JP2004517894A5 - - Google Patents
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- Publication number
- JP2004517894A5 JP2004517894A5 JP2002557938A JP2002557938A JP2004517894A5 JP 2004517894 A5 JP2004517894 A5 JP 2004517894A5 JP 2002557938 A JP2002557938 A JP 2002557938A JP 2002557938 A JP2002557938 A JP 2002557938A JP 2004517894 A5 JP2004517894 A5 JP 2004517894A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazol
- amine
- methyl
- ring
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 description 22
- 239000000203 mixture Substances 0.000 description 20
- 229910052739 hydrogen Inorganic materials 0.000 description 17
- 239000001257 hydrogen Substances 0.000 description 17
- 125000001072 heteroaryl group Chemical group 0.000 description 11
- 125000001931 aliphatic group Chemical group 0.000 description 10
- 150000002431 hydrogen Chemical class 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 125000000623 heterocyclic group Chemical group 0.000 description 8
- 201000002674 obstructive nephropathy Diseases 0.000 description 7
- 125000004663 dialkyl amino group Chemical group 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 6
- -1 alkoxyalkylamino Chemical group 0.000 description 5
- 125000004429 atoms Chemical group 0.000 description 5
- 125000004093 cyano group Chemical group *C#N 0.000 description 5
- 125000005647 linker group Chemical group 0.000 description 5
- 230000001404 mediated Effects 0.000 description 5
- 125000002950 monocyclic group Chemical group 0.000 description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 4
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 description 4
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 description 4
- 125000003282 alkyl amino group Chemical group 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 125000001475 halogen functional group Chemical group 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 2
- 102100010552 AURKA Human genes 0.000 description 2
- 101700007619 AURKA Proteins 0.000 description 2
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 description 2
- 206010012601 Diabetes mellitus Diseases 0.000 description 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000003418 alkyl amino alkoxy group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 125000001118 alkylidene group Chemical group 0.000 description 2
- 125000005418 aryl aryl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- MEVHTHLQPUQANE-UHFFFAOYSA-N aziridine-2,3-dione Chemical compound O=C1NC1=O MEVHTHLQPUQANE-UHFFFAOYSA-N 0.000 description 2
- 125000005605 benzo group Chemical group 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 125000005842 heteroatoms Chemical group 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 2
- 125000002757 morpholinyl group Chemical group 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 150000002829 nitrogen Chemical group 0.000 description 2
- 125000004043 oxo group Chemical group O=* 0.000 description 2
- 125000004193 piperazinyl group Chemical group 0.000 description 2
- 125000003386 piperidinyl group Chemical group 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 description 1
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- CXLPODKWPHSQEB-UHFFFAOYSA-N 2-(dimethylamino)-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-phenylpyrimidin-2-yl]sulfanylphenyl]acetamide Chemical compound C1=CC(NC(=O)CN(C)C)=CC=C1SC1=NC(NC=2NN=C(C)C=2)=CC(C=2C=CC=CC=2)=N1 CXLPODKWPHSQEB-UHFFFAOYSA-N 0.000 description 1
- OKUQCAXYWXFGPK-UHFFFAOYSA-N 2-[(3,5-dimethoxyphenyl)methylsulfanyl]-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidin-4-amine Chemical compound COC1=CC(OC)=CC(CSC=2N=C(C=C(NC=3NN=C(C)C=3)N=2)N2CCOCC2)=C1 OKUQCAXYWXFGPK-UHFFFAOYSA-N 0.000 description 1
- XRAFMWYIOALWSA-UHFFFAOYSA-N 2-[(3,5-dimethoxyphenyl)methylsulfanyl]-N-(5-methyl-1H-pyrazol-3-yl)-6-pyrrolidin-3-ylpyrimidin-4-amine Chemical compound COC1=CC(OC)=CC(CSC=2N=C(C=C(NC=3NN=C(C)C=3)N=2)C2CNCC2)=C1 XRAFMWYIOALWSA-UHFFFAOYSA-N 0.000 description 1
- MPSNETNZTLYXIK-UHFFFAOYSA-N 2-[(3-chlorophenyl)methylsulfanyl]-6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine Chemical compound C1CN(C)CCN1C1=CC(NC=2NN=C(C)C=2)=NC(SCC=2C=C(Cl)C=CC=2)=N1 MPSNETNZTLYXIK-UHFFFAOYSA-N 0.000 description 1
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- WOGTVCHVDBTSJN-UHFFFAOYSA-N 2-benzylsulfanyl-6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine Chemical compound C1CN(C)CCN1C1=CC(NC=2NN=C(C)C=2)=NC(SCC=2C=CC=CC=2)=N1 WOGTVCHVDBTSJN-UHFFFAOYSA-N 0.000 description 1
- RHCLBIQUEJRCEF-UHFFFAOYSA-N 2-benzylsulfanyl-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidin-4-amine Chemical compound N1N=C(C)C=C1NC1=CC(N2CCOCC2)=NC(SCC=2C=CC=CC=2)=N1 RHCLBIQUEJRCEF-UHFFFAOYSA-N 0.000 description 1
- FYAPZIAUATWNOR-UHFFFAOYSA-N 3-methyl-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-phenylpyrimidin-2-yl]sulfanylphenyl]butanamide Chemical compound C1=CC(NC(=O)CC(C)C)=CC=C1SC1=NC(NC=2NN=C(C)C=2)=CC(C=2C=CC=CC=2)=N1 FYAPZIAUATWNOR-UHFFFAOYSA-N 0.000 description 1
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- QOEQKXHMJLFYIS-UHFFFAOYSA-N 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(4-morpholin-4-ylsulfonylphenyl)methylsulfanyl]pyrimidin-4-amine Chemical compound C1CN(C)CCN1C1=CC(NC2=NNC(C)=C2)=NC(SCC=2C=CC(=CC=2)S(=O)(=O)N2CCOCC2)=N1 QOEQKXHMJLFYIS-UHFFFAOYSA-N 0.000 description 1
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- 2001-12-19 WO PCT/US2001/049401 patent/WO2002057259A2/en active Application Filing
- 2001-12-19 CN CN2011101042845A patent/CN102250071A/zh active Pending
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- 2001-12-19 ES ES01994510T patent/ES2265452T3/es not_active Expired - Lifetime
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- 2001-12-19 CN CNB01822105XA patent/CN100406454C/zh not_active Expired - Fee Related
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- 2001-12-19 WO PCT/US2001/050312 patent/WO2002068415A1/en active IP Right Grant
- 2001-12-19 HU HU0400908A patent/HUP0400908A3/hu unknown
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2003
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2004
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- 2004-07-27 HK HK04105510.6A patent/HK1062565A1/xx not_active IP Right Cessation
- 2004-12-17 JP JP2004366925A patent/JP2005097322A/ja not_active Withdrawn
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2006
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2008
- 2008-04-01 JP JP2008095584A patent/JP2008260767A/ja not_active Withdrawn
- 2008-04-01 JP JP2008095581A patent/JP2008189682A/ja not_active Withdrawn
- 2008-04-03 JP JP2008097620A patent/JP2008222719A/ja active Pending
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- 2008-05-07 JP JP2008121727A patent/JP2008247921A/ja active Pending
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2009
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- 2009-08-21 US US12/545,347 patent/US7982037B2/en not_active Expired - Fee Related
- 2009-09-14 JP JP2009212566A patent/JP2009286805A/ja not_active Withdrawn
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2010
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2012
- 2012-09-28 US US13/631,488 patent/US8697698B2/en not_active Expired - Fee Related
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2013
- 2013-07-19 JP JP2013150948A patent/JP2013213068A/ja active Pending
- 2013-12-24 US US14/139,889 patent/US20140187772A1/en not_active Abandoned
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