WO1996012722A1 - Agoniste des recepteurs 5-ht¿4? - Google Patents

Agoniste des recepteurs 5-ht¿4? Download PDF

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Publication number
WO1996012722A1
WO1996012722A1 PCT/JP1995/002157 JP9502157W WO9612722A1 WO 1996012722 A1 WO1996012722 A1 WO 1996012722A1 JP 9502157 W JP9502157 W JP 9502157W WO 9612722 A1 WO9612722 A1 WO 9612722A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
methyl
oxa
azabicyclo
active ingredient
Prior art date
Application number
PCT/JP1995/002157
Other languages
English (en)
Japanese (ja)
Inventor
Haruhiko Kikuchi
Hiroaki Satoh
Masashi Suzuki
Ryuta Fukutomi
Masahiro Ueno
Koichiro Hagihara
Takeo Arai
Setsuko Mino
Yumiko Noguchi
Original Assignee
Nisshin Flour Milling Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Flour Milling Co., Ltd. filed Critical Nisshin Flour Milling Co., Ltd.
Publication of WO1996012722A1 publication Critical patent/WO1996012722A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un agoniste des récepteurs 5-HT4, pouvant être utilisés comme agents excitomoteurs pour les voies digestives, notamment pour le tractus gastro-intestinal. Ledit agoniste contient un composé représenté par la formule générale (I), ou un sel pharmaceutiquement acceptable de ce composé, comme principe actif, et, si nécessaire, des adjuvants médicamenteux pharmaceutiquement acceptables. Dans ladite formule (I), R représente alkyle C3-C6, alcényle C3-C6, cycloalkyle C3-C7 ou cycloalkylméthyle C3-C6.
PCT/JP1995/002157 1994-10-20 1995-10-20 Agoniste des recepteurs 5-ht¿4? WO1996012722A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25490694 1994-10-20
JP6/254906 1994-10-20

Publications (1)

Publication Number Publication Date
WO1996012722A1 true WO1996012722A1 (fr) 1996-05-02

Family

ID=17271496

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/002157 WO1996012722A1 (fr) 1994-10-20 1995-10-20 Agoniste des recepteurs 5-ht¿4?

Country Status (1)

Country Link
WO (1) WO1996012722A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018065827A (ja) * 2012-07-17 2018-04-26 武田薬品工業株式会社 ５−ｈｔ３受容体拮抗薬
US10329306B2 (en) 2014-09-29 2019-06-25 Takeda Pharmaceutical Company Limited Crystalline form of 1-(1-methyl-1H-pyrazol-4-yl)-N-((IR,5S,7S)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1H-indole-3-carboxamide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02202890A (ja) * 1988-12-13 1990-08-10 Beecham Group Plc 新規化合物、その製法及びそれを含む医薬組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02202890A (ja) * 1988-12-13 1990-08-10 Beecham Group Plc 新規化合物、その製法及びそれを含む医薬組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM. LETT., 1992, Vol. 2, No. 6, BERMUDEZ J., "3-Oxagranatane(3-Oxa-9-Azabicyclo(3.3.1)Nonane) Derivatives as Highly Potent Serotonin 5-HT3 Receptor Antagonists", pages 519-522. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018065827A (ja) * 2012-07-17 2018-04-26 武田薬品工業株式会社 ５−ｈｔ３受容体拮抗薬
US10407443B2 (en) 2012-07-17 2019-09-10 Takeda Pharmaceutical Company Limited 5-HT3 receptor antagonists
US10329306B2 (en) 2014-09-29 2019-06-25 Takeda Pharmaceutical Company Limited Crystalline form of 1-(1-methyl-1H-pyrazol-4-yl)-N-((IR,5S,7S)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1H-indole-3-carboxamide

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