IL129407A0 - Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof - Google Patents

Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof

Info

Publication number
IL129407A0
IL129407A0 IL12940797A IL12940797A IL129407A0 IL 129407 A0 IL129407 A0 IL 129407A0 IL 12940797 A IL12940797 A IL 12940797A IL 12940797 A IL12940797 A IL 12940797A IL 129407 A0 IL129407 A0 IL 129407A0
Authority
IL
Israel
Prior art keywords
protease
virus
inhibitors
pharmaceutical compositions
same
Prior art date
Application number
IL12940797A
Other languages
English (en)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IL129407A0 publication Critical patent/IL129407A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL12940797A 1996-10-18 1997-10-17 Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof IL129407A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2829096P 1996-10-18 1996-10-18
PCT/US1997/018968 WO1998017679A1 (en) 1996-10-18 1997-10-17 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (1)

Publication Number Publication Date
IL129407A0 true IL129407A0 (en) 2000-02-17

Family

ID=21842625

Family Applications (3)

Application Number Title Priority Date Filing Date
IL12940797A IL129407A0 (en) 1996-10-18 1997-10-17 Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof
IL129407A IL129407A (en) 1996-10-18 1999-04-13 Siren Protease Inhibitors Especially NS3 Viral Protease of Hepatitis C, Pharmaceutical Preparations Containing Them and Their Use
IL191905A IL191905A0 (en) 1996-10-18 2008-06-03 Inhibitors of serine proteases particularly hepatitis c virus ns3 protease, pharmaceutical compositions containing the same and the use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL129407A IL129407A (en) 1996-10-18 1999-04-13 Siren Protease Inhibitors Especially NS3 Viral Protease of Hepatitis C, Pharmaceutical Preparations Containing Them and Their Use
IL191905A IL191905A0 (en) 1996-10-18 2008-06-03 Inhibitors of serine proteases particularly hepatitis c virus ns3 protease, pharmaceutical compositions containing the same and the use thereof

Country Status (33)

Country Link
US (5) US6265380B1 (cg-RX-API-DMAC7.html)
EP (3) EP0932617B1 (cg-RX-API-DMAC7.html)
JP (3) JP4080541B2 (cg-RX-API-DMAC7.html)
KR (1) KR100509388B1 (cg-RX-API-DMAC7.html)
CN (1) CN1133649C (cg-RX-API-DMAC7.html)
AP (1) AP1019A (cg-RX-API-DMAC7.html)
AT (1) ATE212037T1 (cg-RX-API-DMAC7.html)
BG (1) BG103392A (cg-RX-API-DMAC7.html)
BR (1) BR9712544B1 (cg-RX-API-DMAC7.html)
CA (1) CA2268391A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ298749B6 (cg-RX-API-DMAC7.html)
DE (1) DE69709671T2 (cg-RX-API-DMAC7.html)
DK (1) DK0932617T3 (cg-RX-API-DMAC7.html)
EA (1) EA001915B1 (cg-RX-API-DMAC7.html)
EE (1) EE04023B1 (cg-RX-API-DMAC7.html)
ES (1) ES2169880T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20012471B (cg-RX-API-DMAC7.html)
HU (1) HU227742B1 (cg-RX-API-DMAC7.html)
ID (1) ID21649A (cg-RX-API-DMAC7.html)
IL (3) IL129407A0 (cg-RX-API-DMAC7.html)
IN (1) IN183120B (cg-RX-API-DMAC7.html)
IS (1) IS5028A (cg-RX-API-DMAC7.html)
MX (1) MXPA05003026A (cg-RX-API-DMAC7.html)
NO (2) NO329751B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ335276A (cg-RX-API-DMAC7.html)
PL (2) PL194025B1 (cg-RX-API-DMAC7.html)
PT (1) PT932617E (cg-RX-API-DMAC7.html)
SK (1) SK286105B6 (cg-RX-API-DMAC7.html)
TR (1) TR199901602T2 (cg-RX-API-DMAC7.html)
TW (1) TW530065B (cg-RX-API-DMAC7.html)
UA (2) UA66767C2 (cg-RX-API-DMAC7.html)
WO (1) WO1998017679A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA979327B (cg-RX-API-DMAC7.html)

Families Citing this family (354)

* Cited by examiner, † Cited by third party
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GB9707659D0 (en) * 1997-04-16 1997-06-04 Peptide Therapeutics Ltd Hepatitis C NS3 Protease inhibitors
AU757072B2 (en) * 1997-08-11 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptide analogues
US6767991B1 (en) 1997-08-11 2004-07-27 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptides
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GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
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