EA201590228A1 - Антагонисты 5-ht3 рецептора - Google Patents
Антагонисты 5-ht3 рецептораInfo
- Publication number
- EA201590228A1 EA201590228A1 EA201590228A EA201590228A EA201590228A1 EA 201590228 A1 EA201590228 A1 EA 201590228A1 EA 201590228 A EA201590228 A EA 201590228A EA 201590228 A EA201590228 A EA 201590228A EA 201590228 A1 EA201590228 A1 EA 201590228A1
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- EA
- Eurasian Patent Office
- Prior art keywords
- receptor
- compounds
- antagonists
- vomiting
- neurodegenerative
- Prior art date
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
Изобретение предлагает антагонисты 5-НТ3 рецептора формулы (I)которые пригодны для лечения заболеваний, поддающихся лечению путем ингибирования 5-НТ3 рецептора, таких как рвота, боль, лекарственная зависимость, нейродегенеративные и психиатрические расстройства, а также расстройства желудочно-кишечного тракта. Кроме того, предлагаются фармацевтические композиции, которые содержат такие соединения и способы получения таких соединений.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261672709P | 2012-07-17 | 2012-07-17 | |
US201261708521P | 2012-10-01 | 2012-10-01 | |
PCT/US2013/050746 WO2014014951A1 (en) | 2012-07-17 | 2013-07-16 | 5-ht3 receptor antagonists |
Publications (2)
Publication Number | Publication Date |
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EA201590228A1 true EA201590228A1 (ru) | 2015-05-29 |
EA025986B1 EA025986B1 (ru) | 2017-02-28 |
Family
ID=48877569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590228A EA025986B1 (ru) | 2012-07-17 | 2013-07-16 | Антагонисты 5-ht3 рецептора |
Country Status (43)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20130213B1 (ar) * | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
RU2669701C2 (ru) * | 2014-03-06 | 2018-10-15 | Шанхай Хайянь Фармасьютикал Текнолоджи Ко. Лтд | Производные пиперидина в качестве антагонистов рецептора орексина |
PL3201203T3 (pl) * | 2014-09-29 | 2021-11-22 | Takeda Pharmaceutical Company Limited | Krystaliczna postać 1-(1-metylo-1h-pirazol-4-ilo)-n-((1r,5s,7s)-9-metylo-3-oksa-9-azabicyklo[3.3.1]nonan-7-ylo)-1h-indolo-3-karboksyamidu |
JP6612874B2 (ja) | 2014-12-16 | 2019-11-27 | アクソファント サイエンシーズ ゲーエムベーハー | α7−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換キヌクリジンアミド化合物 |
KR20180044256A (ko) | 2015-06-10 | 2018-05-02 | 엑소반트 사이언시즈 게엠베하 | A7-니코틴성 아세틸콜린 수용체의 작용제로서의 아미노벤즈이소옥사졸 화합물 |
US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
KR102623819B1 (ko) * | 2017-03-27 | 2024-01-10 | 체이스 테라퓨틱스 코포레이션 | 시누클레인병변을 치료하기 위한 조성물 및 방법 |
EA201992532A1 (ru) * | 2017-04-24 | 2020-04-03 | Чейс Терапьютикс Корпорейшн | Композиции и способ для лечения депрессии |
MA49524A (fr) | 2017-06-30 | 2021-05-26 | Chase Therapeutics Corp | Compositions d'antagoniste de nk-1 et méthodes destinées à être utilisées dans le traitement de la dépression |
WO2019180176A1 (en) | 2018-03-21 | 2019-09-26 | Spherium Biomed, S.L. | Composition for the treatment of schizophrenia and/or psychosis |
WO2020068913A1 (en) * | 2018-09-25 | 2020-04-02 | Chase Therapeutics Corporation | Anti-neurodegenerative combinations and use for treatment of neurodegenerative diseases |
WO2021026380A1 (en) * | 2019-08-07 | 2021-02-11 | Alkermes, Inc. | Phenyltriazole compounds for the treatment of pain |
WO2021026378A1 (en) * | 2019-08-07 | 2021-02-11 | Alkermes, Inc. | Indole compounds for the treatment of pain |
WO2023198199A1 (zh) * | 2022-04-15 | 2023-10-19 | 先声再明医药有限公司 | 膜缔合酪氨酸和苏氨酸激酶抑制剂 |
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US4273963A (en) | 1979-05-25 | 1981-06-16 | Bell Telephone Laboratories, Incorporated | Automatic equalization for digital transmission systems |
DE3033568A1 (de) | 1980-09-05 | 1982-05-06 | Marker, Hannes, 8100 Garmisch-Partenkirchen | Fersenhalter einer sicherheits-skibindung |
JPS5816400A (ja) | 1981-07-21 | 1983-01-31 | 松下電器産業株式会社 | 交通信号制御機 |
FI74707C (fi) | 1982-06-29 | 1988-03-10 | Sandoz Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror. |
JPS5936675A (ja) | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
GB8510752D0 (en) * | 1985-04-27 | 1985-06-05 | Beecham Group Plc | Compounds |
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