CN100467471C - 佐匹克隆的制备方法 - Google Patents
佐匹克隆的制备方法 Download PDFInfo
- Publication number
- CN100467471C CN100467471C CNB2007101156360A CN200710115636A CN100467471C CN 100467471 C CN100467471 C CN 100467471C CN B2007101156360 A CNB2007101156360 A CN B2007101156360A CN 200710115636 A CN200710115636 A CN 200710115636A CN 100467471 C CN100467471 C CN 100467471C
- Authority
- CN
- China
- Prior art keywords
- zopiclone
- pyridine
- preparation
- pyrazine
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
背景技术中有关文献 | 产品收率 |
US3862149 | 76.01% |
张雅芳等,中国药物化学杂志,1994,4(1),62-64 | 80.23% |
陈恒昌等,郑州大学学报(自然科学版),1993,25,73-76 | 56%(总收率,包括精制) |
本发明实施例 | |
实施例1 | 92.90% |
实施例2 | 94.59% |
实施例3 | 91.89% |
实施例4 | 90.0% |
Claims (9)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2007101156360A CN100467471C (zh) | 2007-12-19 | 2007-12-19 | 佐匹克隆的制备方法 |
PCT/CN2008/072007 WO2009079939A1 (fr) | 2007-12-19 | 2008-08-15 | Méthode de préparation de zopiclone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2007101156360A CN100467471C (zh) | 2007-12-19 | 2007-12-19 | 佐匹克隆的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101195624A CN101195624A (zh) | 2008-06-11 |
CN100467471C true CN100467471C (zh) | 2009-03-11 |
Family
ID=39546266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2007101156360A Active CN100467471C (zh) | 2007-12-19 | 2007-12-19 | 佐匹克隆的制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN100467471C (zh) |
WO (1) | WO2009079939A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100467471C (zh) * | 2007-12-19 | 2009-03-11 | 齐鲁天和惠世制药有限公司 | 佐匹克隆的制备方法 |
CN106220630B (zh) * | 2016-07-23 | 2019-12-10 | 迪嘉药业集团有限公司 | 一种n-取代吡咯并[3,4-b]吡嗪-5,7(6h)-二酮的制备方法 |
CN111007184B (zh) * | 2019-12-30 | 2023-05-16 | 天津天士力圣特制药有限公司 | 一种4-甲基哌嗪-1-甲酰氯盐酸盐含量的检测方法 |
CN112094275A (zh) * | 2020-09-16 | 2020-12-18 | 迪嘉药业集团有限公司 | 一种(右)佐匹克隆光降解杂质的制备方法 |
CN114763342A (zh) * | 2021-01-09 | 2022-07-19 | 江苏天士力帝益药业有限公司 | 一种高纯度4-甲基哌嗪-1-甲酸酯的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA04285A (fr) * | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. |
WO2004037212A2 (en) * | 2002-10-24 | 2004-05-06 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
WO2008002629A1 (en) * | 2006-06-26 | 2008-01-03 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of zopiclone |
CN100467471C (zh) * | 2007-12-19 | 2009-03-11 | 齐鲁天和惠世制药有限公司 | 佐匹克隆的制备方法 |
-
2007
- 2007-12-19 CN CNB2007101156360A patent/CN100467471C/zh active Active
-
2008
- 2008-08-15 WO PCT/CN2008/072007 patent/WO2009079939A1/zh active Application Filing
Non-Patent Citations (2)
Title |
---|
Applications of dialkylaminopyridine (DMAP) catalysts inorganic synthesis. Ramiah MURUGAN等.Aldrichimica ACTA,Vol.36 No.1. 2003 |
Applications of dialkylaminopyridine (DMAP) catalysts inorganic synthesis. Ramiah MURUGAN等.Aldrichimica ACTA,Vol.36 No.1. 2003 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009079939A1 (fr) | 2009-07-02 |
CN101195624A (zh) | 2008-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100467471C (zh) | 佐匹克隆的制备方法 | |
CN104402862B (zh) | 艾立替尼的制备方法 | |
CN102746294B (zh) | (s,s)-2,8-二氮杂双环【4.3.0】壬烷的制备方法 | |
CN103626775B (zh) | 具有二嗪结构的dpp-4抑制剂 | |
CN101941969A (zh) | 盐酸莫西沙星的制备方法 | |
CN103304492B (zh) | 一种EGFR抑制剂Dacomitinib的合成方法 | |
CN105440034B (zh) | 一种利格列汀及其中间体的制备方法 | |
CN101519361A (zh) | 左氧氟沙星和氧氟沙星的制备方法 | |
CN107365276A (zh) | 一种地西泮‑d5的制备方法 | |
CN103288758A (zh) | 一种达克米替尼的制备方法 | |
CN106674084B (zh) | 一种2-异丙基氧基-5-甲基-4-(哌啶-4-基)苯胺二盐酸盐的制备方法 | |
CN104774174A (zh) | 一种不对称合成s-卡比沙明的方法 | |
CN104311485A (zh) | 一种治疗白血病的药物博舒替尼的制备方法 | |
CN101486687A (zh) | 一种盐酸司他斯汀的制备工艺 | |
CN104177301B (zh) | 一种右丙亚胺的制备方法 | |
CN102786543B (zh) | 咪唑并[1,2-a]吡啶-6-硼酸频哪醇酯及其衍生物的制备方法 | |
CN103193763A (zh) | 一种来那度胺的新制备方法 | |
CN107382897B (zh) | 一种贝曲西班的中间体及其制备方法和应用 | |
CN103113290A (zh) | 一种巴洛沙星中间体的制备方法 | |
CN105153169A (zh) | 一种盐酸依匹斯汀的合成方法 | |
CN101177398B (zh) | 一种精制三氟柳的方法 | |
CN103172638B (zh) | 一种盐酸依匹斯汀的制备方法 | |
CN102070624B (zh) | 一种盐酸噻加宾的合成方法及无水盐酸噻加宾的制备方法 | |
CN103044361B (zh) | 一种(2r,3s)-环氧化氨基苯丁烷的制备方法 | |
CN101717370A (zh) | 一种制备2-正丙基-4-甲基-6-(1-甲基苯并咪唑-2-基)苯并咪唑的新方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: QILU PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: QILU TIANHE HUISHI PHARMACY CO., LTD. Effective date: 20140901 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20140901 Address after: Xinluo Avenue high tech Zone of Ji'nan City, Shandong Province, No. 317 250100 Patentee after: Qilu Pharmaceutical Co., Ltd. Address before: 250100 No. 849 Dong Jia town, Licheng District, Shandong, Ji'nan Patentee before: Qilu Tianhe Huishi Pharmacy Co., Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201023 Address after: 570314 -A, Nanhai Avenue, national hi tech Development Zone, Hainan, Haikou, 273 Patentee after: QILU PHARMACEUTICAL (HAINAN) Co.,Ltd. Patentee after: Qilu Pharmaceutical Co.,Ltd. Address before: Xinluo Avenue high tech Zone of Ji'nan City, Shandong Province, No. 317 250100 Patentee before: Qilu Pharmaceutical Co.,Ltd. |