OA04285A - Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. - Google Patents

Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.

Info

Publication number
OA04285A
OA04285A OA54780A OA54780A OA04285A OA 04285 A OA04285 A OA 04285A OA 54780 A OA54780 A OA 54780A OA 54780 A OA54780 A OA 54780A OA 04285 A OA04285 A OA 04285A
Authority
OA
OAPI
Prior art keywords
pyrrolo
pyrazine
preparation
new derivatives
derivatives
Prior art date
Application number
OA54780A
Other languages
English (en)
Original Assignee
Rhone Poulenc Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7200505A external-priority patent/FR2166314A1/fr
Priority claimed from FR7239731A external-priority patent/FR2205318A2/fr
Application filed by Rhone Poulenc Sa filed Critical Rhone Poulenc Sa
Publication of OA04285A publication Critical patent/OA04285A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
OA54780A 1972-01-07 1972-12-14 Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. OA04285A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7200505A FR2166314A1 (en) 1972-01-07 1972-01-07 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls
FR7239731A FR2205318A2 (en) 1972-11-09 1972-11-09 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls

Publications (1)

Publication Number Publication Date
OA04285A true OA04285A (fr) 1979-12-31

Family

ID=26216824

Family Applications (1)

Application Number Title Priority Date Filing Date
OA54780A OA04285A (fr) 1972-01-07 1972-12-14 Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.

Country Status (22)

Country Link
US (1) US3862149A (fr)
JP (3) JPS523952B2 (fr)
AR (1) AR195097A1 (fr)
AT (1) AT323181B (fr)
AU (1) AU466586B2 (fr)
BE (1) BE793730A (fr)
CA (1) CA991183A (fr)
CY (1) CY915A (fr)
DD (1) DD102698A5 (fr)
DE (1) DE2300491C3 (fr)
DK (1) DK139359B (fr)
FI (1) FI54124C (fr)
GB (1) GB1358680A (fr)
HK (1) HK60077A (fr)
HU (1) HU164821B (fr)
IE (1) IE37056B1 (fr)
IL (1) IL41232A (fr)
LU (1) LU66800A1 (fr)
NL (1) NL7217852A (fr)
NO (1) NO136843C (fr)
OA (1) OA04285A (fr)
SE (1) SE398503B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2322601A1 (fr) * 1975-09-04 1977-04-01 Rhone Poulenc Ind Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent
AR208414A1 (es) * 1974-11-07 1976-12-27 Rhone Poulenc Ind Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
JPS5680585A (en) * 1979-11-30 1981-07-01 Toyoda Gosei Kk High pressure hose
JPS57144860A (en) * 1981-03-04 1982-09-07 Matsushita Electric Ind Co Ltd Secondary side water pressure controller for water cooler
US4590189A (en) * 1982-04-02 1986-05-20 Takeda Chemical Industries, Ltd. Condensed pyrrolinone derivatives, their production and use
JPS6169773A (ja) * 1984-09-14 1986-04-10 Takeda Chem Ind Ltd イソインドリノン誘導体
JPS6297400U (fr) * 1985-12-09 1987-06-20
FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2671800B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
WO1993010788A1 (fr) * 1991-12-02 1993-06-10 Sepracor, Inc. Procedes et compositions de traitement de troubles du sommeil, d'attaques epileptiques et d'autres troubles au moyen de zopiclone (-) optiquement pure
WO1993010787A1 (fr) * 1991-12-02 1993-06-10 Sepracor, Inc. Procedes et compositions therapeutiques de troubles du sommeil, d'attaques epileptiques et d'autres troubles au moyen de zopiclone (+) optiquement pure
US5786357A (en) 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
WO1999063977A2 (fr) 1998-06-09 1999-12-16 Takeda Chemical Industries, Ltd. Composition pharmaceutique destinee a traiter ou prevenir les troubles du sommeil
US6339086B1 (en) 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
ES2203319B1 (es) * 2002-04-03 2005-03-01 Universidad De Oviedo Nuevos carbonatos opticamente activos como intermedios en la sintesis de (+)-zopiclona.
AU2004305563C1 (en) 2003-12-11 2011-07-07 Sunovion Pharmaceuticals Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
AU2006264317B2 (en) 2005-07-06 2012-02-23 Sunovion Pharmaceuticals Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
MX2008000249A (es) * 2005-07-06 2008-03-18 Sepracor Inc Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos.
EP2258358A3 (fr) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenèse avec un inhibiteur de l'acetylcholinestérase
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7476737B2 (en) * 2005-09-05 2009-01-13 Dr. Reddy's Laboratories Limited Eszopiclone process
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
AU2006308889A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
AR059296A1 (es) * 2006-02-03 2008-03-26 Synthon Bv Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona.
AU2007223036A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20080027223A1 (en) * 2006-03-23 2008-01-31 Teva Pharmaceutical Industries Ltd. Polymorphs of eszopiclone malate
US20070270590A1 (en) * 2006-04-20 2007-11-22 Marioara Mendelovici Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
CN101058581B (zh) * 2006-04-21 2011-06-08 天津天士力集团有限公司 右佐匹克隆中间体6-(5-氯-2-吡啶基)-5,7-二氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪的制备方法
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
US20080015197A1 (en) * 2006-06-26 2008-01-17 Alex Mainfeld Process for the preparatrion of zopiclone
US7998971B2 (en) * 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
EP2066355A2 (fr) * 2006-09-19 2009-06-10 Braincells, Inc. Combinaison comprenant un agent ppar et un deuxième agent neurogène pour le traitement d'une maladie du système nerveux central, pour augmenter la différentiation neuronale et pour augmenter la neurogenèse
US7786304B2 (en) * 2006-11-06 2010-08-31 Centaur Pharmaceutical Pvt. Ltd. Process for the preparation of eszopiclone
WO2008094690A2 (fr) * 2007-01-31 2008-08-07 Teva Pharmaceutical Industries Ltd. Procédés de préparation d'eszopiclone
US20080305171A1 (en) * 2007-06-07 2008-12-11 Kristin Anne Arnold Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
WO2009002552A1 (fr) * 2007-06-25 2008-12-31 Teva Pharmaceutical Industries Ltd. Procédé de racémisation du r-zopiclone
EP2020403A1 (fr) 2007-08-02 2009-02-04 Esteve Quimica, S.A. Procédé pour la résolution de zopiclone et de composés intermédiaires
WO2009063486A2 (fr) * 2007-08-06 2009-05-22 Usv Limited Processus de préparation d'isomère dextrogyre de 6-(5-chloro-pyrid-2-yi)-5-[(4-méthyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone)
WO2009087667A2 (fr) * 2007-12-11 2009-07-16 Cipla Ltd. Nouveau procédé de préparation de zopiclone et de ses polymorphes
US8198277B2 (en) * 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8269005B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8212036B2 (en) 2007-12-19 2012-07-03 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
CN100467471C (zh) * 2007-12-19 2009-03-11 齐鲁天和惠世制药有限公司 佐匹克隆的制备方法
CA2812705C (fr) * 2007-12-19 2015-08-18 Sunovion Pharmaceuticals Inc. Sels de maleate, de besylate et de l-malate de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]-pyrazine
CA2747008C (fr) * 2007-12-19 2017-12-12 Richard Hsia Sels de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b] pyrazine
US8268832B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
CA2750059C (fr) 2009-01-30 2014-11-18 Sunovion Pharmaceuticals Inc. Comprimes de 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine enrobes, et procede pour mesurer l'efficacite de l'enrobage
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
CN105399745A (zh) * 2015-12-17 2016-03-16 天津华津制药有限公司 一种吡嗪并羟基吡咯烷酮类化合物的制备方法
WO2017214442A1 (fr) 2016-06-08 2017-12-14 President And Fellows Of Harvard College Procédés et compositions pour réduire le dysfonctionnement tactile et l'anxiété associés au trouble du spectre de l'autisme, au syndrome de rett et au syndrome de l'x fragile
CN106220630B (zh) * 2016-07-23 2019-12-10 迪嘉药业集团有限公司 一种n-取代吡咯并[3,4-b]吡嗪-5,7(6h)-二酮的制备方法
AU2019279858A1 (en) 2018-05-29 2020-11-26 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment

Also Published As

Publication number Publication date
FI54124B (fi) 1978-06-30
DK139359B (da) 1979-02-05
LU66800A1 (fr) 1973-07-18
JPS5248687A (en) 1977-04-18
IE37056B1 (en) 1977-04-27
AU466586B2 (en) 1975-10-30
JPS5248688A (en) 1977-04-18
JPS535315B2 (fr) 1978-02-25
JPS5231358B2 (fr) 1977-08-13
JPS523952B2 (fr) 1977-01-31
CA991183A (fr) 1976-06-15
US3862149A (en) 1975-01-21
JPS4876892A (fr) 1973-10-16
NL7217852A (fr) 1973-07-10
CY915A (en) 1977-12-23
DE2300491B2 (de) 1977-09-08
AU5075473A (en) 1974-07-04
HK60077A (en) 1977-12-09
GB1358680A (en) 1974-07-03
IL41232A (en) 1975-12-31
BE793730A (fr) 1973-07-05
DE2300491C3 (de) 1978-05-18
IE37056L (en) 1973-07-07
HU164821B (fr) 1974-04-11
NO136843C (no) 1977-11-16
DE2300491A1 (de) 1973-07-19
AR195097A1 (es) 1973-09-10
AT323181B (de) 1975-06-25
DD102698A5 (fr) 1973-12-20
FI54124C (fi) 1978-10-10
SE398503B (sv) 1977-12-27
DK139359C (fr) 1979-07-09
IL41232A0 (en) 1973-03-30
NO136843B (no) 1977-08-08

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