NO20085398L - Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse - Google Patents

Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse

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Publication number
NO20085398L
NO20085398L NO20085398A NO20085398A NO20085398L NO 20085398 L NO20085398 L NO 20085398L NO 20085398 A NO20085398 A NO 20085398A NO 20085398 A NO20085398 A NO 20085398A NO 20085398 L NO20085398 L NO 20085398L
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Norway
Prior art keywords
diseases
disorders
derivatives
compounds
nonyloxadiazolyl
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Application number
NO20085398A
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English (en)
Inventor
Gunnar M Olsen
Dan Peters
Elsebet Ostergaard Nielsen
Daniel B Timmermann
Steven Charles Loechel
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Neurosearch As
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Publication of NO20085398L publication Critical patent/NO20085398L/no

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

og deres anvendelse ved fremstilling av farmasøytiske preparater. Forbindelsene ifølge oppfinnelsen er funnet å være kolinerge ligander ved nikotinacetylkolinreseptorene. På grunn av deres farmakologiske profil kan forbindelsene ifølge oppfinnelsen være anvendbare til behandling av sykdommer eller forstyrrelser som er så forskjellige som de som er relatert til det kolinerge system i sentralnervesystemet (CNS), det perifere nervesystem (PNS), sykdommer eller forstyrrelser relatert til glattmuskelkontraksjon, endokrine sykdommer eller forstyrrelser, sykdommer eller forstyrrelser relatert til nervedegenerasjon, sykdommer eller forstyrrelser relatert til betennelse, smerte og abstinenssymptomer forårsaket av avsluttet misbruk av kjemiske stoffer. Ar er en fenyl-gruppe som er substituert med metylendioksy eller etylendioksy.
NO20085398A 2006-05-30 2008-12-29 Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse NO20085398L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80902406P 2006-05-30 2006-05-30
DKPA200600731 2006-05-30
PCT/EP2007/055169 WO2007138038A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (1)

Publication Number Publication Date
NO20085398L true NO20085398L (no) 2008-12-29

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ID=40616686

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NO20085398A NO20085398L (no) 2006-05-30 2008-12-29 Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse

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Country Link
US (4) US8158619B2 (no)
EP (3) EP2032575B1 (no)
JP (2) JP5290964B2 (no)
KR (1) KR101458194B1 (no)
CN (2) CN101426790B (no)
AT (3) ATE518862T1 (no)
AU (2) AU2007267174B2 (no)
BR (1) BRPI0708843A2 (no)
CA (2) CA2653769A1 (no)
DE (2) DE602007006486D1 (no)
DK (2) DK2032574T3 (no)
ES (1) ES2342334T3 (no)
IL (1) IL193925A (no)
MX (2) MX2008014886A (no)
MY (1) MY147764A (no)
NO (1) NO20085398L (no)
NZ (1) NZ571288A (no)
PL (1) PL2032575T3 (no)
PT (1) PT2032575E (no)
RU (1) RU2427581C2 (no)
UA (1) UA95946C2 (no)
WO (2) WO2007138038A1 (no)
ZA (1) ZA200807756B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158619B2 (en) 2006-05-30 2012-04-17 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use
EP2079734A1 (en) * 2006-10-25 2009-07-22 NeuroSearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US7935695B2 (en) 2007-08-17 2011-05-03 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
MX2010009580A (es) 2008-03-11 2010-09-24 Neurosearch As Nuevos derivados 1,4-diaza-biciclo[3.2.2]nonil-oxadiazolilo utiles como moduladores de los receptores nicotinicos de acetilcolina.
US20110112078A1 (en) * 2008-06-10 2011-05-12 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010043539A1 (en) * 2008-10-13 2010-04-22 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
CA2750450A1 (en) 2009-01-26 2010-07-29 Neurosearch A/S Novel indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120238553A1 (en) * 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110319397A1 (en) 2009-01-27 2011-12-29 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010130768A1 (en) * 2009-05-14 2010-11-18 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
EP2498826A1 (en) 2009-11-11 2012-09-19 NeuroSearch AS Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
WO2011073296A1 (en) 2009-12-18 2011-06-23 Neurosearch A/S Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
WO2012139925A1 (en) 2011-04-15 2012-10-18 Neurosearch A/S Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
BR122020005073A2 (pt) 2017-08-04 2020-10-13 Skyhawk Therapeutics, Inc. Composto, composição farmacêutica e uso do composto
EA202092490A1 (ru) 2018-04-18 2020-12-23 Констеллейшен Фармасьютикалс, Инк. Модуляторы метилмодифицирующих ферментов, композиции и их применения
CA3100977A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
JP2022519294A (ja) * 2019-02-04 2022-03-22 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
EP3920915A4 (en) 2019-02-05 2022-10-05 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICE
CN113677344A (zh) 2019-02-06 2021-11-19 斯基霍克疗法公司 用于调节剪接的方法和组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809732B1 (fr) 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
FR2809731B1 (fr) 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2832712B1 (fr) 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
FR2832713B1 (fr) 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
US7220741B2 (en) 2002-09-30 2007-05-22 Neurosearch A/S 1,4-diazabicycloalkane derivatives, their preparation and use
MXPA05003344A (es) * 2002-09-30 2005-11-23 Neurosearch As Derivados novedosos de 1,4-diazabicicloalcano, su preparacion y uso.
ATE345342T1 (de) * 2002-11-11 2006-12-15 Neurosearch As 1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung
US6996399B2 (en) * 2003-01-13 2006-02-07 Micrel, Inc. Wireless device and method using frequency hopping and sweep modes
WO2005074940A1 (en) 2004-02-04 2005-08-18 Neurosearch A/S Diazabicyclic aryl derivatives as cholinergic receptor modulators
WO2006087306A2 (en) 2005-02-16 2006-08-24 Neurosearch A/S Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
US8158619B2 (en) 2006-05-30 2012-04-17 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use

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