DE60309740D1 - 1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung - Google Patents

1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung

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Publication number
DE60309740D1
DE60309740D1 DE60309740T DE60309740T DE60309740D1 DE 60309740 D1 DE60309740 D1 DE 60309740D1 DE 60309740 T DE60309740 T DE 60309740T DE 60309740 T DE60309740 T DE 60309740T DE 60309740 D1 DE60309740 D1 DE 60309740D1
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DE
Germany
Prior art keywords
diseases
disorders
dizabicyclo
preparation
nervous system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60309740T
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English (en)
Other versions
DE60309740T2 (de
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Ostergaard Nielsen
Tino Dyhring Jorgensen
Philip K Ahring
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NTG Nordic Transport Group AS
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Neurosearch AS
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Publication of DE60309740D1 publication Critical patent/DE60309740D1/de
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Publication of DE60309740T2 publication Critical patent/DE60309740T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
DE60309740T 2002-11-11 2003-11-10 1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zu ihrer herstellung und therapeutical verwendung Expired - Lifetime DE60309740T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201737 2002-11-11
DK200201737 2002-11-11
PCT/DK2003/000769 WO2004043960A1 (en) 2002-11-11 2003-11-10 1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof

Publications (2)

Publication Number Publication Date
DE60309740D1 true DE60309740D1 (de) 2006-12-28
DE60309740T2 DE60309740T2 (de) 2007-03-29

Family

ID=32309262

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60309740T Expired - Lifetime DE60309740T2 (de) 2002-11-11 2003-11-10 1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zu ihrer herstellung und therapeutical verwendung

Country Status (7)

Country Link
EP (1) EP1562945B1 (de)
JP (1) JP2006508109A (de)
AT (1) ATE345342T1 (de)
AU (1) AU2003280309A1 (de)
DE (1) DE60309740T2 (de)
DK (1) DK1562945T3 (de)
WO (1) WO2004043960A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
EP1603585A2 (de) 2003-03-14 2005-12-14 Bristol-Myers Squibb Company Polynucleotid kodierend für eine neue humane g-proteingekoppelte rezeptor-variante von hm74, hgprbmy74
SE0303076D0 (sv) * 2003-11-19 2003-11-19 Astrazeneca Ab 5-substituted imidazoles
SE0303075D0 (sv) * 2003-11-19 2003-11-19 Astrazeneca Ab 4-substituted imidazoles
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
EP1819709B1 (de) * 2004-11-30 2009-02-11 Neurosearch A/S Neuartige diazabicyclische arylderivate als cholinerge liganden
WO2006087305A1 (en) 2005-02-16 2006-08-24 Neurosearch A/S Novel diazabicyclic aryl derivatives and their medical use
US7662812B2 (en) 2005-02-16 2010-02-16 Neurosearch A/S Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors
CA2632642A1 (en) 2005-12-06 2007-06-14 Neurosearch A/S Novel diazabicyclic aryl derivatives and their medical use
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
EP1987032A1 (de) * 2006-02-14 2008-11-05 NeuroSearch A/S 3, 9-diazabicyclo(3.3.1)non-3-yl-arylmethanon-derivate als nikotin-acetylcholin-rezeptoragonisten
JP2009538868A (ja) 2006-05-30 2009-11-12 ノイロサーチ アクティーゼルスカブ 新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルピリミジニル誘導体及びその医学的使用
ES2342334T3 (es) * 2006-05-30 2010-07-05 Neurosearch A/S Nuevo derivado del 1,4-diaza-biciclo(3.2.2.)nonilo oxadiazolilo y su uso medico.
US8778987B2 (en) 2007-03-13 2014-07-15 Symrise Ag Use of 4-hydroxychalcone derivatives for masking an unpleasant taste
EP1977655B1 (de) 2007-03-29 2011-05-18 Symrise AG Aromakompositionen von Alkamiden mit Hesperetin und/oder 4-Hydroxydihydrochalkonen und deren Salzen zur Verstärkung süßer sensorischer Eindrücke
AU2008322958A1 (en) 2007-11-14 2009-05-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
PL3029039T3 (pl) 2010-05-17 2018-04-30 Forum Pharmaceuticals Inc. Formulacje farmaceutyczne zawierające postacie krystaliczne jednowodnego chlorowodorku (R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidu
EP2559346B1 (de) 2011-08-15 2014-03-26 Symrise AG Oleanen-artige Triterpenglycoside als Maskierungsmittel
EP2846796A4 (de) 2012-05-08 2015-10-21 Forum Pharmaceuticals Inc Verfahren zur aufrechterhaltung, behandlung oder verbesserung der kognitiven funktion
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
EP3027600B1 (de) 2013-07-31 2022-04-06 Novartis AG 1,4-disubstituierte pyridazin-derivate sowie ihre verwendung zur behandlung von krankheiten in zusammenhang mit smn-defiziten

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2809730B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique
FR2809731B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
FR2832712B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
FR2832714B1 (fr) * 2001-11-23 2004-07-16 Sanofi Synthelabo Derives de 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2832713B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
DE10162442A1 (de) * 2001-12-19 2003-07-03 Bayer Ag Monocyclische N-Aryl-amide

Also Published As

Publication number Publication date
EP1562945B1 (de) 2006-11-15
DK1562945T3 (da) 2007-03-05
AU2003280309A1 (en) 2004-06-03
WO2004043960A1 (en) 2004-05-27
EP1562945A1 (de) 2005-08-17
DE60309740T2 (de) 2007-03-29
JP2006508109A (ja) 2006-03-09
ATE345342T1 (de) 2006-12-15

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