JP2022515766A5 - - Google Patents

Info

Publication number
JP2022515766A5
JP2022515766A5 JP2021535939A JP2021535939A JP2022515766A5 JP 2022515766 A5 JP2022515766 A5 JP 2022515766A5 JP 2021535939 A JP2021535939 A JP 2021535939A JP 2021535939 A JP2021535939 A JP 2021535939A JP 2022515766 A5 JP2022515766 A5 JP 2022515766A5
Authority
JP
Japan
Prior art keywords
disorder
disorders
psychosis
pharmaceutically acceptable
obsessive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021535939A
Other languages
English (en)
Japanese (ja)
Other versions
JP7377871B2 (ja
JP2022515766A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/067902 external-priority patent/WO2020132474A1/en
Publication of JP2022515766A publication Critical patent/JP2022515766A/ja
Publication of JP2022515766A5 publication Critical patent/JP2022515766A5/ja
Application granted granted Critical
Publication of JP7377871B2 publication Critical patent/JP7377871B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021535939A 2018-12-21 2019-12-20 有機化合物 Active JP7377871B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862783685P 2018-12-21 2018-12-21
US62/783,685 2018-12-21
PCT/US2019/067902 WO2020132474A1 (en) 2018-12-21 2019-12-20 Organic compound

Publications (3)

Publication Number Publication Date
JP2022515766A JP2022515766A (ja) 2022-02-22
JP2022515766A5 true JP2022515766A5 (https=) 2022-12-14
JP7377871B2 JP7377871B2 (ja) 2023-11-10

Family

ID=71102341

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021535939A Active JP7377871B2 (ja) 2018-12-21 2019-12-20 有機化合物

Country Status (4)

Country Link
US (1) US12195463B2 (https=)
EP (1) EP3897643B1 (https=)
JP (1) JP7377871B2 (https=)
WO (1) WO2020132474A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
EP3658144B1 (en) 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy
US11440911B2 (en) 2017-09-26 2022-09-13 Intra-Cellular Therapies, Inc. Salts and crystals
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
JP7520013B2 (ja) 2018-12-17 2024-07-22 イントラ-セルラー・セラピーズ・インコーポレイテッド 置換複素環縮合γ-カルボリンの合成
IL315005B2 (en) 2018-12-17 2026-04-01 Intra Cellular Therapies Inc Synthesis of condensed gamma-carbolines and converted heterocycles
WO2020131899A1 (en) 2018-12-17 2020-06-25 Intra-Cellular Therapies, Inc. Organic compound
JP7649743B2 (ja) * 2018-12-21 2025-03-21 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
CN117425652A (zh) * 2021-06-07 2024-01-19 细胞内治疗公司 新盐和晶体
JP2025509569A (ja) * 2022-03-14 2025-04-11 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
WO2025257090A1 (en) 2024-06-10 2025-12-18 Interquim, S.A. Process for the preparation of synthesis intermediates of lumateperone and lumateperone analogues

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238607A (en) 1972-06-19 1980-12-09 Endo Laboratories Inc. Pyridopyrrolo benzheterocycles
IE41352B1 (en) 1974-04-01 1979-12-19 Pfizer 5-aryl-1,2,3,4-tetrahydro- -carbolines
ES2019275B3 (es) 1985-10-09 1991-06-16 Desitin Arzneimittel Gmbh Metodo para la produccion de una forma de administracion y de dosificacion para farmacos reactivos u otros principios activos.
HU208484B (en) 1988-08-17 1993-11-29 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition containing acid additional salt of selegilin as active component for treating schisofrenia
US5114976A (en) 1989-01-06 1992-05-19 Norden Michael J Method for treating certain psychiatric disorders and certain psychiatric symptoms
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
ATE277048T1 (de) 1999-06-15 2004-10-15 Bristol Myers Squibb Pharma Co Substituierte hetercyclisch kondensierte gamma carboline
US6849619B2 (en) 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
SK7042003A3 (en) 2000-12-20 2004-07-07 Bristol Myers Squibb Co Substituted pyridoindoles as serotonin agonists and antagonists
CA2453537A1 (en) 2001-08-08 2003-02-20 Pharmacia & Upjohn Company Therapeutic 1h-pyrido¬4,3-b|indoles
US20050222209A1 (en) 2004-04-01 2005-10-06 Zeldis Jerome B Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
CA2580619C (en) 2004-09-20 2013-11-12 Mount Sinai School Of Medicine Use of memantine (namenda) to treat autism, compulsivity, and impulsivity
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
KR102107954B1 (ko) 2007-03-12 2020-05-07 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
MX2010001218A (es) 2007-08-01 2010-04-07 Medivation Neurology Inc Metodos y composiciones para tratamiento contra esquizofrenia mediante uso de terapia combinada de agentes antipsicoticos.
NZ586963A (en) 2008-02-05 2012-11-30 Clera Inc Use of dopamine d2 receptor inhibitors for alleviating depression or improving cognition
AU2009223701B2 (en) 2008-03-12 2015-04-16 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines solid
EP3085231A1 (en) 2008-05-27 2016-10-26 Intra-Cellular Therapies, Inc. Method and compositions for sleep disorders and other disorders
CA2796756A1 (en) 2010-04-22 2011-10-27 Intra-Cellular Therapies, Inc. Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式-四氫-螺旋(環己烷-1,1’-吡啶[3,4-b]吲哚)-4-胺-衍生物
KR20140146192A (ko) 2012-04-14 2014-12-24 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
AR092568A1 (es) 2012-09-14 2015-04-22 Abbvie Deutschland Derivados triciclicos de quinolinas y de quinoxalinas
US9708322B2 (en) 2013-03-15 2017-07-18 Intra-Cellular Therapies, Inc. Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
KR102373288B1 (ko) 2013-12-03 2022-03-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
CA2944755A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
AU2016272089B2 (en) 2015-06-03 2021-02-18 Triastek, Inc. Dosage forms and use thereof
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
DK3407889T3 (da) 2016-03-25 2021-08-09 Intra Cellular Therapies Inc Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet
US20200392135A1 (en) 2016-03-25 2020-12-17 Intra-Cellular Therapies, Inc. Organic compounds
US11014925B2 (en) 2016-03-28 2021-05-25 Intra-Cellular Therapies, Inc. Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide
EP3436455A4 (en) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. NOVEL SALTS AND CRYSTALS
EP3562484B1 (en) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
WO2019023062A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
EP3658144B1 (en) 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy
CN112040940A (zh) * 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
EP3801527B1 (en) 2018-06-08 2025-02-19 Intra-Cellular Therapies, Inc. Fused gamma-carbolines for acute treatment of anxiety or depression
EP3833346A4 (en) 2018-08-08 2022-08-03 Torralva Medical Therapeutics LLC Compositions for opiate and opioid prevention and reversal, and methods of their use
WO2020131899A1 (en) 2018-12-17 2020-06-25 Intra-Cellular Therapies, Inc. Organic compound
JP7649743B2 (ja) 2018-12-21 2025-03-21 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
CA3134674A1 (en) 2019-04-04 2020-10-08 Intra-Cellular Therapies, Inc. Methods of treating neuropathic pain
JP7397095B2 (ja) 2019-05-07 2023-12-12 ニーサム・ラボラトリーズ・インコーポレイテッド オピオイド受容体アンタゴニストプロドラッグ

Similar Documents

Publication Publication Date Title
JP2022515766A5 (https=)
JP2021519267A5 (https=)
RU2018130727A (ru) Органические соединения
JP2022514264A5 (https=)
JP2022515158A5 (https=)
JP2015028053A (ja) α7選択的リガンドを用いる治療
JP2005539068A5 (https=)
JP2019534327A5 (https=)
JP2008524262A5 (https=)
JP2012508275A5 (https=)
JP2003504303A5 (https=)
JP2009527462A5 (https=)
JP2005517036A5 (https=)
JP2007520539A5 (https=)
RU2004112546A (ru) Частичная агонистическая активность в отношении d2 рецепторов допамина и/или ингибирующая активность в отношении норадреналина
RU2008110911A (ru) Новые диазабициклические арильные производные и их медицинское применение
RU2007106970A (ru) Новые хромен-2-оновые производные и их применение в качестве ингибиторов обратного захвата моноаминовых нейромедиаторов
JP2006503062A5 (https=)
AR079103A1 (es) Compuesto de sal de mesilato de (s) -2-(4-(3-fluoro-benciloxi)-bencilamino)-propionamida, forma polimorfica (nf6) , composicion farmaceutica, uso del mismo para la preparacion de un medicamento y su procesos de preparacion
JP2009526816A5 (https=)
JP2018508556A5 (https=)
JP2007523206A5 (https=)
JP2012526775A5 (https=)
JP2020520936A5 (https=)
JP2006517567A5 (https=)