MX2010001638A - Derivados de 1,4-diaza-biciclo(3.2.2)nonilpirimidinil utiles como ligandos del receptor acetilcolina nicotinico. - Google Patents

Derivados de 1,4-diaza-biciclo(3.2.2)nonilpirimidinil utiles como ligandos del receptor acetilcolina nicotinico.

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Publication number
MX2010001638A
MX2010001638A MX2010001638A MX2010001638A MX2010001638A MX 2010001638 A MX2010001638 A MX 2010001638A MX 2010001638 A MX2010001638 A MX 2010001638A MX 2010001638 A MX2010001638 A MX 2010001638A MX 2010001638 A MX2010001638 A MX 2010001638A
Authority
MX
Mexico
Prior art keywords
diseases
diaza
disorders
nicotinic acetylcholine
n0nyl
Prior art date
Application number
MX2010001638A
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Oestergaard Nielsen
Daniel B Timmermann
John Paul Redrobe
Tino Dyhring
Jeppe Kejser Christensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of MX2010001638A publication Critical patent/MX2010001638A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/02—Nutrients, e.g. vitamins, minerals
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    • A61P9/06—Antiarrhythmics
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

Esta invención se refiere a derivados de 1,4-diaza- biciclo(3.2.2)nonilpirimidinilo y su uso en la fabricación de composiciones farmacéuticas. Se encontró que los compuestos de la invención son ligandos colinérgicos en los receptores de acetilcolina nicotínicos. Debido a su perfil farmacológico los compuestos de la invención pueden ser útiles para el tratamiento de enfermedades o trastornos tan diversos como los relacionados con el sistema colinérgico del sistema nervioso central (CNS) , sistema nervioso periférico (PNS) , enfermedades o trastornos relacionados con la contracción del músculo liso, enfermedades o trastornos endocrinos, enfermedades o trastornos relacionados con neurodegeneración, enfermedades o trastornos relacionados con inflamación, dolor, y síntomas de abstinencia causados por la conclusión del abuso de sustancias químicas.
MX2010001638A 2007-08-17 2008-08-14 Derivados de 1,4-diaza-biciclo(3.2.2)nonilpirimidinil utiles como ligandos del receptor acetilcolina nicotinico. MX2010001638A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200701173 2007-08-17
US95685207P 2007-08-20 2007-08-20
PCT/EP2008/060652 WO2009024515A1 (en) 2007-08-17 2008-08-14 1,4-diaza-bicycl0(3.2.2)n0nyl pyrimidinyl derivatives useful as nicotinic acetylcholine- receptor ligands

Publications (1)

Publication Number Publication Date
MX2010001638A true MX2010001638A (es) 2010-03-15

Family

ID=39862976

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001638A MX2010001638A (es) 2007-08-17 2008-08-14 Derivados de 1,4-diaza-biciclo(3.2.2)nonilpirimidinil utiles como ligandos del receptor acetilcolina nicotinico.

Country Status (8)

Country Link
US (1) US20100286128A1 (es)
EP (1) EP2190846A1 (es)
JP (1) JP2010536724A (es)
CN (1) CN101796054A (es)
AU (1) AU2008290647A1 (es)
CA (1) CA2696680A1 (es)
MX (1) MX2010001638A (es)
WO (1) WO2009024515A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009538869A (ja) 2006-05-30 2009-11-12 ノイロサーチ アクティーゼルスカブ 新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルピリミジニル誘導体及びその医学的使用
CA2705752A1 (en) 2007-11-14 2009-05-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
WO2010026176A1 (en) * 2008-09-05 2010-03-11 Neurosearch A/S 1,4 -diaza- bicyclo [3.2.2]n0nyl pyrimidine derivatives as nicotinic and monoamine receptor modulators
WO2010084120A1 (en) * 2009-01-21 2010-07-29 Neurosearch A/S N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands
US20120028967A1 (en) * 2009-01-21 2012-02-02 Neurosearch A/S Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use
CN109988173A (zh) * 2019-04-03 2019-07-09 北京师范大学 芴酮类α7烟碱型乙酰胆碱受体的配体化合物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
WO2004024729A1 (en) * 2002-09-10 2004-03-25 Pfizer Products Inc. Diazabicyclic compounds useful in the treatment of cns and other disorders
DK1551835T3 (da) * 2002-09-30 2007-06-04 Neurosearch As Hidtil ukendte 1,4-diazabicycloalkanderivater, deres fremstilling og anvendelse
US20080227772A1 (en) * 2004-02-04 2008-09-18 Neurosearch A/S Diazabicyclic Aryl Derivatives as Nicotinic Acetylcholine Receptor Ligands
DK1713487T3 (da) * 2004-02-04 2010-04-06 Neurosearch As Diazabicykliske aryl-derivater som kolinerge receptor-modulatorer

Also Published As

Publication number Publication date
WO2009024515A1 (en) 2009-02-26
EP2190846A1 (en) 2010-06-02
AU2008290647A1 (en) 2009-02-26
JP2010536724A (ja) 2010-12-02
US20100286128A1 (en) 2010-11-11
CN101796054A (zh) 2010-08-04
CA2696680A1 (en) 2009-02-26

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