|
US3121076A
(en)
|
|
1964-02-11 |
|
Benzodiazepinones and processes |
|
US1873732A
(en)
|
1928-12-28 |
1932-08-23 |
Abbott Lab |
Bactericide applicable to acid-fast bacteria
|
|
US3019843A
(en)
|
1956-07-27 |
1962-02-06 |
Powell Dawson |
Fire inhibitor and extinguisher
|
|
US2942572A
(en)
|
1958-06-17 |
1960-06-28 |
Pall Corp |
Magnetic pressure indicator
|
|
US3371085A
(en)
|
1959-12-10 |
1968-02-27 |
Hoffmann La Roche |
5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
|
|
US3136815A
(en)
|
1959-12-10 |
1964-06-09 |
Hoffmann La Roche |
Amino substituted benzophenone oximes and derivatives thereof
|
|
US3116203A
(en)
|
1962-03-14 |
1963-12-31 |
Hoffmann La Roche |
Oleaginous systems
|
|
NL298071A
(https=)
|
1963-06-04 |
|
|
|
|
CH449645A
(de)
|
1963-07-09 |
1968-01-15 |
Ciba Geigy |
Verfahren zur Herstellung neuer Aminosäuren
|
|
CH427803A
(de)
|
1963-12-06 |
1967-01-15 |
Geigy Ag J R |
Verfahren zur Herstellung eines neuen Isoxazolderivates
|
|
NL129434C
(https=)
|
1966-03-12 |
|
|
|
|
US3885046A
(en)
|
1969-12-04 |
1975-05-20 |
Burroughs Wellcome Co |
Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
|
|
BE759838A
(fr)
|
1969-12-04 |
1971-06-03 |
Wellcome Found |
Cetones a activite biologique
|
|
FR2077918B1
(https=)
|
1970-02-24 |
1973-04-06 |
Berthier Laboratoires |
|
|
US3758528A
(en)
|
1970-03-13 |
1973-09-11 |
Science Union & Cie |
Tricyclic compounds
|
|
US3821249A
(en)
|
1970-03-13 |
1974-06-28 |
En Nom Collectif Science Union |
Dibenzothiazefin derivatives
|
|
US3819631A
(en)
|
1970-12-15 |
1974-06-25 |
May & Baker Ltd |
Azapurinones
|
|
OA04285A
(fr)
|
1972-01-07 |
1979-12-31 |
Rhone Poulenc Sa |
Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
|
|
USRE31617E
(en)
|
1972-02-04 |
1984-06-26 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
US3932407A
(en)
|
1973-11-19 |
1976-01-13 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
US4036840A
(en)
|
1972-06-07 |
1977-07-19 |
Icn Pharmaceuticals |
2-Substituted-s-triazolo[1,5a]pyrimidines
|
|
GB1457873A
(en)
|
1973-01-04 |
1976-12-08 |
Allen & Hanburys Ltd |
Imidazotriazines
|
|
GB1422263A
(en)
|
1973-01-30 |
1976-01-21 |
Ferrosan As |
4-phenyl-piperidine compounds
|
|
US4051236A
(en)
|
1973-02-15 |
1977-09-27 |
E. R. Squibb & Sons, Inc. |
Inhibition of blood platelet aggregation
|
|
US4314081A
(en)
|
1974-01-10 |
1982-02-02 |
Eli Lilly And Company |
Arloxyphenylpropylamines
|
|
US4280957A
(en)
|
1974-09-11 |
1981-07-28 |
Hoffmann-La Roche Inc. |
Imidazodiazepines and processes therefor
|
|
AR208414A1
(es)
|
1974-11-07 |
1976-12-27 |
Rhone Poulenc Ind |
Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
|
|
US4093617A
(en)
|
1974-11-12 |
1978-06-06 |
Icn Pharmaceuticals, Inc. |
3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines
|
|
DE2460891C2
(de)
|
1974-12-21 |
1982-09-23 |
Gödecke AG, 1000 Berlin |
1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
|
|
US3960927A
(en)
|
1975-03-18 |
1976-06-01 |
Richardson-Merrell Inc. |
Olefinic derivatives of amino acids
|
|
NL7503310A
(nl)
|
1975-03-20 |
1976-09-22 |
Philips Nv |
Verbindingen met antidepressieve werking.
|
|
NL189199C
(nl)
|
1975-04-05 |
1993-02-01 |
Akzo Nv |
Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
|
|
FR2319338A1
(fr)
|
1975-08-01 |
1977-02-25 |
Synthelabo |
Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent
|
|
GB1526331A
(en)
|
1976-01-14 |
1978-09-27 |
Kefalas As |
Phthalanes
|
|
YU96177A
(en)
|
1976-04-24 |
1982-08-31 |
Wuelfing Johann A |
Process for obtaining adenine derivatives
|
|
US4107307A
(en)
|
1977-02-03 |
1978-08-15 |
American Cyanamid Company |
Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
USRE30511E
(en)
|
1977-02-03 |
1981-02-10 |
American Cyanamid Company |
Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
US4404380A
(en)
|
1977-02-14 |
1983-09-13 |
Mead Johnson & Company |
Triazolopyrimidines
|
|
CA1095906A
(en)
|
1977-02-14 |
1981-02-17 |
Davis L. Temple, Jr. |
Heterocyclopyrimidines, compositions and therapeutic process
|
|
US4096257A
(en)
|
1977-05-23 |
1978-06-20 |
American Cyanamid Company |
Substituted imidazo [1,2-d]-as-triazines
|
|
US4107309A
(en)
|
1977-05-23 |
1978-08-15 |
American Cyanamid Company |
Substituted imidazo[1,2-d]-as-triazines
|
|
IN148482B
(https=)
|
1977-06-03 |
1981-03-07 |
Pfizer |
|
|
DK270278A
(da)
|
1977-06-20 |
1978-12-21 |
Krogsgaard Larsen P |
Cycliske aminosyrer
|
|
US4370328A
(en)
|
1977-11-03 |
1983-01-25 |
Pfizer Inc. |
Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
|
|
CA1086735A
(en)
|
1977-11-03 |
1980-09-30 |
John C. Danilewicz |
Piperidino-quinazolines
|
|
IL56369A
(en)
|
1978-01-20 |
1984-05-31 |
Erba Farmitalia |
Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
|
|
US4146718A
(en)
|
1978-04-10 |
1979-03-27 |
Bristol-Myers Company |
Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
|
|
US4366156A
(en)
|
1979-03-05 |
1982-12-28 |
Mead Johnson & Company |
Antiallergic methods using diazaheterocyclopurines
|
|
CA1143728A
(en)
|
1979-10-04 |
1983-03-29 |
Max Gerecke |
Imidazodiazepine derivatives
|
|
US4536518A
(en)
|
1979-11-01 |
1985-08-20 |
Pfizer Inc. |
Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
|
|
JPS5668695A
(en)
|
1979-11-10 |
1981-06-09 |
Sankyo Co Ltd |
Enzyme inhibitor griseolic acid and its preparation
|
|
US4642345A
(en)
|
1980-08-14 |
1987-02-10 |
Mead Johnson & Company |
6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones
|
|
US4301176A
(en)
|
1980-08-18 |
1981-11-17 |
Warner-Lambert Company |
Method of administering calcium valproate
|
|
US4361583A
(en)
|
1980-08-19 |
1982-11-30 |
Synthelabo |
Analgesic agent
|
|
FR2492258A1
(fr)
|
1980-10-17 |
1982-04-23 |
Pharmindustrie |
Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
|
|
FR2492382A1
(fr)
|
1980-10-22 |
1982-04-23 |
Synthelabo |
Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
|
|
US4489078A
(en)
|
1980-11-24 |
1984-12-18 |
Mead Johnson & Company |
Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators
|
|
US4338317A
(en)
|
1981-03-16 |
1982-07-06 |
Mead Johnson & Company |
Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
|
|
US4383999A
(en)
|
1981-05-26 |
1983-05-17 |
Smithkline Beckman Corporation |
Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
|
|
FR2508035A1
(fr)
|
1981-06-23 |
1982-12-24 |
Fabre Sa Pierre |
Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
|
|
LU83729A1
(fr)
|
1981-11-04 |
1983-09-01 |
Galephar |
Sels d'acide valproique,leur preparation et leur utilisation
|
|
CH655110A5
(de)
|
1982-09-03 |
1986-03-27 |
Otsuka Pharma Co Ltd |
Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
|
|
US4663320A
(en)
|
1983-02-16 |
1987-05-05 |
Syntex (U.S.A.) Inc. |
(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
|
|
US4490371A
(en)
|
1983-02-16 |
1984-12-25 |
Syntex (U.S.A.) Inc. |
N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
|
|
US4626538A
(en)
|
1983-06-23 |
1986-12-02 |
American Cyanamid Company |
[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
|
|
US4521422A
(en)
|
1983-06-23 |
1985-06-04 |
American Cyanamid Company |
Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
|
|
US4900836A
(en)
|
1983-06-23 |
1990-02-13 |
American Cyanamid Company |
(3-amino-1H-pyrazol-4-yl) (aryl)methanones
|
|
US4513006A
(en)
|
1983-09-26 |
1985-04-23 |
Mcneil Lab., Inc. |
Anticonvulsant sulfamate derivatives
|
|
US4761501A
(en)
|
1983-10-26 |
1988-08-02 |
American Home Products Corporation |
Substituted phenylacetamides
|
|
US4593029A
(en)
|
1984-02-15 |
1986-06-03 |
Syntex (U.S.A.) Inc. |
Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
|
|
GB8425872D0
(en)
|
1984-10-12 |
1984-11-21 |
Ciba Geigy Ag |
Chemical compounds
|
|
US4855290A
(en)
|
1985-05-10 |
1989-08-08 |
State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research |
Derivatives of quinuclidine
|
|
DK288385D0
(da)
|
1985-06-26 |
1985-06-26 |
Novo Industri As |
Aminosyrederivater
|
|
EP0220044B1
(en)
|
1985-10-17 |
1991-01-30 |
Smith Kline & French Laboratories Limited |
4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives
|
|
US4670434A
(en)
|
1985-11-14 |
1987-06-02 |
Syntex (U.S.A.) Inc. |
(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
|
|
US4775674A
(en)
|
1986-05-23 |
1988-10-04 |
Bristol-Myers Company |
Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
|
|
FR2600650B1
(fr)
|
1986-06-27 |
1988-09-09 |
Synthelabo |
Procede de preparation d'imidazopyridines et composes intermediaires
|
|
GB8615785D0
(en)
|
1986-06-27 |
1986-08-06 |
Beecham Group Plc |
Compounds
|
|
DE3789039T2
(de)
|
1986-06-27 |
1994-06-09 |
Beecham Group Plc |
Verbrückte bicyclische N-heterocyclische Verbindungen.
|
|
US4701459A
(en)
|
1986-07-08 |
1987-10-20 |
Bristol-Myers Company |
7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
|
|
US4709094A
(en)
|
1986-07-10 |
1987-11-24 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Sigma brain receptor ligands and their use
|
|
US5312840A
(en)
|
1986-07-10 |
1994-05-17 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5093525A
(en)
|
1986-07-10 |
1992-03-03 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
|
|
US5502255A
(en)
|
1986-07-10 |
1996-03-26 |
State Of Oregon Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US4761416A
(en)
|
1986-07-25 |
1988-08-02 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds
|
|
US4739056A
(en)
|
1986-11-26 |
1988-04-19 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds
|
|
US4710508A
(en)
|
1986-12-08 |
1987-12-01 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4786648A
(en)
|
1986-12-08 |
1988-11-22 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4721784A
(en)
|
1986-12-22 |
1988-01-26 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
|
|
US4956388A
(en)
|
1986-12-22 |
1990-09-11 |
Eli Lilly And Company |
3-aryloxy-3-substituted propanamines
|
|
US4766118A
(en)
|
1986-12-22 |
1988-08-23 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones and pharmaceutical use
|
|
US5081242A
(en)
|
1986-12-22 |
1992-01-14 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones
|
|
US4992457A
(en)
|
1987-03-18 |
1991-02-12 |
Schulman Jerome M |
Pharmacologically active cholinergic compositions, and methods for making same and use thereof in treating disease
|
|
US4929734A
(en)
|
1987-03-31 |
1990-05-29 |
Warner-Lambert Company |
Tetrahydropyridine oxime compounds
|
|
EP0287356B1
(en)
|
1987-04-15 |
1996-01-24 |
Beecham Group Plc |
Bridgehead substituted azabicyclic derivatives
|
|
GB8714789D0
(en)
|
1987-06-24 |
1987-07-29 |
Lundbeck & Co As H |
Heterocyclic compounds
|
|
US4981858A
(en)
|
1987-08-13 |
1991-01-01 |
State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research |
Optical isomers
|
|
USRE35517E
(en)
|
1987-08-25 |
1997-05-20 |
University Of Southern California |
Method, compositions, and compounds for modulating brain excitability
|
|
US5232917A
(en)
|
1987-08-25 |
1993-08-03 |
University Of Southern California |
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
|
|
DE3853758T2
(de)
|
1987-10-05 |
1995-09-07 |
Yamanouchi Pharma Co Ltd |
Heterozyklische Spiroverbindungen und ihre Herstellung.
|
|
US5412096A
(en)
|
1987-10-05 |
1995-05-02 |
Yamanouchi Pharmaceutical Co., Ltd. |
Hydrochloride salts of heterocyclic spiro compounds
|
|
IL88156A
(en)
|
1987-11-13 |
1997-02-18 |
Novo Nordisk As |
Azacyclic compounds their preparation and pharmaceutical compositions containing them
|
|
EP0322182A3
(en)
|
1987-12-22 |
1992-01-02 |
Beecham Group Plc |
Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
|
|
US4831031A
(en)
|
1988-01-22 |
1989-05-16 |
Pfizer Inc. |
Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
|
|
US5091431A
(en)
|
1988-02-08 |
1992-02-25 |
Schering Corporation |
Phosphodiesterase inhibitors
|
|
DK177889A
(da)
|
1988-04-15 |
1989-10-16 |
Beecham Group Plc |
Hidtil ukendte forbindelser
|
|
US4957916A
(en)
|
1988-08-05 |
1990-09-18 |
Janssen Pharmaceutica N.V. |
Antipsychotic 3-piperazinylbenzazole derivatives
|
|
US4861891A
(en)
|
1988-08-31 |
1989-08-29 |
Pfizer Inc. |
Antidepressant N-substituted nicotinamide compounds
|
|
CA2000041A1
(en)
|
1988-10-13 |
1990-04-13 |
Barry S. Orlek |
Compounds
|
|
US5286864A
(en)
|
1988-11-22 |
1994-02-15 |
Boehringer Ingelheim Kg |
Quinuclidines, their use as medicaments and processes for their preparation
|
|
DE3839385A1
(de)
|
1988-11-22 |
1990-05-23 |
Boehringer Ingelheim Kg |
Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung
|
|
US5043345A
(en)
|
1989-02-22 |
1991-08-27 |
Novo Nordisk A/S |
Piperidine compounds and their preparation and use
|
|
US4981870A
(en)
|
1989-03-07 |
1991-01-01 |
Pfizer Inc. |
Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
|
|
US4971972A
(en)
|
1989-03-23 |
1990-11-20 |
Schering Corporation |
Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
|
|
US5278170A
(en)
|
1989-04-13 |
1994-01-11 |
Beecham Group P.L.C. |
Azabicylo oxime compounds
|
|
DK0392803T3
(da)
|
1989-04-13 |
2004-10-18 |
Beecham Group Plc |
Hidtil ukendte forbindelser
|
|
US4956368A
(en)
|
1989-07-24 |
1990-09-11 |
Bristol-Myers Company |
Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
|
|
US5109002A
(en)
|
1989-09-08 |
1992-04-28 |
Du Pont Merck Pharmaceutical Company |
Antipsychotic 1-cycloalkylpiperidines
|
|
DE69026197T2
(de)
|
1989-10-07 |
1997-01-09 |
Beecham Group Plc |
Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
|
|
US4943573A
(en)
|
1989-11-01 |
1990-07-24 |
Bristol-Myers Squibb Company |
Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
|
|
CA2029497C
(en)
*
|
1989-11-08 |
2002-06-04 |
Kunihiro Ninomiya (Deceased) |
4-acylaminopyridine derivative
|
|
US5010086A
(en)
|
1990-02-28 |
1991-04-23 |
Sterling Drug Inc. |
Imidazopyridines, compositions and use
|
|
US4963561A
(en)
|
1990-02-28 |
1990-10-16 |
Sterling Drug Inc. |
Imidazopyridines, their preparation and use
|
|
US5149817A
(en)
|
1990-03-05 |
1992-09-22 |
Shionogi & Co., Ltd. |
Teirahydropyridine derivatives
|
|
GB9005737D0
(en)
|
1990-03-14 |
1990-05-09 |
Beecham Group Plc |
Novel compounds
|
|
US5169855A
(en)
|
1990-03-28 |
1992-12-08 |
Du Pont Merck Pharmaceutical Company |
Piperidine ether derivatives as psychotropic drugs or plant fungicides
|
|
US5852029A
(en)
|
1990-04-10 |
1998-12-22 |
Israel Institute For Biological Research |
Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
|
|
US5407938A
(en)
|
1990-04-10 |
1995-04-18 |
Israel Institute For Biological Research |
Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
|
|
US5534520A
(en)
|
1990-04-10 |
1996-07-09 |
Fisher; Abraham |
Spiro compounds containing five-membered rings
|
|
US5116995A
(en)
|
1990-05-25 |
1992-05-26 |
Taisho Pharmaceutical Co., Ltd. |
Carbazole compounds
|
|
WO1991018868A1
(en)
|
1990-05-25 |
1991-12-12 |
STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5612211A
(en)
|
1990-06-08 |
1997-03-18 |
New York University |
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
|
|
US5250534A
(en)
|
1990-06-20 |
1993-10-05 |
Pfizer Inc. |
Pyrazolopyrimidinone antianginal agents
|
|
US5095015A
(en)
|
1990-07-24 |
1992-03-10 |
Neurogen Corporation |
Certain azacycloalkyl imidazopyrimidines; a new class of gaba brain receptor ligands
|
|
JP2935541B2
(ja)
|
1990-06-28 |
1999-08-16 |
サントリー株式会社 |
縮合複素環化合物
|
|
US5086054A
(en)
|
1990-07-31 |
1992-02-04 |
Sri International |
Novel arylcycloalkanepolyalkylamines
|
|
US5376668A
(en)
|
1990-08-21 |
1994-12-27 |
Novo Nordisk A/S |
Heterocyclic compounds
|
|
DK198590D0
(da)
|
1990-08-21 |
1990-08-21 |
Novo Nordisk As |
Heterocykliske forbindelser, deres fremstilling og anvendelse
|
|
US5527813A
(en)
|
1990-08-21 |
1996-06-18 |
Novo Nordisk A/S |
Heterocyclic compounds and their preparation and use
|
|
IE912974A1
(en)
|
1990-08-24 |
1992-02-26 |
Beecham Group Plc |
Novel compounds
|
|
CA2050264A1
(en)
|
1990-08-30 |
1992-03-01 |
Raymond Baker |
Substituted pyrazine and its salts, compositions containing them and their use in medicine
|
|
GB9019095D0
(en)
|
1990-09-01 |
1990-10-17 |
Beecham Group Plc |
Novel compounds
|
|
US5185446A
(en)
|
1990-09-04 |
1993-02-09 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
|
|
JPH06502147A
(ja)
|
1990-10-09 |
1994-03-10 |
ニューロゲン コーポレイション |
或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド
|
|
JPH06501933A
(ja)
|
1990-10-12 |
1994-03-03 |
ビーチャム・グループ・パブリック・リミテッド・カンパニー |
１，２，５，６−テトラヒドロピリジン・オキシム誘導体
|
|
US5139802A
(en)
|
1990-10-15 |
1992-08-18 |
Nestec S.A. |
Oxidation of tea
|
|
DE69107396T2
(de)
|
1990-10-15 |
1995-06-14 |
Nestle Sa |
Behandlung von schwarzem Tee.
|
|
US5091242A
(en)
|
1990-10-30 |
1992-02-25 |
The Research Foundation Of State Univ. Of N.Y. |
Carbon fiber composites having improved fatigue resistance
|
|
US5130430A
(en)
|
1990-10-31 |
1992-07-14 |
Neurogen Corporation |
2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands
|
|
US5744602A
(en)
|
1990-10-31 |
1998-04-28 |
Neurogen Corporation |
Certain imidazoquinoxalines; a new class of GABA brain receptor ligands
|
|
US6268496B1
(en)
|
1990-10-31 |
2001-07-31 |
Neurogen Corporation |
Certain imidazoquinoxalines: a new class of GABA brain receptor ligands
|
|
US5116837A
(en)
|
1990-12-21 |
1992-05-26 |
Ortho Pharmaceutical Corporation |
2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines
|
|
US5162341A
(en)
|
1991-02-22 |
1992-11-10 |
Du Pont Merck Pharmaceutical Company |
Use of sigma receptor antagonists for treatment of amphetamine abuse
|
|
US5137895A
(en)
|
1991-04-29 |
1992-08-11 |
A. H. Robins Company, Incorporated |
3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols
|
|
US5093333A
(en)
|
1991-04-29 |
1992-03-03 |
American Home Products Corporation |
N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system
|
|
US5124460A
(en)
|
1991-05-06 |
1992-06-23 |
Merck Sharp & Dohme Ltd. |
Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
|
|
WO1992020683A1
(fr)
|
1991-05-15 |
1992-11-26 |
Yamanouchi Pharmaceutical Co., Ltd. |
L-tartrate de (-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8-azaspiro[4,5]decane
|
|
NZ243065A
(en)
|
1991-06-13 |
1995-07-26 |
Lundbeck & Co As H |
Piperidine derivatives and pharmaceutical compositions
|
|
US5641791A
(en)
|
1991-08-13 |
1997-06-24 |
Novo Nordisk A.S |
Heterocyclic compounds and their preparation and use
|
|
US5182290A
(en)
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
|
|
US5182386A
(en)
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
|
|
US5369108A
(en)
|
1991-10-04 |
1994-11-29 |
Sloan-Kettering Institute For Cancer Research |
Potent inducers of terminal differentiation and methods of use thereof
|
|
US5585490A
(en)
|
1991-10-08 |
1996-12-17 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands
|
|
US5212310A
(en)
|
1991-12-19 |
1993-05-18 |
Neurogen Corporation |
Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
|
|
US5243049A
(en)
|
1992-01-22 |
1993-09-07 |
Neurogen Corporation |
Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
|
|
MX9300875A
(es)
|
1992-02-20 |
1993-08-31 |
Smithkline Beecham Plc |
Procedimiento para la preparacion de compuestos azabiciclicos.
|
|
US6225115B1
(en)
|
1992-03-04 |
2001-05-01 |
Synaptic Pharmaceutical Corporation |
DNA encoding taurine and GABA transporters and uses thereof
|
|
US5298657A
(en)
|
1992-03-20 |
1994-03-29 |
Cambridge Neuroscience Inc. |
Preparation of substituted guanidines
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
US5367077A
(en)
|
1992-04-08 |
1994-11-22 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
|
|
AU4117493A
(en)
|
1992-04-08 |
1994-11-21 |
Neurogen Corporation |
Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands
|
|
US5266698A
(en)
|
1992-04-30 |
1993-11-30 |
Neurogen Corporation |
Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
|
|
SE9201478D0
(sv)
|
1992-05-11 |
1992-05-11 |
Kabi Pharmacia Ab |
Heteroaromatic quinuclidinenes, their use and preparation
|
|
ES2060547B1
(es)
|
1992-06-04 |
1995-06-16 |
Ferrer Int |
Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
|
|
GB9212673D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
GB9212693D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
JP2683783B2
(ja)
|
1992-07-10 |
1997-12-03 |
雪印乳業株式会社 |
シェーグレン症候群治療剤
|
|
US5928947A
(en)
|
1992-07-27 |
1999-07-27 |
California Institute Of Technology |
Mammalian multipotent neural stem cells
|
|
US5306819A
(en)
|
1992-08-27 |
1994-04-26 |
Neurogen Corporation |
Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
|
|
ZA937382B
(en)
|
1992-10-06 |
1994-04-29 |
Warner Lambert Co |
Novel composition for peroral therapy of cognitionimpairment and a process therefor
|
|
GB9222253D0
(en)
|
1992-10-23 |
1992-12-09 |
Celltech Ltd |
Chemical compounds
|
|
US5286860A
(en)
|
1992-11-12 |
1994-02-15 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5668283A
(en)
|
1992-11-12 |
1997-09-16 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5814651A
(en)
|
1992-12-02 |
1998-09-29 |
Pfizer Inc. |
Catechol diethers as selective PDEIV inhibitors
|
|
US5622977A
(en)
|
1992-12-23 |
1997-04-22 |
Celltech Therapeutics Limited |
Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
|
|
US5610299A
(en)
|
1993-01-06 |
1997-03-11 |
Neurogen Corporation |
Certain aryl substituted imidazopyrazinones; a new class of GABA brain receptor ligands
|
|
EP0608713B1
(de)
|
1993-01-23 |
1996-12-27 |
Hoechst Aktiengesellschaft |
2,3-Difluor-6-nitrobenzonitril und 2-Chlor-5,6-difluorbenzonitril, Verfahren zu deren Herstellung und ihre Verwendung zur Herstellung von 2,3,6-Trifluorbenzoesäure
|
|
US5362860A
(en)
|
1993-02-01 |
1994-11-08 |
Warner-Lambert Company |
Neutral stabilization complex for CI-979 HCl, a cognition activator
|
|
US5424301A
(en)
|
1993-02-01 |
1995-06-13 |
Warner-Lambert Company |
Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
|
|
US6013799A
(en)
|
1993-03-03 |
2000-01-11 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimides, a new class of gaba brain receptor ligands
|
|
GB9304920D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
GB9304919D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
WO1994022843A1
(en)
|
1993-03-26 |
1994-10-13 |
Schering Corporation |
2-substituted morpholine and thiomorpholine derivatives as gaba-b antagonists
|
|
US5750702A
(en)
|
1993-10-27 |
1998-05-12 |
Neurogen Corporation |
Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
|
|
KR20030097618A
(ko)
|
1993-05-27 |
2003-12-31 |
캠브리지 뉴로사이언스, 인코포레이티드 |
치료용 치환 구아니딘류
|
|
GB9311920D0
(en)
|
1993-06-09 |
1993-07-28 |
Pfizer Ltd |
Therapeutic agents
|
|
CA2166100A1
(en)
|
1993-06-23 |
1995-01-05 |
Richard A. Glennon |
Sigma receptor ligands and the use thereof
|
|
ES2176252T3
(es)
|
1993-07-02 |
2002-12-01 |
Altana Pharma Ag |
Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos.
|
|
ES2074946B1
(es)
|
1993-07-19 |
1996-06-16 |
Ferrer Int |
Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
|
|
US5665754A
(en)
|
1993-09-20 |
1997-09-09 |
Glaxo Wellcome Inc. |
Substituted pyrrolidines
|
|
US5484944A
(en)
|
1993-10-27 |
1996-01-16 |
Neurogen Corporation |
Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
|
|
WO1995014680A1
(en)
|
1993-11-26 |
1995-06-01 |
Pfizer Inc. |
3-aryl-2-isoxazolines as antiinflammatory agents
|
|
ATE154932T1
(de)
|
1993-11-26 |
1997-07-15 |
Pfizer |
Isoxazolinverbindungen als entzündungshemmende mittel
|
|
US5502072A
(en)
|
1993-11-26 |
1996-03-26 |
Pfizer Inc. |
Substituted oxindoles
|
|
US5500420A
(en)
|
1993-12-20 |
1996-03-19 |
Cornell Research Foundation, Inc. |
Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia
|
|
GB9326173D0
(en)
|
1993-12-22 |
1994-02-23 |
Celltech Ltd |
Chemical compounds and process
|
|
GB9326699D0
(en)
|
1993-12-22 |
1994-03-02 |
Celltech Ltd |
Chemical compounds
|
|
DE69433594T2
(de)
|
1993-12-22 |
2004-08-05 |
Celltech R&D Ltd., Slough |
Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
|
|
US5668174A
(en)
|
1993-12-29 |
1997-09-16 |
Kowa Tekuno Sachi Co., Ltd. |
Method of treating hyperparathyroidism
|
|
US7060450B1
(en)
|
1993-12-30 |
2006-06-13 |
President And Fellows Of Harvard College |
Screening assays for agonists and antagonists of the hedgehog signaling pathway
|
|
GB9514465D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9401090D0
(en)
|
1994-01-21 |
1994-03-16 |
Glaxo Lab Sa |
Chemical compounds
|
|
US5939545A
(en)
|
1994-02-14 |
1999-08-17 |
Cocensys, Inc. |
Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
|
|
KR100338287B1
(ko)
|
1994-02-14 |
2002-11-30 |
푸르듀 파머 리미티드 |
감마-아미노부티르산a수용체의알로오스테리조절용안드로스탄및프레그난
|
|
EP0750621B1
(en)
|
1994-03-14 |
1999-07-21 |
Novo Nordisk A/S |
Heterocyclic compounds, their preparation and use
|
|
US5783575A
(en)
|
1994-03-14 |
1998-07-21 |
Novo Nordisk A/S |
Antagonists, their preparation and use
|
|
US5696148A
(en)
|
1994-03-14 |
1997-12-09 |
Novo Nordisk A/S |
Indole compounds and their use in treating diseases of the central nervous system
|
|
US5637617A
(en)
|
1994-04-01 |
1997-06-10 |
The Regents Of The University Of California |
Methods for use of GABAa receptor GABAergic compounds
|
|
GB9409718D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
GB9409705D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6245774B1
(en)
|
1994-06-21 |
2001-06-12 |
Celltech Therapeutics Limited |
Tri-substituted phenyl or pyridine derivatives
|
|
US5786354A
(en)
|
1994-06-21 |
1998-07-28 |
Celltech Therapeutics, Limited |
Tri-substituted phenyl derivatives and processes for their preparation
|
|
GB9412571D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412573D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412672D0
(en)
|
1994-06-23 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
JP2852608B2
(ja)
|
1994-06-27 |
1999-02-03 |
雪印乳業株式会社 |
口腔乾燥症治療剤
|
|
US5750566A
(en)
|
1994-08-12 |
1998-05-12 |
Eli Lilly And Company |
Synthetic excitatory amino acids
|
|
JP3708962B2
(ja)
|
1994-08-24 |
2005-10-19 |
アストラゼネカ・アクチエボラーグ |
治療に有用なスピロ−アザ二環式化合物
|
|
KR970705562A
(ko)
|
1994-08-29 |
1997-10-09 |
오노다 마사요시 |
신규한 나프티리딘 유도체 및 이의 의약 조성물(Novel naphthyridine derivatives and medicinal composition thereof)
|
|
WO1996010570A1
(en)
|
1994-09-30 |
1996-04-11 |
Pfizer Inc. |
NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
|
|
US5554645A
(en)
|
1994-10-03 |
1996-09-10 |
Mars, Incorporated |
Antineoplastic cocoa extracts and methods for making and using the same
|
|
DE4436509A1
(de)
|
1994-10-13 |
1996-04-18 |
Hoechst Schering Agrevo Gmbh |
Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
|
|
JP3993651B2
(ja)
|
1994-10-21 |
2007-10-17 |
アスビオファーマ株式会社 |
シクロプロパクロメンカルボン酸誘導体
|
|
US5605908A
(en)
|
1994-10-24 |
1997-02-25 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
US5646289A
(en)
|
1994-10-24 |
1997-07-08 |
Eli Lilly And Company |
Heterocyclic compounds and their preparation and use
|
|
US5473077A
(en)
|
1994-11-14 |
1995-12-05 |
Eli Lilly And Company |
Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor agonists
|
|
US5571819A
(en)
|
1994-11-22 |
1996-11-05 |
Sabb; Annmarie L. |
Imidazopyridines as muscarinic agents
|
|
US5510478A
(en)
|
1994-11-30 |
1996-04-23 |
American Home Products Corporation |
2-arylamidothiazole derivatives with CNS activity
|
|
US5512574A
(en)
|
1994-12-21 |
1996-04-30 |
American Home Products Corporation |
Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
|
|
US5468875A
(en)
|
1994-12-22 |
1995-11-21 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
GB9503601D0
(en)
|
1995-02-23 |
1995-04-12 |
Merck Sharp & Dohme |
Method of treatment and method of manufacture of medicament
|
|
US5488055A
(en)
|
1995-03-10 |
1996-01-30 |
Sanofi Winthrop Inc. |
Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amines and compositions and methods of use thereof
|
|
RU2135493C1
(ru)
|
1995-04-21 |
1999-08-27 |
Нюросерч А/С |
Производное бензимидазола, фармацевтический состав и способ модуляции гамка-рецепторного комплекса
|
|
WO1996034863A1
(en)
|
1995-05-05 |
1996-11-07 |
Novo Nordisk A/S |
Novel heterocyclic chemistry
|
|
DE19518082A1
(de)
|
1995-05-17 |
1996-11-21 |
Merck Patent Gmbh |
4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
|
|
ES2191754T3
(es)
|
1995-05-18 |
2003-09-16 |
Altana Pharma Ag |
Fenil-dihidrobenzofuranos.
|
|
WO1996036626A1
(de)
|
1995-05-18 |
1996-11-21 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Cyclohexyldihydrobenzofurane
|
|
US6514996B2
(en)
|
1995-05-19 |
2003-02-04 |
Kyowa Hakko Kogyo Co., Ltd. |
Derivatives of benzofuran or benzodioxole
|
|
US5637725A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
US5637724A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
RU2194712C2
(ru)
|
1995-06-06 |
2002-12-20 |
Коукенсис, Инк. |
НЕЙРОАКТИВНЫЕ СТЕРОИДЫ, ФАРМАЦЕВТИЧЕСКИЙ ПРЕПАРАТ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАЗЛИЧНЫХ НАРУШЕНИЙ, СПОСОБ ИНДУКЦИИ СНА И СПОСОБ ИНДУКЦИИ АНЕСТЕЗИИ С ИХ ИСПОЛЬЗОВАНИЕМ, СПОСОБ МОДУЛИРОВАНИЯ КОМПЛЕКСА РЕЦЕПТОР ГАМКa-ХЛОРИДНЫЙ ИОНОФОР
|
|
US5534522A
(en)
|
1995-06-07 |
1996-07-09 |
Warner-Lambert Company |
(R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
|
|
US5910590A
(en)
|
1995-06-07 |
1999-06-08 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
GB9514464D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
|
NZ305940A
(en)
|
1995-07-26 |
1999-05-28 |
Pfizer |
N-(aroyl)glycine hydroxamic acid derivatives and related compounds that inhibit the production of tnf and are useful in treating asthma
|
|
US20010018074A1
(en)
|
1995-07-29 |
2001-08-30 |
Smithkline Beecham P.L.C. |
Process for preparing solid dosage forms of very low-dose drugs
|
|
US5945417A
(en)
|
1995-07-31 |
1999-08-31 |
Novo Nordisk |
Heterocyclic compounds, their preparation and use
|
|
DE19533975A1
(de)
|
1995-09-14 |
1997-03-20 |
Merck Patent Gmbh |
Arylalkyl-diazinone
|
|
US6166041A
(en)
|
1995-10-11 |
2000-12-26 |
Euro-Celtique, S.A. |
2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
|
|
US5800539A
(en)
|
1995-11-08 |
1998-09-01 |
Emory University |
Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease
|
|
ZA969485B
(en)
|
1995-11-16 |
1998-05-12 |
Lilly Co Eli |
Excitatory amino acid receptor antagonists.
|
|
US5912248A
(en)
|
1995-11-16 |
1999-06-15 |
Eli Lilly And Company |
Excitatory amino acid receptor antagonists
|
|
US5688826A
(en)
|
1995-11-16 |
1997-11-18 |
Eli Lilly And Company |
Excitatory amino acid derivatives
|
|
US5756501A
(en)
|
1995-12-13 |
1998-05-26 |
American Home Products Corporation |
Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
|
|
GB9603723D0
(en)
|
1996-02-22 |
1996-04-24 |
Merck & Co Inc |
Diphenyl pyridyl derivatives as pde iv inhibitors
|
|
US5710170A
(en)
|
1995-12-15 |
1998-01-20 |
Merck Frosst Canada, Inc. |
Tri-aryl ethane derivatives as PDE IV inhibitors
|
|
GB9526243D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526245D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526246D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US5804686A
(en)
|
1996-01-19 |
1998-09-08 |
Neurogen Corporation |
fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
US6211365B1
(en)
|
1996-01-19 |
2001-04-03 |
Neurogen Corporation |
Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
UA48216C2
(uk)
|
1996-01-31 |
2002-08-15 |
Бік Гулден Ломберг Кеміше Фабрік Гмбх |
Фенантридини та лікарський засіб для лікування захворювань дихальних шляхів
|
|
GB9604926D0
(en)
|
1996-03-08 |
1996-05-08 |
Sandoz Ltd |
Organic compounds
|
|
US5792766A
(en)
|
1996-03-13 |
1998-08-11 |
Neurogen Corporation |
Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
|
|
WO1997034870A1
(en)
|
1996-03-22 |
1997-09-25 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides as gaba brain receptor ligands
|
|
US5677309A
(en)
|
1996-03-22 |
1997-10-14 |
Neurogen Corporation |
1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
|
|
US6777217B1
(en)
|
1996-03-26 |
2004-08-17 |
President And Fellows Of Harvard College |
Histone deacetylases, and uses related thereto
|
|
US6127378A
(en)
|
1996-03-26 |
2000-10-03 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Phenanthridines substituted in the 6 position
|
|
FR2746800B1
(fr)
|
1996-03-29 |
1998-06-05 |
Jouveinal Inst Rech |
Diazepino-indoles inhibiteurs de phosphodiesterases 4
|
|
US6297273B1
(en)
|
1996-04-02 |
2001-10-02 |
Mars, Inc. |
Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
|
|
FR2754260B1
(fr)
|
1996-10-04 |
1998-10-30 |
Adir |
Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5723462A
(en)
|
1996-04-26 |
1998-03-03 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
|
|
US20020103194A1
(en)
|
1997-04-30 |
2002-08-01 |
Anabella Villalobos |
Novel muscarinic receptor agonists
|
|
ES2175404T3
(es)
|
1996-05-10 |
2002-11-16 |
Icos Corp |
Derivados de carbolina.
|
|
US6017924A
(en)
|
1996-06-27 |
2000-01-25 |
Ligand Pharmaceuticals Incorporated |
Androgen receptor modulator compounds and methods
|
|
ES2194205T3
(es)
|
1996-07-25 |
2003-11-16 |
Merck Sharp & Dohme |
Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.
|
|
US20020127271A1
(en)
|
1996-07-25 |
2002-09-12 |
Smithkline Beecham P.L.C. |
Formulation for the treatment and/or prophylaxis of dementia
|
|
NZ513800A
(en)
|
1996-08-12 |
2001-09-28 |
Welfide Corp |
Treatment of diseases using Rho kinase inhibitors
|
|
DE19632549A1
(de)
|
1996-08-13 |
1998-02-19 |
Merck Patent Gmbh |
Arylalkanoylpyridazine
|
|
WO1998007715A1
(en)
|
1996-08-19 |
1998-02-26 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Novel benzofuran-4-carboxamides
|
|
EP0920426B9
(de)
|
1996-08-26 |
2005-04-06 |
ALTANA Pharma AG |
Neue thiazol-derivate mit phosphodiesterase inhibierender wirkung
|
|
US20010003588A1
(en)
|
1996-09-12 |
2001-06-14 |
Smithkline Beecham Corporation |
Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride
|
|
US5834458A
(en)
|
1996-10-09 |
1998-11-10 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
AU4920397A
(en)
|
1996-10-11 |
1998-05-11 |
Chiron Corporation |
Purine inhibitors of glycogen synthase kinase 3 (gsk3)
|
|
DE19642451A1
(de)
|
1996-10-15 |
1998-04-16 |
Merck Patent Gmbh |
Aminothiophencarbonsäureamide
|
|
GB9621789D0
(en)
|
1996-10-18 |
1996-12-11 |
Lilly Industries Ltd |
Pharmaceutical compounds
|
|
JP2001502675A
(ja)
|
1996-10-21 |
2001-02-27 |
ニューロサーチ・アクティーゼルスカブ |
１―フエニル―ベンズイミダゾール化合物及びこれをｂａｇａ▲下ａ▼―レセプターモデュレーターとして使用する方法
|
|
GB9622386D0
(en)
|
1996-10-28 |
1997-01-08 |
Sandoz Ltd |
Organic compounds
|
|
US5773458A
(en)
|
1996-10-30 |
1998-06-30 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
|
US6069151A
(en)
|
1996-11-06 |
2000-05-30 |
Darwin Discovery, Ltd. |
Quinolines and their therapeutic use
|
|
AU5652698A
(en)
|
1996-11-12 |
1998-06-03 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
(2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
|
|
EP0941221B1
(en)
|
1996-11-20 |
2003-02-26 |
ALTANA Pharma AG |
Substituted dihydrobenzofurans as pde inhibitors
|
|
GB9625184D0
(en)
|
1996-12-04 |
1997-01-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
TR199901653T2
(xx)
|
1997-01-15 |
1999-10-21 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Fitalazinonlar.
|
|
GB9702524D0
(en)
|
1997-02-07 |
1997-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AU6823098A
(en)
|
1997-02-28 |
1998-09-18 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Synergistic combination of pde inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists
|
|
US6297248B1
(en)
|
1997-04-06 |
2001-10-02 |
Suntory Limited |
1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor
|
|
ES2131463B1
(es)
|
1997-04-08 |
2000-03-01 |
Lilly Sa |
Derivados de ciclopropilglicina con propiedades farmaceuticas.
|
|
GB9708945D0
(en)
|
1997-05-01 |
1997-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6387673B1
(en)
|
1997-05-01 |
2002-05-14 |
The Salk Institute For Biological Studies |
Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
|
|
US6043252A
(en)
|
1997-05-05 |
2000-03-28 |
Icos Corporation |
Carboline derivatives
|
|
EP0986562B1
(en)
|
1997-05-08 |
2002-08-07 |
MERCK SHARP & DOHME LTD. |
Substituted 1,2,4-triazolo 3,4-a]phthalazine derivatives as gaba alpha 5 ligands
|
|
ZA983930B
(en)
|
1997-05-14 |
1999-11-08 |
Lilly Co Eli |
Excitatory amino acid receptor modulators.
|
|
ATE273007T1
(de)
|
1997-05-29 |
2004-08-15 |
Lundbeck & Co As H |
Behandlung der schizophrenie und der psychose
|
|
JP2001515839A
(ja)
|
1997-07-18 |
2001-09-25 |
ジョージタウン・ユニバーシティ |
二環式向代謝性グルタミン酸受容体リガンド
|
|
US6825211B1
(en)
|
1997-07-18 |
2004-11-30 |
Georgetown University |
Bicyclic metabotropic glutamate receptor ligands
|
|
JP2001510827A
(ja)
|
1997-07-25 |
2001-08-07 |
ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング |
置換６−フェニルフェナントリジン
|
|
ES2137113B1
(es)
|
1997-07-29 |
2000-09-16 |
Almirall Prodesfarma Sa |
Nuevos derivados de triazolo-piridazinas heterociclicos.
|
|
GB9715977D0
(en)
|
1997-07-29 |
1997-10-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6107295A
(en)
|
1997-08-01 |
2000-08-22 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Arylalkanoyl pyridazines
|
|
US6143760A
(en)
|
1997-08-25 |
2000-11-07 |
Neurogen Corporation |
Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
|
|
US6207842B1
(en)
|
1997-10-09 |
2001-03-27 |
Mars Incorporated |
Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
|
|
US6127363A
(en)
|
1997-10-28 |
2000-10-03 |
Vivus, Inc. |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
US6156753A
(en)
|
1997-10-28 |
2000-12-05 |
Vivus, Inc. |
Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
UA64769C2
(uk)
|
1997-11-07 |
2004-03-15 |
Х. Луннбек А/С |
Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування
|
|
US6362178B1
(en)
|
1997-11-12 |
2002-03-26 |
Bayer Aktiengesellschaft |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
|
|
US6429207B1
(en)
|
1997-11-21 |
2002-08-06 |
Nps Pharmaceuticals, Inc. |
Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
|
|
DE19882892T1
(de)
|
1997-12-12 |
2001-02-22 |
Euro Celtique Sa |
Herstellung von 3-substituierten Adeninen und Imidazopyridinen
|
|
IT1296985B1
(it)
|
1997-12-19 |
1999-08-03 |
Zambon Spa |
Derivati benzazinici inibitori della fosfodiesterasi 4
|
|
EP1047697A1
(en)
|
1998-01-14 |
2000-11-02 |
MERCK SHARP & DOHME LTD. |
Triazolo-pyridazine derivatives as ligands for gaba receptors
|
|
GB9801234D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801208D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801202D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801210D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
YU43800A
(sh)
|
1998-01-21 |
2002-12-10 |
Merck Sharp & Dohme Limited |
Triazolo-piridazin derivati kao ligandi za gaba receptore
|
|
GB9801397D0
(en)
|
1998-01-22 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
HUP0002353A3
(en)
|
1998-01-29 |
2001-11-28 |
Daiichi Asubio Pharma Co Ltd |
1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them
|
|
WO1999043681A1
(en)
|
1998-02-26 |
1999-09-02 |
Neurogen Corporation |
4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands
|
|
BR9908321A
(pt)
|
1998-02-26 |
2001-12-18 |
Neurogen Corp |
Composto
|
|
WO1999043682A1
(en)
|
1998-02-26 |
1999-09-02 |
Neurogen Corporation |
2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors
|
|
AU2881199A
(en)
|
1998-02-26 |
1999-09-15 |
Neurogen Corporation |
Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
|
|
US6900228B1
(en)
|
1998-03-10 |
2005-05-31 |
Research Triangle Institute |
Opiate compounds, methods of making and methods of use
|
|
US6805883B2
(en)
|
1998-03-12 |
2004-10-19 |
Mars, Incorporated |
Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
|
|
GB9806102D0
(en)
|
1998-03-20 |
1998-05-20 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
FR2776660B1
(fr)
|
1998-03-27 |
2000-05-12 |
Parke Davis |
Diazepino-indoles de phosphodiesterases iv
|
|
US6528529B1
(en)
|
1998-03-31 |
2003-03-04 |
Acadia Pharmaceuticals Inc. |
Compounds with activity on muscarinic receptors
|
|
WO1999054280A1
(en)
|
1998-04-17 |
1999-10-28 |
Kenneth Curry |
Cubane derivatives as metabotropic glutamate receptor antagonists and process for their preparation
|
|
HRP20000712A2
(en)
|
1998-04-20 |
2001-06-30 |
Pfizer |
PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
|
|
TR200003130T2
(tr)
|
1998-04-28 |
2001-01-22 |
Arzneimittelwerk Dresden Gmbh |
Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
|
|
US6897305B2
(en)
|
1998-06-08 |
2005-05-24 |
Theravance, Inc. |
Calcium channel drugs and uses
|
|
US6303789B1
(en)
|
1998-06-10 |
2001-10-16 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
|
|
US6479506B1
(en)
|
1998-06-16 |
2002-11-12 |
Merck Sharp & Dohme Ltd. |
Triazolo-pyridine derivatives as ligands for GABA receptors
|
|
GB9813006D0
(en)
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
KR100581199B1
(ko)
|
1998-06-19 |
2006-05-17 |
카이론 코포레이션 |
글리코겐 신타제 키나제 3의 억제제
|
|
PT1095040E
(pt)
|
1998-07-06 |
2004-08-31 |
Altana Pharma Ag |
Novos benzoxazoles com actividade inibidora da pde
|
|
ITMI981671A1
(it)
|
1998-07-21 |
2000-01-21 |
Zambon Spa |
Derivati ftalazinici inibitori della fosfodisterasi 4
|
|
US6177569B1
(en)
|
1998-08-25 |
2001-01-23 |
Neurogen Corporation |
Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
|
|
ATE269293T1
(de)
|
1998-08-31 |
2004-07-15 |
Taisho Pharmaceutical Co Ltd |
6-fluoro(3.1.0)hexan-derivate
|
|
CH694053A5
(de)
|
1998-09-03 |
2004-06-30 |
Hoffmann La Roche |
Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
|
|
MXPA01002102A
(es)
|
1998-09-03 |
2003-02-24 |
Kyowa Hakko Kogyo Kk |
Compuestos heterociclicos que contienen oxigeno.
|
|
AU1025899A
(en)
|
1998-09-16 |
2000-04-03 |
Icos Corporation |
Carboline derivatives as cgmp phosphodiesterase inhibitors
|
|
US6719520B2
(en)
|
1998-10-08 |
2004-04-13 |
Smithkline Beecham Corporation |
Method and compounds
|
|
CA2346289A1
(en)
|
1998-10-16 |
2000-04-27 |
Merck Sharp & Dohme Limited |
Pyrazolo-triazine derivatives as ligands for gaba receptors
|
|
WO2000027849A2
(en)
|
1998-11-12 |
2000-05-18 |
Merck & Co., Inc. |
Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
|
|
PE20001236A1
(es)
|
1998-11-13 |
2000-11-10 |
Lilly Co Eli |
Moduladores del receptor de aminoacidos excitadores
|
|
SE9804064D0
(sv)
|
1998-11-25 |
1998-11-25 |
A & Science Invest Ab |
Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
|
|
US6130333A
(en)
|
1998-11-27 |
2000-10-10 |
Monsanto Company |
Bicyclic imidazolyl derivatives as phosphodiesterase inhibitors, pharmaceutical compositions and method of use
|
|
WO2000037471A1
(en)
|
1998-12-23 |
2000-06-29 |
Neurogen Corporation |
2-amino-9-alkylpurines: gaba brain receptor ligands
|
|
JP2002535407A
(ja)
|
1999-01-27 |
2002-10-22 |
メルク シャープ エンド ドーム リミテッド |
Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体
|
|
US6342496B1
(en)
|
1999-03-01 |
2002-01-29 |
Sepracor Inc. |
Bupropion metabolites and methods of use
|
|
US6498176B1
(en)
|
1999-03-04 |
2002-12-24 |
Smithklinebeecham Corporation |
3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
|
|
TW575561B
(en)
|
1999-03-25 |
2004-02-11 |
Hoffmann La Roche |
1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
|
|
CA2367787C
(en)
|
1999-04-28 |
2011-07-26 |
Alan P. Kozikowski |
Ligands for metabotropic glutamate receptors
|
|
FR2792938B1
(fr)
|
1999-04-28 |
2001-07-06 |
Warner Lambert Co |
NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
|
|
US6528499B1
(en)
|
2000-04-27 |
2003-03-04 |
Georgetown University |
Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
|
|
US6943166B1
(en)
|
1999-04-30 |
2005-09-13 |
Lilly Icos Llc. |
Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
|
|
US6316472B1
(en)
|
1999-05-13 |
2001-11-13 |
Merck Frosst Canada & Co. |
Heterosubstituted pyridine derivatives as PDE 4 inhibitors
|
|
AU5289600A
(en)
|
1999-05-25 |
2000-12-12 |
Neurogen Corporation |
4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
|
|
EP1189873A1
(en)
|
1999-06-03 |
2002-03-27 |
Lilly, S.A. |
Excitatory amino acid receptor modulators
|
|
EP1186615A4
(en)
|
1999-06-10 |
2006-05-03 |
Takeda Pharmaceutical |
PROTEIN AND DNA OF THIS PROTEIN
|
|
US6146876A
(en)
|
1999-06-11 |
2000-11-14 |
Millennium Pharmaceuticals, Inc. |
22025, a novel human cyclic nucleotide phosphodiesterase
|
|
US6297256B1
(en)
|
1999-06-15 |
2001-10-02 |
Neurogen Corporation |
Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
|
|
DE19928146A1
(de)
|
1999-06-19 |
2000-12-21 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
WO2001005770A1
(en)
|
1999-07-21 |
2001-01-25 |
Fujisawa Pharmaceutical Co., Ltd. |
Benzimidazolone derivatives and their use as phosphodiesterase inhibitors
|
|
US6821975B1
(en)
|
1999-08-03 |
2004-11-23 |
Lilly Icos Llc |
Beta-carboline drug products
|
|
DE60006618T2
(de)
|
1999-08-06 |
2004-09-23 |
F. Hoffmann-La Roche Ag |
Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten
|
|
US6476019B1
(en)
|
1999-08-13 |
2002-11-05 |
Sepracor Inc. |
Spirocyclic ligands for sigma receptors, and libraries and methods of use thereof
|
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
US6313159B1
(en)
|
1999-08-20 |
2001-11-06 |
Guilford Pharmaceuticals Inc. |
Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
|
|
GB9919957D0
(en)
|
1999-08-23 |
1999-10-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6956049B1
(en)
|
1999-08-31 |
2005-10-18 |
Merck & Co., Inc. |
Methods of modulating processes mediated by excitatory amino acid receptors
|
|
US20050014939A1
(en)
|
1999-08-31 |
2005-01-20 |
Neurogen Corporation |
Fused pyrrolecarboxamides: GABA brain receptor ligands
|
|
GB9921150D0
(en)
|
1999-09-07 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9921351D0
(en)
|
1999-09-09 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
TWI265925B
(en)
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
US6552016B1
(en)
|
1999-10-14 |
2003-04-22 |
Curis, Inc. |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
|
|
CA2386980C
(en)
|
1999-10-15 |
2010-03-16 |
Geo Adam |
Benzodiazepine derivatives for use in acute or chronic neurological disorders
|
|
US7491742B2
(en)
|
1999-10-21 |
2009-02-17 |
Merck Patent Gmbh |
Imidazole derivatives as phosphodiesterase VII inhibitors
|
|
US6534287B1
(en)
|
1999-10-25 |
2003-03-18 |
Nps Pharmaceuticals, Inc. |
Human metabotropic glutamate receptor
|
|
AR029185A1
(es)
|
1999-10-25 |
2003-06-18 |
Yamanouchi Pharma Co Ltd |
Derivado de naftiridina
|
|
DE19953025A1
(de)
|
1999-11-04 |
2001-05-10 |
Merck Patent Gmbh |
Pyrrolderivate als Phosphodiesterase VII-Hemmer
|
|
DE19953414A1
(de)
|
1999-11-06 |
2001-05-10 |
Merck Patent Gmbh |
Imidazopyridinderivate als Phospodiesterase VII-Hemmer
|
|
DE19954707A1
(de)
|
1999-11-13 |
2001-05-17 |
Merck Patent Gmbh |
Imidazolverbindungen als Phosphodiesterase VII-Hemmer
|
|
GB9927687D0
(en)
|
1999-11-23 |
2000-01-19 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
KR20020070285A
(ko)
|
1999-11-23 |
2002-09-05 |
메틸진, 인크. |
히스톤 디아세틸라제의 억제제
|
|
US6642250B2
(en)
|
1999-12-08 |
2003-11-04 |
Grelan Pharmaceutical Co., Ltd. |
1,8-naphthyridin-2(1H)-one derivatives
|
|
EP1106180B1
(en)
|
1999-12-08 |
2003-11-12 |
Centre National de la Recherche Scientifique (CNRS) |
Use of hymenialdisine or derivatives thereof in the manufacture of medicaments
|
|
GB9929687D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6376489B1
(en)
|
1999-12-23 |
2002-04-23 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6680336B2
(en)
|
1999-12-15 |
2004-01-20 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
GB9929685D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CN100335479C
(zh)
|
1999-12-17 |
2007-09-05 |
希龙公司 |
糖元合成酶激酶3的双环抑制剂
|
|
US6313156B1
(en)
|
1999-12-23 |
2001-11-06 |
Icos Corporation |
Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors
|
|
US6258833B1
(en)
|
1999-12-23 |
2001-07-10 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6348602B1
(en)
|
1999-12-23 |
2002-02-19 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6569885B1
(en)
|
1999-12-23 |
2003-05-27 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6372777B1
(en)
|
1999-12-23 |
2002-04-16 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6362213B1
(en)
|
1999-12-23 |
2002-03-26 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6294561B1
(en)
|
1999-12-23 |
2001-09-25 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
GB0000564D0
(en)
|
2000-01-11 |
2000-03-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EE200200426A
(et)
|
2000-01-31 |
2003-12-15 |
Pfizer Products Inc. |
PDE4 isosüümide inhibiitoritena kasulikud pürimidiinkarboksamiidid
|
|
JP2003523741A
(ja)
|
2000-02-01 |
2003-08-12 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
Ｂｃｌ−２様ポリヌクレオチド、ポリペプチドおよび抗体
|
|
WO2001056990A2
(en)
|
2000-02-03 |
2001-08-09 |
Eli Lilly And Company |
Pyridine derivates as potentiators of glutamate receptors
|
|
US20010039275A1
(en)
|
2000-02-04 |
2001-11-08 |
Bowler Andrew Neil |
Use of 2,4-diaminothiazole derivatives
|
|
US20010034373A1
(en)
*
|
2000-02-09 |
2001-10-25 |
Matthew Miller |
Low dose modafinil for enhancement of cognitive function
|
|
GB0003254D0
(en)
|
2000-02-11 |
2000-04-05 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
FR2804959B1
(fr)
|
2000-02-15 |
2006-04-28 |
Centre Nat Rech Scient |
Utilisation de derives de paullones pour la fabrication de medicaments
|
|
NZ521576A
(en)
|
2000-02-29 |
2005-06-24 |
Mitsubishi Pharma Corp |
Novel cyclic amide derivatives
|
|
GB0005700D0
(en)
|
2000-03-09 |
2000-05-03 |
Glaxo Group Ltd |
Therapy
|
|
AU2001250892A1
(en)
|
2000-03-20 |
2001-10-03 |
Teva Pharmaceutical Industries Ltd. |
Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide
|
|
CA2404226A1
(en)
|
2000-03-23 |
2001-09-27 |
Takeda Chemical Industries, Ltd. |
Furoisoquinoline derivatives, process for producing the same and use thereof
|
|
AU2001248701A1
(en)
|
2000-03-24 |
2001-10-03 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
GB0007193D0
(en)
|
2000-03-25 |
2000-05-17 |
Univ Manchester |
Treatment of movrmrnt disorders
|
|
GB0008696D0
(en)
|
2000-04-07 |
2000-05-31 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
RU2303373C2
(ru)
|
2000-04-14 |
2007-07-27 |
Марс, Инкорпорейтед |
Композиции и способы улучшения состояния сосудистой системы
|
|
CA2306170A1
(en)
|
2000-04-18 |
2001-10-18 |
Kenneth Curry |
Novel amino, carboxy derivatives of barbituric acid
|
|
CN1249051C
(zh)
|
2000-04-28 |
2006-04-05 |
阿卡蒂亚药品公司 |
毒蕈碱性激动剂
|
|
NZ522674A
(en)
|
2000-05-11 |
2004-10-29 |
Kenneth Curry |
Novel spiro[2.4]heptane amino carboxy compounds and derivatives thereof
|
|
MXPA02011079A
(es)
|
2000-05-11 |
2004-08-19 |
Consejo Superior Investigacion |
Inhibidores heterociclicos de quinasa de sintasa de glucogeno gsk3.
|
|
UA74826C2
(en)
|
2000-05-17 |
2006-02-15 |
Ortho Mcneil Pharm Inc |
?-carboline derivatives as phosphodiesterase inhibitors
|
|
UA72611C2
(uk)
|
2000-05-17 |
2005-03-15 |
Орто-Макнейл Фармацевтикал, Інк. |
Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
|
|
EP1294723A1
(en)
|
2000-05-24 |
2003-03-26 |
MERCK SHARP & DOHME LTD. |
3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
|
|
DE60119315T2
(de)
|
2000-05-30 |
2006-08-31 |
Société des Produits Nestlé S.A. |
Primärzusammensetzung enthaltend einen lipophilen, bioaktiven stoff
|
|
US7081481B2
(en)
|
2000-05-31 |
2006-07-25 |
Eli Lilly And Company |
Excitatory amino acid receptor modulators
|
|
WO2001094350A1
(en)
|
2000-06-07 |
2001-12-13 |
Almirall Prodesfarma S.A. |
6-phenylpyrrolopyrimidinedione derivatives
|
|
ES2269408T3
(es)
|
2000-06-23 |
2007-04-01 |
Lilly Icos Llc |
Inhibidores de fosfodiesterasa especifica de gmp ciclico.
|
|
US6589978B2
(en)
|
2000-06-30 |
2003-07-08 |
Hoffman-La Roche Inc. |
1-sulfonyl pyrrolidine derivatives
|
|
US6399641B1
(en)
|
2000-07-13 |
2002-06-04 |
Hoffmann-La Roche Inc. |
2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists
|
|
GB0018473D0
(en)
|
2000-07-27 |
2000-09-13 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO2002009713A2
(de)
|
2000-08-01 |
2002-02-07 |
Bayer Aktiengesellschaft |
Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
|
|
US6645990B2
(en)
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
|
IL154425A0
(en)
|
2000-08-24 |
2003-09-17 |
Univ Tennessee Res H Corp |
Selective androgen receptor modulators and methods of use thereof
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
US6576644B2
(en)
|
2000-09-06 |
2003-06-10 |
Bristol-Myers Squibb Co. |
Quinoline inhibitors of cGMP phosphodiesterase
|
|
WO2002022579A2
(en)
|
2000-09-11 |
2002-03-21 |
Sepracor, Inc. |
Antipsychotic sulfonamide-heterocycles, and methods of use thereof
|
|
EP1317450B1
(en)
|
2000-09-15 |
2006-11-22 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6613776B2
(en)
|
2000-09-15 |
2003-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6610677B2
(en)
|
2000-09-15 |
2003-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
EP1335898B1
(en)
|
2000-09-29 |
2005-11-23 |
TopoTarget UK Limited |
Carbamic acid compounds comprising an amide linkage as hdac inhibitors
|
|
CA2423744C
(en)
|
2000-09-29 |
2012-04-03 |
Prolifix Limited |
Hydroxamic acid compounds comprising a sulfonamide linkage as hdac inhibitors
|
|
GB0023983D0
(en)
|
2000-09-29 |
2000-11-15 |
Prolifix Ltd |
Therapeutic compounds
|
|
EP1193261A1
(en)
|
2000-10-02 |
2002-04-03 |
Warner-Lambert Company |
New thiadiazoles and their use as phosphodiesterase-7 inhibitors
|
|
CN1703403A
(zh)
|
2000-10-02 |
2005-11-30 |
詹森药业有限公司 |
趋代谢的谷氨酸盐受体拮抗剂
|
|
US20020103192A1
(en)
|
2000-10-26 |
2002-08-01 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
CA2427779A1
(en)
|
2000-11-10 |
2002-05-16 |
Merck Sharp & Dohme Limited |
Imidazo-triazine derivatives as ligands for gaba receptors
|
|
GB0027561D0
(en)
|
2000-11-10 |
2000-12-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0117277D0
(en)
|
2001-07-16 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CA2428527A1
(en)
|
2000-11-14 |
2002-05-23 |
Altana Pharma Ag |
(dihydro)isoquinoline derivatives as phosphodiesterase inhibitors
|
|
AR035659A1
(es)
|
2000-12-07 |
2004-06-23 |
Hoffmann La Roche |
Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos
|
|
CA2431326A1
(en)
|
2000-12-13 |
2002-06-20 |
Bayer Aktiengesellschaft |
Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
|
|
US6900215B2
(en)
|
2000-12-15 |
2005-05-31 |
Merck Sharp & Dohme Ltd. |
Imidazo-pyrimidine derivatives as ligands for gaba receptors
|
|
US6720445B2
(en)
|
2000-12-21 |
2004-04-13 |
Beacon Laboratories, Inc. |
Acetyloxymethyl esters and methods for using the same
|
|
US6562995B1
(en)
|
2000-12-21 |
2003-05-13 |
Beacon Laboratories, Inc. |
Delta dicarbonyl compounds and methods for using the same
|
|
NZ526472A
(en)
|
2000-12-21 |
2004-04-30 |
Vertex Pharma |
Pyrazole compounds useful as protein kinase inhibitors
|
|
PT1345609E
(pt)
|
2000-12-22 |
2005-08-31 |
Hoffmann La Roche |
Derivados de tetra-hidro-(benzo ou tieno)-azepina-pirazina como antagonistas de mglur 1
|
|
AR035513A1
(es)
|
2000-12-23 |
2004-06-02 |
Hoffmann La Roche |
Derivados de tetrahidropiridina, proceso para prepararlos, composiciones farmaceuticas que los contienen, y uso de dichos compuestos en la preparacion de medicamentos
|
|
GR1003861B
(el)
|
2000-12-29 |
2002-04-11 |
|
Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
|
|
US6974824B2
(en)
|
2001-01-08 |
2005-12-13 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
AR035417A1
(es)
|
2001-01-27 |
2004-05-26 |
Hoffmann La Roche |
Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
|
|
ATE305467T1
(de)
|
2001-01-31 |
2005-10-15 |
Pfizer Prod Inc |
Als inhibitoren von pde4-isozymen geeignete etherderivate
|
|
WO2002060898A1
(en)
|
2001-01-31 |
2002-08-08 |
Pfizer Products Inc. |
Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
|
|
IL156413A0
(en)
|
2001-01-31 |
2004-01-04 |
Pfizer Prod Inc |
Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
|
|
US6559159B2
(en)
|
2001-02-01 |
2003-05-06 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
US6617357B2
(en)
|
2001-03-06 |
2003-09-09 |
Smithkline Beecham Corporation |
Compounds and their use as PDE inhibitors
|
|
US20020177594A1
(en)
|
2001-03-14 |
2002-11-28 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
WO2002076953A1
(en)
|
2001-03-21 |
2002-10-03 |
Warner-Lambert Company Llc |
New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
|
|
US6900329B2
(en)
|
2001-03-21 |
2005-05-31 |
Schering Corporation |
MCH antagonists and their use in the treatment of obesity
|
|
WO2002085910A1
(en)
*
|
2001-04-19 |
2002-10-31 |
Mitsubishi Pharma Corporation |
Polymorph forms of n-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2- oxopyrrolidin -1 -yl)acetamide
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
GB0111191D0
(en)
|
2001-05-08 |
2001-06-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO2002089782A2
(en)
|
2001-05-09 |
2002-11-14 |
President And Fellows Of Harvard College |
Dioxanes and uses thereof
|
|
US6762179B2
(en)
|
2001-05-31 |
2004-07-13 |
Vertex Pharmaceuticals Incorporated |
Thiazole compounds useful as inhibitors of protein kinase
|
|
KR20040007672A
(ko)
|
2001-06-12 |
2004-01-24 |
에스케이 주식회사 |
신규한 페닐알킬디아민 및 아미드 유사체
|
|
JP2005500294A
(ja)
|
2001-06-19 |
2005-01-06 |
ブリストル−マイヤーズ スクイブ カンパニー |
ホスホジエステラーゼ７に対するピリミジン阻害剤
|
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
GB0117060D0
(en)
|
2001-07-12 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
JPWO2003013522A1
(ja)
*
|
2001-08-06 |
2004-12-02 |
三菱ウェルファーマ株式会社 |
コリン作動性神経障害予防・治療薬
|
|
EP1285922A1
(en)
|
2001-08-13 |
2003-02-26 |
Warner-Lambert Company |
1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
|
|
JO2311B1
(en)
|
2001-08-29 |
2005-09-12 |
ميرك فروست كندا ليمتد |
Alkyl inhibitors Ariel phosphodiesterase-4
|
|
US6897220B2
(en)
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
EP1429765A2
(en)
|
2001-09-14 |
2004-06-23 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
EP1295885A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives
|
|
EP1295884A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
|
|
BR0212864A
(pt)
|
2001-09-26 |
2004-08-17 |
Bayer Pharmaceuticals Corp |
Derivados de 1,6-naftiridina como antidiabéticos
|
|
ATE516030T1
(de)
|
2001-10-02 |
2011-07-15 |
Acadia Pharm Inc |
Benzimidazolidinon-derivate als muscarinische mittel
|
|
US6951849B2
(en)
|
2001-10-02 |
2005-10-04 |
Acadia Pharmaceuticals Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
US6924311B2
(en)
|
2001-10-17 |
2005-08-02 |
X-Ceptor Therapeutics, Inc. |
Methods for affecting various diseases utilizing LXR compounds
|
|
WO2003035055A1
(en)
|
2001-10-25 |
2003-05-01 |
Schering Corporation |
Mch antagonists for the treatment of obesity
|
|
CA2463821A1
(en)
|
2001-11-01 |
2003-05-08 |
Janssen Pharmaceutica N.V. |
Amide derivatives as glycogen synthase kinase 3-beta inhibitors
|
|
MXPA04004178A
(es)
|
2001-11-01 |
2004-09-06 |
Janssen Pharmaceutica Nv |
Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta.
|
|
PT1448562E
(pt)
|
2001-11-14 |
2007-08-31 |
Ortho Mcneil Pharm Inc |
Derivados da pirroloquinolona tetracíclica substituídos, úteis como inibidores da fosfodiesterase
|
|
FR2832711B1
(fr)
|
2001-11-26 |
2004-01-30 |
Warner Lambert Co |
Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
|
|
EP1453815A4
(en)
|
2001-11-30 |
2005-04-06 |
Merck & Co Inc |
METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS
|
|
DE60222931T2
(de)
|
2001-12-13 |
2008-07-10 |
Asubio Pharma Co., Ltd. |
Pyrazolopyrimidinonderivate mit pde7-hemmender wirkung
|
|
WO2003051833A2
(en)
|
2001-12-18 |
2003-06-26 |
Merck & Co., Inc. |
Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
|
|
CA2469821C
(en)
|
2001-12-18 |
2009-10-20 |
Merck & Co., Inc. |
Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
|
|
CA2470612A1
(en)
|
2001-12-19 |
2003-07-03 |
Merck & Co., Inc. |
Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
|
|
CA2470519C
(en)
|
2001-12-21 |
2009-11-17 |
Merck & Co., Inc. |
Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5
|
|
DE10163991A1
(de)
|
2001-12-24 |
2003-07-03 |
Merck Patent Gmbh |
Pyrrolo-pyrimidine
|
|
CA2366325A1
(en)
|
2001-12-27 |
2003-06-27 |
Todd Howley |
Method of forming turbine blade root
|
|
CA2471642C
(en)
|
2001-12-27 |
2011-05-24 |
Taisho Pharmaceutical Co., Ltd. |
6-fluorobicyclo[3.1.0]hexane derivatives
|
|
MXPA04006280A
(es)
|
2001-12-28 |
2004-09-27 |
Acadia Pharm Inc |
Compuestos espiroazaciclicos como moduladores de receptor de monoamina.
|
|
NZ533566A
(en)
|
2001-12-28 |
2007-03-30 |
Acadia Pharm Inc |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
US7550459B2
(en)
|
2001-12-28 |
2009-06-23 |
Acadia Pharmaceuticals, Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
US6495700B1
(en)
|
2002-01-09 |
2002-12-17 |
Axonyx, Inc. |
Process for producing phenserine and its analog
|
|
WO2003061658A1
(en)
|
2002-01-22 |
2003-07-31 |
Eisai Co., Ltd. |
Sigma receptor binder containing indanone derivative
|
|
US7378428B2
(en)
|
2002-01-31 |
2008-05-27 |
Ono Pharmaceutical Co., Ltd. |
Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
|
|
KR100698982B1
(ko)
|
2002-02-11 |
2007-03-26 |
화이자 인코포레이티드 |
Ｐｄｅ4 억제제로서 유용한 니코틴아미드 유도체
|
|
MXPA04007961A
(es)
|
2002-02-22 |
2004-11-26 |
Teijin Ltd |
Derivados de pirrolopirimidina.
|
|
DE60334781D1
(de)
|
2002-03-12 |
2010-12-16 |
Merck Sharp & Dohme |
Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5
|
|
ES2306859T3
(es)
|
2002-03-13 |
2008-11-16 |
Janssen Pharmaceutica Nv |
Derivados de sulfonil como nuevos inhibidores de histona deacetilasa.
|
|
OA12793A
(en)
|
2002-03-13 |
2006-07-10 |
Janssen Pharmaceutica Nv |
Sulfonylamino-derivatives as novel inhibitors of histone deacetylase.
|
|
KR20040093692A
(ko)
|
2002-03-13 |
2004-11-08 |
얀센 파마슈티카 엔.브이. |
히스톤 디아세틸라제의 신규한 저해제로서의 피페라지닐-,피페리디닐- 및 모르폴리닐-유도체
|
|
DE60326436D1
(en)
|
2002-03-13 |
2009-04-16 |
Janssen Pharmaceutica Nv |
Aminoderivate als histone-deacetylase-inhibitoren
|
|
EP1346640B1
(en)
|
2002-03-20 |
2007-05-09 |
Société des Produits Nestlé S.A. |
A low fat cocoa extract
|
|
US7514107B2
(en)
|
2002-03-21 |
2009-04-07 |
Mars, Incorporated |
Treatment of diseases involving defective gap junctional communication
|
|
CA2479906C
(en)
|
2002-04-03 |
2011-02-08 |
Topotarget Uk Limited |
Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors
|
|
GB0210124D0
(en)
|
2002-05-02 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0212048D0
(en)
|
2002-05-24 |
2002-07-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6800625B2
(en)
|
2002-06-19 |
2004-10-05 |
Janssen Pharmaceutica N.V. |
Substituted 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives useful as phosphodiesterase inhibitors
|
|
EP1539697A1
(en)
|
2002-07-19 |
2005-06-15 |
Memory Pharmaceutical Corporation |
Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
|
|
EP1400244A1
(en)
|
2002-09-17 |
2004-03-24 |
Warner-Lambert Company LLC |
New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
|
|
US7323334B2
(en)
|
2002-10-04 |
2008-01-29 |
The Regents Of The University Of California |
Screening and therapeutic methods relating to neurogenesis
|
|
JP2006506383A
(ja)
|
2002-10-21 |
2006-02-23 |
カイロン コーポレイション |
グリコーゲンシンターゼキナーゼ３のインヒビター
|
|
US6969702B2
(en)
|
2002-11-20 |
2005-11-29 |
Neuronova Ab |
Compounds and methods for increasing neurogenesis
|
|
DE60335743D1
(de)
|
2002-11-20 |
2011-02-24 |
Neuronova Ab |
Verbindungen und verfahren zur erhöhung der neurogenese
|
|
AU2003293409A1
(en)
|
2002-12-09 |
2004-06-30 |
Karl K. Johe |
Method for discovering neurogenic agents
|
|
ES2209650B2
(es)
|
2002-12-09 |
2006-11-01 |
Laboratorios Del Dr. Esteve, S.A. |
Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones.
|
|
JP4598674B2
(ja)
*
|
2003-01-08 |
2010-12-15 |
田辺三菱製薬株式会社 |
統合失調症治療剤
|
|
TW200418806A
(en)
|
2003-01-13 |
2004-10-01 |
Fujisawa Pharmaceutical Co |
HDAC inhibitor
|
|
WO2004069813A1
(en)
|
2003-01-31 |
2004-08-19 |
Astrazeneca Ab |
Saturated quinoxaline derivatives and their use as metabotropic glutamate receptor ligands
|
|
JP2006518381A
(ja)
|
2003-02-07 |
2006-08-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼのインヒビターとして有用なヘテロアリール置換ピロール
|
|
US6969716B2
(en)
|
2003-02-07 |
2005-11-29 |
Merck Sharp & Dohme Ltd. |
5-phenyl[1,2,4]triazines as ligands for GABA-A α2/α3 receptors for treating anxiety or depression
|
|
TWI292318B
(en)
|
2003-03-10 |
2008-01-11 |
Hoffmann La Roche |
Imidazol-4-yl-ethynyl-pyridine derivatives
|
|
CA2518318A1
(en)
|
2003-03-17 |
2004-09-30 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
AU2004226430A1
(en)
|
2003-03-28 |
2004-10-14 |
Acadia Pharmaceuticals Inc. |
Muscarinic M1 receptor agonists for pain management
|
|
EP1539181B1
(en)
|
2003-04-04 |
2007-06-27 |
Dynogen Pharmaceuticals Inc. |
Method of treating lower urinary tract disorders
|
|
EP1613590A2
(en)
|
2003-04-16 |
2006-01-11 |
Memory Pharmaceutical Corporation |
4-(3,4-disubstituted phenyl)-pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
|
|
WO2004093802A2
(en)
|
2003-04-17 |
2004-11-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Prevention of deficits in neurogenesis with anti-inflammatory agents
|
|
GB0311859D0
(en)
|
2003-05-22 |
2003-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7763588B2
(en)
|
2003-06-13 |
2010-07-27 |
The Salk Institute For Biological Studies |
Method for increasing cognitive function and neurogenesis
|
|
US7842835B2
(en)
|
2003-07-07 |
2010-11-30 |
Georgetown University |
Histone deacetylase inhibitors and methods of use thereof
|
|
AU2004262897B9
(en)
|
2003-07-25 |
2009-12-17 |
F. Hoffmann-La Roche Ag |
Combination of mGluR2 antagonist and ache inhibitor for treatment of acute and/or chronic neurological disorders
|
|
US20050031538A1
(en)
|
2003-08-05 |
2005-02-10 |
Steindler Dennis A. |
Neural cell assay
|
|
AR045595A1
(es)
|
2003-09-04 |
2005-11-02 |
Vertex Pharma |
Composiciones utiles como inhibidores de proteinas quinasas
|
|
JP2007508316A
(ja)
|
2003-10-10 |
2007-04-05 |
マーズ インコーポレイテッド |
ＥｒｂＢ２キナーゼ過剰発現に関連する病気の治療
|
|
SI1541197T1
(sl)
*
|
2003-12-02 |
2009-08-31 |
Pharmaneuroboost N V |
Uporaba pipamperona in sndri, snri ali ssri za zdravljenje razpoloĺ˝enjskih ali tesnobnih motenj
|
|
WO2005065681A1
(en)
|
2003-12-19 |
2005-07-21 |
Takeda San Diego, Inc. |
N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
|
|
US20050137234A1
(en)
|
2003-12-19 |
2005-06-23 |
Syrrx, Inc. |
Histone deacetylase inhibitors
|
|
SG133606A1
(en)
|
2003-12-22 |
2007-07-30 |
Acadia Pharm Inc |
Amino substituted diaryl [a,d] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
|
|
AU2005209908A1
(en)
|
2004-01-30 |
2005-08-18 |
Mars, Incorporated |
Methods and compositions for treating cancer
|
|
TWI301760B
(en)
|
2004-02-27 |
2008-10-11 |
Merz Pharma Gmbh & Co Kgaa |
Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
|
|
AU2006269231A1
(en)
|
2005-07-08 |
2007-01-18 |
Braincells, Inc. |
Methods for identifying agents and conditions that modulate neurogenesis
|
|
US20090088449A1
(en)
*
|
2006-02-07 |
2009-04-02 |
Mitsubishi Tanabe Pharma Corporation |
4-acylaminopyridine derivative mediated neurogenesis
|