US2819718A - Drainage tube - Google Patents

Drainage tube Download PDF

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Publication number
US2819718A
US2819718A US368375A US36837553A US2819718A US 2819718 A US2819718 A US 2819718A US 368375 A US368375 A US 368375A US 36837553 A US36837553 A US 36837553A US 2819718 A US2819718 A US 2819718A
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Prior art keywords
tube
drainage
catheter
duct
membrane
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Expired - Lifetime
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US368375A
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Isidore H Goldman
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Isidore H Goldman
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Priority to US368375A priority Critical patent/US2819718A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1002Balloon catheters characterised by balloon shape

Description

Jan. 14, 1958 Filed July 16, 1955 l. H. GOLDMAN 2,819,718

DRAINAE' TUBE Z'SheetS-Sheet 1 INVENTOR- 1.5100125 -H. GaLDMAN Jan. 14, 1958 l. H. GOLDMAN DRAINAGE TUBE 2 Shegts-Sheet 2 Filed July 16, 1953 INVENTOR. (8/0025 H. GOLD/YUM 9 Q v i X United States Patent DRAINAGETUBE Isidore H. Goldman, New York; N. Y.. Application July 16, 1953, Serial No. 368,375 a Claims. (Cl.128-'-350)f This invention relates to catheters; This invention has as its mainobject the'alleviation of pain and discomfort caused by' the conventional-type of catheter wherein the retention means wheninflated causes' a compression of the tube thereatresulting in painand discomfort by inability to void at a rate sufficient to relieve the pressure of the waste products.

Catheters currently in use-consistessentially of a flexible elongated tube terminating in a closed poi'nted end adapted'to be inserted into the urinaryorotherbladderor opening of the body and are'provided" nearsaid pointed end' with openings for drainage. Thesecatheters are-further provided with inflatable members adjacent said drainage openings whereby to retain the closedendof the catheter within the bladder and also with independent drainage and inflation ducts'extending to the outer open endofthe device. However, sincethe walls'ofl'the drainage duct also form the inner walls for the inflatableportion, the air or other compressedfluid within theinilatabIe portion tends to collapse the walls of the drainage'du'ct inwardly, seriously impairing the effectiveness of the device.

It is accordingly a principal-object of the present invention to provide an improved catheter of'the type having inflatable retention means wherein collapse of the walls of the drainage-duct is prevented when the retention means are inflated.

It is another object of present invention to provide an drawing. It is to be noted that the drawing is intended to serve the purpose of illustration only, and that it is neither desired nor intended to limit the invention necessary to any or all of the exact details of construction shown except insofar as they may be deemed essential to the invention.

Referring briefly to the drawing,

Figure l is a perspective view of a catheter embodying the features of the present invention and with the retention means shown deflated;

Fig. 2 is a longitudinal sectional view taken along the line 2-2 of Fig. 1;

Fig. 3 is a transverse sectional view taken along the line 3-3 of Fig. 2;

Fig. 4 is a perspective view showing the retention means inflated and the device operative for use;

Fig. 5 is a view similar to Fig. 2 but showing the retention means inflated Within the bladder walls;

"ice

Fig. 6 is aperspective-view ofthe-insert preventing eollapse of the drainage duct, shown alone;

Fig. 7 isaview similar to Fig. 5 of a conventional catheter showing the collapse of thedrainage duct'walls upon inflation of the retention means; and

Fig. 8 is a fragmentary view similar to Fig. 2' but showing' a modified form of-the'invention.

Referring now in detail to the drawing, ltl-represents an elongated flexible tubeof rubber or other suitable material having a closed; pointed end 11 to facilitate insertion intothe urethra or other bodyopening, the outer open end of the tube: ltl being flared'outwardly...as at 12- and terminating in a relatively large cylindrical portion13.

The outer open end of the cylindrical vportion vided with a suitablestopper.14 (Eig.44.).

The tube 10* adjacent the-pointed end11 is provi ed withsuitable drainage openings 15..

The interior of'the tube 101at=one side is reinforced-1a at 16, this reinforced portion extending from near the openings 15 to near theflared portioni1-2 andi being provided with an inflationductli" over substantially: the length thereof.

The tube 10 adjacent the outwardly flaredportion'. 12 is integrally formed with a substantially L-shaped tube 18having an outwardly flared outer open end 19 andcomrnunicating with the inflation duct-17;

The tube 10 near the drainageopenings 15 is providd with anannular slit 20p1'ovidin g an annular outer membrane 21 (Fig. 2). The upper end-ofthe drainage duct 17 communicates with the annular slit 2tlby. meanszofca cut out or opening 22 (Figs. 2 and 3).

A hollow insert 23 of substantially crescent-shaped cross section to facilitate fluid'flowf in the inflationmeans is positioned within the tube lowithin the portion thereof having the annular slit 20, the concave-portion 24iofsthe insert snugly receiving therewithin the correspondingly shaped reinforced portion 16 having the inflation duct-'17 It will be noted that the construction permitsthe membrane 21, when collapsed, to present a smooth exterior to the tube 10' and to thereby facilitate the insertionand removal of the same between the walls 25-- of the bladder.

Reinforcing tubes, I10USh0Wl1; may beprovidedwithin the inflation duct 17 during use.

To inflate the membrane 21 to the positions of Figs. 4 and 5, a hand pump, not shown, or other suitable inflating means may be connected to the flared portion 19 of the tube 18. After inflation of the membrane 21, the tube 18 is doubled up, as shown in Fig. 4, and closed off with a rubber band 26, or other suitable means.

Thus, the catheter will be retained in the proper position within the bladder walls 25 by means of the inflated membrane 21 after the catheter has been inserted to the proper position.

The insert 23 prevents the inward movement of the walls surrounding the drainage duct 27 when the membrane 21 is inflated. Were it not for the insert 23, the walls of the drainage duct 27 would be forced inwardly, as shown in Fig. 7, and preventing the proper drainage of the body liquid passing into the tube through the drainage openings 15.

The insert 23 may be fabricated of any suitable material which will not be affected by the drainage liquid, its only requirement being that it have sutficient rigidity to prevent the collapsing of the drainage duct 27 within the membrane portion 21. This member 23 may be molded or aflixed integrally with the catheter during production or this portion of the catheter may be treated for greater hardness and rigidityduring vulcanization.

By providing the insert 23, it will be apparent that greater pressure may be exerted within the membrane 21, without closing the drainage duct 27, permitting a 13 isprogreater expansion of the membrane and greater control of the internal pressure upon the walls 25. This is particularly important when it is desired to control bleeding from blood vessels Within the walls 25 in post-operative cases.

Also, while in the drawing the invention has been shown in connection with a catheter having one inflation duct 17, it will be readily apparent that several inflation ducts may be provided on opposite sides of the tube, and that the present invention is equally applicable in such cases. Also, while there has been shown an annular membrane 21, it will be apparent that the invention is equally applicable to cases where a plurality of independent membranes 21 are provided for retaining the catheter within the bladder or wound.

Referring now particularly to Fig. 8, there is shown a modified form of the invention wherein the insert 23a of substantially crescent-shaped cross section is now formed from a continuous strip of spring wire.

In other respects the form of the invention shown in Fig. 8 is the same as that shown in Figs. 1 through 7, and like reference numerals identify like parts throughout the several views.

While various changes may be made in the detail construction, it shall be understood that such changes shall be within the spirit and scope of the present invention as defined by the appended claims.

I claim:

1. A catheter comprising an elongated flexible tube having a closed inner end provided with drainage openings, inflatable membrane means Provided in said tube near said drainage openings, inflation duct means communicating with said inflatable membrane means, and a rigid hollow section forming part of said tube and formed of the same material adjacent said membrane means whereby to prevent collapse of the main drainage opening within said tube upon inflation of said membrane means.

2. In combination, a catheter tube having an external and inflatable retention wall portion adjacent the opening of said tube, a removable insert within the tube and opposite the retention wall portion, said insert comprising a hollow member open at both ends and being relatively rigid.

3. A catheter comprising an elongated flexible tube having a central drainage duct, said tube being closed at 4 one end provided with drainage openings communicating 4 with said, drainage duct, the interior of said tube atleast one side being integrally formed with a reinforced portion, said reinforced portion having an inflation duct extending substantially the length thereof, said tube surrounding the end of said inflation duct near said drainage openings being provided with at least one slit providing at least one outer membrane, said inflation duct communicating with said slit, and a hollow insert open at both ends adapted to fit snugly within said drainage opening within the portion of said tube having said slit whereby to prevent closing of said drainage duct upon inflation of said membrane.

4. A catheter according to claim 3, said tube at the end remote from said closed end having an enlarged substantially cylindrical portion open at its outer end, said tube further having an auxiliary tube integrally formed therein and communicating with said inflation duct, said auxiliary tube having an enlarged open outer end.

5. A catheter according to claim 3, said insert having a concave portion adapted to receive therewithin said reinforced portion.

6. A catheter according to claim 5, said insert being formed from a unitary piece of non-corrosive material.

7. A catheter according to claim 5, said insert being formed from a continuous strip of spring wire.

8. In the combination of claim 2, said hollow member being substantially crescent-shaped in .cross section and 'formed from a unitary piece of non-corrosive material.

9. In the combination of claim 2, said hollow member being substantially crescent-shaped in cross section and formed from a continuous strip of spring wire.

10. A catheter comprising a hollow tube having inflatable retention means near one end thereof, a hollow insert open at both ends and frictionally fixed within and adjacent the end of said tube and Within said retention means whereby to prevent obstruction of the central bore of said tube when said retention means are inflated.

References Cited in the file of this patent

US368375A 1953-07-16 1953-07-16 Drainage tube Expired - Lifetime US2819718A (en)

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Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112748A (en) * 1960-04-04 1963-12-03 Pharmaseal Lab Surgical tube
US3331371A (en) * 1965-03-09 1967-07-18 Prosit Service Corp Catheter having internal flow valve at distal end thereof
US3769980A (en) * 1971-06-28 1973-11-06 Medical Concepts Inc Medical instruments
US3771527A (en) * 1971-08-16 1973-11-13 J Ruisi Surgical drainage tube
US3773034A (en) * 1971-11-24 1973-11-20 Itt Research Institute Steerable catheter
US4013077A (en) * 1974-09-23 1977-03-22 M.E.D.S. Corporation Collecting device
US4311140A (en) * 1976-05-10 1982-01-19 Henry Bridgman Vacuum curet having an improved curetting opening
US4692141A (en) * 1982-03-08 1987-09-08 Mahurkar Sakharam D Double lumen catheter
US4734094A (en) * 1986-06-09 1988-03-29 Jacob Erwin T Catheter and method for cholangiography
US4770652A (en) * 1985-02-12 1988-09-13 Mahurkar Sakharam D Method and apparatus for using dual-lumen catheters for extracorporeal treatment
US4808155A (en) * 1986-02-27 1989-02-28 Mahurkar Sakharam D Simple double lumen catheter
US4850982A (en) * 1987-03-09 1989-07-25 Erlich Brian H Catheter
US4861337A (en) * 1988-03-02 1989-08-29 Sherwood Medical Company Collapsible urethral catheter
US4863424A (en) * 1983-11-18 1989-09-05 Blake Joseph W Iii Tubular medical device and method of making and using the same
US4932959A (en) * 1988-12-01 1990-06-12 Advanced Cardiovascular Systems, Inc. Vascular catheter with releasably secured guidewire
US5195989A (en) * 1990-09-17 1993-03-23 Scimed Life Systems, Inc. Low profile catheter for increasing lumen size of a blood vessel and guide wire therefor
US5197951A (en) * 1983-12-14 1993-03-30 Mahurkar Sakharam D Simple double lumen catheter
US5221255A (en) * 1990-01-10 1993-06-22 Mahurkar Sakharam D Reinforced multiple lumen catheter
US5318532A (en) * 1989-10-03 1994-06-07 C. R. Bard, Inc. Multilumen catheter with variable cross-section lumens
US5348536A (en) * 1993-08-02 1994-09-20 Quinton Instrument Company Coextruded catheter and method of forming
US5360403A (en) * 1990-05-16 1994-11-01 Lake Region Manufacturing Co., Inc. Balloon catheter with lumen occluder
US5374245A (en) * 1990-01-10 1994-12-20 Mahurkar; Sakharam D. Reinforced multiple-lumen catheter and apparatus and method for making the same
US5403291A (en) * 1993-08-02 1995-04-04 Quinton Instrument Company Catheter with elongated side holes
US5556390A (en) * 1995-03-07 1996-09-17 Quinton Instrument Company Catheter with oval or elliptical lumens
US5797869A (en) * 1987-12-22 1998-08-25 Vas-Cath Incorporated Multiple lumen catheter
US5807329A (en) * 1996-05-07 1998-09-15 Gelman; Martin L. Displaceable catheter device
US6251084B1 (en) * 1989-08-09 2001-06-26 Medtronic Ave, Inc. Guide catheter and guidewires for effecting rapid catheter exchange
WO2002005701A2 (en) * 2000-07-18 2002-01-24 Teitelbaum George P Anti-occlusion catheter
US20040133156A1 (en) * 2003-01-06 2004-07-08 Diaz Joseph Robert Balloon catheter with improved resistance to non-deflation
US20050228339A1 (en) * 2004-04-12 2005-10-13 The Trustees Of The University Of Pennsylvania Multi-lumen catheter
WO2007005734A2 (en) 2005-07-01 2007-01-11 C.R. Bard, Inc. Indwelling urinary drainage catheter
US20070071685A1 (en) * 2003-12-22 2007-03-29 Bracco Research S.A. Gas-filled microvesicle assembly for contrast imaging
EP2075014A2 (en) 2002-05-24 2009-07-01 Angiotech International Ag Compositions and methods for coating medical implants
US20110009641A1 (en) * 2005-06-15 2011-01-13 Anderson Daniel G Amine-containing lipids and uses thereof
US20130331783A1 (en) * 2010-12-16 2013-12-12 Ams Research Corporation Micro-needle bladder balloon
US20140257243A1 (en) * 2013-03-11 2014-09-11 Covidien Lp Controlling catheter flow
US8969353B2 (en) 2008-11-07 2015-03-03 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
US9193827B2 (en) 2010-08-26 2015-11-24 Massachusetts Institute Of Technology Poly(beta-amino alcohols), their preparation, and uses thereof
US9238716B2 (en) 2011-03-28 2016-01-19 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
US9308281B2 (en) 2011-06-08 2016-04-12 Shire Human Genetic Therapies, Inc. MRNA therapy for Fabry disease
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
US9333321B2 (en) 2004-04-12 2016-05-10 Aegis Medical Technologies, Llc Multi-lumen catheter
US9522176B2 (en) 2013-10-22 2016-12-20 Shire Human Genetic Therapies, Inc. MRNA therapy for phenylketonuria
US9629804B2 (en) 2013-10-22 2017-04-25 Shire Human Genetic Therapies, Inc. Lipid formulations for delivery of messenger RNA
US9713626B2 (en) 2013-03-14 2017-07-25 Rana Therapeutics, Inc. CFTR mRNA compositions and related methods and uses
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
US9850269B2 (en) 2014-04-25 2017-12-26 Translate Bio, Inc. Methods for purification of messenger RNA
US9957499B2 (en) 2013-03-14 2018-05-01 Translate Bio, Inc. Methods for purification of messenger RNA
US10022455B2 (en) 2014-05-30 2018-07-17 Translate Bio, Inc. Biodegradable lipids for delivery of nucleic acids
US10138213B2 (en) 2014-06-24 2018-11-27 Translate Bio, Inc. Stereochemically enriched compositions for delivery of nucleic acids

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH64792A (en) * 1913-02-10 1914-05-01 Charnaux Louis Marie D Clement Turbulaire device intended to be introduced into the body
US2330399A (en) * 1937-09-11 1943-09-28 American Anode Inc Distensible bag catheter
US2650801A (en) * 1949-10-11 1953-09-01 Michael B Collito Heat exchanger

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH64792A (en) * 1913-02-10 1914-05-01 Charnaux Louis Marie D Clement Turbulaire device intended to be introduced into the body
US2330399A (en) * 1937-09-11 1943-09-28 American Anode Inc Distensible bag catheter
US2650801A (en) * 1949-10-11 1953-09-01 Michael B Collito Heat exchanger

Cited By (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112748A (en) * 1960-04-04 1963-12-03 Pharmaseal Lab Surgical tube
US3331371A (en) * 1965-03-09 1967-07-18 Prosit Service Corp Catheter having internal flow valve at distal end thereof
US3769980A (en) * 1971-06-28 1973-11-06 Medical Concepts Inc Medical instruments
US3771527A (en) * 1971-08-16 1973-11-13 J Ruisi Surgical drainage tube
US3773034A (en) * 1971-11-24 1973-11-20 Itt Research Institute Steerable catheter
US4013077A (en) * 1974-09-23 1977-03-22 M.E.D.S. Corporation Collecting device
US4311140A (en) * 1976-05-10 1982-01-19 Henry Bridgman Vacuum curet having an improved curetting opening
US4692141A (en) * 1982-03-08 1987-09-08 Mahurkar Sakharam D Double lumen catheter
US4863424A (en) * 1983-11-18 1989-09-05 Blake Joseph W Iii Tubular medical device and method of making and using the same
US5197951A (en) * 1983-12-14 1993-03-30 Mahurkar Sakharam D Simple double lumen catheter
US4770652A (en) * 1985-02-12 1988-09-13 Mahurkar Sakharam D Method and apparatus for using dual-lumen catheters for extracorporeal treatment
US4808155A (en) * 1986-02-27 1989-02-28 Mahurkar Sakharam D Simple double lumen catheter
US4734094A (en) * 1986-06-09 1988-03-29 Jacob Erwin T Catheter and method for cholangiography
US4850982A (en) * 1987-03-09 1989-07-25 Erlich Brian H Catheter
US20010044594A1 (en) * 1987-12-22 2001-11-22 Vas-Cath Incorporated Multiple lumen catheter
US6206849B1 (en) 1987-12-22 2001-03-27 Vas-Cath Incorporated Multiple lumen catheter
US5797869A (en) * 1987-12-22 1998-08-25 Vas-Cath Incorporated Multiple lumen catheter
US7229429B2 (en) 1987-12-22 2007-06-12 Vas-Cath Inc. Multiple lumen catheter
US4861337A (en) * 1988-03-02 1989-08-29 Sherwood Medical Company Collapsible urethral catheter
US4932959A (en) * 1988-12-01 1990-06-12 Advanced Cardiovascular Systems, Inc. Vascular catheter with releasably secured guidewire
US6251084B1 (en) * 1989-08-09 2001-06-26 Medtronic Ave, Inc. Guide catheter and guidewires for effecting rapid catheter exchange
US5318532A (en) * 1989-10-03 1994-06-07 C. R. Bard, Inc. Multilumen catheter with variable cross-section lumens
US5221255A (en) * 1990-01-10 1993-06-22 Mahurkar Sakharam D Reinforced multiple lumen catheter
US5374245A (en) * 1990-01-10 1994-12-20 Mahurkar; Sakharam D. Reinforced multiple-lumen catheter and apparatus and method for making the same
US5360403A (en) * 1990-05-16 1994-11-01 Lake Region Manufacturing Co., Inc. Balloon catheter with lumen occluder
US5292315A (en) * 1990-09-17 1994-03-08 Scimed Life Systems, Inc. Low profile catheter for increasing lumen size of a blood vessel and guide wire therefor
US5195989A (en) * 1990-09-17 1993-03-23 Scimed Life Systems, Inc. Low profile catheter for increasing lumen size of a blood vessel and guide wire therefor
US5348536A (en) * 1993-08-02 1994-09-20 Quinton Instrument Company Coextruded catheter and method of forming
US5403291A (en) * 1993-08-02 1995-04-04 Quinton Instrument Company Catheter with elongated side holes
US5489278A (en) * 1993-08-02 1996-02-06 Quinton Instrument Company Catheter with elongated side openings
US5556390A (en) * 1995-03-07 1996-09-17 Quinton Instrument Company Catheter with oval or elliptical lumens
US5807329A (en) * 1996-05-07 1998-09-15 Gelman; Martin L. Displaceable catheter device
WO2002005701A3 (en) * 2000-07-18 2002-05-30 George P Teitelbaum Anti-occlusion catheter
US6692459B2 (en) 2000-07-18 2004-02-17 George P. Teitelbaum Anti-occlusion catheter
US20040181191A1 (en) * 2000-07-18 2004-09-16 Teitelbaum George P. Anti-occlusion catheter
WO2002005701A2 (en) * 2000-07-18 2002-01-24 Teitelbaum George P Anti-occlusion catheter
EP2075014A2 (en) 2002-05-24 2009-07-01 Angiotech International Ag Compositions and methods for coating medical implants
US20040133156A1 (en) * 2003-01-06 2004-07-08 Diaz Joseph Robert Balloon catheter with improved resistance to non-deflation
US7628784B2 (en) * 2003-01-06 2009-12-08 C. R. Bard, Inc. Balloon catheter with improved resistance to non-deflation
US20070071685A1 (en) * 2003-12-22 2007-03-29 Bracco Research S.A. Gas-filled microvesicle assembly for contrast imaging
US8517978B2 (en) 2004-04-12 2013-08-27 Aegis Medical Technologies, Llc Multi-lumen catheter
US7569029B2 (en) 2004-04-12 2009-08-04 Clark Timothy W I Multi-lumen catheter
US20090247927A1 (en) * 2004-04-12 2009-10-01 Clark Timothy W I Multi-lumen catheter
US20050228339A1 (en) * 2004-04-12 2005-10-13 The Trustees Of The University Of Pennsylvania Multi-lumen catheter
US10220184B2 (en) 2004-04-12 2019-03-05 Aegis Medical Technologies, Llc Multi-lumen catheter
US9333321B2 (en) 2004-04-12 2016-05-10 Aegis Medical Technologies, Llc Multi-lumen catheter
US20110009641A1 (en) * 2005-06-15 2011-01-13 Anderson Daniel G Amine-containing lipids and uses thereof
US9006487B2 (en) 2005-06-15 2015-04-14 Massachusetts Institute Of Technology Amine-containing lipids and uses thereof
WO2007005734A2 (en) 2005-07-01 2007-01-11 C.R. Bard, Inc. Indwelling urinary drainage catheter
US10189802B2 (en) 2008-11-07 2019-01-29 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
US9556110B2 (en) 2008-11-07 2017-01-31 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
US8969353B2 (en) 2008-11-07 2015-03-03 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
US9193827B2 (en) 2010-08-26 2015-11-24 Massachusetts Institute Of Technology Poly(beta-amino alcohols), their preparation, and uses thereof
US20130331783A1 (en) * 2010-12-16 2013-12-12 Ams Research Corporation Micro-needle bladder balloon
US9238716B2 (en) 2011-03-28 2016-01-19 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
US10117934B2 (en) 2011-03-28 2018-11-06 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
US10238754B2 (en) 2011-06-08 2019-03-26 Translate Bio, Inc. Lipid nanoparticle compositions and methods for MRNA delivery
US9597413B2 (en) 2011-06-08 2017-03-21 Shire Human Genetic Therapies, Inc. Pulmonary delivery of mRNA
US9308281B2 (en) 2011-06-08 2016-04-12 Shire Human Genetic Therapies, Inc. MRNA therapy for Fabry disease
US20140257243A1 (en) * 2013-03-11 2014-09-11 Covidien Lp Controlling catheter flow
US9463300B2 (en) 2013-03-11 2016-10-11 Covidien Lp Controlling catheter flow
US9138567B2 (en) * 2013-03-11 2015-09-22 Covidien Lp Controlling catheter flow
US9957499B2 (en) 2013-03-14 2018-05-01 Translate Bio, Inc. Methods for purification of messenger RNA
US9713626B2 (en) 2013-03-14 2017-07-25 Rana Therapeutics, Inc. CFTR mRNA compositions and related methods and uses
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
US9522176B2 (en) 2013-10-22 2016-12-20 Shire Human Genetic Therapies, Inc. MRNA therapy for phenylketonuria
US10208295B2 (en) 2013-10-22 2019-02-19 Translate Bio, Inc. MRNA therapy for phenylketonuria
US9629804B2 (en) 2013-10-22 2017-04-25 Shire Human Genetic Therapies, Inc. Lipid formulations for delivery of messenger RNA
US10052284B2 (en) 2013-10-22 2018-08-21 Translate Bio, Inc. Lipid formulations for delivery of messenger RNA
US10155785B2 (en) 2014-04-25 2018-12-18 Translate Bio, Inc. Methods for purification of messenger RNA
US9850269B2 (en) 2014-04-25 2017-12-26 Translate Bio, Inc. Methods for purification of messenger RNA
US10293057B2 (en) 2014-05-30 2019-05-21 Translate Bio, Inc. Biodegradable lipids for delivery of nucleic acids
US10022455B2 (en) 2014-05-30 2018-07-17 Translate Bio, Inc. Biodegradable lipids for delivery of nucleic acids
US10286083B2 (en) 2014-05-30 2019-05-14 Translate Bio, Inc. Biodegradable lipids for delivery of nucleic acids
US10286082B2 (en) 2014-05-30 2019-05-14 Translate Bio, Inc. Biodegradable lipids for delivery of nucleic acids
US10138213B2 (en) 2014-06-24 2018-11-27 Translate Bio, Inc. Stereochemically enriched compositions for delivery of nucleic acids
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof

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