DK156398C - N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives - Google Patents

N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Info

Publication number
DK156398C
DK156398C DK100887A DK100887A DK156398C DK 156398 C DK156398 C DK 156398C DK 100887 A DK100887 A DK 100887A DK 100887 A DK100887 A DK 100887A DK 156398 C DK156398 C DK 156398C
Authority
DK
Denmark
Prior art keywords
diheteroaryl
butenyl
substituted
carboxylic acid
acid derivatives
Prior art date
Application number
DK100887A
Other languages
English (en)
Other versions
DK100887A (da
DK156398B (da
DK100887D0 (da
Inventor
Frederik Christian Groenvald
Claus Braestrup
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK100887A priority Critical patent/DK156398C/da
Publication of DK100887A publication Critical patent/DK100887A/da
Publication of DK100887D0 publication Critical patent/DK100887D0/da
Publication of DK156398B publication Critical patent/DK156398B/da
Application granted granted Critical
Publication of DK156398C publication Critical patent/DK156398C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK100887A 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives DK156398C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK100887A DK156398C (da) 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK288385A DK288385D0 (da) 1985-06-26 1985-06-26 Aminosyrederivater
DK288385 1985-06-26
DK8600076 1986-06-26
PCT/DK1986/000076 WO1987000171A1 (en) 1985-06-26 1986-06-26 Amino acid derivatives
DK100887 1987-02-26
DK100887A DK156398C (da) 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Publications (4)

Publication Number Publication Date
DK100887A DK100887A (da) 1987-02-26
DK100887D0 DK100887D0 (da) 1987-02-26
DK156398B DK156398B (da) 1989-08-14
DK156398C true DK156398C (da) 1990-01-08

Family

ID=8116767

Family Applications (2)

Application Number Title Priority Date Filing Date
DK288385A DK288385D0 (da) 1985-06-26 1985-06-26 Aminosyrederivater
DK100887A DK156398C (da) 1985-06-26 1987-02-26 N-(4,4-Diheteroaryl-3-butenyl-substituted)azacyclic carboxylic acid derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK288385A DK288385D0 (da) 1985-06-26 1985-06-26 Aminosyrederivater

Country Status (16)

Country Link
US (1) US5010090A (da)
EP (1) EP0236342B1 (da)
JP (1) JPH07103116B2 (da)
AT (1) ATE67196T1 (da)
AU (1) AU599326B2 (da)
CA (1) CA1284503C (da)
DK (2) DK288385D0 (da)
ES (1) ES8800927A1 (da)
FI (1) FI89355C (da)
GR (1) GR861650B (da)
IE (1) IE59084B1 (da)
LU (1) LU90130I2 (da)
NZ (1) NZ216657A (da)
PT (1) PT82841B (da)
WO (1) WO1987000171A1 (da)
ZA (1) ZA864608B (da)

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DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
DK588189D0 (da) * 1989-11-22 1989-11-22 Novo Nordisk As Nye heterocykliske carboxylsyrer
DK58291D0 (da) * 1991-04-02 1991-04-02 Novo Nordisk As Krystalinsk stof og dets fremstilling
IL117295A (en) * 1995-02-28 1999-11-30 Lundbeck & Co As H 4-Aminotetrahydro-benzisoxazole or-isothiazole compounds and pharmaceutical compositions comprising them
US5962449A (en) 1995-04-07 1999-10-05 Novo Nordisk A/S Tricyclic compounds in treating hyperalgesic conditions and NIDDM
MX9708394A (es) * 1995-05-05 1998-02-28 Novo Nordisk As Composicion farmaceutica que contiene clorhidrato de tiagabina y el proceso para su preparacion.
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
US5958951A (en) * 1996-06-14 1999-09-28 Novo Nordiskials Modified form of the R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride
UA52661C2 (uk) * 1996-06-14 2003-01-15 Ново Нордіск А/С Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти
US5914333A (en) * 1996-07-31 1999-06-22 Novo Nordisk A/S Treatment of psychotic disorders
PT991409E (pt) * 1997-08-01 2002-06-28 Elan Corp Plc Composicoes farmaceuticas de libertacao controlada contendo tiagabina
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
US6288083B1 (en) * 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) * 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
DE19840611A1 (de) * 1998-09-05 2000-03-09 Klaus Wanner GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
EP1142584A4 (en) * 1999-01-12 2003-04-16 Takeda Chemical Industries Ltd COMPOSITIONS FOR THE TREATMENT OF COMMON URBANISM AND URINE CONTINENCE
US6872734B2 (en) 2000-10-20 2005-03-29 Abbott Laboratories Use of tiagabine for treatment of diabetic neuropathy and migraine
EE200300249A (et) * 2000-11-30 2003-10-15 Pfizer Products Inc. GABA agonistide ja aldoosreduktaasi inhibiitoritekombinatsioon
EP1337271B1 (en) 2000-11-30 2004-11-03 Pfizer Products Inc. Combination of gaba agonists and sorbitol dehydrogenase inhibitors
SI1368336T1 (sl) 2001-02-16 2006-10-31 Allelix Neuroscience Inc S tiofenom substituirani aminski derivati kot inhibitorji glyt-1
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
CN1382441A (zh) * 2002-05-21 2002-12-04 中国科学院上海生命科学研究院 γ－氨基丁酸转运蛋白抑制剂在制备镇痛药物中的应用
BRPI0410271A (pt) * 2003-05-16 2006-05-16 Pfizer Prod Inc combinações terapêuticas de antipsicóticos atìpicos com moduladores de gaba, anticonvulsivantes ou benzodiazepinas
CA2548917C (en) 2003-12-11 2014-09-23 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
CN1314684C (zh) * 2003-12-24 2007-05-09 中国科学院上海有机化学研究所 噻加宾及其消旋体和s－构型的合成方法及其无定形粉末的制法
WO2005122698A2 (en) * 2003-12-24 2005-12-29 Sun Pharmaceutical Industries Limited Novel stable polymorphic forms of tiagabine hydrochloride
EP1737466A1 (en) * 2004-01-29 2007-01-03 Pfizer Products Inc. COMBINATION OF y-AMINOBUTYRIC ACID MODULATORS AND 5-HT-1b RECEPTOR ANTAGONISTS
WO2005092886A1 (en) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of tiagabine
WO2006013550A2 (en) * 2004-08-04 2006-02-09 Ranbaxy Laboratories Limited Process for preparation of piperidine carboxylic acid
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20080051435A1 (en) * 2006-08-18 2008-02-28 Cephalon, Inc. Crystalline and amorphous forms of tiagabine
US20080064727A1 (en) * 2006-08-18 2008-03-13 Cephalon, Inc. Crystalline forms of tiagabine hydrochloride
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20090082401A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched tiagabine
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN101857591B (zh) * 2009-04-09 2013-06-05 北京京卫燕康药物研究所有限公司 盐酸噻加宾晶型及其制备方法
CN102070624B (zh) * 2011-01-25 2013-04-10 赵学清 一种盐酸噻加宾的合成方法及无水盐酸噻加宾的制备方法
CN102827152B (zh) * 2012-09-17 2014-11-05 扬子江药业集团四川海蓉药业有限公司 噻加宾的制备方法及其前体化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383999A (en) * 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
DE3787657T2 (de) * 1986-01-07 1994-02-03 Novo Ind A S Bagsvaerd Aminosäure-Derivate.

Also Published As

Publication number Publication date
EP0236342B1 (en) 1991-09-11
US5010090A (en) 1991-04-23
JPH07103116B2 (ja) 1995-11-08
DK288385D0 (da) 1985-06-26
DK100887A (da) 1987-02-26
DK156398B (da) 1989-08-14
ES8800927A1 (es) 1987-12-01
IE59084B1 (en) 1994-01-12
ZA864608B (en) 1987-02-25
PT82841B (pt) 1989-01-17
WO1987000171A1 (en) 1987-01-15
NZ216657A (en) 1989-10-27
FI89355C (fi) 1993-09-27
CA1284503C (en) 1991-05-28
LU90130I2 (fr) 1997-10-24
PT82841A (en) 1986-07-01
FI89355B (fi) 1993-06-15
JPS62503172A (ja) 1987-12-17
GR861650B (en) 1986-10-30
ES556659A0 (es) 1987-12-01
ATE67196T1 (de) 1991-09-15
EP0236342A1 (en) 1987-09-16
FI870810A (fi) 1987-02-25
AU599326B2 (en) 1990-07-19
IE861702L (en) 1986-12-26
FI870810A0 (fi) 1987-02-25
AU6133686A (en) 1987-01-30
DK100887D0 (da) 1987-02-26

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