MX2010005040A - Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico. - Google Patents

Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico.

Info

Publication number
MX2010005040A
MX2010005040A MX2010005040A MX2010005040A MX2010005040A MX 2010005040 A MX2010005040 A MX 2010005040A MX 2010005040 A MX2010005040 A MX 2010005040A MX 2010005040 A MX2010005040 A MX 2010005040A MX 2010005040 A MX2010005040 A MX 2010005040A
Authority
MX
Mexico
Prior art keywords
diseases
disorders
diaza
bicyclo
novel
Prior art date
Application number
MX2010005040A
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Oestergaard Nielsen
Daniel B Timmermann
John Paul Redrobe
Tino Dyhring
Jeppe Kejser Christensen
Jens Damsgaard Mikkelsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of MX2010005040A publication Critical patent/MX2010005040A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Esta invención se refiere a los nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina de la fórmula (I) y su uso en la fabricación de composiciones farmacéuticas. Los compuestos de la invención son encontrados como ligandos colinérgicos en los receptores nicotínicos de acetilcolina y moduladores de los receptores y transportadores de monoamina. Debido a su perfil farmacológico, los compuestos de la invención pueden ser útiles para el tratamiento de enfermedades o trastornos tan diversos como aquellos relacionados al sistema colinérgico del sistema nervioso central (SNC), el sistema nervioso periférico (SNP), enfermedades o trastornos relacionados a la contracción del músculo liso, enfermedades o trastornos endócrinos, enfermedades o trastornos relacionados a la neurodegeneración, enfermedades o trastornos relacionados a la inflamación, dolor y síntomas de abstinencia provocados por la terminación de abuso de sustancias químicas.
MX2010005040A 2007-11-14 2008-11-13 Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico. MX2010005040A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200701620 2007-11-14
US98811807P 2007-11-15 2007-11-15
PCT/EP2008/065436 WO2009062988A1 (en) 2007-11-14 2008-11-13 Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use

Publications (1)

Publication Number Publication Date
MX2010005040A true MX2010005040A (es) 2010-05-21

Family

ID=40548548

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005040A MX2010005040A (es) 2007-11-14 2008-11-13 Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico.

Country Status (11)

Country Link
US (1) US8343960B2 (es)
EP (1) EP2209783B8 (es)
JP (1) JP2011503145A (es)
CN (1) CN101855223A (es)
AU (1) AU2008322958A1 (es)
BR (1) BRPI0820259A2 (es)
CA (1) CA2705752A1 (es)
IL (1) IL204933A0 (es)
MX (1) MX2010005040A (es)
RU (1) RU2010114662A (es)
WO (1) WO2009062988A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010004666A (es) * 2007-11-14 2010-05-20 Neurosearch As Derivados novedosos de 1,4-diaza-biciclo[3.2.2]nonil pirimidina y su uso medico.
WO2009062989A1 (en) * 2007-11-14 2009-05-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
WO2010026177A1 (en) * 2008-09-05 2010-03-11 Neurosearch A/S 1,4-diaza-bicyclo [3.2.2] nonyl pyridine derivatives as nicotinic and monoamine receptor modulators
WO2010026176A1 (en) * 2008-09-05 2010-03-11 Neurosearch A/S 1,4 -diaza- bicyclo [3.2.2]n0nyl pyrimidine derivatives as nicotinic and monoamine receptor modulators
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
EP2389380A1 (en) 2009-01-26 2011-11-30 NeuroSearch A/S N-oxides of diazabicyclononyl pyrimidine derivatives and their medical use
JP2013507417A (ja) * 2009-10-13 2013-03-04 エム・エス・ディー・オス・ベー・フェー アセチルコリン受容体に関連する疾患の処置のための縮合アジン誘導体

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786770B1 (fr) 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2804430B1 (fr) 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
AU2003255993A1 (en) * 2002-09-10 2004-04-30 Pfizer Products Inc. Diazabicyclic compounds useful in the treatment of cns and other disorders
ATE353899T1 (de) 2002-09-30 2007-03-15 Neurosearch As Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung
AU2003280309A1 (en) 2002-11-11 2004-06-03 Neurosearch A/S 1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof
US7223753B2 (en) 2002-11-11 2007-05-29 Neurosearch A/S Diazabicyclic biaryl derivatives
KR20060125885A (ko) 2004-02-04 2006-12-06 뉴로서치 에이/에스 콜린 수용체 조절제로서의 디아자바이사이클릭 아릴 유도체
JP2007520527A (ja) * 2004-02-04 2007-07-26 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体リガンドとしてのジアザ２環式アリール誘導体
AU2007267176A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their medical use
EP2190848A1 (en) 2007-08-17 2010-06-02 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
CA2696680A1 (en) 2007-08-17 2009-02-26 Neurosearch A/S 1,4-diaza-bicycl0(3.2.2)n0nyl pyrimidinyl derivatives useful as nicotinic acetylcholine- receptor ligands
WO2009062989A1 (en) 2007-11-14 2009-05-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
MX2010004666A (es) 2007-11-14 2010-05-20 Neurosearch As Derivados novedosos de 1,4-diaza-biciclo[3.2.2]nonil pirimidina y su uso medico.
EP2389380A1 (en) 2009-01-26 2011-11-30 NeuroSearch A/S N-oxides of diazabicyclononyl pyrimidine derivatives and their medical use

Also Published As

Publication number Publication date
CN101855223A (zh) 2010-10-06
US20100298307A1 (en) 2010-11-25
EP2209783B8 (en) 2016-06-01
EP2209783B1 (en) 2016-03-16
AU2008322958A1 (en) 2009-05-22
US8343960B2 (en) 2013-01-01
JP2011503145A (ja) 2011-01-27
EP2209783A1 (en) 2010-07-28
IL204933A0 (en) 2010-11-30
CA2705752A1 (en) 2009-05-22
RU2010114662A (ru) 2011-12-20
WO2009062988A1 (en) 2009-05-22
BRPI0820259A2 (pt) 2015-06-16

Similar Documents

Publication Publication Date Title
ZA200807756B (en) Novel 1,4-diaza-bicyclo[3.2.2] nonyl oxadiazolyl derivatives and their medical use
MX2007013263A (es) Novedosos derivados oxadiazol y su uso medico.
WO2007138041A8 (en) Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
MX2007004269A (es) Derivados de arilo diazabiciclico nuevos y su uso medico.
PL375025A1 (en) Novel 1,4-diazabicycloalkane derivatives, their preparation and use
MX2010001135A (es) Nuevos derivados de 1,2,3-triazol, utiles como modulares de receptores de acetilcolina nicotinicos.
WO2006087306A3 (en) Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
ATE481407T1 (de) Neue diazabicyclische arylderivate und medizinische verwendung dafür
ATE437880T1 (de) Dimere azacyclische verbindungen und deren verwendung
MX2010005040A (es) Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico.
DE602007004307D1 (de) Enantiomerenreine chinuclidinyloxy-pyridazine und ihre verwendung als nikotin-acetylcholin-rezeptorliganden
MX2010001638A (es) Derivados de 1,4-diaza-biciclo(3.2.2)nonilpirimidinil utiles como ligandos del receptor acetilcolina nicotinico.
MX2010004666A (es) Derivados novedosos de 1,4-diaza-biciclo[3.2.2]nonil pirimidina y su uso medico.
MXPA05006861A (es) Derivados arildiazabiciclicos novedosos.
MX2010009580A (es) Nuevos derivados 1,4-diaza-biciclo[3.2.2]nonil-oxadiazolilo utiles como moduladores de los receptores nicotinicos de acetilcolina.
DE60307102D1 (de) 3-substituierte chinuklidine und deren verwendung
MXPA05003344A (es) Derivados novedosos de 1,4-diazabicicloalcano, su preparacion y uso.
MX2007003331A (es) Nuevos derivados de arilo diazabiciclico.
ATE460416T1 (de) Neuartige 1,4-diazabicycloä3.2.2ünonan-derivate und deren medizinische verwendung
ATE525376T1 (de) Neues 1,4- diazabicycloä3.2.2ünonylpyrimidinylderivat und seine medizinische verwendung
WO2009112462A3 (en) Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
ATE496050T1 (de) Neue chinuklidinderivative und deren pharmazeutische verwendung
ATE478869T1 (de) Diazabicycloalkan-derivate und ihre medizinische verwendung
MX2007004245A (es) Nuevos derivados de arilo azabiciclicos y su uso medico.
UA84585C2 (ru) Диазадициклические арильные производные в качестве модуляторов холинэргических рецепторов

Legal Events

Date Code Title Description
FG Grant or registration