DK288385D0 - Aminosyrederivater - Google Patents

Aminosyrederivater

Info

Publication number
DK288385D0
DK288385D0 DK288385A DK288385A DK288385D0 DK 288385 D0 DK288385 D0 DK 288385D0 DK 288385 A DK288385 A DK 288385A DK 288385 A DK288385 A DK 288385A DK 288385 D0 DK288385 D0 DK 288385D0
Authority
DK
Denmark
Prior art keywords
amino acid
acid derivatives
derivatives
carboxytetrahydropyrid
carboxymethylpyrrolidin
Prior art date
Application number
DK288385A
Other languages
English (en)
Inventor
Unknown
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK288385A priority Critical patent/DK288385D0/da
Publication of DK288385D0 publication Critical patent/DK288385D0/da
Priority to ZA864608A priority patent/ZA864608B/xx
Priority to CA000512333A priority patent/CA1284503C/en
Priority to PT82841A priority patent/PT82841B/pt
Priority to IE170286A priority patent/IE59084B1/en
Priority to ES556659A priority patent/ES8800927A1/es
Priority to GR861650A priority patent/GR861650B/el
Priority to NZ216657A priority patent/NZ216657A/xx
Priority to AT86904114T priority patent/ATE67196T1/de
Priority to AU61336/86A priority patent/AU599326B2/en
Priority to EP86904114A priority patent/EP0236342B1/en
Priority to JP61503845A priority patent/JPH07103116B2/ja
Priority to PCT/DK1986/000076 priority patent/WO1987000171A1/en
Priority to DE8686904114T priority patent/DE3681441D1/de
Priority to FI870810A priority patent/FI89355C/fi
Priority to NO870781A priority patent/NO168823C/no
Priority to DK100887A priority patent/DK156398C/da
Priority to US07/254,557 priority patent/US5010090A/en
Priority to LU90130C priority patent/LU90130I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK288385A 1985-06-26 1985-06-26 Aminosyrederivater DK288385D0 (da)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DK288385A DK288385D0 (da) 1985-06-26 1985-06-26 Aminosyrederivater
ZA864608A ZA864608B (en) 1985-06-26 1986-06-20 Amino acid derivatives
CA000512333A CA1284503C (en) 1985-06-26 1986-06-24 N-(butenyl substituted) azaheterocyclic carboxylic acids
PT82841A PT82841B (pt) 1985-06-26 1986-06-25 Processo para a preparacao de novos derivados de aminoacidos e de composicoes farmaceuticas que os contem
IE170286A IE59084B1 (en) 1985-06-26 1986-06-25 Amino acid derivatives
ES556659A ES8800927A1 (es) 1985-06-26 1986-06-25 Un procedimiento para preparar derivados de 1-aminobut-3-eno
GR861650A GR861650B (en) 1985-06-26 1986-06-25 Amino acids derivatives
NZ216657A NZ216657A (en) 1985-06-26 1986-06-25 N-buten-3-yl-azaheterocyclic carboxylic acid compounds and pharmaceutical compositions
DE8686904114T DE3681441D1 (de) 1985-06-26 1986-06-26 Aminosaeureabkoemmlinge.
AT86904114T ATE67196T1 (de) 1985-06-26 1986-06-26 Aminosaeureabkoemmlinge.
AU61336/86A AU599326B2 (en) 1985-06-26 1986-06-26 Amino acid derivatives
EP86904114A EP0236342B1 (en) 1985-06-26 1986-06-26 Amino acid derivatives
JP61503845A JPH07103116B2 (ja) 1985-06-26 1986-06-26 アミノ酸誘導体
PCT/DK1986/000076 WO1987000171A1 (en) 1985-06-26 1986-06-26 Amino acid derivatives
FI870810A FI89355C (fi) 1985-06-26 1987-02-25 Foerfarande foer framstaellning av terapeutiskt aktiva 1-aminobut-3-en-foereningar
NO870781A NO168823C (no) 1985-06-26 1987-02-25 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-aminobut-3-en-forbindelser
DK100887A DK156398C (da) 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives
US07/254,557 US5010090A (en) 1985-06-26 1988-10-07 N-(butenyl substituted) azaheterocyclic carboxylic acids
LU90130C LU90130I2 (fr) 1985-06-26 1997-08-29 Tiagabine anhydre

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK288385A DK288385D0 (da) 1985-06-26 1985-06-26 Aminosyrederivater

Publications (1)

Publication Number Publication Date
DK288385D0 true DK288385D0 (da) 1985-06-26

Family

ID=8116767

Family Applications (2)

Application Number Title Priority Date Filing Date
DK288385A DK288385D0 (da) 1985-06-26 1985-06-26 Aminosyrederivater
DK100887A DK156398C (da) 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK100887A DK156398C (da) 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Country Status (16)

Country Link
US (1) US5010090A (da)
EP (1) EP0236342B1 (da)
JP (1) JPH07103116B2 (da)
AT (1) ATE67196T1 (da)
AU (1) AU599326B2 (da)
CA (1) CA1284503C (da)
DK (2) DK288385D0 (da)
ES (1) ES8800927A1 (da)
FI (1) FI89355C (da)
GR (1) GR861650B (da)
IE (1) IE59084B1 (da)
LU (1) LU90130I2 (da)
NZ (1) NZ216657A (da)
PT (1) PT82841B (da)
WO (1) WO1987000171A1 (da)
ZA (1) ZA864608B (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
DK588189D0 (da) * 1989-11-22 1989-11-22 Novo Nordisk As Nye heterocykliske carboxylsyrer
DK58291D0 (da) * 1991-04-02 1991-04-02 Novo Nordisk As Krystalinsk stof og dets fremstilling
US5750140A (en) * 1994-05-20 1998-05-12 Novo Nordisk A/S Transdermal delivery of tiagabine
UA43396C2 (uk) * 1995-02-28 2001-12-17 Х. Луннбек, А/С Похідні 4-амінотетрагідробензізоксазолу та ізотіазолу та фармацевтична композиція на їх основі
US5962449A (en) 1995-04-07 1999-10-05 Novo Nordisk A/S Tricyclic compounds in treating hyperalgesic conditions and NIDDM
EP0830132B1 (en) * 1995-05-05 2002-01-16 Novo Nordisk A/S Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
UA52661C2 (uk) * 1996-06-14 2003-01-15 Ново Нордіск А/С Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти
US5958951A (en) * 1996-06-14 1999-09-28 Novo Nordiskials Modified form of the R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride
US5914333A (en) * 1996-07-31 1999-06-22 Novo Nordisk A/S Treatment of psychotic disorders
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
EP0991409B1 (en) * 1997-08-01 2002-01-30 ELAN CORPORATION, Plc Controlled release pharmaceutical compositions containing tiagabine
US6288083B1 (en) * 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) * 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
DE19840611A1 (de) * 1998-09-05 2000-03-09 Klaus Wanner GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
AU1892800A (en) * 1999-01-12 2000-08-01 Takeda Chemical Industries Ltd. Compositions for treating frequent urination and urinary incontinence
US6872734B2 (en) 2000-10-20 2005-03-29 Abbott Laboratories Use of tiagabine for treatment of diabetic neuropathy and migraine
CA2430309A1 (en) * 2000-11-30 2002-06-06 Pfizer Products Inc. Combination of gaba agonists and aldose reductase inhibitors
AP2001002360A0 (en) 2000-11-30 2001-12-31 Pfizer Prod Inc Combination of gaba agonists and sorbitol dehydrogenase inhibitors.
ATE327986T1 (de) 2001-02-16 2006-06-15 Allelix Neuroscience Inc Thiophen substituierte amin derivate als glyt-1 inhibitoren
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
CN1382441A (zh) * 2002-05-21 2002-12-04 中国科学院上海生命科学研究院 γ－氨基丁酸转运蛋白抑制剂在制备镇痛药物中的应用
EP1633400A2 (en) * 2003-05-16 2006-03-15 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
WO2005122698A2 (en) * 2003-12-24 2005-12-29 Sun Pharmaceutical Industries Limited Novel stable polymorphic forms of tiagabine hydrochloride
CN1314684C (zh) * 2003-12-24 2007-05-09 中国科学院上海有机化学研究所 噻加宾及其消旋体和s－构型的合成方法及其无定形粉末的制法
EP1737466A1 (en) * 2004-01-29 2007-01-03 Pfizer Products Inc. COMBINATION OF y-AMINOBUTYRIC ACID MODULATORS AND 5-HT-1b RECEPTOR ANTAGONISTS
WO2005092886A1 (en) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of tiagabine
US20080269495A1 (en) * 2004-08-04 2008-10-30 Prosenjit Bose Process for Preparation of Piperidine Carboxylic Acid
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20080051435A1 (en) * 2006-08-18 2008-02-28 Cephalon, Inc. Crystalline and amorphous forms of tiagabine
US20080064727A1 (en) * 2006-08-18 2008-03-13 Cephalon, Inc. Crystalline forms of tiagabine hydrochloride
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20090082401A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched tiagabine
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN101857591B (zh) * 2009-04-09 2013-06-05 北京京卫燕康药物研究所有限公司 盐酸噻加宾晶型及其制备方法
CN102070624B (zh) * 2011-01-25 2013-04-10 赵学清 一种盐酸噻加宾的合成方法及无水盐酸噻加宾的制备方法
CN102827152B (zh) * 2012-09-17 2014-11-05 扬子江药业集团四川海蓉药业有限公司 噻加宾的制备方法及其前体化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383999A (en) * 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
IL81179A (en) * 1986-01-07 1992-02-16 Novo Nordisk As N-phenylbutenyl substituted azaheterocyclic carboxylic acids,their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
EP0236342A1 (en) 1987-09-16
DK100887A (da) 1987-02-26
FI870810A0 (fi) 1987-02-25
DK156398C (da) 1990-01-08
EP0236342B1 (en) 1991-09-11
US5010090A (en) 1991-04-23
FI870810L (fi) 1987-02-25
NZ216657A (en) 1989-10-27
DK100887D0 (da) 1987-02-26
ES8800927A1 (es) 1987-12-01
ES556659A0 (es) 1987-12-01
CA1284503C (en) 1991-05-28
ATE67196T1 (de) 1991-09-15
GR861650B (en) 1986-10-30
AU599326B2 (en) 1990-07-19
PT82841B (pt) 1989-01-17
JPH07103116B2 (ja) 1995-11-08
IE861702L (en) 1986-12-26
FI89355C (fi) 1993-09-27
ZA864608B (en) 1987-02-25
WO1987000171A1 (en) 1987-01-15
IE59084B1 (en) 1994-01-12
LU90130I2 (fr) 1997-10-24
JPS62503172A (ja) 1987-12-17
DK156398B (da) 1989-08-14
FI89355B (fi) 1993-06-15
AU6133686A (en) 1987-01-30
PT82841A (en) 1986-07-01

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment