CN101553486A - 二唑和噻二唑化合物以及它们作为烟碱乙酰胆碱受体调节剂的用途 - Google Patents

二唑和噻二唑化合物以及它们作为烟碱乙酰胆碱受体调节剂的用途 Download PDF

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Publication number
CN101553486A
CN101553486A CNA2007800391836A CN200780039183A CN101553486A CN 101553486 A CN101553486 A CN 101553486A CN A2007800391836 A CNA2007800391836 A CN A2007800391836A CN 200780039183 A CN200780039183 A CN 200780039183A CN 101553486 A CN101553486 A CN 101553486A
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CN
China
Prior art keywords
oxadiazole
phenyl
yls
fluoro
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800391836A
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English (en)
Chinese (zh)
Inventor
B·H·达尔
D·彼得斯
G·M·奥尔森
D·B·蒂默曼
S·哲根森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of CN101553486A publication Critical patent/CN101553486A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2007800391836A 2006-10-25 2007-10-24 二唑和噻二唑化合物以及它们作为烟碱乙酰胆碱受体调节剂的用途 Pending CN101553486A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200601380 2006-10-25
DKPA200601380 2006-10-25

Publications (1)

Publication Number Publication Date
CN101553486A true CN101553486A (zh) 2009-10-07

Family

ID=40996458

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800391836A Pending CN101553486A (zh) 2006-10-25 2007-10-24 二唑和噻二唑化合物以及它们作为烟碱乙酰胆碱受体调节剂的用途

Country Status (7)

Country Link
KR (1) KR20090069183A (ru)
CN (1) CN101553486A (ru)
BR (1) BRPI0717306A2 (ru)
NZ (1) NZ575354A (ru)
RU (1) RU2009113451A (ru)
UA (1) UA99443C2 (ru)
ZA (1) ZA200901521B (ru)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103402983A (zh) * 2011-02-25 2013-11-20 詹森药业有限公司 作为α7nAChR的别构调节剂的(吡啶-4-基)苄基酰胺
CN103420998A (zh) * 2012-05-16 2013-12-04 苏州爱斯鹏药物研发有限责任公司 一种新型噁二唑衍生物的合成方法
CN111362930A (zh) * 2020-04-15 2020-07-03 安徽医科大学 一种1，2，4-噁二唑-吡啶类化合物及其应用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103402983A (zh) * 2011-02-25 2013-11-20 詹森药业有限公司 作为α7nAChR的别构调节剂的(吡啶-4-基)苄基酰胺
CN103402983B (zh) * 2011-02-25 2015-12-23 詹森药业有限公司 作为α7nAChR的别构调节剂的(吡啶-4-基)苄基酰胺
CN103420998A (zh) * 2012-05-16 2013-12-04 苏州爱斯鹏药物研发有限责任公司 一种新型噁二唑衍生物的合成方法
CN111362930A (zh) * 2020-04-15 2020-07-03 安徽医科大学 一种1，2，4-噁二唑-吡啶类化合物及其应用
CN111362930B (zh) * 2020-04-15 2023-02-03 安徽医科大学 一种1，2，4-噁二唑-吡啶类化合物及其应用

Also Published As

Publication number Publication date
KR20090069183A (ko) 2009-06-29
ZA200901521B (en) 2010-06-30
RU2009113451A (ru) 2010-11-27
NZ575354A (en) 2012-05-25
UA99443C2 (ru) 2012-08-27
BRPI0717306A2 (pt) 2014-04-15

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