EA200970806A1 - Сокристаллы и содержащие их фармацевтические композиции - Google Patents

Сокристаллы и содержащие их фармацевтические композиции

Info

Publication number
EA200970806A1
EA200970806A1 EA200970806A EA200970806A EA200970806A1 EA 200970806 A1 EA200970806 A1 EA 200970806A1 EA 200970806 A EA200970806 A EA 200970806A EA 200970806 A EA200970806 A EA 200970806A EA 200970806 A1 EA200970806 A1 EA 200970806A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acid
socrystals
pharmaceutical compositions
compositions
hydroxybenzoate
Prior art date
Application number
EA200970806A
Other languages
English (en)
Inventor
Патрик Р. Коннелли
Ирина Кадияла
Кэти Ставрополус
Юэган Чжан
Стив Джонстон
Говинда Рао Бхисетти
Валдас Юркаускас
Питер Роуз
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of EA200970806A1 publication Critical patent/EA200970806A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Изобретение относится к композициям и сокристаллам, каждый из которых содержит VX-950 и сокристаллообразователь, выбранный из группы, состоящей из 4-гидроксибензойной кислоты, 4-аминосалициловой кислоты, фенилаланина, треонина, винной кислоты, адипиновой кислоты, ацетата янтарной кислоты, пролина, метил-4-гидроксибензоата, антраниловой кислоты и d-биотина. Также в объем настоящего изобретения входят способы их изготовления и применения.
EA200970806A 2007-02-27 2008-02-27 Сокристаллы и содержащие их фармацевтические композиции EA200970806A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90358707P 2007-02-27 2007-02-27
PCT/US2008/002568 WO2008106151A2 (en) 2007-02-27 2008-02-27 Co-crystals and pharmaceutical compositions comprising the same

Publications (1)

Publication Number Publication Date
EA200970806A1 true EA200970806A1 (ru) 2010-08-30

Family

ID=39672669

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970806A EA200970806A1 (ru) 2007-02-27 2008-02-27 Сокристаллы и содержащие их фармацевтические композиции

Country Status (28)

Country Link
US (1) US8759353B2 (ru)
EP (3) EP2463285A1 (ru)
JP (1) JP2010519330A (ru)
KR (1) KR20090115970A (ru)
CN (1) CN101687856A (ru)
AP (1) AP2009004960A0 (ru)
AR (1) AR065498A1 (ru)
AT (1) ATE542815T1 (ru)
AU (1) AU2008219607B2 (ru)
BR (1) BRPI0807907A2 (ru)
CA (1) CA2679312A1 (ru)
CO (1) CO6220963A2 (ru)
CY (1) CY1112865T1 (ru)
DK (1) DK2114924T3 (ru)
EA (1) EA200970806A1 (ru)
EC (1) ECSP099600A (ru)
ES (1) ES2379905T3 (ru)
GE (1) GEP20125645B (ru)
HR (1) HRP20120330T1 (ru)
IL (1) IL200616A0 (ru)
MX (1) MX2009009182A (ru)
NZ (1) NZ579442A (ru)
PL (1) PL2114924T3 (ru)
PT (1) PT2114924E (ru)
RS (1) RS52306B (ru)
SI (1) SI2114924T1 (ru)
TW (1) TW200846343A (ru)
WO (1) WO2008106151A2 (ru)

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CN103819379A (zh) * 2014-02-18 2014-05-28 中国科学院上海药物研究所 维生素d3的胆甾烷醇共结晶及其制备方法和应用
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