SK286105B6 - Inhibítory serínových proteáz, najmä NS3 proteázyvírusu hepatitídy C, farmaceutická kompozícia a použitie - Google Patents

Inhibítory serínových proteáz, najmä NS3 proteázyvírusu hepatitídy C, farmaceutická kompozícia a použitie Download PDF

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Publication number
SK286105B6
SK286105B6 SK510-99A SK51099A SK286105B6 SK 286105 B6 SK286105 B6 SK 286105B6 SK 51099 A SK51099 A SK 51099A SK 286105 B6 SK286105 B6 SK 286105B6
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SK
Slovakia
Prior art keywords
group
compound
alkyl
aryl
term
Prior art date
Application number
SK510-99A
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English (en)
Slovak (sk)
Other versions
SK51099A3 (en
Inventor
Roger D. Tung
Scott L. Harbeson
David D. Deininger
Mark A. Murcko
Govinda Rao Bhisetti
Luc J. Farmer
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of SK51099A3 publication Critical patent/SK51099A3/sk
Publication of SK286105B6 publication Critical patent/SK286105B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
SK510-99A 1996-10-18 1997-10-17 Inhibítory serínových proteáz, najmä NS3 proteázyvírusu hepatitídy C, farmaceutická kompozícia a použitie SK286105B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2829096P 1996-10-18 1996-10-18
PCT/US1997/018968 WO1998017679A1 (en) 1996-10-18 1997-10-17 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (2)

Publication Number Publication Date
SK51099A3 SK51099A3 (en) 2000-04-10
SK286105B6 true SK286105B6 (sk) 2008-03-05

Family

ID=21842625

Family Applications (1)

Application Number Title Priority Date Filing Date
SK510-99A SK286105B6 (sk) 1996-10-18 1997-10-17 Inhibítory serínových proteáz, najmä NS3 proteázyvírusu hepatitídy C, farmaceutická kompozícia a použitie

Country Status (33)

Country Link
US (5) US6265380B1 (cg-RX-API-DMAC7.html)
EP (3) EP2409985A3 (cg-RX-API-DMAC7.html)
JP (3) JP4080541B2 (cg-RX-API-DMAC7.html)
KR (1) KR100509388B1 (cg-RX-API-DMAC7.html)
CN (1) CN1133649C (cg-RX-API-DMAC7.html)
AP (1) AP1019A (cg-RX-API-DMAC7.html)
AT (1) ATE212037T1 (cg-RX-API-DMAC7.html)
BG (1) BG103392A (cg-RX-API-DMAC7.html)
BR (1) BR9712544B1 (cg-RX-API-DMAC7.html)
CA (1) CA2268391A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ298749B6 (cg-RX-API-DMAC7.html)
DE (1) DE69709671T2 (cg-RX-API-DMAC7.html)
DK (1) DK0932617T3 (cg-RX-API-DMAC7.html)
EA (1) EA001915B1 (cg-RX-API-DMAC7.html)
EE (1) EE04023B1 (cg-RX-API-DMAC7.html)
ES (1) ES2169880T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20012471B (cg-RX-API-DMAC7.html)
HU (1) HU227742B1 (cg-RX-API-DMAC7.html)
ID (1) ID21649A (cg-RX-API-DMAC7.html)
IL (3) IL129407A0 (cg-RX-API-DMAC7.html)
IN (1) IN183120B (cg-RX-API-DMAC7.html)
IS (1) IS5028A (cg-RX-API-DMAC7.html)
MX (1) MXPA05003026A (cg-RX-API-DMAC7.html)
NO (2) NO329751B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ335276A (cg-RX-API-DMAC7.html)
PL (2) PL192280B1 (cg-RX-API-DMAC7.html)
PT (1) PT932617E (cg-RX-API-DMAC7.html)
SK (1) SK286105B6 (cg-RX-API-DMAC7.html)
TR (1) TR199901602T2 (cg-RX-API-DMAC7.html)
TW (1) TW530065B (cg-RX-API-DMAC7.html)
UA (2) UA66767C2 (cg-RX-API-DMAC7.html)
WO (1) WO1998017679A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA979327B (cg-RX-API-DMAC7.html)

Families Citing this family (354)

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