UA99443C2 - Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators - Google Patents

Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators

Info

Publication number
UA99443C2
UA99443C2 UAA200903386A UAA200903386A UA99443C2 UA 99443 C2 UA99443 C2 UA 99443C2 UA A200903386 A UAA200903386 A UA A200903386A UA A200903386 A UAA200903386 A UA A200903386A UA 99443 C2 UA99443 C2 UA 99443C2
Authority
UA
Ukraine
Prior art keywords
diseases
disorders
nicotinic acetylcholine
oxadiazole
receptor modulators
Prior art date
Application number
UAA200903386A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Бьярне Г. Даль
Дан ПЕТЕРС
Гуннар М. Ольсен
Даниэль Б. Тиммерманн
Сусанне Йергенсен
Original Assignee
Ньюросерч А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюросерч А/С filed Critical Ньюросерч А/С
Publication of UA99443C2 publication Critical patent/UA99443C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.(I)
UAA200903386A 2006-10-25 2007-10-24 Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators UA99443C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200601380 2006-10-25

Publications (1)

Publication Number Publication Date
UA99443C2 true UA99443C2 (en) 2012-08-27

Family

ID=40996458

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200903386A UA99443C2 (en) 2006-10-25 2007-10-24 Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators

Country Status (7)

Country Link
KR (1) KR20090069183A (en)
CN (1) CN101553486A (en)
BR (1) BRPI0717306A2 (en)
NZ (1) NZ575354A (en)
RU (1) RU2009113451A (en)
UA (1) UA99443C2 (en)
ZA (1) ZA200901521B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2563113T3 (en) * 2011-02-25 2016-03-10 Janssen Pharmaceutica, N.V. (Pyridin-4-yl) benzylamides as allosteric modulators of nAChR alpha 7
CN103420998A (en) * 2012-05-16 2013-12-04 苏州爱斯鹏药物研发有限责任公司 Synthesis method of novel oxadiazoles derivative
CN111362930B (en) * 2020-04-15 2023-02-03 安徽医科大学 1,2,4-oxadiazole-pyridine compound and application thereof

Also Published As

Publication number Publication date
CN101553486A (en) 2009-10-07
KR20090069183A (en) 2009-06-29
ZA200901521B (en) 2010-06-30
RU2009113451A (en) 2010-11-27
NZ575354A (en) 2012-05-25
BRPI0717306A2 (en) 2014-04-15

Similar Documents

Publication Publication Date Title
MX2009003892A (en) Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators.
IL186360A0 (en) Novel oxadiazole derivatives and their medical use
MX2010001135A (en) Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors.
MX2007004269A (en) Novel diazabicyclic aryl derivatives and their medical use.
WO2006087306A3 (en) Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
IL176260A0 (en) Diazabicyclic aryl derivatives as cholinergic receptor modulators
DE602007004307D1 (en) ENANTIOMERINE CHINUCLIDINYLOXY PYRIDAZINE AND THEIR USE AS NICOTIN ACETYLCHOLINE RECEPTOR LIGANDS
ZA200807756B (en) Novel 1,4-diaza-bicyclo[3.2.2] nonyl oxadiazolyl derivatives and their medical use
ATE481407T1 (en) NEW DIAZABICYCLIC ARYL DERIVATIVES AND MEDICAL USE THEREOF
AU2002220517A1 (en) 3-substituted quinuclidines and their use as nicotinic agonists
MXPA04010966A (en) Novel diazabicyclic biaryl derivatives.
ATE437880T1 (en) DIMERE AZACYCLIC COMPOUNDS AND THEIR USE
WO2005111033A3 (en) Novel azabicyclic aryl derivatives
HK1106513A1 (en) Novel azabicyclic aryl derivatives and their medical use
HK1079528A1 (en) Azacyclic ethynyl derivatives
MXPA05006861A (en) Novel diazabicyclic aryl derivatives.
MX2010005040A (en) Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use.
DE60307102D1 (en) 3-SUBSTITUTED CHINUCLIDINES AND THEIR USE
UA99443C2 (en) Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
MX2010009580A (en) Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors.
MX2007003331A (en) Novel diazabicyclic aryl derivatives as cholinergy ligands.
MX2010004666A (en) Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use.
ATE460416T1 (en) NOVEL 1,4-DIAZABICYCLOÄ3.2.2ÜNONANE DERIVATIVES AND THEIR MEDICAL USE
ATE478869T1 (en) DIAZABICYCLOALKAN DERIVATIVES AND THEIR MEDICAL USES
MX2007004245A (en) Novel azabicyclic aryl derivatives and their medical use.