|
US3121076A
(en)
*
|
|
1964-02-11 |
|
Benzodiazepinones and processes |
|
US1873732A
(en)
|
1928-12-28 |
1932-08-23 |
Abbott Lab |
Bactericide applicable to acid-fast bacteria
|
|
US3019843A
(en)
*
|
1956-07-27 |
1962-02-06 |
Powell Dawson |
Fire inhibitor and extinguisher
|
|
US2942572A
(en)
*
|
1958-06-17 |
1960-06-28 |
Pall Corp |
Magnetic pressure indicator
|
|
US3136815A
(en)
|
1959-12-10 |
1964-06-09 |
Hoffmann La Roche |
Amino substituted benzophenone oximes and derivatives thereof
|
|
US3371085A
(en)
*
|
1959-12-10 |
1968-02-27 |
Hoffmann La Roche |
5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
|
|
US3116203A
(en)
*
|
1962-03-14 |
1963-12-31 |
Hoffmann La Roche |
Oleaginous systems
|
|
NL298071A
(https=)
*
|
1963-06-04 |
|
|
|
|
CH449645A
(de)
|
1963-07-09 |
1968-01-15 |
Ciba Geigy |
Verfahren zur Herstellung neuer Aminosäuren
|
|
CH427803A
(de)
*
|
1963-12-06 |
1967-01-15 |
Geigy Ag J R |
Verfahren zur Herstellung eines neuen Isoxazolderivates
|
|
NL129434C
(https=)
|
1966-03-12 |
|
|
|
|
US3885046A
(en)
|
1969-12-04 |
1975-05-20 |
Burroughs Wellcome Co |
Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
|
|
BE759838A
(fr)
|
1969-12-04 |
1971-06-03 |
Wellcome Found |
Cetones a activite biologique
|
|
FR2077918B1
(https=)
|
1970-02-24 |
1973-04-06 |
Berthier Laboratoires |
|
|
US3758528A
(en)
|
1970-03-13 |
1973-09-11 |
Science Union & Cie |
Tricyclic compounds
|
|
US3821249A
(en)
|
1970-03-13 |
1974-06-28 |
En Nom Collectif Science Union |
Dibenzothiazefin derivatives
|
|
US3819631A
(en)
|
1970-12-15 |
1974-06-25 |
May & Baker Ltd |
Azapurinones
|
|
OA04285A
(fr)
*
|
1972-01-07 |
1979-12-31 |
Rhone Poulenc Sa |
Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
|
|
USRE31617E
(en)
|
1972-02-04 |
1984-06-26 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
US3932407A
(en)
*
|
1973-11-19 |
1976-01-13 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
US4036840A
(en)
|
1972-06-07 |
1977-07-19 |
Icn Pharmaceuticals |
2-Substituted-s-triazolo[1,5a]pyrimidines
|
|
GB1457873A
(en)
*
|
1973-01-04 |
1976-12-08 |
Allen & Hanburys Ltd |
Imidazotriazines
|
|
GB1422263A
(en)
*
|
1973-01-30 |
1976-01-21 |
Ferrosan As |
4-phenyl-piperidine compounds
|
|
US4051236A
(en)
|
1973-02-15 |
1977-09-27 |
E. R. Squibb & Sons, Inc. |
Inhibition of blood platelet aggregation
|
|
US4314081A
(en)
*
|
1974-01-10 |
1982-02-02 |
Eli Lilly And Company |
Arloxyphenylpropylamines
|
|
US4280957A
(en)
|
1974-09-11 |
1981-07-28 |
Hoffmann-La Roche Inc. |
Imidazodiazepines and processes therefor
|
|
AR208414A1
(es)
|
1974-11-07 |
1976-12-27 |
Rhone Poulenc Ind |
Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
|
|
US4093617A
(en)
|
1974-11-12 |
1978-06-06 |
Icn Pharmaceuticals, Inc. |
3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines
|
|
DE2460891C2
(de)
|
1974-12-21 |
1982-09-23 |
Gödecke AG, 1000 Berlin |
1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
|
|
US3960927A
(en)
|
1975-03-18 |
1976-06-01 |
Richardson-Merrell Inc. |
Olefinic derivatives of amino acids
|
|
NL7503310A
(nl)
|
1975-03-20 |
1976-09-22 |
Philips Nv |
Verbindingen met antidepressieve werking.
|
|
NL189199C
(nl)
*
|
1975-04-05 |
1993-02-01 |
Akzo Nv |
Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
|
|
FR2319338A1
(fr)
|
1975-08-01 |
1977-02-25 |
Synthelabo |
Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent
|
|
GB1526331A
(en)
*
|
1976-01-14 |
1978-09-27 |
Kefalas As |
Phthalanes
|
|
YU96177A
(en)
|
1976-04-24 |
1982-08-31 |
Wuelfing Johann A |
Process for obtaining adenine derivatives
|
|
US4107307A
(en)
|
1977-02-03 |
1978-08-15 |
American Cyanamid Company |
Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
USRE30511E
(en)
*
|
1977-02-03 |
1981-02-10 |
American Cyanamid Company |
Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
CA1095906A
(en)
|
1977-02-14 |
1981-02-17 |
Davis L. Temple, Jr. |
Heterocyclopyrimidines, compositions and therapeutic process
|
|
US4404380A
(en)
|
1977-02-14 |
1983-09-13 |
Mead Johnson & Company |
Triazolopyrimidines
|
|
US4107309A
(en)
|
1977-05-23 |
1978-08-15 |
American Cyanamid Company |
Substituted imidazo[1,2-d]-as-triazines
|
|
US4096257A
(en)
|
1977-05-23 |
1978-06-20 |
American Cyanamid Company |
Substituted imidazo [1,2-d]-as-triazines
|
|
IN148482B
(https=)
|
1977-06-03 |
1981-03-07 |
Pfizer |
|
|
DK270378A
(da)
|
1977-06-20 |
1978-12-21 |
Krogsgaard Larsen P |
Isoxazolderivater
|
|
US4370328A
(en)
*
|
1977-11-03 |
1983-01-25 |
Pfizer Inc. |
Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
|
|
CA1086735A
(en)
*
|
1977-11-03 |
1980-09-30 |
John C. Danilewicz |
Piperidino-quinazolines
|
|
IL56369A
(en)
|
1978-01-20 |
1984-05-31 |
Erba Farmitalia |
Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
|
|
US4146718A
(en)
*
|
1978-04-10 |
1979-03-27 |
Bristol-Myers Company |
Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
|
|
US4366156A
(en)
*
|
1979-03-05 |
1982-12-28 |
Mead Johnson & Company |
Antiallergic methods using diazaheterocyclopurines
|
|
CA1143728A
(en)
*
|
1979-10-04 |
1983-03-29 |
Max Gerecke |
Imidazodiazepine derivatives
|
|
US4536518A
(en)
|
1979-11-01 |
1985-08-20 |
Pfizer Inc. |
Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
|
|
JPS5668695A
(en)
|
1979-11-10 |
1981-06-09 |
Sankyo Co Ltd |
Enzyme inhibitor griseolic acid and its preparation
|
|
US4642345A
(en)
*
|
1980-08-14 |
1987-02-10 |
Mead Johnson & Company |
6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones
|
|
US4301176A
(en)
|
1980-08-18 |
1981-11-17 |
Warner-Lambert Company |
Method of administering calcium valproate
|
|
US4361583A
(en)
|
1980-08-19 |
1982-11-30 |
Synthelabo |
Analgesic agent
|
|
FR2492258A1
(fr)
|
1980-10-17 |
1982-04-23 |
Pharmindustrie |
Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
|
|
FR2492382A1
(fr)
|
1980-10-22 |
1982-04-23 |
Synthelabo |
Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
|
|
US4489078A
(en)
*
|
1980-11-24 |
1984-12-18 |
Mead Johnson & Company |
Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators
|
|
US4338317A
(en)
|
1981-03-16 |
1982-07-06 |
Mead Johnson & Company |
Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
|
|
US4383999A
(en)
|
1981-05-26 |
1983-05-17 |
Smithkline Beckman Corporation |
Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
|
|
FR2508035A1
(fr)
|
1981-06-23 |
1982-12-24 |
Fabre Sa Pierre |
Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
|
|
LU83729A1
(fr)
|
1981-11-04 |
1983-09-01 |
Galephar |
Sels d'acide valproique,leur preparation et leur utilisation
|
|
CH655110A5
(de)
*
|
1982-09-03 |
1986-03-27 |
Otsuka Pharma Co Ltd |
Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
|
|
US4663320A
(en)
|
1983-02-16 |
1987-05-05 |
Syntex (U.S.A.) Inc. |
(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
|
|
US4490371A
(en)
*
|
1983-02-16 |
1984-12-25 |
Syntex (U.S.A.) Inc. |
N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
|
|
US4521422A
(en)
|
1983-06-23 |
1985-06-04 |
American Cyanamid Company |
Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
|
|
US4900836A
(en)
*
|
1983-06-23 |
1990-02-13 |
American Cyanamid Company |
(3-amino-1H-pyrazol-4-yl) (aryl)methanones
|
|
US4626538A
(en)
*
|
1983-06-23 |
1986-12-02 |
American Cyanamid Company |
[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
|
|
US4513006A
(en)
|
1983-09-26 |
1985-04-23 |
Mcneil Lab., Inc. |
Anticonvulsant sulfamate derivatives
|
|
US4761501A
(en)
|
1983-10-26 |
1988-08-02 |
American Home Products Corporation |
Substituted phenylacetamides
|
|
US4593029A
(en)
|
1984-02-15 |
1986-06-03 |
Syntex (U.S.A.) Inc. |
Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
|
|
GB8425872D0
(en)
|
1984-10-12 |
1984-11-21 |
Ciba Geigy Ag |
Chemical compounds
|
|
US4855290A
(en)
|
1985-05-10 |
1989-08-08 |
State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research |
Derivatives of quinuclidine
|
|
DK288385D0
(da)
|
1985-06-26 |
1985-06-26 |
Novo Industri As |
Aminosyrederivater
|
|
ES2031821T3
(es)
*
|
1985-10-17 |
1993-01-01 |
Smith Kline & French Laboratories Limited |
Procedimiento para preparar derivados de 4(4-oxo-1,4-dihidropiridin-1-il)fenilo.
|
|
US4670434A
(en)
|
1985-11-14 |
1987-06-02 |
Syntex (U.S.A.) Inc. |
(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
|
|
US4775674A
(en)
|
1986-05-23 |
1988-10-04 |
Bristol-Myers Company |
Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
|
|
FR2600650B1
(fr)
*
|
1986-06-27 |
1988-09-09 |
Synthelabo |
Procede de preparation d'imidazopyridines et composes intermediaires
|
|
ES2061502T3
(es)
|
1986-06-27 |
1994-12-16 |
Beecham Group Plc |
Nuevos n-heterociclos biciclicos puenteados.
|
|
GB8615785D0
(en)
|
1986-06-27 |
1986-08-06 |
Beecham Group Plc |
Compounds
|
|
US4701459A
(en)
|
1986-07-08 |
1987-10-20 |
Bristol-Myers Company |
7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
|
|
US5478863A
(en)
|
1986-07-10 |
1995-12-26 |
State Of Oregon, Oregon Health Sciences University Of Oregon |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5093525A
(en)
|
1986-07-10 |
1992-03-03 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
|
|
US4709094A
(en)
|
1986-07-10 |
1987-11-24 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Sigma brain receptor ligands and their use
|
|
US5312840A
(en)
|
1986-07-10 |
1994-05-17 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US4761416A
(en)
|
1986-07-25 |
1988-08-02 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds
|
|
US4739056A
(en)
|
1986-11-26 |
1988-04-19 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds
|
|
US4786648A
(en)
|
1986-12-08 |
1988-11-22 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4710508A
(en)
*
|
1986-12-08 |
1987-12-01 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4956388A
(en)
|
1986-12-22 |
1990-09-11 |
Eli Lilly And Company |
3-aryloxy-3-substituted propanamines
|
|
US4721784A
(en)
*
|
1986-12-22 |
1988-01-26 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
|
|
US4766118A
(en)
|
1986-12-22 |
1988-08-23 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones and pharmaceutical use
|
|
US5081242A
(en)
*
|
1986-12-22 |
1992-01-14 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones
|
|
US4992457A
(en)
*
|
1987-03-18 |
1991-02-12 |
Schulman Jerome M |
Pharmacologically active cholinergic compositions, and methods for making same and use thereof in treating disease
|
|
US4929734A
(en)
|
1987-03-31 |
1990-05-29 |
Warner-Lambert Company |
Tetrahydropyridine oxime compounds
|
|
AU614513B2
(en)
|
1987-04-15 |
1991-09-05 |
Beecham Group Plc |
1-azabicyclic compounds
|
|
GB8714789D0
(en)
*
|
1987-06-24 |
1987-07-29 |
Lundbeck & Co As H |
Heterocyclic compounds
|
|
US4981858A
(en)
*
|
1987-08-13 |
1991-01-01 |
State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research |
Optical isomers
|
|
US5232917A
(en)
*
|
1987-08-25 |
1993-08-03 |
University Of Southern California |
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
|
|
USRE35517E
(en)
|
1987-08-25 |
1997-05-20 |
University Of Southern California |
Method, compositions, and compounds for modulating brain excitability
|
|
DE3853758T2
(de)
|
1987-10-05 |
1995-09-07 |
Yamanouchi Pharma Co Ltd |
Heterozyklische Spiroverbindungen und ihre Herstellung.
|
|
US5412096A
(en)
|
1987-10-05 |
1995-05-02 |
Yamanouchi Pharmaceutical Co., Ltd. |
Hydrochloride salts of heterocyclic spiro compounds
|
|
IL88156A
(en)
|
1987-11-13 |
1997-02-18 |
Novo Nordisk As |
Azacyclic compounds their preparation and pharmaceutical compositions containing them
|
|
EP0322182A3
(en)
|
1987-12-22 |
1992-01-02 |
Beecham Group Plc |
Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
|
|
US4831031A
(en)
|
1988-01-22 |
1989-05-16 |
Pfizer Inc. |
Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
|
|
US5091431A
(en)
*
|
1988-02-08 |
1992-02-25 |
Schering Corporation |
Phosphodiesterase inhibitors
|
|
DK177889A
(da)
|
1988-04-15 |
1989-10-16 |
Beecham Group Plc |
Hidtil ukendte forbindelser
|
|
US4957916A
(en)
|
1988-08-05 |
1990-09-18 |
Janssen Pharmaceutica N.V. |
Antipsychotic 3-piperazinylbenzazole derivatives
|
|
US4861891A
(en)
|
1988-08-31 |
1989-08-29 |
Pfizer Inc. |
Antidepressant N-substituted nicotinamide compounds
|
|
CA2000041A1
(en)
*
|
1988-10-13 |
1990-04-13 |
Barry S. Orlek |
Compounds
|
|
DE8817121U1
(de)
|
1988-11-22 |
1993-02-04 |
Boehringer Ingelheim Kg, 55218 Ingelheim |
Neue Quinuclidine
|
|
US5286864A
(en)
*
|
1988-11-22 |
1994-02-15 |
Boehringer Ingelheim Kg |
Quinuclidines, their use as medicaments and processes for their preparation
|
|
US5043345A
(en)
|
1989-02-22 |
1991-08-27 |
Novo Nordisk A/S |
Piperidine compounds and their preparation and use
|
|
US4981870A
(en)
|
1989-03-07 |
1991-01-01 |
Pfizer Inc. |
Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
|
|
US4971972A
(en)
|
1989-03-23 |
1990-11-20 |
Schering Corporation |
Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
|
|
US5278170A
(en)
*
|
1989-04-13 |
1994-01-11 |
Beecham Group P.L.C. |
Azabicylo oxime compounds
|
|
SG48315A1
(en)
|
1989-04-13 |
1998-04-17 |
Beecham Group Plc |
Novel compounds
|
|
US4956368A
(en)
|
1989-07-24 |
1990-09-11 |
Bristol-Myers Company |
Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
|
|
US5109002A
(en)
|
1989-09-08 |
1992-04-28 |
Du Pont Merck Pharmaceutical Company |
Antipsychotic 1-cycloalkylpiperidines
|
|
DE69026197T2
(de)
*
|
1989-10-07 |
1997-01-09 |
Beecham Group Plc |
Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
|
|
US4943573A
(en)
|
1989-11-01 |
1990-07-24 |
Bristol-Myers Squibb Company |
Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
|
|
CA2029497C
(en)
|
1989-11-08 |
2002-06-04 |
Kunihiro Ninomiya (Deceased) |
4-acylaminopyridine derivative
|
|
US5010086A
(en)
|
1990-02-28 |
1991-04-23 |
Sterling Drug Inc. |
Imidazopyridines, compositions and use
|
|
US4963561A
(en)
|
1990-02-28 |
1990-10-16 |
Sterling Drug Inc. |
Imidazopyridines, their preparation and use
|
|
US5149817A
(en)
|
1990-03-05 |
1992-09-22 |
Shionogi & Co., Ltd. |
Teirahydropyridine derivatives
|
|
GB9005737D0
(en)
|
1990-03-14 |
1990-05-09 |
Beecham Group Plc |
Novel compounds
|
|
US5169855A
(en)
*
|
1990-03-28 |
1992-12-08 |
Du Pont Merck Pharmaceutical Company |
Piperidine ether derivatives as psychotropic drugs or plant fungicides
|
|
US5407938A
(en)
|
1990-04-10 |
1995-04-18 |
Israel Institute For Biological Research |
Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
|
|
US5534520A
(en)
|
1990-04-10 |
1996-07-09 |
Fisher; Abraham |
Spiro compounds containing five-membered rings
|
|
US5852029A
(en)
*
|
1990-04-10 |
1998-12-22 |
Israel Institute For Biological Research |
Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
|
|
US5116995A
(en)
|
1990-05-25 |
1992-05-26 |
Taisho Pharmaceutical Co., Ltd. |
Carbazole compounds
|
|
US5574070A
(en)
*
|
1990-05-25 |
1996-11-12 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5612211A
(en)
|
1990-06-08 |
1997-03-18 |
New York University |
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
|
|
US5250534A
(en)
*
|
1990-06-20 |
1993-10-05 |
Pfizer Inc. |
Pyrazolopyrimidinone antianginal agents
|
|
US5095015A
(en)
|
1990-07-24 |
1992-03-10 |
Neurogen Corporation |
Certain azacycloalkyl imidazopyrimidines; a new class of gaba brain receptor ligands
|
|
JP2935541B2
(ja)
|
1990-06-28 |
1999-08-16 |
サントリー株式会社 |
縮合複素環化合物
|
|
US5086054A
(en)
*
|
1990-07-31 |
1992-02-04 |
Sri International |
Novel arylcycloalkanepolyalkylamines
|
|
DK198590D0
(da)
*
|
1990-08-21 |
1990-08-21 |
Novo Nordisk As |
Heterocykliske forbindelser, deres fremstilling og anvendelse
|
|
US5527813A
(en)
*
|
1990-08-21 |
1996-06-18 |
Novo Nordisk A/S |
Heterocyclic compounds and their preparation and use
|
|
US5376668A
(en)
*
|
1990-08-21 |
1994-12-27 |
Novo Nordisk A/S |
Heterocyclic compounds
|
|
MX9100779A
(es)
*
|
1990-08-24 |
1992-04-01 |
Beecham Group Plc |
Compuestos azabiciclicos y procedimiento para su preparacion
|
|
CA2050264A1
(en)
*
|
1990-08-30 |
1992-03-01 |
Raymond Baker |
Substituted pyrazine and its salts, compositions containing them and their use in medicine
|
|
GB9019095D0
(en)
|
1990-09-01 |
1990-10-17 |
Beecham Group Plc |
Novel compounds
|
|
US5185446A
(en)
*
|
1990-09-04 |
1993-02-09 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
|
|
EP0738717A1
(en)
|
1990-10-09 |
1996-10-23 |
Neurogen Corporation |
Certain substituted pyrimidines as intermediates for production of cycloalkyl and azacycloalkyl pyrrolopyrimidines
|
|
EP0552213A1
(en)
|
1990-10-12 |
1993-07-28 |
Beecham Group Plc |
1,2,5,6-tetrahydropyridine oxime derivatives
|
|
EP0481262B1
(en)
|
1990-10-15 |
1995-02-15 |
Societe Des Produits Nestle S.A. |
Treatment of black tea
|
|
US5139802A
(en)
|
1990-10-15 |
1992-08-18 |
Nestec S.A. |
Oxidation of tea
|
|
US5091242A
(en)
*
|
1990-10-30 |
1992-02-25 |
The Research Foundation Of State Univ. Of N.Y. |
Carbon fiber composites having improved fatigue resistance
|
|
US5744602A
(en)
|
1990-10-31 |
1998-04-28 |
Neurogen Corporation |
Certain imidazoquinoxalines; a new class of GABA brain receptor ligands
|
|
US6268496B1
(en)
|
1990-10-31 |
2001-07-31 |
Neurogen Corporation |
Certain imidazoquinoxalines: a new class of GABA brain receptor ligands
|
|
US5130430A
(en)
|
1990-10-31 |
1992-07-14 |
Neurogen Corporation |
2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands
|
|
US5116837A
(en)
|
1990-12-21 |
1992-05-26 |
Ortho Pharmaceutical Corporation |
2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines
|
|
US5162341A
(en)
*
|
1991-02-22 |
1992-11-10 |
Du Pont Merck Pharmaceutical Company |
Use of sigma receptor antagonists for treatment of amphetamine abuse
|
|
US5093333A
(en)
|
1991-04-29 |
1992-03-03 |
American Home Products Corporation |
N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system
|
|
US5137895A
(en)
|
1991-04-29 |
1992-08-11 |
A. H. Robins Company, Incorporated |
3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols
|
|
US5124460A
(en)
|
1991-05-06 |
1992-06-23 |
Merck Sharp & Dohme Ltd. |
Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
|
|
EP0590150B1
(en)
|
1991-05-15 |
1998-07-08 |
Yamanouchi Pharmaceutical Co. Ltd. |
(-)-(s)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro 4,5]decane l-tartrate
|
|
NZ243065A
(en)
|
1991-06-13 |
1995-07-26 |
Lundbeck & Co As H |
Piperidine derivatives and pharmaceutical compositions
|
|
US5641791A
(en)
*
|
1991-08-13 |
1997-06-24 |
Novo Nordisk A.S |
Heterocyclic compounds and their preparation and use
|
|
US5182290A
(en)
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
|
|
US5182386A
(en)
*
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
|
|
US5369108A
(en)
*
|
1991-10-04 |
1994-11-29 |
Sloan-Kettering Institute For Cancer Research |
Potent inducers of terminal differentiation and methods of use thereof
|
|
US5585490A
(en)
*
|
1991-10-08 |
1996-12-17 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands
|
|
US5212310A
(en)
|
1991-12-19 |
1993-05-18 |
Neurogen Corporation |
Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
|
|
US5243049A
(en)
|
1992-01-22 |
1993-09-07 |
Neurogen Corporation |
Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
|
|
MX9300875A
(es)
|
1992-02-20 |
1993-08-31 |
Smithkline Beecham Plc |
Procedimiento para la preparacion de compuestos azabiciclicos.
|
|
US6225115B1
(en)
|
1992-03-04 |
2001-05-01 |
Synaptic Pharmaceutical Corporation |
DNA encoding taurine and GABA transporters and uses thereof
|
|
US5298657A
(en)
|
1992-03-20 |
1994-03-29 |
Cambridge Neuroscience Inc. |
Preparation of substituted guanidines
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
US5367077A
(en)
*
|
1992-04-08 |
1994-11-22 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
|
|
AU4117493A
(en)
|
1992-04-08 |
1994-11-21 |
Neurogen Corporation |
Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands
|
|
US5266698A
(en)
*
|
1992-04-30 |
1993-11-30 |
Neurogen Corporation |
Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
|
|
SE9201478D0
(sv)
*
|
1992-05-11 |
1992-05-11 |
Kabi Pharmacia Ab |
Heteroaromatic quinuclidinenes, their use and preparation
|
|
ES2060547B1
(es)
|
1992-06-04 |
1995-06-16 |
Ferrer Int |
Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
|
|
GB9212693D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
GB9212673D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
JP2683783B2
(ja)
|
1992-07-10 |
1997-12-03 |
雪印乳業株式会社 |
シェーグレン症候群治療剤
|
|
US5672499A
(en)
|
1992-07-27 |
1997-09-30 |
California Institute Of Technology |
Immoralized neural crest stem cells and methods of making
|
|
US5306819A
(en)
|
1992-08-27 |
1994-04-26 |
Neurogen Corporation |
Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
|
|
ZA937382B
(en)
|
1992-10-06 |
1994-04-29 |
Warner Lambert Co |
Novel composition for peroral therapy of cognitionimpairment and a process therefor
|
|
GB9222253D0
(en)
|
1992-10-23 |
1992-12-09 |
Celltech Ltd |
Chemical compounds
|
|
US5286860A
(en)
*
|
1992-11-12 |
1994-02-15 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5668283A
(en)
|
1992-11-12 |
1997-09-16 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5814651A
(en)
|
1992-12-02 |
1998-09-29 |
Pfizer Inc. |
Catechol diethers as selective PDEIV inhibitors
|
|
US5622977A
(en)
|
1992-12-23 |
1997-04-22 |
Celltech Therapeutics Limited |
Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
|
|
WO1994015937A1
(en)
|
1993-01-06 |
1994-07-21 |
Neurogen Corporation |
Certain aryl substituted imidazopyrazinones a new class of gaba brain receptor ligands
|
|
ES2098799T3
(es)
*
|
1993-01-23 |
1997-05-01 |
Hoechst Ag |
2,3-difluoro-6-nitro-benzonitrilo y 2-cloro-5,6-difluoro-benzonitrilo, procedimiento para su preparacion y su utilizacion para la preparacion de acido 2,3,6-trifluoro-benzoico.
|
|
US5362860A
(en)
*
|
1993-02-01 |
1994-11-08 |
Warner-Lambert Company |
Neutral stabilization complex for CI-979 HCl, a cognition activator
|
|
US5424301A
(en)
|
1993-02-01 |
1995-06-13 |
Warner-Lambert Company |
Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
|
|
US6013799A
(en)
*
|
1993-03-03 |
2000-01-11 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimides, a new class of gaba brain receptor ligands
|
|
GB9304920D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
GB9304919D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
CA2158952C
(en)
|
1993-03-26 |
1999-05-18 |
Shen-Chun Kuo |
2-substituted morpholine and thiomorpholine derivatives as gaba-b antagonists
|
|
US5750702A
(en)
|
1993-10-27 |
1998-05-12 |
Neurogen Corporation |
Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
|
|
DE69432984T2
(de)
*
|
1993-05-27 |
2004-05-27 |
Cenes Ltd. |
Therapeutische substituierte guanidine
|
|
GB9311920D0
(en)
|
1993-06-09 |
1993-07-28 |
Pfizer Ltd |
Therapeutic agents
|
|
ZA944513B
(en)
|
1993-06-23 |
1996-01-16 |
Cambridge Neuroscience Inc |
Sigma receptor ligands
|
|
DE59410119D1
(de)
*
|
1993-07-02 |
2002-06-20 |
Byk Gulden Lomberg Chem Fab |
Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren
|
|
ES2074946B1
(es)
|
1993-07-19 |
1996-06-16 |
Ferrer Int |
Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
|
|
US5665754A
(en)
|
1993-09-20 |
1997-09-09 |
Glaxo Wellcome Inc. |
Substituted pyrrolidines
|
|
US5484944A
(en)
*
|
1993-10-27 |
1996-01-16 |
Neurogen Corporation |
Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
|
|
US5502072A
(en)
|
1993-11-26 |
1996-03-26 |
Pfizer Inc. |
Substituted oxindoles
|
|
CN1046274C
(zh)
*
|
1993-11-26 |
1999-11-10 |
辉瑞大药厂 |
用作消炎剂的异噁唑啉化合物
|
|
JP2818820B2
(ja)
*
|
1993-11-26 |
1998-10-30 |
ファイザー・インク. |
抗炎症剤としての3−アリール−2−イソオキサゾリン類
|
|
US5500420A
(en)
|
1993-12-20 |
1996-03-19 |
Cornell Research Foundation, Inc. |
Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia
|
|
GB9326173D0
(en)
|
1993-12-22 |
1994-02-23 |
Celltech Ltd |
Chemical compounds and process
|
|
EP0738268B1
(en)
*
|
1993-12-22 |
2004-03-03 |
Celltech R&D Limited |
Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors
|
|
GB9326600D0
(en)
|
1993-12-22 |
1994-03-02 |
Celltech Ltd |
Chemical compounds
|
|
US5668174A
(en)
|
1993-12-29 |
1997-09-16 |
Kowa Tekuno Sachi Co., Ltd. |
Method of treating hyperparathyroidism
|
|
US7060450B1
(en)
|
1993-12-30 |
2006-06-13 |
President And Fellows Of Harvard College |
Screening assays for agonists and antagonists of the hedgehog signaling pathway
|
|
GB9514465D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9401090D0
(en)
*
|
1994-01-21 |
1994-03-16 |
Glaxo Lab Sa |
Chemical compounds
|
|
ES2296594T3
(es)
|
1994-02-14 |
2008-05-01 |
Euro-Celtique S.A. |
Androstanos y pregnanos para la modulacion alosterica del receptor de gaba.
|
|
US5939545A
(en)
|
1994-02-14 |
1999-08-17 |
Cocensys, Inc. |
Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
|
|
US5783575A
(en)
|
1994-03-14 |
1998-07-21 |
Novo Nordisk A/S |
Antagonists, their preparation and use
|
|
KR970701719A
(ko)
|
1994-03-14 |
1997-04-12 |
안네 제케르 |
헤테로고리화합물과 그것의 제법 및 사용(heterocyclic compounds, their preparation and use)
|
|
US5696148A
(en)
*
|
1994-03-14 |
1997-12-09 |
Novo Nordisk A/S |
Indole compounds and their use in treating diseases of the central nervous system
|
|
US5637617A
(en)
|
1994-04-01 |
1997-06-10 |
The Regents Of The University Of California |
Methods for use of GABAa receptor GABAergic compounds
|
|
GB9409718D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
GB9409705D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
US5786354A
(en)
|
1994-06-21 |
1998-07-28 |
Celltech Therapeutics, Limited |
Tri-substituted phenyl derivatives and processes for their preparation
|
|
US6245774B1
(en)
|
1994-06-21 |
2001-06-12 |
Celltech Therapeutics Limited |
Tri-substituted phenyl or pyridine derivatives
|
|
GB9412571D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412573D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412672D0
(en)
*
|
1994-06-23 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
JP2852608B2
(ja)
*
|
1994-06-27 |
1999-02-03 |
雪印乳業株式会社 |
口腔乾燥症治療剤
|
|
US5750566A
(en)
|
1994-08-12 |
1998-05-12 |
Eli Lilly And Company |
Synthetic excitatory amino acids
|
|
ATE192157T1
(de)
|
1994-08-24 |
2000-05-15 |
Astra Ab |
Therapeutisch verwendbare spiro-azabicyclische verbindungen
|
|
WO1996006843A1
(en)
|
1994-08-29 |
1996-03-07 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel naphthyridine derivative and medicinal composition thereof
|
|
WO1996010570A1
(en)
|
1994-09-30 |
1996-04-11 |
Pfizer Inc. |
NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
|
|
US5554645A
(en)
*
|
1994-10-03 |
1996-09-10 |
Mars, Incorporated |
Antineoplastic cocoa extracts and methods for making and using the same
|
|
DE4436509A1
(de)
*
|
1994-10-13 |
1996-04-18 |
Hoechst Schering Agrevo Gmbh |
Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
|
|
JP3993651B2
(ja)
*
|
1994-10-21 |
2007-10-17 |
アスビオファーマ株式会社 |
シクロプロパクロメンカルボン酸誘導体
|
|
US5672709A
(en)
|
1994-10-24 |
1997-09-30 |
Eli Lilly And Company |
Heterocyclic compounds and their preparation and use
|
|
US5605908A
(en)
*
|
1994-10-24 |
1997-02-25 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
US5473077A
(en)
*
|
1994-11-14 |
1995-12-05 |
Eli Lilly And Company |
Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor agonists
|
|
US5571819A
(en)
*
|
1994-11-22 |
1996-11-05 |
Sabb; Annmarie L. |
Imidazopyridines as muscarinic agents
|
|
US5510478A
(en)
|
1994-11-30 |
1996-04-23 |
American Home Products Corporation |
2-arylamidothiazole derivatives with CNS activity
|
|
US5512574A
(en)
|
1994-12-21 |
1996-04-30 |
American Home Products Corporation |
Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
|
|
US5468875A
(en)
*
|
1994-12-22 |
1995-11-21 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
GB9503601D0
(en)
|
1995-02-23 |
1995-04-12 |
Merck Sharp & Dohme |
Method of treatment and method of manufacture of medicament
|
|
US5488055A
(en)
*
|
1995-03-10 |
1996-01-30 |
Sanofi Winthrop Inc. |
Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amines and compositions and methods of use thereof
|
|
PL183853B1
(pl)
|
1995-04-21 |
2002-07-31 |
Neurosearch As |
Nowa pochodna benzimidazolu i środek farmaceutyczny
|
|
EP0823905A1
(en)
|
1995-05-05 |
1998-02-18 |
Novo Nordisk A/S |
Novel heterocyclic chemistry
|
|
DE19518082A1
(de)
*
|
1995-05-17 |
1996-11-21 |
Merck Patent Gmbh |
4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
|
|
ATE231501T1
(de)
|
1995-05-18 |
2003-02-15 |
Altana Pharma Ag |
Phenyldihydrobenzofurane
|
|
DK0828727T3
(da)
|
1995-05-18 |
2003-04-22 |
Altana Pharma Ag |
Cyclohexyldihydrobenzofuraner
|
|
US6514996B2
(en)
|
1995-05-19 |
2003-02-04 |
Kyowa Hakko Kogyo Co., Ltd. |
Derivatives of benzofuran or benzodioxole
|
|
US5637724A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
US5637725A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
ATE284895T1
(de)
|
1995-06-06 |
2005-01-15 |
Euro Celtique Sa |
Neuroaktive steroide der androstan- und pregnanreihe
|
|
US5534522A
(en)
|
1995-06-07 |
1996-07-09 |
Warner-Lambert Company |
(R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
|
|
US5910590A
(en)
|
1995-06-07 |
1999-06-08 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
GB9514464D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
|
CA2227237C
(en)
|
1995-07-26 |
2005-12-13 |
Pfizer Inc. |
N-(aroyl)glycine hydroxamic acid derivatives and related compounds
|
|
US20010018074A1
(en)
|
1995-07-29 |
2001-08-30 |
Smithkline Beecham P.L.C. |
Process for preparing solid dosage forms of very low-dose drugs
|
|
JPH11509846A
(ja)
|
1995-07-31 |
1999-08-31 |
ノボ ノルディスク アクティーゼルスカブ |
ヘテロ環式化合物、それらの調製及び使用
|
|
DE19533975A1
(de)
|
1995-09-14 |
1997-03-20 |
Merck Patent Gmbh |
Arylalkyl-diazinone
|
|
US6166041A
(en)
*
|
1995-10-11 |
2000-12-26 |
Euro-Celtique, S.A. |
2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
|
|
US5800539A
(en)
|
1995-11-08 |
1998-09-01 |
Emory University |
Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease
|
|
US5688826A
(en)
*
|
1995-11-16 |
1997-11-18 |
Eli Lilly And Company |
Excitatory amino acid derivatives
|
|
ZA969485B
(en)
|
1995-11-16 |
1998-05-12 |
Lilly Co Eli |
Excitatory amino acid receptor antagonists.
|
|
US5912248A
(en)
|
1995-11-16 |
1999-06-15 |
Eli Lilly And Company |
Excitatory amino acid receptor antagonists
|
|
US5756501A
(en)
|
1995-12-13 |
1998-05-26 |
American Home Products Corporation |
Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
|
|
GB9603723D0
(en)
*
|
1996-02-22 |
1996-04-24 |
Merck & Co Inc |
Diphenyl pyridyl derivatives as pde iv inhibitors
|
|
US5710170A
(en)
*
|
1995-12-15 |
1998-01-20 |
Merck Frosst Canada, Inc. |
Tri-aryl ethane derivatives as PDE IV inhibitors
|
|
GB9526245D0
(en)
*
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526246D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526243D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US5804686A
(en)
|
1996-01-19 |
1998-09-08 |
Neurogen Corporation |
fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
US6211365B1
(en)
|
1996-01-19 |
2001-04-03 |
Neurogen Corporation |
Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
BR9707233A
(pt)
*
|
1996-01-31 |
1999-07-20 |
Byk Gulden Lomberg Chem Fab |
Fenantridinas
|
|
GB9604926D0
(en)
|
1996-03-08 |
1996-05-08 |
Sandoz Ltd |
Organic compounds
|
|
US5792766A
(en)
|
1996-03-13 |
1998-08-11 |
Neurogen Corporation |
Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
|
|
US5677309A
(en)
|
1996-03-22 |
1997-10-14 |
Neurogen Corporation |
1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
|
|
WO1997034870A1
(en)
|
1996-03-22 |
1997-09-25 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides as gaba brain receptor ligands
|
|
US6127378A
(en)
|
1996-03-26 |
2000-10-03 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Phenanthridines substituted in the 6 position
|
|
US6777217B1
(en)
|
1996-03-26 |
2004-08-17 |
President And Fellows Of Harvard College |
Histone deacetylases, and uses related thereto
|
|
FR2746800B1
(fr)
|
1996-03-29 |
1998-06-05 |
Jouveinal Inst Rech |
Diazepino-indoles inhibiteurs de phosphodiesterases 4
|
|
US6297273B1
(en)
|
1996-04-02 |
2001-10-02 |
Mars, Inc. |
Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
|
|
FR2754260B1
(fr)
|
1996-10-04 |
1998-10-30 |
Adir |
Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5723462A
(en)
|
1996-04-26 |
1998-03-03 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
|
|
US20020103194A1
(en)
|
1997-04-30 |
2002-08-01 |
Anabella Villalobos |
Novel muscarinic receptor agonists
|
|
BR9709230A
(pt)
|
1996-05-10 |
1999-08-10 |
Icos Corp |
Composto
|
|
US6017924A
(en)
*
|
1996-06-27 |
2000-01-25 |
Ligand Pharmaceuticals Incorporated |
Androgen receptor modulator compounds and methods
|
|
KR20000029548A
(ko)
|
1996-07-25 |
2000-05-25 |
더블유. 지. 콜 |
가바수용체에대한리간드로서의치환된트리아졸로-피리다진유도체
|
|
US20020127271A1
(en)
|
1996-07-25 |
2002-09-12 |
Smithkline Beecham P.L.C. |
Formulation for the treatment and/or prophylaxis of dementia
|
|
BR9711154A
(pt)
|
1996-08-12 |
1999-08-17 |
Yoshitomi Pharmaceutical |
Agente farmac-utico contendo inibidor cinase rho
|
|
DE19632549A1
(de)
*
|
1996-08-13 |
1998-02-19 |
Merck Patent Gmbh |
Arylalkanoylpyridazine
|
|
JP4309475B2
(ja)
|
1996-08-19 |
2009-08-05 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規のベンゾフラン―4―カルボキサミド
|
|
PT920426E
(pt)
*
|
1996-08-26 |
2004-02-27 |
Altana Pharma Ag |
Novos derivados de tiazole com efeito inibidor de fosfodiesterase
|
|
US20010003588A1
(en)
|
1996-09-12 |
2001-06-14 |
Smithkline Beecham Corporation |
Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride
|
|
US5834458A
(en)
*
|
1996-10-09 |
1998-11-10 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
WO1998016528A1
(en)
*
|
1996-10-11 |
1998-04-23 |
Chiron Corporation |
Purine inhibitors of glycogen synthase kinase 3 (gsk3)
|
|
DE19642451A1
(de)
*
|
1996-10-15 |
1998-04-16 |
Merck Patent Gmbh |
Aminothiophencarbonsäureamide
|
|
GB9621789D0
(en)
|
1996-10-18 |
1996-12-11 |
Lilly Industries Ltd |
Pharmaceutical compounds
|
|
WO1998017651A1
(en)
*
|
1996-10-21 |
1998-04-30 |
Neurosearch A/S |
1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators
|
|
GB9622386D0
(en)
|
1996-10-28 |
1997-01-08 |
Sandoz Ltd |
Organic compounds
|
|
US5773458A
(en)
|
1996-10-30 |
1998-06-30 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
US6331543B1
(en)
*
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
|
US6069151A
(en)
|
1996-11-06 |
2000-05-30 |
Darwin Discovery, Ltd. |
Quinolines and their therapeutic use
|
|
WO1998021207A1
(de)
|
1996-11-12 |
1998-05-22 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
(2,3-dihydrobenzofuranyl)-thiazole als phosphodiesterasehemmer
|
|
US6054475A
(en)
|
1996-11-20 |
2000-04-25 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Substituted dihydrobenzofuran-based phosphodiesterase 4 inhibitors useful for treating airway disorders
|
|
GB9625184D0
(en)
*
|
1996-12-04 |
1997-01-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
BR9806752A
(pt)
|
1997-01-15 |
2000-03-14 |
Byk Gulden Lomberg Chem Fab |
Ftalazinonas.
|
|
GB9702524D0
(en)
|
1997-02-07 |
1997-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
ES2302350T3
(es)
*
|
1997-02-28 |
2008-07-01 |
Nycomed Gmbh |
Combinacion sinergica de inhibidores de pde y agonistas de adenilatociclasa o agonistas de guanililciclasa.
|
|
ES2131463B1
(es)
|
1997-04-08 |
2000-03-01 |
Lilly Sa |
Derivados de ciclopropilglicina con propiedades farmaceuticas.
|
|
GB9708945D0
(en)
|
1997-05-01 |
1997-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6387673B1
(en)
|
1997-05-01 |
2002-05-14 |
The Salk Institute For Biological Studies |
Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
|
|
US6043252A
(en)
|
1997-05-05 |
2000-03-28 |
Icos Corporation |
Carboline derivatives
|
|
CA2288789C
(en)
|
1997-05-08 |
2009-07-21 |
Merck Sharp & Dohme Limited |
Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
|
|
ZA983930B
(en)
|
1997-05-14 |
1999-11-08 |
Lilly Co Eli |
Excitatory amino acid receptor modulators.
|
|
EP1014974B1
(en)
|
1997-05-29 |
2004-08-11 |
H. Lundbeck A/S |
Treatment of schizophrenia and psychosis
|
|
US6825211B1
(en)
*
|
1997-07-18 |
2004-11-30 |
Georgetown University |
Bicyclic metabotropic glutamate receptor ligands
|
|
JP2001515839A
(ja)
|
1997-07-18 |
2001-09-25 |
ジョージタウン・ユニバーシティ |
二環式向代謝性グルタミン酸受容体リガンド
|
|
JP2001510827A
(ja)
|
1997-07-25 |
2001-08-07 |
ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング |
置換6−フェニルフェナントリジン
|
|
ES2137113B1
(es)
|
1997-07-29 |
2000-09-16 |
Almirall Prodesfarma Sa |
Nuevos derivados de triazolo-piridazinas heterociclicos.
|
|
GB9715977D0
(en)
*
|
1997-07-29 |
1997-10-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6107295A
(en)
|
1997-08-01 |
2000-08-22 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Arylalkanoyl pyridazines
|
|
CA2268190A1
(en)
|
1997-08-06 |
1999-02-18 |
Suntory Limited |
1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor
|
|
US6143760A
(en)
|
1997-08-25 |
2000-11-07 |
Neurogen Corporation |
Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
|
|
US6207842B1
(en)
*
|
1997-10-09 |
2001-03-27 |
Mars Incorporated |
Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
|
|
US6127363A
(en)
|
1997-10-28 |
2000-10-03 |
Vivus, Inc. |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
US6156753A
(en)
*
|
1997-10-28 |
2000-12-05 |
Vivus, Inc. |
Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
UA64769C2
(uk)
*
|
1997-11-07 |
2004-03-15 |
Х. Луннбек А/С |
Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування
|
|
CA2395558C
(en)
|
1997-11-12 |
2007-07-17 |
Bayer Aktiengesellschaft |
Intermediates for 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
|
|
US6429207B1
(en)
*
|
1997-11-21 |
2002-08-06 |
Nps Pharmaceuticals, Inc. |
Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
|
|
CN1294590A
(zh)
|
1997-12-12 |
2001-05-09 |
欧罗赛铁克股份有限公司 |
通过2-硫代黄嘌呤制备3-取代腺嘌呤的方法
|
|
IT1296985B1
(it)
|
1997-12-19 |
1999-08-03 |
Zambon Spa |
Derivati benzazinici inibitori della fosfodiesterasi 4
|
|
CA2315219A1
(en)
|
1998-01-14 |
1999-07-22 |
Merck Sharp & Dohme Limited |
Triazolo-pyridazine derivatives as ligands for gaba receptors
|
|
HUP0100575A3
(en)
|
1998-01-21 |
2003-03-28 |
Merck Sharp & Dohme Ltd Hoddes |
Triazolo-pyridazine derivatives as ligands for gaba receptors
|
|
GB9801234D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801202D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801210D0
(en)
*
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801208D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801397D0
(en)
|
1998-01-22 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
HUP0002353A3
(en)
*
|
1998-01-29 |
2001-11-28 |
Daiichi Asubio Pharma Co Ltd |
1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them
|
|
AU2881199A
(en)
*
|
1998-02-26 |
1999-09-15 |
Neurogen Corporation |
Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
|
|
US6166203A
(en)
*
|
1998-02-26 |
2000-12-26 |
Neurogen Corporation |
Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
|
|
US6103903A
(en)
|
1998-02-26 |
2000-08-15 |
Neurogen Corporation |
4-(4-piperidylmethyhlamino) substituted heteroaryl fused pyridines: GABA brain receptor ligands
|
|
EP1056724B1
(en)
|
1998-02-26 |
2005-05-25 |
Neurogen Corporation |
Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands
|
|
US6900228B1
(en)
|
1998-03-10 |
2005-05-31 |
Research Triangle Institute |
Opiate compounds, methods of making and methods of use
|
|
US6805883B2
(en)
|
1998-03-12 |
2004-10-19 |
Mars, Incorporated |
Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
|
|
GB9806102D0
(en)
*
|
1998-03-20 |
1998-05-20 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
FR2776660B1
(fr)
|
1998-03-27 |
2000-05-12 |
Parke Davis |
Diazepino-indoles de phosphodiesterases iv
|
|
US6528529B1
(en)
|
1998-03-31 |
2003-03-04 |
Acadia Pharmaceuticals Inc. |
Compounds with activity on muscarinic receptors
|
|
WO1999054280A1
(en)
|
1998-04-17 |
1999-10-28 |
Kenneth Curry |
Cubane derivatives as metabotropic glutamate receptor antagonists and process for their preparation
|
|
RS50011B
(sr)
|
1998-04-20 |
2008-09-29 |
Pfizer Inc., |
Derivati piridin-3-karboksilne kiseline i njihova upotreba kao intermedijera
|
|
PL198983B1
(pl)
|
1998-04-28 |
2008-08-29 |
Elbion Ag |
Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania
|
|
US6897305B2
(en)
|
1998-06-08 |
2005-05-24 |
Theravance, Inc. |
Calcium channel drugs and uses
|
|
PT1086096E
(pt)
|
1998-06-10 |
2003-12-31 |
Altana Pharma Ag |
Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
|
|
EP1087968A1
(en)
*
|
1998-06-16 |
2001-04-04 |
MERCK SHARP & DOHME LTD. |
Triazolo-pyridine derivatives as ligands for gaba receptors
|
|
GB9813006D0
(en)
*
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO1999065897A1
(en)
*
|
1998-06-19 |
1999-12-23 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
JP2002519423A
(ja)
|
1998-07-06 |
2002-07-02 |
ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング |
Ped阻害作用を有する新規ベンゾオキサゾール
|
|
ITMI981671A1
(it)
|
1998-07-21 |
2000-01-21 |
Zambon Spa |
Derivati ftalazinici inibitori della fosfodisterasi 4
|
|
US6177569B1
(en)
|
1998-08-25 |
2001-01-23 |
Neurogen Corporation |
Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
|
|
KR100469182B1
(ko)
*
|
1998-08-31 |
2005-02-02 |
다이쇼 세이야꾸 가부시끼가이샤 |
6-플루오로비시클로[3.1.0]헥산 유도체
|
|
MXPA01002102A
(es)
|
1998-09-03 |
2003-02-24 |
Kyowa Hakko Kogyo Kk |
Compuestos heterociclicos que contienen oxigeno.
|
|
CH694053A5
(de)
|
1998-09-03 |
2004-06-30 |
Hoffmann La Roche |
Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
|
|
AU1025899A
(en)
|
1998-09-16 |
2000-04-03 |
Icos Corporation |
Carboline derivatives as cgmp phosphodiesterase inhibitors
|
|
US6719520B2
(en)
*
|
1998-10-08 |
2004-04-13 |
Smithkline Beecham Corporation |
Method and compounds
|
|
ATE371659T1
(de)
*
|
1998-10-16 |
2007-09-15 |
Merck Sharp & Dohme |
Pyrazolotriazinderivate als gaba-rezeptorliganden
|
|
WO2000027849A2
(en)
|
1998-11-12 |
2000-05-18 |
Merck & Co., Inc. |
Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
|
|
PE20001236A1
(es)
*
|
1998-11-13 |
2000-11-10 |
Lilly Co Eli |
Moduladores del receptor de aminoacidos excitadores
|
|
SE9804064D0
(sv)
*
|
1998-11-25 |
1998-11-25 |
A & Science Invest Ab |
Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
|
|
US6130333A
(en)
|
1998-11-27 |
2000-10-10 |
Monsanto Company |
Bicyclic imidazolyl derivatives as phosphodiesterase inhibitors, pharmaceutical compositions and method of use
|
|
WO2000037471A1
(en)
|
1998-12-23 |
2000-06-29 |
Neurogen Corporation |
2-amino-9-alkylpurines: gaba brain receptor ligands
|
|
ATE284403T1
(de)
|
1999-01-27 |
2004-12-15 |
Merck Sharp & Dohme |
Triazolopyridazinderivate als liganden für gaba- rezeptoren
|
|
US6342496B1
(en)
*
|
1999-03-01 |
2002-01-29 |
Sepracor Inc. |
Bupropion metabolites and methods of use
|
|
US6498176B1
(en)
|
1999-03-04 |
2002-12-24 |
Smithklinebeecham Corporation |
3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
|
|
TW575561B
(en)
|
1999-03-25 |
2004-02-11 |
Hoffmann La Roche |
1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
|
|
FR2792938B1
(fr)
|
1999-04-28 |
2001-07-06 |
Warner Lambert Co |
NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
|
|
US6528499B1
(en)
|
2000-04-27 |
2003-03-04 |
Georgetown University |
Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
|
|
AU773915B2
(en)
*
|
1999-04-28 |
2004-06-10 |
Georgetown University |
Ligands for metabotropic glutamate receptors
|
|
US6943166B1
(en)
|
1999-04-30 |
2005-09-13 |
Lilly Icos Llc. |
Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
|
|
US6316472B1
(en)
*
|
1999-05-13 |
2001-11-13 |
Merck Frosst Canada & Co. |
Heterosubstituted pyridine derivatives as PDE 4 inhibitors
|
|
WO2000071528A1
(en)
|
1999-05-25 |
2000-11-30 |
Neurogen Corporation |
4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
|
|
EP1189873A1
(en)
|
1999-06-03 |
2002-03-27 |
Lilly, S.A. |
Excitatory amino acid receptor modulators
|
|
WO2000077045A1
(fr)
|
1999-06-10 |
2000-12-21 |
Takeda Chemical Industries, Ltd. |
Proteine et adn de cette proteine
|
|
US6146876A
(en)
*
|
1999-06-11 |
2000-11-14 |
Millennium Pharmaceuticals, Inc. |
22025, a novel human cyclic nucleotide phosphodiesterase
|
|
US6297256B1
(en)
|
1999-06-15 |
2001-10-02 |
Neurogen Corporation |
Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
|
|
DE19928146A1
(de)
|
1999-06-19 |
2000-12-21 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
IL147309A0
(en)
|
1999-07-21 |
2002-08-14 |
Fujisawa Pharmaceutical Co |
Benzimidazolone derivatives and pharmaceutical compositions containg the same
|
|
US6821975B1
(en)
*
|
1999-08-03 |
2004-11-23 |
Lilly Icos Llc |
Beta-carboline drug products
|
|
ES2209728T3
(es)
|
1999-08-06 |
2004-07-01 |
F. Hoffmann-La Roche Ag |
Tetrahidro-benzo(d)azepinas y su uso como antagonistas de receptores de glutamato metabotropico.
|
|
WO2001012630A1
(en)
|
1999-08-13 |
2001-02-22 |
Sepracor Inc. |
Spirocyclic ligands for sigma receptors, and libraries and methods of use thereof
|
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
US6313159B1
(en)
*
|
1999-08-20 |
2001-11-06 |
Guilford Pharmaceuticals Inc. |
Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
|
|
GB9919957D0
(en)
|
1999-08-23 |
1999-10-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6956049B1
(en)
|
1999-08-31 |
2005-10-18 |
Merck & Co., Inc. |
Methods of modulating processes mediated by excitatory amino acid receptors
|
|
US20050014939A1
(en)
*
|
1999-08-31 |
2005-01-20 |
Neurogen Corporation |
Fused pyrrolecarboxamides: GABA brain receptor ligands
|
|
GB9921150D0
(en)
|
1999-09-07 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9921351D0
(en)
|
1999-09-09 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
TWI265925B
(en)
*
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
US6552016B1
(en)
|
1999-10-14 |
2003-04-22 |
Curis, Inc. |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
|
|
ATE261945T1
(de)
|
1999-10-15 |
2004-04-15 |
Hoffmann La Roche |
Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
|
|
US7491742B2
(en)
|
1999-10-21 |
2009-02-17 |
Merck Patent Gmbh |
Imidazole derivatives as phosphodiesterase VII inhibitors
|
|
US6534287B1
(en)
|
1999-10-25 |
2003-03-18 |
Nps Pharmaceuticals, Inc. |
Human metabotropic glutamate receptor
|
|
TWI262919B
(en)
|
1999-10-25 |
2006-10-01 |
Yamanouchi Pharma Co Ltd |
Naphthyridine derivative
|
|
DE19953025A1
(de)
|
1999-11-04 |
2001-05-10 |
Merck Patent Gmbh |
Pyrrolderivate als Phosphodiesterase VII-Hemmer
|
|
DE19953414A1
(de)
|
1999-11-06 |
2001-05-10 |
Merck Patent Gmbh |
Imidazopyridinderivate als Phospodiesterase VII-Hemmer
|
|
DE19954707A1
(de)
|
1999-11-13 |
2001-05-17 |
Merck Patent Gmbh |
Imidazolverbindungen als Phosphodiesterase VII-Hemmer
|
|
GB9927687D0
(en)
|
1999-11-23 |
2000-01-19 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1748046A3
(en)
|
1999-11-23 |
2007-08-22 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
CN1224624C
(zh)
*
|
1999-12-08 |
2005-10-26 |
格勒兰制药株式会社 |
1,8-二氮杂萘-2(1h)-酮衍生物
|
|
ES2213996T3
(es)
|
1999-12-08 |
2004-09-01 |
Centre National De La Recherche Scientifique (Cnrs) |
Uso de himenialdisina o sus derivados en la fabricacion de medicamentos.
|
|
GB9929687D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6680336B2
(en)
*
|
1999-12-15 |
2004-01-20 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6376489B1
(en)
|
1999-12-23 |
2002-04-23 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
GB9929685D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CN100335479C
(zh)
*
|
1999-12-17 |
2007-09-05 |
希龙公司 |
糖元合成酶激酶3的双环抑制剂
|
|
US6258833B1
(en)
|
1999-12-23 |
2001-07-10 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6348602B1
(en)
|
1999-12-23 |
2002-02-19 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6362213B1
(en)
|
1999-12-23 |
2002-03-26 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6372777B1
(en)
|
1999-12-23 |
2002-04-16 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6294561B1
(en)
|
1999-12-23 |
2001-09-25 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6569885B1
(en)
|
1999-12-23 |
2003-05-27 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6313156B1
(en)
*
|
1999-12-23 |
2001-11-06 |
Icos Corporation |
Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors
|
|
GB0000564D0
(en)
|
2000-01-11 |
2000-03-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CZ20022413A3
(cs)
|
2000-01-31 |
2003-08-13 |
Pfizer Products Inc. |
Pyrimidinkarboxamidy užitečné jako inhibitory isozymů PDE4
|
|
JP2003523741A
(ja)
|
2000-02-01 |
2003-08-12 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
Bcl−2様ポリヌクレオチド、ポリペプチドおよび抗体
|
|
US6800651B2
(en)
*
|
2000-02-03 |
2004-10-05 |
Eli Lilly And Company |
Potentiators of glutamate receptors
|
|
US20010039275A1
(en)
*
|
2000-02-04 |
2001-11-08 |
Bowler Andrew Neil |
Use of 2,4-diaminothiazole derivatives
|
|
US20010034373A1
(en)
*
|
2000-02-09 |
2001-10-25 |
Matthew Miller |
Low dose modafinil for enhancement of cognitive function
|
|
GB0003254D0
(en)
*
|
2000-02-11 |
2000-04-05 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
FR2804959B1
(fr)
|
2000-02-15 |
2006-04-28 |
Centre Nat Rech Scient |
Utilisation de derives de paullones pour la fabrication de medicaments
|
|
US7166617B2
(en)
*
|
2000-02-29 |
2007-01-23 |
Mitsubishi Pharma Corporation |
Cyclic amide derivatives
|
|
GB0005700D0
(en)
|
2000-03-09 |
2000-05-03 |
Glaxo Group Ltd |
Therapy
|
|
AU2001250892A1
(en)
|
2000-03-20 |
2001-10-03 |
Teva Pharmaceutical Industries Ltd. |
Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide
|
|
DE60125026T2
(de)
|
2000-03-23 |
2007-06-28 |
Takeda Pharmaceutical Co. Ltd. |
Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung
|
|
WO2001070675A2
(en)
|
2000-03-24 |
2001-09-27 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
GB0007193D0
(en)
|
2000-03-25 |
2000-05-17 |
Univ Manchester |
Treatment of movrmrnt disorders
|
|
GB0008696D0
(en)
|
2000-04-07 |
2000-05-31 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1274319B1
(en)
*
|
2000-04-14 |
2009-08-12 |
Mars, Incorporated |
Compositions and methods for improving vascular health
|
|
CA2306170A1
(en)
|
2000-04-18 |
2001-10-18 |
Kenneth Curry |
Novel amino, carboxy derivatives of barbituric acid
|
|
AR028385A1
(es)
|
2000-04-28 |
2003-05-07 |
Acadia Pharm Inc |
Agonistas muscarinicos
|
|
NZ522674A
(en)
|
2000-05-11 |
2004-10-29 |
Kenneth Curry |
Novel spiro[2.4]heptane amino carboxy compounds and derivatives thereof
|
|
AU783615B2
(en)
|
2000-05-11 |
2005-11-17 |
Consejo Superior De Investigaciones Cientificas |
Heterocyclic inhibitors of glycogen synthase kinase GSK-3
|
|
UA74826C2
(en)
*
|
2000-05-17 |
2006-02-15 |
Ortho Mcneil Pharm Inc |
?-carboline derivatives as phosphodiesterase inhibitors
|
|
UA72611C2
(uk)
*
|
2000-05-17 |
2005-03-15 |
Орто-Макнейл Фармацевтикал, Інк. |
Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
|
|
EP1294723A1
(en)
*
|
2000-05-24 |
2003-03-26 |
MERCK SHARP & DOHME LTD. |
3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
|
|
EP1289383B1
(fr)
|
2000-05-30 |
2006-05-03 |
Societe Des Produits Nestle S.A. |
Composition primaire contenant un compose bioactif lipophile
|
|
US7081481B2
(en)
|
2000-05-31 |
2006-07-25 |
Eli Lilly And Company |
Excitatory amino acid receptor modulators
|
|
WO2001094350A1
(en)
|
2000-06-07 |
2001-12-13 |
Almirall Prodesfarma S.A. |
6-phenylpyrrolopyrimidinedione derivatives
|
|
MXPA02012470A
(es)
*
|
2000-06-23 |
2004-01-26 |
Lilly Icos Llc |
Inhibidores de fosfodiesterasa especificos para gmp ciclico.
|
|
US6589978B2
(en)
|
2000-06-30 |
2003-07-08 |
Hoffman-La Roche Inc. |
1-sulfonyl pyrrolidine derivatives
|
|
US6399641B1
(en)
|
2000-07-13 |
2002-06-04 |
Hoffmann-La Roche Inc. |
2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists
|
|
GB0018473D0
(en)
|
2000-07-27 |
2000-09-13 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1307201B1
(de)
|
2000-08-01 |
2004-11-24 |
Bayer HealthCare AG |
Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
|
|
US6645990B2
(en)
*
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
|
IL154425A0
(en)
*
|
2000-08-24 |
2003-09-17 |
Univ Tennessee Res H Corp |
Selective androgen receptor modulators and methods of use thereof
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
US6576644B2
(en)
|
2000-09-06 |
2003-06-10 |
Bristol-Myers Squibb Co. |
Quinoline inhibitors of cGMP phosphodiesterase
|
|
WO2002022579A2
(en)
|
2000-09-11 |
2002-03-21 |
Sepracor, Inc. |
Antipsychotic sulfonamide-heterocycles, and methods of use thereof
|
|
WO2002022605A1
(en)
|
2000-09-15 |
2002-03-21 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6613776B2
(en)
|
2000-09-15 |
2003-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6610677B2
(en)
|
2000-09-15 |
2003-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
GB0023983D0
(en)
|
2000-09-29 |
2000-11-15 |
Prolifix Ltd |
Therapeutic compounds
|
|
EP1335898B1
(en)
|
2000-09-29 |
2005-11-23 |
TopoTarget UK Limited |
Carbamic acid compounds comprising an amide linkage as hdac inhibitors
|
|
JP4975941B2
(ja)
|
2000-09-29 |
2012-07-11 |
トポターゲット ユーケー リミテッド |
(e)−n−ヒドロキシ−3−(3−スルファモイル−フェニル)アクリルアミド化合物及びその治療用途
|
|
EP1193261A1
(en)
|
2000-10-02 |
2002-04-03 |
Warner-Lambert Company |
New thiadiazoles and their use as phosphodiesterase-7 inhibitors
|
|
CZ20031145A3
(cs)
|
2000-10-02 |
2003-12-17 |
Janssen Pharmaceutica N.V. |
Antagonisté metabotropního glutamátového receptoru
|
|
US20020103192A1
(en)
|
2000-10-26 |
2002-08-01 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
CA2427779A1
(en)
|
2000-11-10 |
2002-05-16 |
Merck Sharp & Dohme Limited |
Imidazo-triazine derivatives as ligands for gaba receptors
|
|
GB0027561D0
(en)
|
2000-11-10 |
2000-12-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0117277D0
(en)
*
|
2001-07-16 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CZ20031334A3
(cs)
*
|
2000-11-14 |
2003-09-17 |
Altana Pharma Ag |
Isochinolinové deriváty a jejich použití jako inhibitory
|
|
AR035659A1
(es)
|
2000-12-07 |
2004-06-23 |
Hoffmann La Roche |
Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos
|
|
US6930114B2
(en)
|
2000-12-13 |
2005-08-16 |
Bayer Pharmaceuticals Corporation |
Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
|
|
US6900215B2
(en)
|
2000-12-15 |
2005-05-31 |
Merck Sharp & Dohme Ltd. |
Imidazo-pyrimidine derivatives as ligands for gaba receptors
|
|
US6989385B2
(en)
|
2000-12-21 |
2006-01-24 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6720445B2
(en)
|
2000-12-21 |
2004-04-13 |
Beacon Laboratories, Inc. |
Acetyloxymethyl esters and methods for using the same
|
|
US6562995B1
(en)
|
2000-12-21 |
2003-05-13 |
Beacon Laboratories, Inc. |
Delta dicarbonyl compounds and methods for using the same
|
|
KR100545906B1
(ko)
|
2000-12-22 |
2006-01-26 |
에프. 호프만-라 로슈 아게 |
mGluR 1 길항물질로서의 테트라하이드로-(벤조 또는티에노)-아제핀-피라진 및 트리아진 유도체
|
|
AR035513A1
(es)
|
2000-12-23 |
2004-06-02 |
Hoffmann La Roche |
Derivados de tetrahidropiridina, proceso para prepararlos, composiciones farmaceuticas que los contienen, y uso de dichos compuestos en la preparacion de medicamentos
|
|
GR1003861B
(el)
|
2000-12-29 |
2002-04-11 |
|
Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
|
|
US6974824B2
(en)
|
2001-01-08 |
2005-12-13 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
AR035417A1
(es)
|
2001-01-27 |
2004-05-26 |
Hoffmann La Roche |
Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
|
|
ES2248231T3
(es)
|
2001-01-31 |
2006-03-16 |
Pfizer Products Inc. |
Derivados de eteres utiles como inhibidores de las isozimas pde4.
|
|
EE200300360A
(et)
|
2001-01-31 |
2003-12-15 |
Pfizer Products Inc. |
PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid
|
|
CN1489588A
(zh)
|
2001-01-31 |
2004-04-14 |
�Ʒ� |
用作pde4同功酶抑制剂的噻唑基,噁唑基,吡咯基,和咪唑基羧酸酰胺衍生物
|
|
US6559159B2
(en)
|
2001-02-01 |
2003-05-06 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
US6617357B2
(en)
|
2001-03-06 |
2003-09-09 |
Smithkline Beecham Corporation |
Compounds and their use as PDE inhibitors
|
|
US20020177594A1
(en)
*
|
2001-03-14 |
2002-11-28 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
US6900329B2
(en)
|
2001-03-21 |
2005-05-31 |
Schering Corporation |
MCH antagonists and their use in the treatment of obesity
|
|
AP1699A
(en)
*
|
2001-03-21 |
2006-12-26 |
Warner Lambert Co |
New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
|
|
TWI332503B
(en)
|
2001-04-19 |
2010-11-01 |
Mitsubishi Tanabe Pharma Corp |
Polymorph forms of n-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
GB0111191D0
(en)
|
2001-05-08 |
2001-06-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO2002089782A2
(en)
|
2001-05-09 |
2002-11-14 |
President And Fellows Of Harvard College |
Dioxanes and uses thereof
|
|
MXPA03010961A
(es)
|
2001-05-31 |
2004-02-27 |
Vertex Pharma |
Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
|
|
KR20040007672A
(ko)
|
2001-06-12 |
2004-01-24 |
에스케이 주식회사 |
신규한 페닐알킬디아민 및 아미드 유사체
|
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
CA2450934A1
(en)
|
2001-06-19 |
2002-12-27 |
Marco Dodier |
Pyrimidine inhibitors of phosphodiesterase (pde) 7
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
GB0117060D0
(en)
|
2001-07-12 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO2003013522A1
(en)
*
|
2001-08-06 |
2003-02-20 |
Mitsubishi Pharma Corporation |
Preventives/remedies for cholinergic neuropathy
|
|
EP1285922A1
(en)
|
2001-08-13 |
2003-02-26 |
Warner-Lambert Company |
1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
|
|
JO2311B1
(en)
|
2001-08-29 |
2005-09-12 |
ميرك فروست كندا ليمتد |
Alkyl inhibitors Ariel phosphodiesterase-4
|
|
CN101851173A
(zh)
|
2001-09-14 |
2010-10-06 |
梅特希尔基因公司 |
组蛋白脱乙酰化酶抑制剂
|
|
US6897220B2
(en)
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
EP1295884A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
|
|
EP1295885A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives
|
|
CN1578781A
(zh)
|
2001-09-26 |
2005-02-09 |
拜尔药品公司 |
用作抗糖尿病药物的1,8-萘啶衍生物
|
|
BR0213611A
(pt)
|
2001-10-02 |
2005-12-20 |
Acadia Pharm Inc |
Composto, composição farmacêutica, seus usos, método para aumentar a atividade de um receptor colinérgico, métodos para tratamento ou prevenção de distúrbio mental, dor, pressão intraocular aumentada e progressão ou formação de placas amilóides
|
|
US6951849B2
(en)
|
2001-10-02 |
2005-10-04 |
Acadia Pharmaceuticals Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
US6924311B2
(en)
|
2001-10-17 |
2005-08-02 |
X-Ceptor Therapeutics, Inc. |
Methods for affecting various diseases utilizing LXR compounds
|
|
CN100548291C
(zh)
|
2001-10-25 |
2009-10-14 |
先灵公司 |
用于治疗肥胖的mch拮抗剂
|
|
ES2294190T3
(es)
|
2001-11-01 |
2008-04-01 |
Janssen Pharmaceutica N.V. |
Derivados de amida como inhibidores de la glucogeno sintasa quinasa 3-beta.
|
|
HUP0402106A3
(en)
*
|
2001-11-01 |
2009-07-28 |
Janssen Pharmaceutica Nv |
Heteroaryl amines as glycogen synthase kinase 3 beta inhibitors, process for their preparation and pharmaceutical compositions containing them
|
|
ES2289159T3
(es)
*
|
2001-11-14 |
2008-02-01 |
Ortho-Mcneil Pharmaceutical Corporation |
Derivados tetraciclicos sustituidos de pirroloquinolona utilizados como inhibidores de fosfodiesterasa.
|
|
FR2832711B1
(fr)
|
2001-11-26 |
2004-01-30 |
Warner Lambert Co |
Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
|
|
WO2003048137A1
(en)
|
2001-11-30 |
2003-06-12 |
Merck & Co., Inc. |
Metabotropic glutamate receptor-5 modulators
|
|
HU228316B1
(en)
|
2001-12-13 |
2013-03-28 |
Daiichi Sankyo Company |
Pyrazolopyrimidinone derivatives having pde7-inhibitory activity
|
|
DE60223720T2
(de)
*
|
2001-12-18 |
2008-10-30 |
Merck & Co., Inc. |
Heteroaryl-substituierte pyrazol-modulatoren des metabotropen glutamatrezeptors-5
|
|
DE60222698T2
(de)
*
|
2001-12-18 |
2008-06-19 |
Merck & Co., Inc. |
Heteroarylsubstituierte triazolmodulatoren des metabotropen glutamatarezeptors 5
|
|
WO2003053922A2
(en)
|
2001-12-19 |
2003-07-03 |
Merck & Co., Inc. |
Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
|
|
EP1458710A4
(en)
|
2001-12-21 |
2005-04-20 |
Merck & Co Inc |
Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5
|
|
DE10163991A1
(de)
|
2001-12-24 |
2003-07-03 |
Merck Patent Gmbh |
Pyrrolo-pyrimidine
|
|
CA2366325A1
(en)
|
2001-12-27 |
2003-06-27 |
Todd Howley |
Method of forming turbine blade root
|
|
KR20090031962A
(ko)
|
2001-12-27 |
2009-03-30 |
다이쇼 세이야꾸 가부시끼가이샤 |
6-플루오로비시클로[3.1.0]헥산 유도체
|
|
US7550459B2
(en)
|
2001-12-28 |
2009-06-23 |
Acadia Pharmaceuticals, Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
WO2003057698A2
(en)
|
2001-12-28 |
2003-07-17 |
Acadia Pharmaceuticals, Inc. |
Spiroazacyclic compounds as monoamine receptor modulators
|
|
ES2251624T3
(es)
|
2001-12-28 |
2006-05-01 |
Acadia Pharmaceuticals Inc. |
Analogos de la tetrahidroquinolina como los agonistas muscarinicos.
|
|
US6495700B1
(en)
*
|
2002-01-09 |
2002-12-17 |
Axonyx, Inc. |
Process for producing phenserine and its analog
|
|
US20050107432A1
(en)
|
2002-01-22 |
2005-05-19 |
Yoichi Iimura |
Sigma receptor binder containing indanone derivative
|
|
TW200302726A
(en)
|
2002-01-31 |
2003-08-16 |
Ono Pharmaceutical Co |
Nitrogen-containing bicyclic compound and medicament containing same as active ingredient
|
|
MXPA04007737A
(es)
|
2002-02-11 |
2004-10-15 |
Pfizer |
Derivados de nicotinamida utiles como inhibidores de fosfodesterasas 4.
|
|
CA2477117A1
(en)
|
2002-02-22 |
2003-08-28 |
Teijin Limited |
Pyrrolopyrimidine derivative
|
|
EP1485093B1
(en)
|
2002-03-12 |
2010-11-03 |
Merck Sharp & Dohme Corp. |
Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
|
|
MXPA04008797A
(es)
|
2002-03-13 |
2004-11-26 |
Janssen Pharmaceutica Nv |
Inhibidores de histona desacetilasa.
|
|
EA007099B1
(ru)
|
2002-03-13 |
2006-06-30 |
Янссен Фармацевтика Н. В. |
Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы
|
|
CA2475766C
(en)
|
2002-03-13 |
2012-06-05 |
Janssen Pharmaceutica N.V. |
Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
|
|
CN100445276C
(zh)
|
2002-03-13 |
2008-12-24 |
詹森药业有限公司 |
用作组蛋白去乙酰酶抑制剂的磺酰基衍生物
|
|
DE60220016T2
(de)
*
|
2002-03-20 |
2008-01-10 |
Société des Produits Nestlé S.A. |
Kakaoextrakt mit niedrigem Fettgehalt
|
|
US7514107B2
(en)
|
2002-03-21 |
2009-04-07 |
Mars, Incorporated |
Treatment of diseases involving defective gap junctional communication
|
|
NZ536116A
(en)
|
2002-04-03 |
2007-01-26 |
Topotarget Uk Ltd |
Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
|
|
GB0210124D0
(en)
|
2002-05-02 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0212048D0
(en)
|
2002-05-24 |
2002-07-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
DE60317684T4
(de)
|
2002-06-19 |
2011-06-22 |
Janssen Pharmaceutica N.V., 2340 |
SUBSTITUIERTE 2,4-DIHYDROPYRROLOc3,4BÜCHINOLIN-9-ONDERIVATE, DIE SICH ALS PHOSPHODIESTERASEINHIBITOREN EIGNEN
|
|
AU2003256616B2
(en)
|
2002-07-19 |
2009-08-27 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
|
|
EP1400244A1
(en)
|
2002-09-17 |
2004-03-24 |
Warner-Lambert Company LLC |
New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
|
|
WO2004032851A2
(en)
*
|
2002-10-04 |
2004-04-22 |
The Regents Of The University Of California |
Screening and therapeutic methods relating to neurogenesis
|
|
CN1717391A
(zh)
|
2002-10-21 |
2006-01-04 |
希龙公司 |
糖元合成酶激酶3的抑制剂
|
|
US6969702B2
(en)
*
|
2002-11-20 |
2005-11-29 |
Neuronova Ab |
Compounds and methods for increasing neurogenesis
|
|
DK1583541T3
(da)
*
|
2002-11-20 |
2011-04-11 |
Neuronova Ab |
Forbindelser og fremgangsmåder til at øge neurogenese
|
|
US20040185429A1
(en)
|
2002-12-09 |
2004-09-23 |
Judith Kelleher-Andersson |
Method for discovering neurogenic agents
|
|
ES2209650B2
(es)
|
2002-12-09 |
2006-11-01 |
Laboratorios Del Dr. Esteve, S.A. |
Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones.
|
|
EP1598355A4
(en)
|
2003-01-08 |
2010-01-27 |
Mitsubishi Tanabe Pharma Corp |
THERAPEUTIC ACTIVE FOR THE TREATMENT OF SCHIZOPHRENIA
|
|
US7135493B2
(en)
*
|
2003-01-13 |
2006-11-14 |
Astellas Pharma Inc. |
HDAC inhibitor
|
|
WO2004069813A1
(en)
*
|
2003-01-31 |
2004-08-19 |
Astrazeneca Ab |
Saturated quinoxaline derivatives and their use as metabotropic glutamate receptor ligands
|
|
JP2006518381A
(ja)
|
2003-02-07 |
2006-08-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼのインヒビターとして有用なヘテロアリール置換ピロール
|
|
US6969716B2
(en)
|
2003-02-07 |
2005-11-29 |
Merck Sharp & Dohme Ltd. |
5-phenyl[1,2,4]triazines as ligands for GABA-A α2/α3 receptors for treating anxiety or depression
|
|
TWI292318B
(en)
*
|
2003-03-10 |
2008-01-11 |
Hoffmann La Roche |
Imidazol-4-yl-ethynyl-pyridine derivatives
|
|
US7381825B2
(en)
|
2003-03-17 |
2008-06-03 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
NZ542690A
(en)
|
2003-03-28 |
2009-04-30 |
Acadia Pharm Inc |
Muscarinic M1 receptor agonists for pain management
|
|
JP2006522144A
(ja)
*
|
2003-04-04 |
2006-09-28 |
ダイノゲン ファーマシューティカルズ,インコーポレイテッド |
下部尿路障害の治療方法
|
|
SG169900A1
(en)
*
|
2003-04-16 |
2011-04-29 |
Memory Pharm Corp |
4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
|
|
US20040254152A1
(en)
|
2003-04-17 |
2004-12-16 |
Monje Michelle L. |
Prevention of deficits in neurogenesis with anti-inflammatory agents
|
|
GB0311859D0
(en)
|
2003-05-22 |
2003-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7763588B2
(en)
*
|
2003-06-13 |
2010-07-27 |
The Salk Institute For Biological Studies |
Method for increasing cognitive function and neurogenesis
|
|
US7842835B2
(en)
*
|
2003-07-07 |
2010-11-30 |
Georgetown University |
Histone deacetylase inhibitors and methods of use thereof
|
|
ES2293287T3
(es)
|
2003-07-25 |
2008-03-16 |
F. Hoffmann-La Roche Ag |
Combinacion de antagonista de mglur2 y de inhibidor de ache para el tratamiento de trastornos neurologicos agudos y/o cronicos.
|
|
WO2005017189A2
(en)
*
|
2003-08-05 |
2005-02-24 |
University Of Florida Research Foundation, Inc. |
Neural cell assay
|
|
TWI339206B
(en)
|
2003-09-04 |
2011-03-21 |
Vertex Pharma |
Compositions useful as inhibitors of protein kinases
|
|
RU2006115615A
(ru)
*
|
2003-10-10 |
2007-11-27 |
Марс, Инкорпорейтед (Us) |
Лечение заболеваний, в патогенез которых вовлечена гиперэкспрессия киназы erbb2
|
|
SI1541197T1
(sl)
|
2003-12-02 |
2009-08-31 |
Pharmaneuroboost N V |
Uporaba pipamperona in sndri, snri ali ssri za zdravljenje razpoloĺ˝enjskih ali tesnobnih motenj
|
|
US20050137234A1
(en)
|
2003-12-19 |
2005-06-23 |
Syrrx, Inc. |
Histone deacetylase inhibitors
|
|
US20050159470A1
(en)
|
2003-12-19 |
2005-07-21 |
Syrrx, Inc. |
Histone deacetylase inhibitors
|
|
PT1696931E
(pt)
|
2003-12-22 |
2009-06-12 |
Acadia Pharm Inc |
Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas
|
|
CA2554140A1
(en)
|
2004-01-30 |
2005-08-18 |
Mars, Incorporated |
Methods and compositions for treating cancer
|
|
TWI301760B
(en)
|
2004-02-27 |
2008-10-11 |
Merz Pharma Gmbh & Co Kgaa |
Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
|
|
EP2317316A3
(en)
*
|
2005-07-08 |
2011-06-15 |
Braincells, Inc. |
Methods for identifying agent and conditions that modulate neurogenesis
|
|
US20090088449A1
(en)
*
|
2006-02-07 |
2009-04-02 |
Mitsubishi Tanabe Pharma Corporation |
4-acylaminopyridine derivative mediated neurogenesis
|