ATE467634T1 - Neuartige 1,4-diaza-bicycloä3.2.2ünonyl- oxadiazolyl-derivate und ihre medizinische verwendung - Google Patents

Neuartige 1,4-diaza-bicycloä3.2.2ünonyl- oxadiazolyl-derivate und ihre medizinische verwendung

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Publication number
ATE467634T1
ATE467634T1 AT07729590T AT07729590T ATE467634T1 AT E467634 T1 ATE467634 T1 AT E467634T1 AT 07729590 T AT07729590 T AT 07729590T AT 07729590 T AT07729590 T AT 07729590T AT E467634 T1 ATE467634 T1 AT E467634T1
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AT
Austria
Prior art keywords
diseases
disorders
diaza
novel
compounds
Prior art date
Application number
AT07729590T
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English (en)
Inventor
Dan Peters
Gunnar Olsen
Elsebet Nielsen
Daniel Timmermann
Steven Loechel
Jens Mikkelsen
Henrik Hansen
John Paul Redrobe
Jeppe Christensen
Tino Dyhring
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Neurosearch As
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Publication of ATE467634T1 publication Critical patent/ATE467634T1/de

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
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AT07729590T 2006-05-30 2007-05-29 Neuartige 1,4-diaza-bicycloä3.2.2ünonyl- oxadiazolyl-derivate und ihre medizinische verwendung ATE467634T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80902406P 2006-05-30 2006-05-30
DKPA200600731 2006-05-30
PCT/EP2007/055168 WO2007138037A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (1)

Publication Number Publication Date
ATE467634T1 true ATE467634T1 (de) 2010-05-15

Family

ID=40616686

Family Applications (3)

Application Number Title Priority Date Filing Date
AT07729591T ATE463497T1 (de) 2006-05-30 2007-05-29 Neues 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivat und seine medizinische verwendung
AT10154049T ATE518862T1 (de) 2006-05-30 2007-05-29 Neue 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivate und deren medizinische verwendung
AT07729590T ATE467634T1 (de) 2006-05-30 2007-05-29 Neuartige 1,4-diaza-bicycloä3.2.2ünonyl- oxadiazolyl-derivate und ihre medizinische verwendung

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT07729591T ATE463497T1 (de) 2006-05-30 2007-05-29 Neues 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivat und seine medizinische verwendung
AT10154049T ATE518862T1 (de) 2006-05-30 2007-05-29 Neue 1,4-diaza-bicycloä3.2.2ünonyl-oxadiazolyl- derivate und deren medizinische verwendung

Country Status (23)

Country Link
US (4) US7807667B2 (de)
EP (3) EP2032575B1 (de)
JP (2) JP2009538866A (de)
KR (1) KR101458194B1 (de)
CN (2) CN101432286A (de)
AT (3) ATE463497T1 (de)
AU (2) AU2007267175A1 (de)
BR (1) BRPI0708843A2 (de)
CA (2) CA2653769A1 (de)
DE (2) DE602007006486D1 (de)
DK (2) DK2032575T3 (de)
ES (1) ES2342334T3 (de)
IL (1) IL193925A (de)
MX (2) MX2008014886A (de)
MY (1) MY147764A (de)
NO (1) NO20085398L (de)
NZ (1) NZ571288A (de)
PL (1) PL2032575T3 (de)
PT (1) PT2032575E (de)
RU (1) RU2427581C2 (de)
UA (1) UA95946C2 (de)
WO (2) WO2007138038A1 (de)
ZA (1) ZA200807756B (de)

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MX2009003892A (es) * 2006-10-25 2009-04-23 Neurosearch As Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico.
EP2190848A1 (de) 2007-08-17 2010-06-02 Neurosearch A/S Als nikotin-actelcholin-rezeptorliganden geeignete neuartige 1,4-diaza-bicyclo[3.2.2]nonyl-heteroaryl-derivate
KR20100125307A (ko) 2008-03-11 2010-11-30 뉴로서치 에이/에스 니코틴성 아세틸콜린 수용체의 조절제로서 유용한 신규한 1,4-디아자-비사이클로[3.2.2]노닐 옥사디아졸릴 유도체
WO2009150138A1 (en) * 2008-06-10 2009-12-17 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
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MX2011007449A (es) 2009-01-26 2011-10-24 Neurosearch As Derivados de indolil-oxadiazolil-diazabiciclononano y su uso medico y diagnostico.
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WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
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TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α7活化劑之用途
WO2011058002A1 (en) 2009-11-11 2011-05-19 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
US8946412B2 (en) 2009-12-18 2015-02-03 Danpet Ab Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
CA3098428A1 (en) 2018-04-18 2019-10-24 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
WO2019226491A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
JP2022519294A (ja) * 2019-02-04 2022-03-22 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
KR20210135507A (ko) 2019-02-06 2021-11-15 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물

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Publication number Publication date
MY147764A (en) 2013-01-31
CN101426790B (zh) 2012-03-14
US20090118266A1 (en) 2009-05-07
DE602007005802D1 (de) 2010-05-20
JP5290964B2 (ja) 2013-09-18
AU2007267174B2 (en) 2012-08-02
CA2653769A1 (en) 2007-12-06
DE602007006486D1 (de) 2010-06-24
US8158619B2 (en) 2012-04-17
EP2032574A1 (de) 2009-03-11
US20120172353A1 (en) 2012-07-05
PT2032575E (pt) 2010-07-09
MX2008014886A (es) 2008-12-05
US20100317654A1 (en) 2010-12-16
EP2194056A1 (de) 2010-06-09
ES2342334T3 (es) 2010-07-05
EP2032574B1 (de) 2010-05-12
ATE518862T1 (de) 2011-08-15
CN101432286A (zh) 2009-05-13
JP2009538867A (ja) 2009-11-12
RU2008139481A (ru) 2010-07-10
WO2007138037A1 (en) 2007-12-06
DK2032575T3 (da) 2010-07-12
CA2653818A1 (en) 2007-12-06
AU2007267174A1 (en) 2007-12-06
BRPI0708843A2 (pt) 2011-06-14
CN101426790A (zh) 2009-05-06
DK2032574T3 (da) 2010-09-20
PL2032575T3 (pl) 2010-09-30
UA95946C2 (ru) 2011-09-26
KR101458194B1 (ko) 2014-11-03
KR20090015155A (ko) 2009-02-11
ATE463497T1 (de) 2010-04-15
NZ571288A (en) 2011-05-27
AU2007267175A1 (en) 2007-12-06
US20100216780A1 (en) 2010-08-26
JP2009538866A (ja) 2009-11-12
MX2008014887A (es) 2008-12-05
NO20085398L (no) 2008-12-29
ZA200807756B (en) 2009-11-25
US8372832B2 (en) 2013-02-12
EP2032575B1 (de) 2010-04-07
WO2007138038A1 (en) 2007-12-06
EP2032575A1 (de) 2009-03-11
IL193925A (en) 2013-08-29
US7807667B2 (en) 2010-10-05
US8101598B2 (en) 2012-01-24
EP2194056B1 (de) 2011-08-03
RU2427581C2 (ru) 2011-08-27

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