ATE518862T1 - Neue 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivate und deren medizinische verwendung - Google Patents
Neue 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivate und deren medizinische verwendungInfo
- Publication number
- ATE518862T1 ATE518862T1 AT10154049T AT10154049T ATE518862T1 AT E518862 T1 ATE518862 T1 AT E518862T1 AT 10154049 T AT10154049 T AT 10154049T AT 10154049 T AT10154049 T AT 10154049T AT E518862 T1 ATE518862 T1 AT E518862T1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80902406P | 2006-05-30 | 2006-05-30 | |
DKPA200600731 | 2006-05-30 |
Publications (1)
Publication Number | Publication Date |
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ATE518862T1 true ATE518862T1 (de) | 2011-08-15 |
Family
ID=40616686
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT10154049T ATE518862T1 (de) | 2006-05-30 | 2007-05-29 | Neue 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivate und deren medizinische verwendung |
AT07729591T ATE463497T1 (de) | 2006-05-30 | 2007-05-29 | Neues 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivat und seine medizinische verwendung |
AT07729590T ATE467634T1 (de) | 2006-05-30 | 2007-05-29 | Neuartige 1,4-diaza-bicycloä3.2.2ünonyl- oxadiazolyl-derivate und ihre medizinische verwendung |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07729591T ATE463497T1 (de) | 2006-05-30 | 2007-05-29 | Neues 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivat und seine medizinische verwendung |
AT07729590T ATE467634T1 (de) | 2006-05-30 | 2007-05-29 | Neuartige 1,4-diaza-bicycloä3.2.2ünonyl- oxadiazolyl-derivate und ihre medizinische verwendung |
Country Status (23)
Country | Link |
---|---|
US (4) | US8158619B2 (de) |
EP (3) | EP2194056B1 (de) |
JP (2) | JP2009538866A (de) |
KR (1) | KR101458194B1 (de) |
CN (2) | CN101426790B (de) |
AT (3) | ATE518862T1 (de) |
AU (2) | AU2007267175A1 (de) |
BR (1) | BRPI0708843A2 (de) |
CA (2) | CA2653818A1 (de) |
DE (2) | DE602007005802D1 (de) |
DK (2) | DK2032574T3 (de) |
ES (1) | ES2342334T3 (de) |
IL (1) | IL193925A (de) |
MX (2) | MX2008014886A (de) |
MY (1) | MY147764A (de) |
NO (1) | NO20085398L (de) |
NZ (1) | NZ571288A (de) |
PL (1) | PL2032575T3 (de) |
PT (1) | PT2032575E (de) |
RU (1) | RU2427581C2 (de) |
UA (1) | UA95946C2 (de) |
WO (2) | WO2007138037A1 (de) |
ZA (1) | ZA200807756B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007267175A1 (en) * | 2006-05-30 | 2007-12-06 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use |
JP2010507619A (ja) * | 2006-10-25 | 2010-03-11 | ノイロサーチ アクティーゼルスカブ | オキサジアゾール及びチアジアゾール化合物並びにニコチン性アセチルコリン受容体調節物質としてのその使用 |
US7935695B2 (en) | 2007-08-17 | 2011-05-03 | Neurosearch A/S | 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands |
EP2257550A1 (de) * | 2008-03-11 | 2010-12-08 | NeuroSearch A/S | Neuartige 1,4-diaza-bicyclo¦3.2.2 nonyl-oxadiazolyl-derivate als modulatoren von nikotinacetylcholin-rezeptoren |
EP2288608A1 (de) * | 2008-06-10 | 2011-03-02 | NeuroSearch A/S | Neuartige oxadiazolyl-diazabicyclononanderivate und deren medizinische verwendung |
WO2010043539A1 (en) * | 2008-10-13 | 2010-04-22 | Neurosearch A/S | Novel oxadiazolyl-diazabicyclononane derivatives and their medical use |
US20110257161A1 (en) * | 2008-12-04 | 2011-10-20 | Neurosearch A/S | Novel diaza-bicyclononyl-phenyl derivatives and their medical use |
US8778928B2 (en) | 2009-01-26 | 2014-07-15 | Danpet Ab | Indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use |
US20110319397A1 (en) | 2009-01-27 | 2011-12-29 | Neurosearch A/S | Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010086279A1 (en) | 2009-01-27 | 2010-08-05 | Neurosearch A/S | Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010086278A1 (en) | 2009-01-27 | 2010-08-05 | Neurosearch A/S | Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010130768A1 (en) * | 2009-05-14 | 2010-11-18 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
EP2498826A1 (de) | 2009-11-11 | 2012-09-19 | NeuroSearch AS | Markierte pyrrolyl-oxadiazolyl-diazabicyclononanderivative und ihre verwendung für diagnoseverfahren |
EP2513097A1 (de) | 2009-12-18 | 2012-10-24 | NeuroSearch AS | Diazabicyclononyl-oxadiazol-verbindungen und ihre verwendung als nikotinische acetylcholinrezeptormodulatoren |
WO2012139925A1 (en) | 2011-04-15 | 2012-10-18 | Neurosearch A/S | Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
EP3689863A1 (de) | 2017-08-04 | 2020-08-05 | Skyhawk Therapeutics, Inc. | Verfahren und zusammensetzungen zur modulierung der spleissung |
PT3781561T (pt) | 2018-04-18 | 2024-06-18 | Constellation Pharmaceuticals Inc | Moduladores de enzimas modificadoras de metilo, composições e usos dos mesmos |
WO2019226491A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
CN113660936A (zh) * | 2019-02-04 | 2021-11-16 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
WO2020163405A1 (en) | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
KR20210135507A (ko) | 2019-02-06 | 2021-11-15 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2809732B1 (fr) | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
FR2809731B1 (fr) | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
FR2832713B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
FR2832712B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
ATE426602T1 (de) | 2002-09-30 | 2009-04-15 | Neurosearch As | 1,4-diazabicycloalkanderivate, deren herstellung und verwendung |
RU2323218C2 (ru) * | 2002-09-30 | 2008-04-27 | НьюроСёрч А/С | Новые производные 1,4-диазабициклоалкана и фармацевтическая композиция на их основе |
DK1562945T3 (da) * | 2002-11-11 | 2007-03-05 | Neurosearch As | Hidtil ukendte diazebicykliske biarylderivater |
US6996399B2 (en) * | 2003-01-13 | 2006-02-07 | Micrel, Inc. | Wireless device and method using frequency hopping and sweep modes |
EP2172469A1 (de) * | 2004-02-04 | 2010-04-07 | NeuroSearch A/S | Diazabicyclische Arylderivate als Modulatoren cholinergischer Receptoren |
WO2006087306A2 (en) | 2005-02-16 | 2006-08-24 | Neurosearch A/S | Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors |
AU2007267175A1 (en) * | 2006-05-30 | 2007-12-06 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use |
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2007
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