JP7377871B2 - 有機化合物 - Google Patents

有機化合物 Download PDF

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Publication number
JP7377871B2
JP7377871B2 JP2021535939A JP2021535939A JP7377871B2 JP 7377871 B2 JP7377871 B2 JP 7377871B2 JP 2021535939 A JP2021535939 A JP 2021535939A JP 2021535939 A JP2021535939 A JP 2021535939A JP 7377871 B2 JP7377871 B2 JP 7377871B2
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Japan
Prior art keywords
disorder
disorders
compound
psychosis
compounds
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JP2021535939A
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English (en)
Japanese (ja)
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JP2022515766A (ja
JP2022515766A5 (https=
Inventor
リ，ポン
バノーバー，キンバリー
デイビス，ロバート
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Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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Publication of JP2022515766A5 publication Critical patent/JP2022515766A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021535939A 2018-12-21 2019-12-20 有機化合物 Active JP7377871B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862783685P 2018-12-21 2018-12-21
US62/783,685 2018-12-21
PCT/US2019/067902 WO2020132474A1 (en) 2018-12-21 2019-12-20 Organic compound

Publications (3)

Publication Number Publication Date
JP2022515766A JP2022515766A (ja) 2022-02-22
JP2022515766A5 JP2022515766A5 (https=) 2022-12-14
JP7377871B2 true JP7377871B2 (ja) 2023-11-10

Family

ID=71102341

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021535939A Active JP7377871B2 (ja) 2018-12-21 2019-12-20 有機化合物

Country Status (4)

Country Link
US (1) US12195463B2 (https=)
EP (1) EP3897643B1 (https=)
JP (1) JP7377871B2 (https=)
WO (1) WO2020132474A1 (https=)

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EP3658144B1 (en) 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy
US11440911B2 (en) 2017-09-26 2022-09-13 Intra-Cellular Therapies, Inc. Salts and crystals
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
JP7520013B2 (ja) 2018-12-17 2024-07-22 イントラ－セルラー・セラピーズ・インコーポレイテッド 置換複素環縮合γ－カルボリンの合成
IL315005B2 (en) 2018-12-17 2026-04-01 Intra Cellular Therapies Inc Synthesis of condensed gamma-carbolines and converted heterocycles
WO2020131899A1 (en) 2018-12-17 2020-06-25 Intra-Cellular Therapies, Inc. Organic compound
JP7649743B2 (ja) * 2018-12-21 2025-03-21 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
CN117425652A (zh) * 2021-06-07 2024-01-19 细胞内治疗公司 新盐和晶体
JP2025509569A (ja) * 2022-03-14 2025-04-11 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
WO2025257090A1 (en) 2024-06-10 2025-12-18 Interquim, S.A. Process for the preparation of synthesis intermediates of lumateperone and lumateperone analogues

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US6552017B1 (en) 1999-06-15 2003-04-22 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
US7183282B2 (en) 1999-06-15 2007-02-27 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused γ-carbolines
US20170319580A1 (en) 2016-01-26 2017-11-09 Intra-Cellular Therapies, Inc. Organic compounds

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CN112040940A (zh) * 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
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Patent Citations (3)

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US6552017B1 (en) 1999-06-15 2003-04-22 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
US7183282B2 (en) 1999-06-15 2007-02-27 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused γ-carbolines
US20170319580A1 (en) 2016-01-26 2017-11-09 Intra-Cellular Therapies, Inc. Organic compounds

Also Published As

Publication number Publication date
EP3897643A1 (en) 2021-10-27
EP3897643C0 (en) 2023-11-15
WO2020132474A1 (en) 2020-06-25
JP2022515766A (ja) 2022-02-22
US12195463B2 (en) 2025-01-14
EP3897643A4 (en) 2022-09-07
EP3897643B1 (en) 2023-11-15
US20220056031A1 (en) 2022-02-24

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