CN101426790B - 1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 - Google Patents
1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 Download PDFInfo
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- CN101426790B CN101426790B CN200780014526.3A CN200780014526A CN101426790B CN 101426790 B CN101426790 B CN 101426790B CN 200780014526 A CN200780014526 A CN 200780014526A CN 101426790 B CN101426790 B CN 101426790B
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract
Description
化合物编号 | IC50 (μM) |
A1 | <0.01 |
Claims (20)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200600731 | 2006-05-30 | ||
DKPA200600731 | 2006-05-30 | ||
PCT/EP2007/055169 WO2007138038A1 (en) | 2006-05-30 | 2007-05-29 | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101426790A CN101426790A (zh) | 2009-05-06 |
CN101426790B true CN101426790B (zh) | 2012-03-14 |
Family
ID=40616686
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780014526.3A Expired - Fee Related CN101426790B (zh) | 2006-05-30 | 2007-05-29 | 1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 |
CNA200780015245XA Pending CN101432286A (zh) | 2006-05-30 | 2007-05-29 | 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA200780015245XA Pending CN101432286A (zh) | 2006-05-30 | 2007-05-29 | 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 |
Country Status (23)
Country | Link |
---|---|
US (4) | US8158619B2 (zh) |
EP (3) | EP2032574B1 (zh) |
JP (2) | JP2009538866A (zh) |
KR (1) | KR101458194B1 (zh) |
CN (2) | CN101426790B (zh) |
AT (3) | ATE467634T1 (zh) |
AU (2) | AU2007267174B2 (zh) |
BR (1) | BRPI0708843A2 (zh) |
CA (2) | CA2653769A1 (zh) |
DE (2) | DE602007006486D1 (zh) |
DK (2) | DK2032575T3 (zh) |
ES (1) | ES2342334T3 (zh) |
IL (1) | IL193925A (zh) |
MX (2) | MX2008014887A (zh) |
MY (1) | MY147764A (zh) |
NO (1) | NO20085398L (zh) |
NZ (1) | NZ571288A (zh) |
PL (1) | PL2032575T3 (zh) |
PT (1) | PT2032575E (zh) |
RU (1) | RU2427581C2 (zh) |
UA (1) | UA95946C2 (zh) |
WO (2) | WO2007138037A1 (zh) |
ZA (1) | ZA200807756B (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2032575T3 (pl) | 2006-05-30 | 2010-09-30 | Neurosearch As | Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie |
EP2079734A1 (en) * | 2006-10-25 | 2009-07-22 | NeuroSearch A/S | Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators |
EP2190848A1 (en) | 2007-08-17 | 2010-06-02 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands |
JP2011513459A (ja) * | 2008-03-11 | 2011-04-28 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体のモジュレーターとして有用な、新規な1,4−ジアザ−ビシクロ[3.2.2]ノニルオキサジアゾリル誘導体 |
US20110112078A1 (en) * | 2008-06-10 | 2011-05-12 | Neurosearch A/S | Novel oxadiazolyl-diazabicyclononane derivatives and their medical use |
US20110263577A1 (en) * | 2008-10-13 | 2011-10-27 | Neurosearch A/S | Novel oxadiazolyl-diazabicyclononane derivatives and their medical use |
US20110257161A1 (en) * | 2008-12-04 | 2011-10-20 | Neurosearch A/S | Novel diaza-bicyclononyl-phenyl derivatives and their medical use |
CN102300574A (zh) | 2009-01-26 | 2011-12-28 | 神经研究公司 | 新的吲哚基-*二唑基-二氮杂二环壬烷衍生物及它们的医药和诊断用途 |
US20120028968A1 (en) | 2009-01-27 | 2012-02-02 | Neurosearch A/S | Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010086278A1 (en) | 2009-01-27 | 2010-08-05 | Neurosearch A/S | Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
US20110319397A1 (en) | 2009-01-27 | 2011-12-29 | Neurosearch A/S | Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010130768A1 (en) * | 2009-05-14 | 2010-11-18 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
US20120288443A1 (en) | 2009-11-11 | 2012-11-15 | Neurosearch A/S | Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods |
EP2513097A1 (en) | 2009-12-18 | 2012-10-24 | NeuroSearch AS | Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators |
US8986654B2 (en) | 2011-04-15 | 2015-03-24 | Danpet Ab | Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2019028440A1 (en) | 2017-08-04 | 2019-02-07 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICING |
UA127357C2 (uk) | 2018-04-18 | 2023-07-26 | Констеллатіон Фармацеутікалс, Інк. | Модулятори метилмодифікуючих ферментів, композиції та їх використання |
EP3797108B1 (en) | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP3920910A4 (en) * | 2019-02-04 | 2022-11-09 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING |
WO2020163405A1 (en) | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
CN113677344A (zh) | 2019-02-06 | 2021-11-19 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005074940A1 (en) * | 2004-02-04 | 2005-08-18 | Neurosearch A/S | Diazabicyclic aryl derivatives as cholinergic receptor modulators |
CN1684965A (zh) * | 2002-09-30 | 2005-10-19 | 神经研究公司 | 新的1,4-二氮杂双环烷烃衍生物、其制备和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2809731B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
FR2809732B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
FR2832713B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
FR2832712B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
ATE353899T1 (de) * | 2002-09-30 | 2007-03-15 | Neurosearch As | Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung |
ATE345342T1 (de) * | 2002-11-11 | 2006-12-15 | Neurosearch As | 1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung |
US6996399B2 (en) * | 2003-01-13 | 2006-02-07 | Micrel, Inc. | Wireless device and method using frequency hopping and sweep modes |
EP1863819B1 (en) | 2005-02-16 | 2011-01-12 | NeuroSearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at the nicotinic acetylcholine receptors |
PL2032575T3 (pl) * | 2006-05-30 | 2010-09-30 | Neurosearch As | Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1684965A (zh) * | 2002-09-30 | 2005-10-19 | 神经研究公司 | 新的1,4-二氮杂双环烷烃衍生物、其制备和应用 |
WO2005074940A1 (en) * | 2004-02-04 | 2005-08-18 | Neurosearch A/S | Diazabicyclic aryl derivatives as cholinergic receptor modulators |
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