EP1675943A4 - Nanoliter-scale synthesis of arrayed biomaterials and screening thereof - Google Patents

Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

Info

Publication number
EP1675943A4
EP1675943A4 EP04788758A EP04788758A EP1675943A4 EP 1675943 A4 EP1675943 A4 EP 1675943A4 EP 04788758 A EP04788758 A EP 04788758A EP 04788758 A EP04788758 A EP 04788758A EP 1675943 A4 EP1675943 A4 EP 1675943A4
Authority
EP
European Patent Office
Prior art keywords
nanoliter
screening
scale synthesis
biomaterials
arrayed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04788758A
Other languages
German (de)
French (fr)
Other versions
EP1675943A2 (en
Inventor
Daniel G Anderson
Shulamit Levenberg
Robert S Langer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/843,707 external-priority patent/US20050019747A1/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of EP1675943A2 publication Critical patent/EP1675943A2/en
Publication of EP1675943A4 publication Critical patent/EP1675943A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP04788758A 2003-09-15 2004-09-15 Nanoliter-scale synthesis of arrayed biomaterials and screening thereof Withdrawn EP1675943A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50316503P 2003-09-15 2003-09-15
US57018704P 2004-05-12 2004-05-12
US10/843,707 US20050019747A1 (en) 2002-08-07 2004-05-12 Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
PCT/US2004/030095 WO2005028619A2 (en) 2003-09-15 2004-09-15 Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

Publications (2)

Publication Number Publication Date
EP1675943A2 EP1675943A2 (en) 2006-07-05
EP1675943A4 true EP1675943A4 (en) 2007-12-05

Family

ID=34381975

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04788758A Withdrawn EP1675943A4 (en) 2003-09-15 2004-09-15 Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

Country Status (3)

Country Link
EP (1) EP1675943A4 (en)
CA (1) CA2539670A1 (en)
WO (1) WO2005028619A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2476756A1 (en) 2005-06-15 2012-07-18 Massachusetts Institute of Technology Amine-containing lipids and uses thereof
EP2064375B1 (en) * 2006-06-06 2012-11-21 Société de Commercialisation des Produits de la Recherche Appliquée - SOCPRA- Sciences et Génie s.e.c. Assay supports comprising a peg support, said support attached from a peg solution in cloud point (theta solvent) conditions
EP2240536B1 (en) 2008-01-30 2019-09-04 Asterias Biotherapeutics, Inc. Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
US8329469B2 (en) * 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
CA2712891A1 (en) * 2008-01-30 2009-08-06 Corning Incorporated Synthetic surfaces for culturing stem cell derived cardiomyocytes
ATE555191T1 (en) * 2008-01-30 2012-05-15 Geron Corp SYNTHETIC SURFACES FOR CULTIVATION OF CELLS IN CHEMICALLY DEFINED MEDIA
WO2009099539A2 (en) * 2008-01-30 2009-08-13 Corning Incorporated (meth)acrylate surfaces for cell culture, methods of making and using the surfaces
MX353900B (en) 2008-11-07 2018-02-01 Massachusetts Inst Technology Aminoalcohol lipidoids and uses thereof.
WO2011014845A1 (en) * 2009-07-31 2011-02-03 Nanoink, Inc. Screening system to identify patterns on substrate surfaces for inducing stem cell differentiation and producing homogenous population of a desired cell type
RS58405B1 (en) 2009-12-01 2019-04-30 Translate Bio Inc Steroid derivative for the delivery of mrna in human genetic diseases
EP2609135A4 (en) 2010-08-26 2015-05-20 Massachusetts Inst Technology Poly(beta-amino alcohols), their preparation, and uses thereof
WO2012135025A2 (en) 2011-03-28 2012-10-04 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
RS59037B1 (en) 2011-06-08 2019-08-30 Translate Bio Inc Lipid nanoparticle compositions and methods for mrna delivery
EP2859102A4 (en) 2012-06-08 2016-05-11 Shire Human Genetic Therapies Nuclease resistant polynucleotides and uses thereof
WO2014028487A1 (en) 2012-08-13 2014-02-20 Massachusetts Institute Of Technology Amine-containing lipidoids and uses thereof
AU2014236396A1 (en) 2013-03-14 2015-08-13 Shire Human Genetic Therapies, Inc. Methods for purification of messenger RNA
EP3446712A1 (en) 2013-03-14 2019-02-27 Translate Bio Ma, Inc. Cftr mrna compositions and related methods and uses
WO2014179562A1 (en) 2013-05-01 2014-11-06 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
US11224642B2 (en) 2013-10-22 2022-01-18 Translate Bio, Inc. MRNA therapy for argininosuccinate synthetase deficiency
EA034103B1 (en) 2013-10-22 2019-12-27 Транслейт Био, Инк. METHOD OF TREATING PHENYLKETONURIA USING mRNA
MX2016005238A (en) 2013-10-22 2016-08-12 Shire Human Genetic Therapies Lipid formulations for delivery of messenger rna.
BR112016024632A2 (en) 2014-04-25 2018-01-30 Shire Human Genetic Therapies messenger rna purification methods
EP3148552B1 (en) 2014-05-30 2019-07-31 Translate Bio, Inc. Biodegradable lipids for delivery of nucleic acids
AU2015279968B2 (en) 2014-06-24 2019-11-14 Translate Bio, Inc. Stereochemically enriched compositions for delivery of nucleic acids
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
GB201416078D0 (en) * 2014-09-11 2014-10-29 Univ Nottingham Cell culture substrate
MX2019010155A (en) 2017-02-27 2020-12-10 Translate Bio Inc Novel codon-optimized cftr mrna.
MA49138A (en) 2017-05-16 2020-03-25 Translate Bio Inc TREATMENT OF CYSTIC FIBROSIS BY ADMINISTRATION OF CODON-OPTIMIZED MRNA CODING FOR CFTR
AU2019325702A1 (en) 2018-08-24 2021-02-25 Translate Bio, Inc. Methods for purification of messenger RNA

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097068A2 (en) * 2001-05-31 2002-12-05 Inserm Keratinocytes obtained from embryonic stem cells of mammals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097068A2 (en) * 2001-05-31 2002-12-05 Inserm Keratinocytes obtained from embryonic stem cells of mammals

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALI N N ET AL: "DERIVATION OF TYPE II ALVEOLAR EPITHELIAL CELLS FROM MURINE EMBRYONIC STEM CELLS", TISSUE ENGINEERING, LARCHMONT, NY, US, vol. 8, no. 4, August 2002 (2002-08-01), pages 541 - 550, XP008025656, ISSN: 1076-3279 *
ANDERSON DANIEL G ET AL: "Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells.", NATURE BIOTECHNOLOGY JUL 2004, vol. 22, no. 7, July 2004 (2004-07-01), pages 863 - 866, XP002454174, ISSN: 1087-0156 *
CHEN RUTH R ET AL: "Polymeric growth factor delivery strategies for tissue engineering.", PHARMACEUTICAL RESEARCH AUG 2003, vol. 20, no. 8, August 2003 (2003-08-01), pages 1103 - 1112, XP002454034, ISSN: 0724-8741 *
LYLE S ET AL: "Cytokeratin 15(K15) as an epithelial stem cell marker: Implication for aging and carcinogenesis", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 112, no. 4, 5 May 1999 (1999-05-05), pages 623, XP003010867, ISSN: 0022-202X *
SAKIYAMA-ELBERT SE ET AL.: "Functional Biomaterials:design of novel biomaterials", ANNU.REV.MATER.RES., vol. 31, 2001, pages 183 - 201, XP009090540 *
SPRADLING ALLAN ET AL: "STEM CELLS FIND THEIR NICHE", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 414, no. 6859, November 2001 (2001-11-01), pages 98 - 104, XP009078342, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2005028619A3 (en) 2005-09-09
EP1675943A2 (en) 2006-07-05
CA2539670A1 (en) 2005-03-31
WO2005028619A2 (en) 2005-03-31

Similar Documents

Publication Publication Date Title
EP1675943A4 (en) Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
EP1963360A4 (en) Neuregulin variants and methods of screening and using thereof
ZA200705543B (en) Molecular sieve SSZ-70 composition of matter and synthesis thereof
ZA200710148B (en) Methods of synthesizing substituted 3-cyanoquinolines and inermediates thereof
EP1843975A4 (en) Molecular sieve ssz-70 composition of matter and synthesis thereof
GB0425644D0 (en) Personal customization of stamps
EP1660013A4 (en) Protein biomaterials and biocoacervates and methods of making and using thereof
HK1080549A1 (en) Methods of screening for trpm4b modulators trpm4b
EP1778618A4 (en) Synthesis of triethylenetetramines
ZA200800650B (en) Molecular sieve SSZ-56 composition of matter and synthesis thereof
EP1909947A4 (en) Molecular sieve ssz-56 composition of matter and synthesis thereof
EP1685240A4 (en) Improved methods of in vitro protein synthesis
ZA200806549B (en) Molecular sieve SSZ-74 composition of matter and synthesis thereof
IL176932A0 (en) Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
IL223579A0 (en) Synthesis of amines and intermediates for the synthesis thereof
EP1711484A4 (en) Synthesis of cyanoimino-benzoimidazoles
EP1735281A4 (en) Synthesis of indenoisoquinoliniums and methods of use
AU2003262794A8 (en) Total synthesis of heparin
EP1639121A4 (en) Synthesis of beta -l-2-deoxy nucleosides
EP1984313A4 (en) Molecular sieve ssz-74 composition of matter and synthesis thereof
GB0324147D0 (en) Functionilisation of particles
EP1802560A4 (en) Halocombstatins and methods of synthesis thereof
ZA200705545B (en) Molecular sieve SSZ-71 composition of matter and synthesis thereof
EP1461020A4 (en) Synthesis of small particles
EP1743944A4 (en) Novel method of screening

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060412

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20071105

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110401