ATE477253T1 - Neuartige oxadiazol-derivate und deren medizinische verwendung - Google Patents
Neuartige oxadiazol-derivate und deren medizinische verwendungInfo
- Publication number
- ATE477253T1 ATE477253T1 AT06754801T AT06754801T ATE477253T1 AT E477253 T1 ATE477253 T1 AT E477253T1 AT 06754801 T AT06754801 T AT 06754801T AT 06754801 T AT06754801 T AT 06754801T AT E477253 T1 ATE477253 T1 AT E477253T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- disorders
- oxadiazole derivatives
- medical use
- novel oxadiazole
- Prior art date
Links
- 150000004866 oxadiazoles Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
- 201000010099 disease Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 2
- 208000017701 Endocrine disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000030172 endocrine system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000016160 smooth muscle contraction Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67471105P | 2005-04-26 | 2005-04-26 | |
| DKPA200500612 | 2005-04-26 | ||
| PCT/EP2006/061773 WO2006114400A1 (en) | 2005-04-26 | 2006-04-24 | Novel oxadiazole derivatives and their medical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE477253T1 true ATE477253T1 (de) | 2010-08-15 |
Family
ID=36697471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06754801T ATE477253T1 (de) | 2005-04-26 | 2006-04-24 | Neuartige oxadiazol-derivate und deren medizinische verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8017631B2 (de) |
| EP (1) | EP1881979B1 (de) |
| JP (1) | JP2008539195A (de) |
| KR (1) | KR20080000622A (de) |
| AT (1) | ATE477253T1 (de) |
| AU (1) | AU2006239418A1 (de) |
| CA (1) | CA2606087A1 (de) |
| IL (1) | IL186360A0 (de) |
| MX (1) | MX2007013263A (de) |
| NO (1) | NO20076036L (de) |
| RU (1) | RU2007139255A (de) |
| WO (1) | WO2006114400A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790757B2 (en) | 1998-06-16 | 2010-09-07 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| IL169855A (en) * | 2005-07-25 | 2014-05-28 | Elta Systems Ltd | A system and method for locating a receiver location |
| AU2006272978B2 (en) | 2005-07-26 | 2012-06-07 | Bial - Portela & Ca, S.A. | Nitrocatechol derivatives as COMT inhibitors |
| EP1845097A1 (de) | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazolderivate als COMT Inihibitoren |
| US20100234349A1 (en) * | 2006-09-04 | 2010-09-16 | Olsen Gunnar M | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| AR061841A1 (es) | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
| CL2007002593A1 (es) | 2006-09-07 | 2008-06-13 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 4-heteroaril-piridina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como rechazo de organos transplantados, sindromes autoinmunes y cancer. |
| SI2069335T1 (sl) | 2006-09-08 | 2013-04-30 | Actelion Pharmaceuticals Ltd. | Derivati piridin-3-ila kot imunomodulacijska sredstva |
| EP2069318B1 (de) | 2006-09-21 | 2012-09-12 | Actelion Pharmaceuticals Ltd. | Phenylderivate und ihre verwendung als immunmodulatoren |
| DE102006050516A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dihydropyrazolone und ihre Verwendung |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| CN101631548B (zh) | 2007-01-31 | 2014-08-27 | 比艾尔-坡特拉有限公司 | Comt抑制剂的单次药物剂量单元和药物组合物 |
| JP2010521450A (ja) | 2007-03-16 | 2010-06-24 | アクテリオン ファーマシューティカルズ リミテッド | S1p1/edg1受容体アゴニストとしてのアミノ−ピリジン誘導体 |
| HUE036519T2 (hu) * | 2007-08-13 | 2018-07-30 | Monsanto Technology Llc | Készítmények és eljárások nematódák irtására |
| PL2195311T3 (pl) | 2007-08-17 | 2011-08-31 | Actelion Pharmaceuticals Ltd | Pochodne pirydynowe jako modulatory receptora S1P1/EDG1 |
| US20090170842A1 (en) * | 2007-11-14 | 2009-07-02 | University Of Kansas | Brca1-based breast or ovarian cancer prevention agents and methods of use |
| CN102026995B (zh) | 2007-12-07 | 2014-10-29 | Abbvie德国有限责任两合公司 | 5,6-二取代的羟吲哚衍生物和其用途 |
| EP2231643B1 (de) | 2007-12-07 | 2012-10-31 | Abbott GmbH & Co. KG | Amidomethyl-substitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen |
| CN101952276B (zh) | 2007-12-07 | 2014-10-22 | Abbvie德国有限责任两合公司 | 5-卤素取代的羟吲哚衍生物和其用于治疗加压素依赖性疾病的用途 |
| US8703774B2 (en) | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases |
| BRPI0820868A2 (pt) | 2007-12-10 | 2019-09-24 | Actelion Pharmaceuticals Ltd | composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado |
| EP2259777A2 (de) * | 2008-02-28 | 2010-12-15 | BIAL - Portela & Ca., S.A. | Pharmazeutische zusammensetzung für schwer lösliche arzneimittel |
| BRPI0910288A2 (pt) | 2008-03-07 | 2019-09-24 | Actelion Pharmaceuticals Ltd | composto de derivados de aminometil benzeno, composição farmacêutica que compreende esse composto e uso do mesmo. |
| AU2009226221A1 (en) | 2008-03-17 | 2009-09-24 | Bial - Portela & Ca., S.A. | Crystal forms of 5- [3- (2, 5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl) [1,2,3] oxadiazol-5-yl] -3-nit robenzene-1, 2-diol |
| US8383658B2 (en) | 2008-06-04 | 2013-02-26 | Abbott Laboratories | Isoxazole based neuronal nicotinic receptor ligands and methods of use |
| JP2011522818A (ja) * | 2008-06-06 | 2011-08-04 | アボット・ラボラトリーズ | 新規1,2,4オキサジアゾール化合物およびこれらの使用方法 |
| BRPI0917693A2 (pt) * | 2008-09-02 | 2016-05-17 | Neurosearch As | composto derivado de triazol, composição farmacêutica, e, uso de um derivado de triazol |
| KR101318689B1 (ko) * | 2008-09-25 | 2013-10-16 | 주식회사 녹십자 | 칸나비노이드 cb1 수용체 길항제로서 황 함유 피라졸-헤테로사이클 유도체 |
| WO2010080757A2 (en) * | 2009-01-07 | 2010-07-15 | Astrazeneca Ab | Combinations with an alpha-4beta-2 nicotinic agonist |
| HUE025314T2 (en) | 2009-02-10 | 2016-02-29 | Monsanto Technology Llc | Preparations and procedures for controlling nematodes |
| WO2010106106A1 (en) * | 2009-03-19 | 2010-09-23 | Neurosearch A/S | 2, 5-disubstituted tetrazole derivatives and their use as nicotinic acetylcholine receptor modulators |
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| US3574842A (en) | 1969-11-10 | 1971-04-13 | American Cyanamid Co | Compositions of 4-(1,2,4-oxadiazole-3 or 5-yl)pyridinium salts and method of lowering blood sugar levels with same |
| US4022901A (en) * | 1975-03-05 | 1977-05-10 | E. R. Squibb & Sons, Inc. | 3-Pyridinyl-5-isothiocyanophenyl oxadiazoles |
| DE2709660A1 (de) * | 1977-03-05 | 1978-09-07 | Basf Ag | Sulfonsaeuregruppenhaltige azofarbstoffe mit oxdiazolylresten |
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| CN1859908A (zh) * | 2003-10-01 | 2006-11-08 | 默克公司 | 作为s1p受体激动剂的3,5-芳基、杂芳基或环烷基取代的-1,2,4-噁二唑类化合物 |
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-
2006
- 2006-04-24 WO PCT/EP2006/061773 patent/WO2006114400A1/en not_active Ceased
- 2006-04-24 CA CA002606087A patent/CA2606087A1/en not_active Abandoned
- 2006-04-24 US US11/919,146 patent/US8017631B2/en not_active Expired - Fee Related
- 2006-04-24 JP JP2008508201A patent/JP2008539195A/ja active Pending
- 2006-04-24 KR KR1020077024814A patent/KR20080000622A/ko not_active Withdrawn
- 2006-04-24 MX MX2007013263A patent/MX2007013263A/es not_active Application Discontinuation
- 2006-04-24 AT AT06754801T patent/ATE477253T1/de not_active IP Right Cessation
- 2006-04-24 RU RU2007139255/04A patent/RU2007139255A/ru not_active Application Discontinuation
- 2006-04-24 EP EP06754801A patent/EP1881979B1/de not_active Expired - Lifetime
- 2006-04-24 AU AU2006239418A patent/AU2006239418A1/en not_active Abandoned
-
2007
- 2007-10-07 IL IL186360A patent/IL186360A0/en unknown
- 2007-11-23 NO NO20076036A patent/NO20076036L/no not_active Application Discontinuation
-
2011
- 2011-07-29 US US13/194,193 patent/US20110294856A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080000622A (ko) | 2008-01-02 |
| CA2606087A1 (en) | 2006-11-02 |
| WO2006114400A1 (en) | 2006-11-02 |
| EP1881979A1 (de) | 2008-01-30 |
| MX2007013263A (es) | 2008-01-22 |
| JP2008539195A (ja) | 2008-11-13 |
| AU2006239418A1 (en) | 2006-11-02 |
| IL186360A0 (en) | 2008-01-20 |
| EP1881979B1 (de) | 2010-08-11 |
| US8017631B2 (en) | 2011-09-13 |
| RU2007139255A (ru) | 2009-06-10 |
| US20110294856A1 (en) | 2011-12-01 |
| NO20076036L (no) | 2007-11-23 |
| US20090312347A1 (en) | 2009-12-17 |
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