NO20085398L - Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse - Google Patents

Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse

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Publication number
NO20085398L
NO20085398L NO20085398A NO20085398A NO20085398L NO 20085398 L NO20085398 L NO 20085398L NO 20085398 A NO20085398 A NO 20085398A NO 20085398 A NO20085398 A NO 20085398A NO 20085398 L NO20085398 L NO 20085398L
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NO
Norway
Prior art keywords
diseases
disorders
derivatives
compounds
nonyloxadiazolyl
Prior art date
Application number
NO20085398A
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English (en)
Inventor
Gunnar M Olsen
Dan Peters
Elsebet Ostergaard Nielsen
Daniel B Timmermann
Steven Charles Loechel
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Neurosearch As
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Publication of NO20085398L publication Critical patent/NO20085398L/no

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

og deres anvendelse ved fremstilling av farmasøytiske preparater. Forbindelsene ifølge oppfinnelsen er funnet å være kolinerge ligander ved nikotinacetylkolinreseptorene. På grunn av deres farmakologiske profil kan forbindelsene ifølge oppfinnelsen være anvendbare til behandling av sykdommer eller forstyrrelser som er så forskjellige som de som er relatert til det kolinerge system i sentralnervesystemet (CNS), det perifere nervesystem (PNS), sykdommer eller forstyrrelser relatert til glattmuskelkontraksjon, endokrine sykdommer eller forstyrrelser, sykdommer eller forstyrrelser relatert til nervedegenerasjon, sykdommer eller forstyrrelser relatert til betennelse, smerte og abstinenssymptomer forårsaket av avsluttet misbruk av kjemiske stoffer. Ar er en fenyl-gruppe som er substituert med metylendioksy eller etylendioksy.
NO20085398A 2006-05-30 2008-12-29 Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse NO20085398L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80902406P 2006-05-30 2006-05-30
DKPA200600731 2006-05-30
PCT/EP2007/055169 WO2007138038A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (1)

Publication Number Publication Date
NO20085398L true NO20085398L (no) 2008-12-29

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NO20085398A NO20085398L (no) 2006-05-30 2008-12-29 Nye 1,4-diazabisyklo[3.2 2]nonyloksadiazolylderivater og deres medisinske anvendelse

Country Status (23)

Country Link
US (4) US8158619B2 (no)
EP (3) EP2032575B1 (no)
JP (2) JP5290964B2 (no)
KR (1) KR101458194B1 (no)
CN (2) CN101432286A (no)
AT (3) ATE463497T1 (no)
AU (2) AU2007267174B2 (no)
BR (1) BRPI0708843A2 (no)
CA (2) CA2653769A1 (no)
DE (2) DE602007005802D1 (no)
DK (2) DK2032575T3 (no)
ES (1) ES2342334T3 (no)
IL (1) IL193925A (no)
MX (2) MX2008014887A (no)
MY (1) MY147764A (no)
NO (1) NO20085398L (no)
NZ (1) NZ571288A (no)
PL (1) PL2032575T3 (no)
PT (1) PT2032575E (no)
RU (1) RU2427581C2 (no)
UA (1) UA95946C2 (no)
WO (2) WO2007138038A1 (no)
ZA (1) ZA200807756B (no)

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JP2010507619A (ja) * 2006-10-25 2010-03-11 ノイロサーチ アクティーゼルスカブ オキサジアゾール及びチアジアゾール化合物並びにニコチン性アセチルコリン受容体調節物質としてのその使用
WO2009024517A1 (en) 2007-08-17 2009-02-26 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
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US20110112078A1 (en) * 2008-06-10 2011-05-12 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
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WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
MX2011007449A (es) 2009-01-26 2011-10-24 Neurosearch As Derivados de indolil-oxadiazolil-diazabiciclononano y su uso medico y diagnostico.
US20120238553A1 (en) * 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086279A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010130768A1 (en) * 2009-05-14 2010-11-18 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
US20120288443A1 (en) 2009-11-11 2012-11-15 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
US8946412B2 (en) 2009-12-18 2015-02-03 Danpet Ab Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
MX2020001425A (es) 2017-08-04 2020-08-06 Skyhawk Therapeutics Inc Metodos y composiciones para modular el empalme.
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CN114007613A (zh) 2019-02-05 2022-02-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物

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IL193925A (en) 2013-08-29
US7807667B2 (en) 2010-10-05
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