IL262808B2 - Combination treatments of hdac inhibitors and pd-l1 inhibitors - Google Patents

Combination treatments of hdac inhibitors and pd-l1 inhibitors

Info

Publication number
IL262808B2
IL262808B2 IL262808A IL26280818A IL262808B2 IL 262808 B2 IL262808 B2 IL 262808B2 IL 262808 A IL262808 A IL 262808A IL 26280818 A IL26280818 A IL 26280818A IL 262808 B2 IL262808 B2 IL 262808B2
Authority
IL
Israel
Prior art keywords
sti
cancer
administered
composition
compound
Prior art date
Application number
IL262808A
Other languages
English (en)
Hebrew (he)
Other versions
IL262808B1 (en
IL262808A (en
Inventor
Reid P Bissonnette
Alain Rolland
Mireille Gillings
Original Assignee
Huyabio Int Llc
Reid P Bissonnette
Alain Rolland
Mireille Gillings
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huyabio Int Llc, Reid P Bissonnette, Alain Rolland, Mireille Gillings filed Critical Huyabio Int Llc
Publication of IL262808A publication Critical patent/IL262808A/en
Publication of IL262808B1 publication Critical patent/IL262808B1/en
Publication of IL262808B2 publication Critical patent/IL262808B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
IL262808A 2016-05-11 2018-11-06 Combination treatments of hdac inhibitors and pd-l1 inhibitors IL262808B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662335056P 2016-05-11 2016-05-11
PCT/US2017/032200 WO2017197140A1 (en) 2016-05-11 2017-05-11 Combination therapies of hdac inhibitors and pd-l1 inhibitors

Publications (3)

Publication Number Publication Date
IL262808A IL262808A (en) 2018-12-31
IL262808B1 IL262808B1 (en) 2023-03-01
IL262808B2 true IL262808B2 (en) 2023-07-01

Family

ID=60267123

Family Applications (1)

Application Number Title Priority Date Filing Date
IL262808A IL262808B2 (en) 2016-05-11 2018-11-06 Combination treatments of hdac inhibitors and pd-l1 inhibitors

Country Status (15)

Country Link
US (3) US10385131B2 (enExample)
EP (1) EP3454843A4 (enExample)
JP (2) JP7013388B2 (enExample)
KR (2) KR102471590B1 (enExample)
CN (1) CN109640985A (enExample)
AU (2) AU2017264857B2 (enExample)
BR (1) BR112018073328A2 (enExample)
CA (1) CA3023546A1 (enExample)
EA (1) EA201892581A1 (enExample)
IL (1) IL262808B2 (enExample)
MA (1) MA44990A (enExample)
MX (2) MX390986B (enExample)
NZ (1) NZ748058A (enExample)
TW (1) TWI794171B (enExample)
WO (1) WO2017197140A1 (enExample)

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US10800846B2 (en) 2015-02-26 2020-10-13 Merck Patent Gmbh PD-1/PD-L1 inhibitors for the treatment of cancer
CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
US10869924B2 (en) 2015-06-16 2020-12-22 Merck Patent Gmbh PD-L1 antagonist combination treatments
US20190183870A1 (en) * 2016-01-05 2019-06-20 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Combination of histone deacetylase inhibitor and immunotherapy
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TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
JP7373991B2 (ja) 2016-07-15 2023-11-06 ビラクタ セラピューティクス，インク． 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
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EP3737405A4 (en) * 2018-01-12 2021-10-06 Viracta Therapeutics, Inc. EPIGENETIC MODIFIERS FOR USE IN CELLULAR IMMUNOTHERAPY
CA3125731A1 (en) 2018-01-12 2019-07-18 KDAc Therapeutics, Inc. Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer
JP7414820B2 (ja) * 2018-07-13 2024-01-16 アルカーメス，インコーポレイテッド ヒストンデアセチラーゼの阻害剤
SG11202105136WA (en) * 2018-11-20 2021-06-29 Shenzhen Chipscreen Biosciences Co Ltd Application of chidamide
CN113348165B (zh) 2019-02-01 2024-06-25 拜耳股份有限公司 用于治疗过度增殖性疾病的1,2,4-三嗪-3(2h)-酮化合物
WO2020205885A1 (en) * 2019-04-01 2020-10-08 Houn Simon Hsia Compositions and methods for cancer immunotherapy
KR20210028339A (ko) * 2019-09-04 2021-03-12 크리스탈지노믹스(주) Hdac 저해제와 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 약학 조성물
US11878009B2 (en) * 2019-09-10 2024-01-23 Great Novel Therapeutics Biotech & Medicals Corporation Anticancer combination of chidamide and celecoxib salts
TW202114659A (zh) * 2019-10-02 2021-04-16 德商４Ｓｃ製藥公司 用於癌症治療之含ｈｄａｃ抑制劑、ｃｔｌａ—４抑制劑及ｐｄ—１抑制劑或ｐｄ—ｌ１抑制劑之組合
WO2021092190A1 (en) * 2019-11-05 2021-05-14 Health Research, Inc. Combination therapy for cancer
TW202128224A (zh) * 2019-12-23 2021-08-01 大陸商信達生物製藥（蘇州）有限公司 抗ｐｄ－１抗體和組蛋白去乙醯化酶抑制劑的藥物組合及其用途、使用方法
MX2023002286A (es) * 2020-08-25 2023-05-16 Huyabio Int Llc Metodos y composiciones para modulacion genetica de microambientes tumorales.

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IL262808A (en) 2018-12-31
KR20190022520A (ko) 2019-03-06
MX2018013593A (es) 2019-11-07
KR102471590B1 (ko) 2022-11-29

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