ATE353899T1 - Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung - Google Patents

Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Info

Publication number
ATE353899T1
ATE353899T1 AT03798094T AT03798094T ATE353899T1 AT E353899 T1 ATE353899 T1 AT E353899T1 AT 03798094 T AT03798094 T AT 03798094T AT 03798094 T AT03798094 T AT 03798094T AT E353899 T1 ATE353899 T1 AT E353899T1
Authority
AT
Austria
Prior art keywords
diseases
disorders
compounds
nervous system
disorders related
Prior art date
Application number
AT03798094T
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Nielsen
Tino Joergensen
Philip K Ahring
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE353899T1 publication Critical patent/ATE353899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
AT03798094T 2002-09-30 2003-09-29 Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung ATE353899T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15

Publications (1)

Publication Number Publication Date
ATE353899T1 true ATE353899T1 (de) 2007-03-15

Family

ID=32045613

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03798094T ATE353899T1 (de) 2002-09-30 2003-09-29 Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung
AT07101576T ATE426602T1 (de) 2002-09-30 2003-09-29 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07101576T ATE426602T1 (de) 2002-09-30 2003-09-29 1,4-diazabicycloalkanderivate, deren herstellung und verwendung

Country Status (11)

Country Link
US (1) US7220741B2 (de)
EP (2) EP1551835B1 (de)
AT (2) ATE353899T1 (de)
AU (1) AU2003266222B2 (de)
CA (1) CA2496585C (de)
DE (2) DE60326894D1 (de)
DK (1) DK1551835T3 (de)
ES (1) ES2280836T3 (de)
NZ (1) NZ538512A (de)
PL (1) PL375025A1 (de)
WO (1) WO2004029053A1 (de)

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DE602006016926D1 (de) 2005-02-16 2010-10-28 Neurosearch As Neue diazabicyclische arylderivate und medizinische verwendung dafür
ATE495178T1 (de) 2005-02-16 2011-01-15 Neurosearch As Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren
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US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
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EP2190847A1 (de) * 2007-08-17 2010-06-02 Neurosearch A/S Als nikotin-actelcholin-rezeptor-liganden geeignete neuartige 1,4-diaza-bicyclo-[3,2,2,]-nonyl-oxadiazolyl-derivate
EP2190848A1 (de) 2007-08-17 2010-06-02 Neurosearch A/S Als nikotin-actelcholin-rezeptorliganden geeignete neuartige 1,4-diaza-bicyclo[3.2.2]nonyl-heteroaryl-derivate
CA2696680A1 (en) * 2007-08-17 2009-02-26 Neurosearch A/S 1,4-diaza-bicycl0(3.2.2)n0nyl pyrimidinyl derivatives useful as nicotinic acetylcholine- receptor ligands
DE102007053771A1 (de) * 2007-11-12 2009-05-14 Merck Patent Gmbh Organische Elektrolumineszenzvorrichtungen
EP2209783B8 (de) * 2007-11-14 2016-06-01 Saniona A/S Neuartige 1,4-diaza-bicyclo-[3,2,2]-nonyl-pyrimidin-derivate und ihre medizinische verwendung
WO2009062989A1 (en) * 2007-11-14 2009-05-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
GB0723719D0 (en) * 2007-12-04 2008-01-16 Glaxo Group Ltd Compounds
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
GB0723814D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
WO2009100294A2 (en) 2008-02-07 2009-08-13 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
KR20100125307A (ko) 2008-03-11 2010-11-30 뉴로서치 에이/에스 니코틴성 아세틸콜린 수용체의 조절제로서 유용한 신규한 1,4-디아자-비사이클로[3.2.2]노닐 옥사디아졸릴 유도체
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
WO2009150138A1 (en) * 2008-06-10 2009-12-17 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010018352A1 (en) * 2008-08-12 2010-02-18 Argenta Discovery Limited Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated
WO2010043539A1 (en) * 2008-10-13 2010-04-22 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
US20120028967A1 (en) 2009-01-21 2012-02-02 Neurosearch A/S Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use
WO2010084120A1 (en) 2009-01-21 2010-07-29 Neurosearch A/S N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands
EP2389380A1 (de) * 2009-01-26 2011-11-30 NeuroSearch A/S N-oxide von diazabicyclononylpyrimidinderivaten und deren medizinische verwendung
MX2011007449A (es) 2009-01-26 2011-10-24 Neurosearch As Derivados de indolil-oxadiazolil-diazabiciclononano y su uso medico y diagnostico.
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086278A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
WO2011058002A1 (en) 2009-11-11 2011-05-19 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
US8946412B2 (en) * 2009-12-18 2015-02-03 Danpet Ab Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
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LT3386511T (lt) 2015-12-10 2021-08-25 Ptc Therapeutics, Inc. Hantingtono ligos gydymo būdai
MX2019014514A (es) 2017-06-05 2020-07-20 Ptc Therapeutics Inc Compuestos para tratar la enfermedad de huntington.
CA3067591A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
EP3645121A4 (de) 2017-06-28 2021-03-17 PTC Therapeutics, Inc. Verfahren zur behandlung von morbus huntington
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
EA202092001A1 (ru) 2018-03-27 2021-01-29 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения болезни гентингтона
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FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2804430B1 (fr) 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
FR2809731B1 (fr) 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
US20020086871A1 (en) 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
FR2832712B1 (fr) 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
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Also Published As

Publication number Publication date
DE60326894D1 (de) 2009-05-07
EP1551835A1 (de) 2005-07-13
DE60311853T2 (de) 2007-06-21
AU2003266222A1 (en) 2004-04-19
WO2004029053A1 (en) 2004-04-08
ES2280836T3 (es) 2007-09-16
US20060122172A1 (en) 2006-06-08
EP1785425B1 (de) 2009-03-25
DE60311853D1 (de) 2007-03-29
AU2003266222B2 (en) 2009-10-01
CA2496585A1 (en) 2004-04-08
EP1785425A3 (de) 2007-06-06
ATE426602T1 (de) 2009-04-15
CA2496585C (en) 2012-05-29
EP1785425A2 (de) 2007-05-16
US7220741B2 (en) 2007-05-22
NZ538512A (en) 2006-12-22
PL375025A1 (en) 2005-11-14
DK1551835T3 (da) 2007-06-04
EP1551835B1 (de) 2007-02-14

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