UA99443C2 - Соединения оксадиазола и тиадиазола и их применение в качестве модуляторов никотиновых рецепторов ацетилхолина - Google Patents

Соединения оксадиазола и тиадиазола и их применение в качестве модуляторов никотиновых рецепторов ацетилхолина

Info

Publication number
UA99443C2
UA99443C2 UAA200903386A UAA200903386A UA99443C2 UA 99443 C2 UA99443 C2 UA 99443C2 UA A200903386 A UAA200903386 A UA A200903386A UA A200903386 A UAA200903386 A UA A200903386A UA 99443 C2 UA99443 C2 UA 99443C2
Authority
UA
Ukraine
Prior art keywords
diseases
disorders
nicotinic acetylcholine
oxadiazole
receptor modulators
Prior art date
Application number
UAA200903386A
Other languages
English (en)
Ukrainian (uk)
Inventor
Бьярне Г. Даль
Дан ПЕТЕРС
Гуннар М. Ольсен
Даниэль Б. Тиммерманн
Сусанне Йергенсен
Original Assignee
Ньюросерч А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюросерч А/С filed Critical Ньюросерч А/С
Publication of UA99443C2 publication Critical patent/UA99443C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Представленное изобретение касается производных оксадиазолила и тиадиазолила формулы (I)(I),фармацевтической композиции на их основе, а также применения для лечения или предупреждения заболеваний или расстройств, зависимых от модуляции холинергических рецепторов.
UAA200903386A 2006-10-25 2007-10-24 Соединения оксадиазола и тиадиазола и их применение в качестве модуляторов никотиновых рецепторов ацетилхолина UA99443C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200601380 2006-10-25

Publications (1)

Publication Number Publication Date
UA99443C2 true UA99443C2 (ru) 2012-08-27

Family

ID=40996458

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200903386A UA99443C2 (ru) 2006-10-25 2007-10-24 Соединения оксадиазола и тиадиазола и их применение в качестве модуляторов никотиновых рецепторов ацетилхолина

Country Status (7)

Country Link
KR (1) KR20090069183A (ru)
CN (1) CN101553486A (ru)
BR (1) BRPI0717306A2 (ru)
NZ (1) NZ575354A (ru)
RU (1) RU2009113451A (ru)
UA (1) UA99443C2 (ru)
ZA (1) ZA200901521B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2563113T3 (es) * 2011-02-25 2016-03-10 Janssen Pharmaceutica, N.V. (Piridin-4-il)bencilamidas como moduladores alostéricos de nAChR alfa 7
CN103420998A (zh) * 2012-05-16 2013-12-04 苏州爱斯鹏药物研发有限责任公司 一种新型噁二唑衍生物的合成方法
CN111362930B (zh) * 2020-04-15 2023-02-03 安徽医科大学 一种1，2，4-噁二唑-吡啶类化合物及其应用

Also Published As

Publication number Publication date
CN101553486A (zh) 2009-10-07
KR20090069183A (ko) 2009-06-29
ZA200901521B (en) 2010-06-30
RU2009113451A (ru) 2010-11-27
NZ575354A (en) 2012-05-25
BRPI0717306A2 (pt) 2014-04-15

Similar Documents

Publication Publication Date Title
MX2009003892A (es) Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico.
IL186360A0 (en) Novel oxadiazole derivatives and their medical use
MX2010001135A (es) Nuevos derivados de 1,2,3-triazol, utiles como modulares de receptores de acetilcolina nicotinicos.
MX2007004269A (es) Derivados de arilo diazabiciclico nuevos y su uso medico.
WO2006087306A3 (en) Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
IL176260A0 (en) Diazabicyclic aryl derivatives as cholinergic receptor modulators
DE602007004307D1 (de) Enantiomerenreine chinuclidinyloxy-pyridazine und ihre verwendung als nikotin-acetylcholin-rezeptorliganden
ZA200807756B (en) Novel 1,4-diaza-bicyclo[3.2.2] nonyl oxadiazolyl derivatives and their medical use
ATE481407T1 (de) Neue diazabicyclische arylderivate und medizinische verwendung dafür
AU2002220517A1 (en) 3-substituted quinuclidines and their use as nicotinic agonists
MXPA04010966A (es) Derivados novedosos de biarilo diazabiciclico.
ATE437880T1 (de) Dimere azacyclische verbindungen und deren verwendung
WO2005111033A3 (en) Novel azabicyclic aryl derivatives
HK1106513A1 (en) Novel azabicyclic aryl derivatives and their medical use
HK1079528A1 (en) Azacyclic ethynyl derivatives
MXPA05006861A (es) Derivados arildiazabiciclicos novedosos.
MX2010005040A (es) Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico.
DE60307102D1 (de) 3-substituierte chinuklidine und deren verwendung
UA99443C2 (ru) Соединения оксадиазола и тиадиазола и их применение в качестве модуляторов никотиновых рецепторов ацетилхолина
MX2010009580A (es) Nuevos derivados 1,4-diaza-biciclo[3.2.2]nonil-oxadiazolilo utiles como moduladores de los receptores nicotinicos de acetilcolina.
MX2007003331A (es) Nuevos derivados de arilo diazabiciclico.
MX2010004666A (es) Derivados novedosos de 1,4-diaza-biciclo[3.2.2]nonil pirimidina y su uso medico.
ATE460416T1 (de) Neuartige 1,4-diazabicycloä3.2.2ünonan-derivate und deren medizinische verwendung
ATE478869T1 (de) Diazabicycloalkan-derivate und ihre medizinische verwendung
MX2007004245A (es) Nuevos derivados de arilo azabiciclicos y su uso medico.