコーポレイテッド |
尿素サイクル異常症の治療のためのオルニチントランスカルバミラーゼをコードするポリヌクレオチド
|
|
WO2019104195A1
(en)
|
2017-11-22 |
2019-05-31 |
Modernatx, Inc. |
Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia
|
|
US11939601B2
(en)
|
2017-11-22 |
2024-03-26 |
Modernatx, Inc. |
Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria
|
|
JP7389744B2
(ja)
|
2017-11-30 |
2023-11-30 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
ムコ多糖症ｉｉｉａ型のための遺伝子療法
|
|
CN111989396A
(zh)
|
2017-11-30 |
2020-11-24 |
宾夕法尼亚州大学信托人 |
用于iiib型粘多糖贮积病的基因疗法
|
|
WO2019110067A1
(en)
*
|
2017-12-07 |
2019-06-13 |
Aarhus Universitet |
Hybrid nanoparticle
|
|
WO2019115635A1
(en)
|
2017-12-13 |
2019-06-20 |
Curevac Ag |
Flavivirus vaccine
|
|
WO2019126593A1
(en)
|
2017-12-20 |
2019-06-27 |
Translate Bio, Inc. |
Improved composition and methods for treatment of ornithine transcarbamylase deficiency
|
|
US20230193242A1
(en)
|
2017-12-22 |
2023-06-22 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted dna base editing
|
|
US11802146B2
(en)
|
2018-01-05 |
2023-10-31 |
Modernatx, Inc. |
Polynucleotides encoding anti-chikungunya virus antibodies
|
|
US11975110B2
(en)
|
2018-02-02 |
2024-05-07 |
Translate Bio, Inc. |
Cationic polymers
|
|
EP3755344A1
(en)
|
2018-02-19 |
2020-12-30 |
Combined Therapeutics, Inc. |
Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids
|
|
WO2019176079A1
(ja)
*
|
2018-03-16 |
2019-09-19 |
株式会社 東芝 |
生分解性化合物、脂質粒子、脂質粒子を含む組成物、およびキット
|
|
US10968257B2
(en)
|
2018-04-03 |
2021-04-06 |
The Broad Institute, Inc. |
Target recognition motifs and uses thereof
|
|
WO2019193183A2
(en)
|
2018-04-05 |
2019-10-10 |
Curevac Ag |
Novel yellow fever nucleic acid molecules for vaccination
|
|
EP3773745A1
(en)
|
2018-04-11 |
2021-02-17 |
ModernaTX, Inc. |
Messenger rna comprising functional rna elements
|
|
SG11202008225PA
(en)
|
2018-04-17 |
2020-11-27 |
Curevac Ag |
Novel rsv rna molecules and compositions for vaccination
|
|
EP3784284B1
(en)
|
2018-04-25 |
2023-08-02 |
Ethris GmbH |
Lipid-based formulations for the delivery of rna
|
|
EP3793689A1
(en)
|
2018-05-15 |
2021-03-24 |
Translate Bio, Inc. |
Subcutaneous delivery of messenger rna
|
|
MA52625A
(fr)
|
2018-05-16 |
2021-03-24 |
Translate Bio Inc |
Lipides cationiques de ribose
|
|
WO2019226650A1
(en)
|
2018-05-23 |
2019-11-28 |
Modernatx, Inc. |
Delivery of dna
|
|
CA3100254A1
(en)
|
2018-05-24 |
2019-11-28 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
US20200016274A1
(en)
|
2018-05-30 |
2020-01-16 |
Translate Bio, Inc. |
Messenger rna vaccines and uses thereof
|
|
CA3100214A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Cationic lipids comprising a steroidal moiety
|
|
JP7441802B2
(ja)
|
2018-05-30 |
2024-03-01 |
トランスレイト バイオ， インコーポレイテッド |
ビタミンカチオン性脂質
|
|
WO2019232097A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Phosphoester cationic lipids
|
|
US12357580B2
(en)
|
2018-06-19 |
2025-07-15 |
The Board Of Regents Of The University Of Texas System |
Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
|
|
EP3813874A1
(en)
|
2018-06-27 |
2021-05-05 |
CureVac AG |
Novel lassa virus rna molecules and compositions for vaccination
|
|
WO2020023533A1
(en)
|
2018-07-23 |
2020-01-30 |
Translate Bio, Inc. |
Dry power formulations for messenger rna
|
|
US20220184185A1
(en)
|
2018-07-25 |
2022-06-16 |
Modernatx, Inc. |
Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
|
|
WO2020028729A1
(en)
|
2018-08-01 |
2020-02-06 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
|
EP3833761A1
(en)
|
2018-08-07 |
2021-06-16 |
The Broad Institute, Inc. |
Novel cas12b enzymes and systems
|
|
JP2021534101A
(ja)
|
2018-08-09 |
2021-12-09 |
ヴェルソー セラピューティクス， インコーポレイテッド |
Ｃｃｒ２及びｃｓｆ１ｒを標的とするためのオリゴヌクレオチド組成物ならびにその使用
|
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
|
WO2020041456A1
(en)
|
2018-08-22 |
2020-02-27 |
The Regents Of The University Of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
WO2020041793A1
(en)
|
2018-08-24 |
2020-02-27 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
|
EP3844303A4
(en)
|
2018-08-27 |
2022-06-01 |
The Regents of The University of California |
Reporter nucleic acids for type v crispr-mediated detection
|
|
AU2019333042B2
(en)
|
2018-08-29 |
2025-06-19 |
Translate Bio, Inc. |
Improved process of preparing mRNA-loaded lipid nanoparticles
|
|
EP4596532A3
(en)
|
2018-08-29 |
2025-11-12 |
Ecolab USA Inc. |
Multiple charged ionic compounds derived from polyamines and compositions thereof and methods of preparation thereof
|
|
KR20210102870A
(ko)
|
2018-08-30 |
2021-08-20 |
테나야 테라퓨틱스, 인코포레이티드 |
미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍
|
|
MA53545A
(fr)
|
2018-09-02 |
2021-07-14 |
Modernatx Inc |
Polynucléotides codant pour l'acyl-coa déshydrogénase à très longue chaîne pour le traitement de l'insuffisance en acyl-coa déshydrogénase à très longue chaîne
|
|
GB2592505B
(en)
|
2018-09-04 |
2023-05-03 |
Univ Texas |
Compositions and methods for organ specific delivery of nucleic acids
|
|
WO2020051220A1
(en)
|
2018-09-04 |
2020-03-12 |
The Board of the Regents of the University of Texas System |
Compositions and methods for organ specific delivery of nucleic acids
|
|
EP3847251A1
(en)
|
2018-09-07 |
2021-07-14 |
Astrazeneca AB |
Compositions and methods for improved nucleases
|
|
MX2021003015A
(es)
|
2018-09-13 |
2021-07-15 |
Modernatx Inc |
Polinucleotidos que codifican glucosa-6-fosfatasa para el tratamiento de la glucogenosis.
|
|
EP3849594A2
(en)
|
2018-09-13 |
2021-07-21 |
Modernatx, Inc. |
Polynucleotides encoding branched-chain alpha-ketoacid dehydrogenase complex e1-alpha, e1-beta, and e2 subunits for the treatment of maple syrup urine disease
|
|
EP3849617A1
(en)
|
2018-09-14 |
2021-07-21 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
|
AU2019339430A1
(en)
|
2018-09-14 |
2021-04-29 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide A1 for the treatment of Crigler-Najjar Syndrome
|
|
JP7344300B2
(ja)
|
2018-09-18 |
2023-09-13 |
ブイエヌブイ ニューコ インク． |
Ａｒｃベースのカプシドおよびその使用
|
|
EP3853202A1
(en)
|
2018-09-19 |
2021-07-28 |
ModernaTX, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
EP4509118A3
(en)
|
2018-09-19 |
2025-05-14 |
ModernaTX, Inc. |
High-purity peg lipids and uses thereof
|
|
WO2020061284A1
(en)
|
2018-09-19 |
2020-03-26 |
Modernatx, Inc. |
Peg lipids and uses thereof
|
|
US12090235B2
(en)
|
2018-09-20 |
2024-09-17 |
Modernatx, Inc. |
Preparation of lipid nanoparticles and methods of administration thereof
|
|
MA53734A
(fr)
|
2018-09-27 |
2021-08-04 |
Modernatx Inc |
Polynucléotides codant pour l'arginase 1 pour le traitement d'une déficience en arginase
|
|
CN112888451A
(zh)
|
2018-10-19 |
2021-06-01 |
川斯勒佰尔公司 |
信使rna的无泵包封
|
|
AU2019376004B2
(en)
|
2018-11-08 |
2025-12-18 |
Translate Bio, Inc. |
Methods and compositions for messenger RNA purification
|
|
WO2020097409A2
(en)
|
2018-11-08 |
2020-05-14 |
Modernatx, Inc. |
Use of mrna encoding ox40l to treat cancer in human patients
|
|
AU2019377525B2
(en)
|
2018-11-09 |
2025-10-16 |
Translate Bio, Inc. |
Multi-PEG lipid compounds
|
|
US20220016265A1
(en)
|
2018-11-09 |
2022-01-20 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
|
AU2019374883A1
(en)
|
2018-11-09 |
2021-05-20 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
US12280147B2
(en)
|
2018-11-09 |
2025-04-22 |
Translate Bio, Inc. |
PEG lipidoid compounds
|
|
JP7483294B2
(ja)
|
2018-11-09 |
2024-05-15 |
トランスレイト バイオ， インコーポレイテッド |
層間エステル、チオエステル、ジスルフィドおよび無水部分を含む２，５－ジオキソピペラジン脂質
|
|
CA3119449A1
(en)
|
2018-11-12 |
2020-05-22 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
|
US12257305B2
(en)
|
2018-11-21 |
2025-03-25 |
Translate Bio, Inc. |
Cationic lipid compounds
|
|
MX2021005969A
(es)
|
2018-11-21 |
2021-09-14 |
Translate Bio Inc |
Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr nebulizado.
|
|
TW202039534A
(zh)
|
2018-12-14 |
2020-11-01 |
美商美國禮來大藥廠 |
KRAS變體mRNA分子
|
|
CA3118034A1
(en)
|
2018-12-21 |
2020-06-25 |
Curevac Ag |
Rna for malaria vaccines
|
|
WO2020142754A2
(en)
|
2019-01-04 |
2020-07-09 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
|
JP2022516356A
(ja)
|
2019-01-07 |
2022-02-25 |
トランスレイト バイオ， インコーポレイテッド |
原発性線毛機能不全症の治療のための組成物および方法
|
|
WO2020161342A1
(en)
|
2019-02-08 |
2020-08-13 |
Curevac Ag |
Coding rna administered into the suprachoroidal space in the treatment of ophtalmic diseases
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
EP3935156A4
(en)
|
2019-03-07 |
2022-12-28 |
The Regents of The University of California |
CRISPR-CAS EFFECTIVE POLYPEPTIDES AND METHODS OF USE THEREOF
|
|
US20220154222A1
(en)
|
2019-03-14 |
2022-05-19 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US12534714B2
(en)
|
2019-03-18 |
2026-01-27 |
The Broad Institute, Inc. |
Type VII CRISPR proteins and systems
|
|
US11359291B2
(en)
|
2019-04-16 |
2022-06-14 |
Ecolab Usa Inc. |
Use of multiple charged cationic compounds derived from polyamines and compositions thereof for corrosion inhibition in a water system
|
|
WO2020214946A1
(en)
|
2019-04-18 |
2020-10-22 |
Translate Bio, Inc. |
Cystine cationic lipids
|
|
US20220233444A1
(en)
|
2019-04-22 |
2022-07-28 |
Translate Bio, Inc. |
Thioester cationic lipids
|
|
EP3962902A1
(en)
|
2019-05-03 |
2022-03-09 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
|
JP2022532078A
(ja)
|
2019-05-08 |
2022-07-13 |
アストラゼネカ アクチボラグ |
皮膚及び創傷のための組成物並びにその使用の方法
|
|
WO2020232276A1
(en)
|
2019-05-14 |
2020-11-19 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
WO2020236972A2
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
AU2020280105A1
(en)
|
2019-05-22 |
2022-01-20 |
Massachusetts Institute Of Technology |
Circular RNA compositions and methods
|
|
EP3976593A1
(en)
|
2019-05-31 |
2022-04-06 |
Translate Bio, Inc. |
Macrocyclic lipids
|
|
WO2020254535A1
(en)
|
2019-06-18 |
2020-12-24 |
Curevac Ag |
Rotavirus mrna vaccine
|
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
|
CN114401942B
(zh)
|
2019-06-21 |
2024-01-26 |
川斯勒佰尔公司 |
三(羟甲基)甲基甘氨酸和柠檬酸脂质
|
|
MA56539A
(fr)
|
2019-06-24 |
2022-04-27 |
Modernatx Inc |
Arn messager résistant à l'endonucléase et utilisations correspondantes
|
|
US20220387628A1
(en)
|
2019-06-24 |
2022-12-08 |
Modernatx, Inc. |
Messenger rna comprising functional rna elements and uses thereof
|
|
JP7586886B2
(ja)
|
2019-07-08 |
2024-11-19 |
トランスレイト バイオ， インコーポレイテッド |
改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス
|
|
EP3997226A1
(en)
|
2019-07-11 |
2022-05-18 |
Tenaya Therapeutics, Inc. |
Cardiac cell reprogramming with micrornas and other factors
|
|
US12144871B2
(en)
|
2019-07-23 |
2024-11-19 |
Translate Bio, Inc. |
Stable compositions of MRNA-loaded lipid nanoparticles and processes of making
|
|
CA3148819A1
(en)
|
2019-07-30 |
2021-02-04 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
|
|
JP2022544412A
(ja)
|
2019-08-14 |
2022-10-18 |
キュアバック アーゲー |
免疫賦活特性が減少したｒｎａ組み合わせおよび組成物
|
|
EP4013873A1
(en)
|
2019-08-16 |
2022-06-22 |
Massachusetts Institute Of Technology |
Targeted trans-splicing using crispr/cas13
|
|
BR112022004759A2
(pt)
|
2019-09-19 |
2022-06-21 |
Modernatx Inc |
Composições e compostos lipídicos com cauda ramificada para entrega intracelular de agentes terapêuticos
|
|
WO2021055855A1
(en)
|
2019-09-20 |
2021-03-25 |
The Broad Institute, Inc. |
Compositions and methods for delivering cargo to a target cell
|
|
US20240197825A1
(en)
|
2019-09-20 |
2024-06-20 |
Translate Bio, Inc. |
mRNA Encoding Engineered CFTR
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
WO2021072172A1
(en)
|
2019-10-09 |
2021-04-15 |
Translate Bio, Inc. |
Compositions, methods and uses of messenger rna
|
|
CN114828837A
(zh)
*
|
2019-10-18 |
2022-07-29 |
宾夕法尼亚大学理事会 |
用于CAR mRNA递送的脂质纳米颗粒及其配方
|
|
WO2021077066A1
(en)
*
|
2019-10-18 |
2021-04-22 |
The Trustees Of The University Of Pennsylvania |
Lipid and lipid nanoparticle formulation for drug delivery
|
|
WO2021081058A1
(en)
|
2019-10-21 |
2021-04-29 |
Translate Bio, Inc. |
Compositions, methods and uses of messenger rna
|
|
JP2023504568A
(ja)
|
2019-12-04 |
2023-02-03 |
オルナ セラピューティクス インコーポレイテッド |
環状ｒｎａ組成物及び方法
|
|
WO2021127641A1
(en)
|
2019-12-20 |
2021-06-24 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
IL294073A
(en)
|
2019-12-20 |
2022-08-01 |
Translate Bio Inc |
Rectal administration of messenger rna
|
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
|
KR102198736B1
(ko)
*
|
2020-01-15 |
2021-01-05 |
이화여자대학교 산학협력단 |
생체 내 약물 전달을 위한 지질 나노입자 및 이의 용도
|
|
EP4096644A1
(en)
*
|
2020-01-31 |
2022-12-07 |
Modernatx, Inc. |
Methods of preparing lipid nanoparticles
|
|
JP7793525B2
(ja)
|
2020-02-04 |
2026-01-05 |
キュアバック エスイー |
コロナウイルスワクチン
|
|
US11969480B2
(en)
|
2020-02-25 |
2024-04-30 |
Translate Bio, Inc. |
Processes of preparing mRNA-loaded lipid nanoparticles
|
|
CN115552022A
(zh)
|
2020-03-02 |
2022-12-30 |
特纳亚治疗股份有限公司 |
由心肌细胞表达的微rna控制的基因载体
|
|
US11773391B2
(en)
|
2020-04-01 |
2023-10-03 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Therapeutic and diagnostic target for SARS-CoV-2 and COVID-19
|
|
EP4133069A2
(en)
|
2020-04-08 |
2023-02-15 |
Astrazeneca AB |
Compositions and methods for improved site-specific modification
|
|
WO2021226436A1
(en)
|
2020-05-07 |
2021-11-11 |
Translate Bio, Inc. |
Optimized nucleotide sequences encoding sars-cov-2 antigens
|
|
EP4146680A1
(en)
|
2020-05-07 |
2023-03-15 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
WO2021226468A1
(en)
|
2020-05-07 |
2021-11-11 |
Translate Bio, Inc. |
Improved compositions for cftr mrna therapy
|
|
EP4162059A1
(en)
|
2020-05-12 |
2023-04-12 |
The Trustees of The University of Pennsylvania |
Compositions for drg-specific reduction of transgene expression
|
|
US12514932B2
(en)
|
2020-05-14 |
2026-01-06 |
Translate Bio, Inc. |
PEG lipidoid compounds
|
|
WO2021231901A1
(en)
|
2020-05-15 |
2021-11-18 |
Translate Bio, Inc. |
Lipid nanoparticle formulations for mrna delivery
|
|
WO2021236855A1
(en)
|
2020-05-19 |
2021-11-25 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
EP4153223A1
(en)
|
2020-05-20 |
2023-03-29 |
Flagship Pioneering Innovations VI, LLC |
Immunogenic compositions and uses thereof
|
|
JP2023526422A
(ja)
|
2020-05-20 |
2023-06-21 |
フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー |
コロナウイルス抗原組成物及びそれらの使用
|
|
AU2021281453A1
(en)
|
2020-05-29 |
2022-11-17 |
Flagship Pioneering Innovations Vi, Llc. |
Trem compositions and methods relating thereto
|
|
CN116322758A
(zh)
|
2020-05-29 |
2023-06-23 |
库尔维科欧洲股份公司 |
基于核酸的组合疫苗
|
|
CN116018405A
(zh)
|
2020-05-29 |
2023-04-25 |
旗舰先锋创新Vi有限责任公司 |
Trem组合物及其相关方法
|
|
US20230235298A1
(en)
|
2020-06-01 |
2023-07-27 |
Modernatx, Inc. |
Phenylalanine hydroxylase variants and uses thereof
|
|
IL299167A
(en)
|
2020-06-17 |
2023-02-01 |
Univ Pennsylvania |
Compositions and methods for treating patients with gene therapy
|
|
WO2025056938A1
(en)
|
2023-09-11 |
2025-03-20 |
BioNTech SE |
Rna compositions for delivery of incretin agents
|
|
WO2022006527A1
(en)
|
2020-07-02 |
2022-01-06 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
|
BR112023000578A2
(pt)
|
2020-07-13 |
2023-05-09 |
Univ Pennsylvania |
Composições úteis para tratamento de doença de charcot-marie-tooth
|
|
EP4172194A1
(en)
|
2020-07-31 |
2023-05-03 |
CureVac SE |
Nucleic acid encoded antibody mixtures
|
|
US11406703B2
(en)
|
2020-08-25 |
2022-08-09 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
|
US20240066114A1
(en)
|
2020-08-31 |
2024-02-29 |
CureVac SE |
Multivalent nucleic acid based coronavirus vaccines
|
|
MX2023002439A
(es)
|
2020-09-03 |
2023-05-09 |
Flagship Pioneering Innovations Vi Llc |
Composiciones immunogénicas y usos de las mismas.
|
|
JP2023544197A
(ja)
|
2020-10-06 |
2023-10-20 |
トランスレイト バイオ， インコーポレイテッド |
脂質ナノ粒子の改善された方法および製剤
|
|
KR20230083287A
(ko)
|
2020-10-07 |
2023-06-09 |
리젠엑스바이오 인크. |
Cln2 질환의 안구 징후에 대한 유전자 요법
|
|
CA3195015A1
(en)
|
2020-10-09 |
2022-04-14 |
Jason MCLELLAN |
Prefusion-stabilized hmpv f proteins
|
|
AU2021356684A1
(en)
|
2020-10-09 |
2023-05-11 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of fabry disease
|
|
US20220133631A1
(en)
|
2020-10-12 |
2022-05-05 |
Translate Bio, Inc. |
Process of preparing ice-based lipid nanoparticles
|
|
WO2022081544A1
(en)
|
2020-10-12 |
2022-04-21 |
Translate Bio, Inc. |
Improved process of preparing mrna-loaded lipid nanoparticles
|
|
AU2021373892A1
(en)
|
2020-11-09 |
2023-07-06 |
Translate Bio, Inc. |
Improved compositions for delivery of codon-optimized mrna
|
|
US20230406895A1
(en)
|
2020-11-13 |
2023-12-21 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
|
AU2021386737A1
(en)
|
2020-11-25 |
2023-07-13 |
Translate Bio, Inc. |
Stable liquid lipid nanoparticle formulations
|
|
KR20230128001A
(ko)
|
2020-12-01 |
2023-09-01 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
엔젤만 증후군의 치료를 위한 조성물 및 이의 용도
|
|
EP4256065A2
(en)
|
2020-12-01 |
2023-10-11 |
The Trustees of The University of Pennsylvania |
Novel compositions with tissue-specific targeting motifs and compositions containing same
|
|
JP2023552555A
(ja)
*
|
2020-12-07 |
2023-12-18 |
トラスティーズ オブ タフツ カレッジ |
リピドイド組成物およびその使用方法
|
|
WO2022137133A1
(en)
|
2020-12-22 |
2022-06-30 |
Curevac Ag |
Rna vaccine against sars-cov-2 variants
|
|
WO2022135993A2
(en)
|
2020-12-22 |
2022-06-30 |
Curevac Ag |
Pharmaceutical composition comprising lipid-based carriers encapsulating rna for multidose administration
|
|
KR20230135585A
(ko)
|
2020-12-23 |
2023-09-25 |
플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 |
변형된 trem의 조성물 및 이의 용도
|
|
ES3012121T3
(en)
*
|
2020-12-23 |
2025-04-08 |
Ecolab Usa Inc |
Non-cationic softeners and methods of use
|
|
JP2024500515A
(ja)
*
|
2020-12-24 |
2024-01-09 |
エンハンストバイオ インコーポレイテッド |
脂質ナノ粒子を含む癌の予防または治療用組成物
|
|
CN116981692A
(zh)
|
2021-01-14 |
2023-10-31 |
翻译生物公司 |
递送mRNA编码的抗体的方法和组合物
|
|
CA3208643A1
(en)
|
2021-01-18 |
2022-07-21 |
Conserv Bioscience Limited |
Coronavirus immunogenic compositions, methods and uses thereof
|
|
EP4087938A2
(en)
|
2021-01-27 |
2022-11-16 |
CureVac AG |
Method of reducing the immunostimulatory properties of in vitro transcribed rna
|
|
EP4284335A1
(en)
|
2021-02-01 |
2023-12-06 |
RegenxBio Inc. |
Gene therapy for neuronal ceroid lipofuscinoses
|
|
IL305021A
(en)
|
2021-02-08 |
2023-10-01 |
Univ Texas |
Unsaturated Dendrimer Compositions, Related Formulations, and Methods of Using Them
|
|
US11524023B2
(en)
|
2021-02-19 |
2022-12-13 |
Modernatx, Inc. |
Lipid nanoparticle compositions and methods of formulating the same
|
|
CA3208993A1
(en)
|
2021-02-23 |
2022-09-01 |
Joshua RYCHAK |
Compositions and methods for delivery of nucleic acids
|
|
CN116887812A
(zh)
|
2021-02-26 |
2023-10-13 |
埃泽瑞斯公司 |
用于气溶胶形成的制剂以及用于递送核酸的气溶胶
|
|
WO2022204219A1
(en)
|
2021-03-22 |
2022-09-29 |
Recode Therapeutics, Inc. |
Compositions and methods for targeted delivery to cells
|
|
JP2024511437A
(ja)
|
2021-03-23 |
2024-03-13 |
リコード セラピューティクス，インク． |
ポリヌクレオチド組成物、関連製剤、およびその使用方法
|
|
WO2022204390A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
|
|
WO2022204371A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
|
|
US20240226025A1
(en)
|
2021-03-24 |
2024-07-11 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
|
|
US20240216288A1
(en)
|
2021-03-24 |
2024-07-04 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
|
|
US20240189449A1
(en)
|
2021-03-24 |
2024-06-13 |
Modernatx, Inc. |
Lipid nanoparticles and polynucleotides encoding ornithine transcarbamylase for the treatment of ornithine transcarbamylase deficiency
|
|
US20250268994A1
(en)
|
2021-03-25 |
2025-08-28 |
Translate Bio, Inc. |
Optimized Nucleotide Sequences Encoding the Extracellular Domain of Human ACE2 Protein or a Portion Thereof
|
|
US20240181038A1
(en)
|
2021-03-26 |
2024-06-06 |
Glaxosmithkline Biologicals Sa |
Immunogenic compositions
|
|
CA3214085A1
(en)
|
2021-03-31 |
2022-10-06 |
Darby Rye Schmidt |
Thanotransmission polypeptides and their use in treating cancer
|
|
WO2022207862A2
(en)
|
2021-03-31 |
2022-10-06 |
Curevac Ag |
Syringes containing pharmaceutical compositions comprising rna
|
|
WO2022214522A2
(en)
|
2021-04-07 |
2022-10-13 |
Astrazeneca Ab |
Compositions and methods for site-specific modification
|
|
MX2023012052A
(es)
|
2021-04-12 |
2024-03-15 |
Univ Pennsylvania |
Composiciones útiles para tratar la atrofia muscular espinal y bulbar (sbma).
|
|
JP2024515668A
(ja)
|
2021-04-19 |
2024-04-10 |
トランスレイト バイオ， インコーポレイテッド |
Ｍｒｎａの送達のための改善された組成物
|
|
AU2022262422A1
(en)
|
2021-04-22 |
2023-11-02 |
The Board Of Regents Of The University Of Texas System |
All-in-one dendrimer-based lipid nanoparticles enable precise hdr-mediated gene editing in vivo
|
|
EP4334334A1
(en)
|
2021-04-23 |
2024-03-13 |
The Trustees of The University of Pennsylvania |
Novel compositions with brain-specific targeting motifs and compositions containing same
|
|
EP4083227A1
(en)
|
2021-04-29 |
2022-11-02 |
4basebio, S.L.U. |
Linear dna with enhanced resistance against exonucleases
|
|
CA3171589A1
(en)
|
2021-05-03 |
2022-11-03 |
Moritz THRAN |
Improved nucleic acid sequence for cell type specific expression
|
|
EP4204390A1
(en)
|
2021-05-24 |
2023-07-05 |
Suzhou Abogen Biosciences Co., Ltd. |
Lipid compounds and lipid nanoparticle compositions
|
|
JP2024518793A
(ja)
|
2021-05-27 |
2024-05-02 |
アストラゼネカ・アクチエボラーグ |
向上した安定性を有するｃａｓ９エフェクタータンパク質
|
|
EP4310071A4
(en)
|
2021-05-28 |
2024-11-20 |
Beijing Tricisionbio Therapeutics Inc. |
LIPID COMPOUND AND USE THEREOF IN THE ADMINISTRATION OF NUCLEIC ACID
|
|
BR112023026246A2
(pt)
*
|
2021-06-14 |
2024-02-27 |
Flagship Pioneering Innovations Vi Llc |
Modificação de pacotes mensageiros de planta
|
|
WO2022266083A2
(en)
|
2021-06-15 |
2022-12-22 |
Modernatx, Inc. |
Engineered polynucleotides for cell-type or microenvironment-specific expression
|
|
US20240376445A1
(en)
|
2021-06-22 |
2024-11-14 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
|
|
EP4362920A1
(en)
|
2021-07-01 |
2024-05-08 |
Translate Bio, Inc. |
Compositions for delivery of mrna
|
|
EP4377457A1
(en)
|
2021-07-26 |
2024-06-05 |
Flagship Pioneering Innovations VI, LLC |
Trem compositions and uses thereof
|
|
US20240342206A1
(en)
|
2021-07-30 |
2024-10-17 |
CureVac SE |
mRNAS FOR TREATMENT OR PROPHYLAXIS OF LIVER DISEASES
|
|
CA3227852A1
(en)
|
2021-08-03 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof
|
|
CN115724806B
(zh)
*
|
2021-08-25 |
2025-07-01 |
广州谷森制药有限公司 |
阳离子脂质化合物
|
|
CN118043466A
(zh)
|
2021-09-03 |
2024-05-14 |
葛兰素史克生物有限公司 |
自扩增信使核糖核酸中核苷酸碱基的取代
|
|
EP4395748A1
(en)
|
2021-09-03 |
2024-07-10 |
CureVac SE |
Novel lipid nanoparticles for delivery of nucleic acids
|
|
US20240398933A1
(en)
|
2021-09-03 |
2024-12-05 |
CureVac SE |
Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine
|
|
AR127073A1
(es)
|
2021-09-17 |
2023-12-13 |
Flagship Pioneering Innovations Vi Llc |
Composiciones y métodos para producir polirribonucleótidos circulares
|
|
WO2023056282A1
(en)
*
|
2021-09-28 |
2023-04-06 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for t cell targeted delivery of therapeutic agents
|
|
EP4596697A3
(en)
|
2021-09-28 |
2025-08-27 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
WO2023052508A2
(en)
|
2021-09-30 |
2023-04-06 |
Astrazeneca Ab |
Use of inhibitors to increase efficiency of crispr/cas insertions
|
|
US20250017867A1
(en)
|
2021-10-01 |
2025-01-16 |
Modernatx, Inc. |
Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease
|
|
CA3255883A1
(en)
*
|
2021-10-01 |
2023-04-06 |
The Trustees Of The University Of Pennsylvania |
LIPID NANOPARTICLE (LNP) COMPOSITIONS AND THEIR METHODS OF USE
|
|
WO2023059806A1
(en)
|
2021-10-06 |
2023-04-13 |
Massachusetts Institute Of Technology |
Lipid nanoparticles for drug delivery to microglia in the brain
|
|
AR127312A1
(es)
|
2021-10-08 |
2024-01-10 |
Suzhou Abogen Biosciences Co Ltd |
Compuestos lipídicos ycomposiciones de nanopartículas lipídicas
|
|
CN115957187B
(zh)
*
|
2021-10-09 |
2025-08-22 |
北京启辰生生物科技有限公司 |
一种脂质纳米颗粒组合物以及由其制备的药物递送系统
|
|
AU2022370530A1
(en)
|
2021-10-18 |
2024-05-02 |
Flagship Pioneering Innovations Vi, Llc |
Compositions and methods for purifying polyribonucleotides
|
|
US20250027108A1
(en)
|
2021-10-29 |
2025-01-23 |
CureVac SE |
Improved circular rna for expressing therapeutic proteins
|
|
TW202334080A
(zh)
|
2021-11-08 |
2023-09-01 |
美商歐納醫療公司 |
用於遞送環狀聚核苷酸之脂質奈米粒子組合物
|
|
WO2023086893A1
(en)
|
2021-11-10 |
2023-05-19 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
|
US20250295807A1
(en)
|
2021-11-15 |
2025-09-25 |
The Trustees Of The University Of Pennsylvania |
Compositions for drg-specific reduction of transgene expression
|
|
IL312965A
(en)
|
2021-11-24 |
2024-07-01 |
Flagship Pioneering Innovations Vi Llc |
Immunogenic compositions and their uses
|
|
JP2024541466A
(ja)
|
2021-11-24 |
2024-11-08 |
フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー |
水痘帯状疱疹ウイルス免疫原組成物及びその使用
|
|
JP2024541467A
(ja)
|
2021-11-24 |
2024-11-08 |
フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー |
コロナウイルス免疫原組成物及びそれらの使用
|
|
US11510975B1
(en)
*
|
2021-11-29 |
2022-11-29 |
Replicate Bioscience, Inc. |
Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses
|
|
WO2023102517A1
(en)
|
2021-12-02 |
2023-06-08 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of fabry disease
|
|
AU2022413687A1
(en)
|
2021-12-17 |
2024-06-27 |
Flagship Pioneering Innovations Vi, Llc |
Methods for enrichment of circular rna under denaturing conditions
|
|
EP4453201A1
(en)
|
2021-12-22 |
2024-10-30 |
Flagship Pioneering Innovations VI, LLC |
Compositions and methods for purifying polyribonucleotides
|
|
JP2025500358A
(ja)
|
2021-12-23 |
2025-01-09 |
フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー |
抗膜融合ポリペプチドをコードする環状ポリリボヌクレオチド
|
|
AR128239A1
(es)
|
2022-01-10 |
2024-04-10 |
Univ Pennsylvania |
Composiciones y métodos útiles para el tratamiento de trastornos mediados por c9orf72
|
|
CN114507195B
(zh)
*
|
2022-01-14 |
2024-02-13 |
华南理工大学 |
一种脂质化合物、包含其的组合物及应用
|
|
WO2023144193A1
(en)
|
2022-01-25 |
2023-08-03 |
CureVac SE |
Mrnas for treatment of hereditary tyrosinemia type i
|
|
US20250345416A1
(en)
|
2022-01-27 |
2025-11-13 |
BioNTech SE |
Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
|
|
EP4469091A1
(en)
|
2022-01-28 |
2024-12-04 |
CureVac SE |
Nucleic acid encoded transcription factor inhibitors
|
|
CN116554042A
(zh)
*
|
2022-01-30 |
2023-08-08 |
康希诺生物股份公司 |
一种用于核酸递送的新型可电离脂质及其lnp组合物和疫苗
|
|
WO2023143601A1
(zh)
*
|
2022-01-30 |
2023-08-03 |
康希诺生物股份公司 |
一种用于核酸递送的新型可电离脂质及其lnp组合物和疫苗
|
|
EP4482962A1
(en)
|
2022-02-24 |
2025-01-01 |
IO Biotech ApS |
Nucleotide delivery of cancer therapy
|
|
US20250205167A1
(en)
|
2022-03-25 |
2025-06-26 |
Sail Biomedicines, Inc. |
Novel ionizable lipids and lipid nanoparticles and methods of using the same
|
|
EP4499153A2
(en)
|
2022-03-25 |
2025-02-05 |
ModernaTX, Inc. |
Polynucleotides encoding fanconi anemia, complementation group proteins for the treatment of fanconi anemia
|
|
CA3255225A1
(en)
|
2022-04-04 |
2023-10-12 |
The Regents Of The University Of California |
COMPOSITIONS AND METHODS OF GENETIC COMPLEMENTATION
|
|
JP2025511756A
(ja)
|
2022-04-08 |
2025-04-16 |
フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー |
ワクチン及び関連する方法
|
|
KR20250005214A
(ko)
|
2022-04-13 |
2025-01-09 |
우니버시타트 아우토노마 데 바르셀로나 |
클로토 단백질을 발현시키는 유전자 요법을 통한 신경근 질환의 치료
|
|
CN119563108A
(zh)
|
2022-05-01 |
2025-03-04 |
耶达研究发展公司 |
用于减轻癌症相关恶病质的hnf4a的重表达
|
|
CA3257006A1
(en)
|
2022-05-09 |
2023-11-16 |
Flagship Pioneering Innovations Vi, Llc |
TREM COMPOSITIONS AND METHODS OF USE FOR TREATING PROLIFERATIVE DISORDERS
|
|
CN119487196A
(zh)
|
2022-05-13 |
2025-02-18 |
旗舰创业创新七公司 |
双链dna组合物及相关方法
|
|
US20250345407A1
(en)
|
2022-05-25 |
2025-11-13 |
CureVac SE |
Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide
|
|
WO2023242817A2
(en)
|
2022-06-18 |
2023-12-21 |
Glaxosmithkline Biologicals Sa |
Recombinant rna molecules comprising untranslated regions or segments encoding spike protein from the omicron strain of severe acute respiratory coronavirus-2
|
|
EP4544043A1
(en)
|
2022-06-22 |
2025-04-30 |
Flagship Pioneering Innovations VI, LLC |
Compositions of modified trems and uses thereof
|
|
EP4544051A2
(en)
|
2022-06-24 |
2025-04-30 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
|
US12297285B2
(en)
|
2022-06-24 |
2025-05-13 |
Orna Therapeutics, Inc. |
Circular RNA encoding chimeric antigen receptors targeting BCMA
|
|
MA71619A
(fr)
|
2022-07-26 |
2025-05-30 |
Modernatx, Inc. |
Polynucléotides modifiés pour la régulation temporelle de l'expression
|
|
CA3261283A1
(en)
|
2022-08-01 |
2024-02-08 |
Flagship Pioneering Innovations Vii, Llc |
Immunomodulatory Proteins and Associated Methods
|
|
WO2024035952A1
(en)
|
2022-08-12 |
2024-02-15 |
Remix Therapeutics Inc. |
Methods and compositions for modulating splicing at alternative splice sites
|
|
EP4327829A1
(en)
|
2022-08-26 |
2024-02-28 |
Ethris GmbH |
Stabilization of lipid or lipidoid nanoparticle suspensions
|
|
JP2025529925A
(ja)
|
2022-08-26 |
2025-09-09 |
エスリス ゲーエムベーハー |
安定な脂質またはリピドイドナノ粒子懸濁液
|
|
AU2023334610A1
(en)
|
2022-08-31 |
2025-03-13 |
Sail Biomedicines, Inc. |
Novel ionizable lipids and lipid nanoparticles and methods of using the same
|
|
AU2023347390A1
(en)
|
2022-09-23 |
2025-04-10 |
BioNTech SE |
Compositions for delivery of plasmodium csp antigens and related methods
|
|
WO2024063788A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of malaria antigens and related methods
|
|
AU2023347387A1
(en)
|
2022-09-23 |
2025-04-10 |
BioNTech SE |
Compositions for delivery of liver stage antigens and related methods
|
|
WO2024063789A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of malaria antigens and related methods
|
|
JP2025532686A
(ja)
|
2022-09-26 |
2025-10-01 |
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム |
インフルエンザウイルスワクチン
|
|
EP4598946A1
(en)
|
2022-10-05 |
2025-08-13 |
Flagship Pioneering Innovations V, Inc. |
Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
|
|
US12186389B2
(en)
|
2022-10-28 |
2025-01-07 |
Glaxosmithkline Biologicals Sa |
Nucleic acid base vaccine against emerging SARS-CoV-2 variants
|
|
WO2024097664A1
(en)
|
2022-10-31 |
2024-05-10 |
Flagship Pioneering Innovations Vi, Llc |
Compositions and methods for purifying polyribonucleotides
|
|
TW202434728A
(zh)
|
2022-11-08 |
2024-09-01 |
美商旗艦先鋒創新有限責任公司 |
用於產生環狀多核糖核苷酸的組成物和方法
|
|
TW202425959A
(zh)
|
2022-11-08 |
2024-07-01 |
美商歐納醫療公司 |
遞送多核苷酸的脂質及奈米顆粒組合物
|
|
JP2025537178A
(ja)
|
2022-11-08 |
2025-11-14 |
オーナ セラピューティクス， インコーポレイテッド |
環状ｒｎａ組成物
|
|
WO2024102762A1
(en)
|
2022-11-08 |
2024-05-16 |
Orna Therapeutics, Inc. |
Lipids and lipid nanoparticle compositions for delivering polynucleotides
|
|
WO2024102954A1
(en)
|
2022-11-10 |
2024-05-16 |
Massachusetts Institute Of Technology |
Activation induced clipping system (aics)
|
|
WO2024112652A1
(en)
|
2022-11-21 |
2024-05-30 |
Translate Bio, Inc. |
Compositions of dry powder formulations of messenger rna and methods of use thereof
|
|
CN120693181A
(zh)
|
2022-12-08 |
2025-09-23 |
瑞科德治疗公司 |
脂质纳米颗粒组合物及其用途
|
|
TW202430215A
(zh)
|
2022-12-14 |
2024-08-01 |
美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 |
用於將治療劑遞送至骨之組成物和方法
|
|
AU2023394992A1
(en)
|
2022-12-15 |
2025-07-31 |
Sanofi Pasteur Inc. |
Mrna encoding influenza virus-like particle
|
|
EP4634390A2
(en)
|
2022-12-15 |
2025-10-22 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
KR20250135916A
(ko)
|
2022-12-17 |
2025-09-15 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
심장 및 골격근 특이적 표적화 모티프를 갖는 재조합 aav 돌연변이체 벡터 및 이를 포함하는 조성물
|
|
WO2024130070A2
(en)
|
2022-12-17 |
2024-06-20 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof
|
|
CN120456919A
(zh)
|
2022-12-19 |
2025-08-08 |
葛兰素史克生物有限公司 |
乙型肝炎组合物
|
|
AR131438A1
(es)
|
2022-12-20 |
2025-03-19 |
Sanofi Sa |
VACUNA DE ARNm DE RINOVIRUS
|
|
EP4638766A1
(en)
|
2022-12-20 |
2025-10-29 |
NanoCell Therapeutics Holdings B.V. |
Integrating and self-inactivating viral vectors and constructs and uses thereof
|
|
EP4648794A2
(en)
|
2023-01-09 |
2025-11-19 |
Flagship Pioneering Innovations VII, LLC |
Vaccines and related methods
|
|
WO2024151687A1
(en)
|
2023-01-09 |
2024-07-18 |
Flagship Pioneering Innovations V, Inc. |
Genetic switches and their use in treating cancer
|
|
WO2024151586A2
(en)
|
2023-01-09 |
2024-07-18 |
Board Of Regents, The University Of Texas System |
Prefusion-stabilized human parainfluenza virus 3 f proteins
|
|
US20240252520A1
(en)
|
2023-01-09 |
2024-08-01 |
Beth Israel Deaconess Medical Center, Inc. |
Therapeutic agents and their use for treating chronic wounds
|
|
WO2024151673A2
(en)
|
2023-01-09 |
2024-07-18 |
President And Fellows Of Harvard College |
Recombinant nucleic acid molecules and their use in wound healing
|
|
TW202434263A
(zh)
|
2023-01-27 |
2024-09-01 |
德商拜恩技術股份公司 |
用於遞送單純疱疹病毒醣蛋白ｃ、醣蛋白ｄ、及醣蛋白ｅ抗原之醫藥組成物及相關方法
|
|
WO2024160936A1
(en)
|
2023-02-03 |
2024-08-08 |
Glaxosmithkline Biologicals Sa |
Rna formulation
|
|
TW202438515A
(zh)
|
2023-02-06 |
2024-10-01 |
美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 |
免疫調節組合物及相關方法
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
IL322468A
(en)
|
2023-02-13 |
2025-09-01 |
Flagship Pioneering Innovations Vii Llc |
Ionizable lipids containing degradable crosslinkers and lipid carriers for therapeutic compositions
|
|
GB202302092D0
(en)
|
2023-02-14 |
2023-03-29 |
Glaxosmithkline Biologicals Sa |
Analytical method
|
|
WO2024173836A2
(en)
|
2023-02-17 |
2024-08-22 |
Flagship Pioneering Innovations Vii, Llc |
Dna compositions comprising modified cytosine
|
|
IL322201A
(en)
|
2023-02-17 |
2025-09-01 |
Flagship Pioneering Innovations Vii Llc |
DNA structures containing modified uracil
|
|
AU2024233180A1
(en)
|
2023-03-08 |
2025-09-25 |
CureVac SE |
Novel lipid nanoparticle formulations for delivery of nucleic acids
|
|
JP2026508928A
(ja)
*
|
2023-03-09 |
2026-03-13 |
上海吉量医薬工程有限公司 |
イオン化可能な脂質分子およびその調製方法と使用
|
|
KR20250162610A
(ko)
|
2023-03-15 |
2025-11-18 |
플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 |
폴리리보뉴클레오티드를 포함하는 조성물 및 이의 용도
|
|
CN121358494A
(zh)
|
2023-03-15 |
2026-01-16 |
旗舰创业创新第六有限责任公司 |
免疫原性组合物及其用途
|
|
WO2024197033A1
(en)
|
2023-03-21 |
2024-09-26 |
Modernatx, Inc. |
Polynucleotides encoding relaxin for the treatment of heart failure
|
|
WO2024201368A1
(en)
|
2023-03-29 |
2024-10-03 |
Astrazeneca Ab |
Use of inhibitors to increase efficiency of crispr/cas insertions
|
|
WO2024205657A2
(en)
|
2023-03-29 |
2024-10-03 |
Orna Therapeutics, Inc. |
Lipids and lipid nanoparticle compositions for delivering polynucleotides
|
|
WO2024216128A1
(en)
|
2023-04-12 |
2024-10-17 |
Flagship Pioneering Innovations Vi, Llc |
Trems for use in correction of missense mutations
|
|
EP4695393A1
(en)
|
2023-04-12 |
2026-02-18 |
Flagship Pioneering Innovations VI, LLC |
Modified trems, compositions, and related methods thereof
|
|
EP4698156A1
(en)
|
2023-04-17 |
2026-02-25 |
Sanofi Pasteur Inc. |
Reconstitutable dry powder formulations and methods of use thereof
|
|
WO2024220746A2
(en)
|
2023-04-21 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting fatty acid synthase and related methods
|
|
EP4701658A1
(en)
|
2023-04-27 |
2026-03-04 |
GlaxoSmithKline Biologicals S.A. |
Influenza virus vaccines
|
|
EP4701657A1
(en)
|
2023-04-27 |
2026-03-04 |
GlaxoSmithKline Biologicals S.A. |
Influenza virus vaccines
|
|
WO2024229321A1
(en)
|
2023-05-03 |
2024-11-07 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
|
AU2024265158A1
(en)
|
2023-05-03 |
2025-11-06 |
BioNTech SE |
Optimized csp variants and related methods
|
|
WO2024228044A1
(en)
|
2023-05-03 |
2024-11-07 |
BioNTech SE |
Optimized csp variants and related methods
|
|
AU2024269222A1
(en)
|
2023-05-05 |
2025-10-09 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
|
WO2024230934A1
(en)
|
2023-05-11 |
2024-11-14 |
CureVac SE |
Therapeutic nucleic acid for the treatment of ophthalmic diseases
|
|
CN116803995B
(zh)
*
|
2023-05-16 |
2025-06-06 |
河北大学 |
一类氨基酰胺类脂质化合物及其制备方法和应用
|
|
WO2024240962A1
(en)
|
2023-05-25 |
2024-11-28 |
Ethris Gmbh |
Gm-csf-encoding nucleic acids, pharmaceutical compositions, methods and uses thereof
|
|
WO2024258961A1
(en)
|
2023-06-12 |
2024-12-19 |
The Trustees Of The University Of Pennsylvania |
Aav gene therapy for mucopolysaccharidosis iiib
|
|
WO2024258829A1
(en)
|
2023-06-12 |
2024-12-19 |
Flagship Pioneering Innovations Vii, Llc |
Sars-cov-2 vaccine compositions and related methods
|
|
WO2025006684A1
(en)
|
2023-06-28 |
2025-01-02 |
Flagship Pioneering Innovations Vi, Llc |
Circular polyribonucleotides encoding antifusogenic polypeptides
|
|
TW202516019A
(zh)
|
2023-06-29 |
2025-04-16 |
賓州大學委員會 |
具中樞神經系統靶向模體的突變aav及含有其之組成物
|
|
WO2025012671A1
(en)
|
2023-07-07 |
2025-01-16 |
Institute National De La Sante Et De La Recherche Medicale (Inserm) |
Sars-cov-2 5'utr sequences and linkage thereof to coding sequences
|
|
CN121532514A
(zh)
|
2023-07-07 |
2026-02-13 |
上海环码生物医药有限公司 |
用于季节性流感的环状rna疫苗及使用方法
|
|
WO2025024324A1
(en)
|
2023-07-21 |
2025-01-30 |
BioNTech SE |
Compositions for delivery of plasmodium antigens and related methods
|
|
WO2025024335A2
(en)
|
2023-07-21 |
2025-01-30 |
BioNTech SE |
Compositions for delivery of plasmodium antigens and related methods
|
|
AU2024299365A1
(en)
|
2023-07-24 |
2026-01-08 |
BioNTech SE |
Compositions for delivery of plasmodium antigens and related methods
|
|
AU2024299627A1
(en)
|
2023-07-25 |
2026-01-22 |
Flagship Pioneering Innovations Vii, Llc |
Cas endonucleases and related methods
|
|
AU2024316307A1
(en)
|
2023-08-03 |
2026-02-26 |
BioNTech SE |
Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
|
|
WO2025030154A1
(en)
|
2023-08-03 |
2025-02-06 |
The Trustees Of The University Of Pennsylvania |
Pharmaceutical compositions for delivery of herpes simplex virus glycoprotein b antigens and related methods
|
|
WO2025035143A1
(en)
|
2023-08-10 |
2025-02-13 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for treatment of spinal muscular atrophy
|
|
WO2025042786A1
(en)
|
2023-08-18 |
2025-02-27 |
Flagship Pioneering Innovations Vi, Llc |
Compositions comprising circular polyribonucleotides and uses thereof
|
|
WO2025045767A1
(en)
|
2023-08-25 |
2025-03-06 |
Ethris Gmbh |
Stabilized lipid and lipidoid nanoparticle formulations with specific surfactant properties for enhanced pharmaceutical applications
|
|
WO2025045142A1
(en)
|
2023-08-29 |
2025-03-06 |
Shanghai Circode Biomed Co., Ltd. |
Circular rna encoding vegf polypeptides, formulations, and methods of uses
|
|
EP4520345A1
(en)
|
2023-09-06 |
2025-03-12 |
Myneo Nv |
Product
|
|
WO2025054236A2
(en)
|
2023-09-06 |
2025-03-13 |
Flagship Pioneering Innovations Vii, Llc |
Sars-cov-2 vaccine compositions and related methods
|
|
WO2025054556A1
(en)
|
2023-09-07 |
2025-03-13 |
BioNTech SE |
Rna compositions for delivery of mpox antigens and related methods
|
|
WO2025057088A1
(en)
|
2023-09-11 |
2025-03-20 |
BioNTech SE |
Rna compositions for delivery of incretin agents
|
|
WO2025059107A1
(en)
*
|
2023-09-11 |
2025-03-20 |
The Trustees Of The University Of Pennsylvania |
Degradable, branched lipid compounds, methods of preparation thereof, lipid nanoparticles (lnps) comprising the same, and methods of use thereof
|
|
WO2025059215A1
(en)
|
2023-09-12 |
2025-03-20 |
Aadigen, Llc |
Methods and compositions for treating or preventing cancer
|
|
TW202525266A
(zh)
|
2023-09-18 |
2025-07-01 |
美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 |
可電離類脂質組成物及其治療用途
|
|
WO2025072383A1
(en)
|
2023-09-25 |
2025-04-03 |
The Broad Institute, Inc. |
Viral open reading frames, uses thereof, and methods of detecting the same
|
|
WO2025072331A1
(en)
|
2023-09-26 |
2025-04-03 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
WO2025072482A1
(en)
|
2023-09-27 |
2025-04-03 |
Modernatx, Inc. |
Immunoglobulin a protease polypeptides, polynucleotides, and uses thereof
|
|
CN117164468B
(zh)
*
|
2023-10-26 |
2024-01-30 |
南京澄实生物医药科技有限公司 |
一种可电离脂质化合物及其应用
|
|
WO2025088192A1
(en)
|
2023-10-27 |
2025-05-01 |
Xl-Protein Gmbh |
Methods for the coupling of di(alkyl)amines to polypeptides
|
|
WO2025096807A2
(en)
|
2023-10-31 |
2025-05-08 |
Flagship Pioneering Innovations Vii, Llc |
Novel therapeutic dna forms
|
|
WO2025097055A2
(en)
|
2023-11-02 |
2025-05-08 |
The Broad Institute, Inc. |
Compositions and methods of use of t cells in immunotherapy
|
|
WO2025101501A1
(en)
|
2023-11-07 |
2025-05-15 |
Orna Therapeutics, Inc. |
Circular rna compositions
|
|
WO2025102034A1
(en)
|
2023-11-10 |
2025-05-15 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for barth syndrome
|
|
WO2025106670A1
(en)
|
2023-11-14 |
2025-05-22 |
Flagship Pioneering Innovations Vii, Llc |
Ionizable lipidoid compositions and therapeutic uses thereof
|
|
WO2025106661A1
(en)
|
2023-11-14 |
2025-05-22 |
The Trustees Of The University Of Pennsylvania |
Compositions with cardiac and skeletal musclespecific targeting motifs and uses thereof
|
|
WO2025111526A1
(en)
|
2023-11-22 |
2025-05-30 |
Flagship Pioneering Innovations Vii, Llc |
Methods and compositions for treating non-alcoholic fatty liver disease
|
|
WO2025117877A2
(en)
|
2023-12-01 |
2025-06-05 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
US12364773B2
(en)
|
2023-12-01 |
2025-07-22 |
Recode Therapeutics, Inc. |
Lipid nanoparticle compositions and uses thereof
|
|
US12553042B2
(en)
|
2023-12-01 |
2026-02-17 |
Recode Therapeutics, Inc. |
Method for quantifying an amount of capped messenger RNA
|
|
US12539279B2
(en)
|
2023-12-11 |
2026-02-03 |
The Governing Council Of The University Of Toronto |
Supramolecular ionizable lipid molecules with heteroatomic tuning for nucleic acid delivery
|
|
WO2025129158A1
(en)
|
2023-12-15 |
2025-06-19 |
The Broad Institute, Inc. |
Engineered arc delivery vesicles and uses thereof
|
|
WO2025132839A1
(en)
|
2023-12-21 |
2025-06-26 |
Glaxosmithkline Biologicals Sa |
Influenza virus vaccines
|
|
WO2025137646A1
(en)
|
2023-12-22 |
2025-06-26 |
Recode Therapeutics, Inc. |
Gene editing methods and compositions for treating cystic fibrosis
|
|
WO2025160334A1
(en)
|
2024-01-26 |
2025-07-31 |
Flagship Pioneering Innovations Vii, Llc |
Immunoreceptor inhibitory proteins and related methods
|
|
WO2025172421A1
(en)
|
2024-02-14 |
2025-08-21 |
Astrazeneca Ab |
Compositions and methods for treatment of huntington's disease
|
|
WO2025184172A1
(en)
|
2024-02-27 |
2025-09-04 |
Overt Bio, Inc. |
Cancer reactive t cell receptors
|
|
WO2025184170A1
(en)
|
2024-02-27 |
2025-09-04 |
Overt Bio, Inc. |
Methods and compositions for improving t cell function in an immunosuppressive environment
|
|
WO2025193628A2
(en)
|
2024-03-09 |
2025-09-18 |
Aadigen, Llc |
Compositions for treating cancer with kras mutations and uses thereof
|
|
WO2025194019A1
(en)
|
2024-03-14 |
2025-09-18 |
Flagship Pioneering Innovations Vii, Llc |
Methods for treating liver fibrosis and non-alcoholic fatty liver disease
|
|
WO2025196065A1
(en)
|
2024-03-20 |
2025-09-25 |
Sanofi |
Novel homocysteine based lipids and their use for delivery of nucleic acids
|
|
WO2025202937A1
(en)
|
2024-03-26 |
2025-10-02 |
BioNTech SE |
Cancer vaccines
|
|
GB202404607D0
(en)
|
2024-03-29 |
2024-05-15 |
Glaxosmithkline Biologicals Sa |
RNA formulation
|
|
WO2025213131A1
(en)
|
2024-04-05 |
2025-10-09 |
BioNTech SE |
Rna compositions for delivery of orthopox antigens and related methods
|
|
WO2025217275A2
(en)
|
2024-04-10 |
2025-10-16 |
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
|
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|