MXPA04008797A - Inhibidores de histona desacetilasa. - Google Patents

Inhibidores de histona desacetilasa.

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Publication number
MXPA04008797A
MXPA04008797A MXPA04008797A MXPA04008797A MXPA04008797A MX PA04008797 A MXPA04008797 A MX PA04008797A MX PA04008797 A MXPA04008797 A MX PA04008797A MX PA04008797 A MXPA04008797 A MX PA04008797A MX PA04008797 A MXPA04008797 A MX PA04008797A
Authority
MX
Mexico
Prior art keywords
histone deacetylase
inhibitors
medicine
formula
preparation
Prior art date
Application number
MXPA04008797A
Other languages
English (en)
Inventor
Alexey Borisovich Dyatkin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04008797A publication Critical patent/MXPA04008797A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Esta invencion comprende los compuestos novedosos de la formula (I)(Ver formula I)en donde n, R1, R2, R3, R4, Q, X, Y, y Z tienen significados definidos, teniendo actividad enzimatica inhibidora de histona desacetilasa; su preparacion, composiciones que las contienen y su uso como una medicina.
MXPA04008797A 2002-03-13 2003-03-11 Inhibidores de histona desacetilasa. MXPA04008797A (es)

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US8114999B2 (en) 2012-02-14
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AR039566A1 (es) 2005-02-23
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US8268833B2 (en) 2012-09-18
US8697717B2 (en) 2014-04-15
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