EP1675943A4 - Synthese, a l'echelle du nanolitre, de biomateriaux en reseaux et criblage de ceux-ci - Google Patents

Synthese, a l'echelle du nanolitre, de biomateriaux en reseaux et criblage de ceux-ci

Info

Publication number
EP1675943A4
EP1675943A4 EP04788758A EP04788758A EP1675943A4 EP 1675943 A4 EP1675943 A4 EP 1675943A4 EP 04788758 A EP04788758 A EP 04788758A EP 04788758 A EP04788758 A EP 04788758A EP 1675943 A4 EP1675943 A4 EP 1675943A4
Authority
EP
European Patent Office
Prior art keywords
nanoliter
screening
scale synthesis
biomaterials
arrayed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04788758A
Other languages
German (de)
English (en)
Other versions
EP1675943A2 (fr
Inventor
Daniel G Anderson
Shulamit Levenberg
Robert S Langer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/843,707 external-priority patent/US20050019747A1/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of EP1675943A2 publication Critical patent/EP1675943A2/fr
Publication of EP1675943A4 publication Critical patent/EP1675943A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
EP04788758A 2003-09-15 2004-09-15 Synthese, a l'echelle du nanolitre, de biomateriaux en reseaux et criblage de ceux-ci Withdrawn EP1675943A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50316503P 2003-09-15 2003-09-15
US57018704P 2004-05-12 2004-05-12
US10/843,707 US20050019747A1 (en) 2002-08-07 2004-05-12 Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
PCT/US2004/030095 WO2005028619A2 (fr) 2003-09-15 2004-09-15 Synthese, a l'echelle du nanolitre, de biomateriaux en reseaux et criblage de ceux-ci

Publications (2)

Publication Number Publication Date
EP1675943A2 EP1675943A2 (fr) 2006-07-05
EP1675943A4 true EP1675943A4 (fr) 2007-12-05

Family

ID=34381975

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04788758A Withdrawn EP1675943A4 (fr) 2003-09-15 2004-09-15 Synthese, a l'echelle du nanolitre, de biomateriaux en reseaux et criblage de ceux-ci

Country Status (3)

Country Link
EP (1) EP1675943A4 (fr)
CA (1) CA2539670A1 (fr)
WO (1) WO2005028619A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2611944A1 (fr) 2005-06-15 2006-12-28 Massachusetts Institute Of Technology Lipides contenant des amines et utilisations
WO2007140595A1 (fr) * 2006-06-06 2007-12-13 Societe De Commercialisation Des Produits De La Recherche Appliquee - Socpra-Sciences Et Genie S.E.C. Supports d'essai comportant un support de polyéthylène glycol, ledit support fixé provenant d'une solution de polyéthylène glycol dans des conditions de point de trouble (solvent thêta)
WO2009099539A2 (fr) * 2008-01-30 2009-08-13 Corning Incorporated Surfaces de (méth)acrylate de culture cellulaire, et procédé de fabrication et d'utilisation desdites surfaces
KR101635750B1 (ko) * 2008-01-30 2016-07-04 아스테리아스 바이오세라퓨틱스, 인크. 줄기 세포 유래 올리고덴드로사이트 전구 세포를 배양하기 위한 합성 표면
US8329469B2 (en) * 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
CA2712891A1 (fr) * 2008-01-30 2009-08-06 Corning Incorporated Surfaces synthetiques pour la culture de cardiomyocytes issus de cellules souches
DK2247716T3 (da) * 2008-01-30 2012-05-29 Geron Corp Syntetiske overflader til dyrkning af celler i kemisk defineret medie
US8969353B2 (en) 2008-11-07 2015-03-03 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
WO2011014845A1 (fr) * 2009-07-31 2011-02-03 Nanoink, Inc. Système de criblage destiné à identifier des motifs sur des surfaces de substrats pour induire la différenciation des cellules souches et pour produire une population homogène d'un type de cellule recherché
ES2734973T3 (es) 2009-12-01 2019-12-13 Translate Bio Inc Administración de ARNm para el aumento de proteínas y enzimas en enfermedades genéticas humanas
EP2609135A4 (fr) 2010-08-26 2015-05-20 Massachusetts Inst Technology Poly(bêta-amino-alcools), leur préparation et utilisations de ceux-ci
PL2691443T3 (pl) 2011-03-28 2021-08-30 Massachusetts Institute Of Technology Sprzężone lipomery i ich zastosowania
EP2717893B1 (fr) 2011-06-08 2019-05-08 Translate Bio, Inc. Compositions de nanoparticules lipides et procédés pour le transfert d'arnm
WO2013185067A1 (fr) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Polynucléotides résistant à la nucléase et leurs utilisations
CA2884870C (fr) 2012-08-13 2022-03-29 Massachusetts Institute Of Technology Lipidoides contenant des amines et leurs utilisations
IL290953B2 (en) 2013-03-14 2024-01-01 Ethris Gmbh CFTR mRNA Assemblies and Related Methods and Uses
EP3467108B1 (fr) 2013-03-14 2024-05-22 Translate Bio, Inc. Procédés de purification d'arn messager
WO2014179562A1 (fr) 2013-05-01 2014-11-06 Massachusetts Institute Of Technology Dérivés de 1,3,5-triazinane-2,4,6-trione et leurs utilisations
MX2016005237A (es) 2013-10-22 2016-08-12 Shire Human Genetic Therapies Terapia de acido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa.
EP3060257B1 (fr) 2013-10-22 2021-02-24 Translate Bio, Inc. Compositions des lipides pour l'administation arnm
EP3060258A1 (fr) 2013-10-22 2016-08-31 Shire Human Genetic Therapies, Inc. Thérapie à l'arnm pour la phénylcétonurie
CN117402871A (zh) 2014-04-25 2024-01-16 川斯勒佰尔公司 信使rna的纯化方法
EP3148552B1 (fr) 2014-05-30 2019-07-31 Translate Bio, Inc. Lipides biodégradables pour l'administration d'acides nucléiques
NZ727281A (en) 2014-06-24 2024-02-23 Translate Bio Inc Stereochemically enriched compositions for delivery of nucleic acids
EP3164379A1 (fr) 2014-07-02 2017-05-10 Massachusetts Institute of Technology Lipidoïdes dérivés de polyamine-acide gras et leurs utilisations
GB201416078D0 (en) * 2014-09-11 2014-10-29 Univ Nottingham Cell culture substrate
EA201991747A1 (ru) 2017-02-27 2020-06-04 Транслейт Био, Инк. НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR
CA3063531A1 (fr) 2017-05-16 2018-11-22 Translate Bio, Inc. Traitement de la fibrose kystique par administration d'arnm a codons optimises codant pour la cftr
US11174500B2 (en) 2018-08-24 2021-11-16 Translate Bio, Inc. Methods for purification of messenger RNA

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097068A2 (fr) * 2001-05-31 2002-12-05 Inserm Keratinocytes obtenus a partir de cellules souches embryonnaires de mammiferes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097068A2 (fr) * 2001-05-31 2002-12-05 Inserm Keratinocytes obtenus a partir de cellules souches embryonnaires de mammiferes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALI N N ET AL: "DERIVATION OF TYPE II ALVEOLAR EPITHELIAL CELLS FROM MURINE EMBRYONIC STEM CELLS", TISSUE ENGINEERING, LARCHMONT, NY, US, vol. 8, no. 4, August 2002 (2002-08-01), pages 541 - 550, XP008025656, ISSN: 1076-3279 *
ANDERSON DANIEL G ET AL: "Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells.", NATURE BIOTECHNOLOGY JUL 2004, vol. 22, no. 7, July 2004 (2004-07-01), pages 863 - 866, XP002454174, ISSN: 1087-0156 *
CHEN RUTH R ET AL: "Polymeric growth factor delivery strategies for tissue engineering.", PHARMACEUTICAL RESEARCH AUG 2003, vol. 20, no. 8, August 2003 (2003-08-01), pages 1103 - 1112, XP002454034, ISSN: 0724-8741 *
LYLE S ET AL: "Cytokeratin 15(K15) as an epithelial stem cell marker: Implication for aging and carcinogenesis", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 112, no. 4, 5 May 1999 (1999-05-05), pages 623, XP003010867, ISSN: 0022-202X *
SAKIYAMA-ELBERT SE ET AL.: "Functional Biomaterials:design of novel biomaterials", ANNU.REV.MATER.RES., vol. 31, 2001, pages 183 - 201, XP009090540 *
SPRADLING ALLAN ET AL: "STEM CELLS FIND THEIR NICHE", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 414, no. 6859, November 2001 (2001-11-01), pages 98 - 104, XP009078342, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2005028619A3 (fr) 2005-09-09
CA2539670A1 (fr) 2005-03-31
EP1675943A2 (fr) 2006-07-05
WO2005028619A2 (fr) 2005-03-31

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