CL2015000121A1 - El compuesto 1-(1-metil-1h-pirazol-4-il)-n-((1r,5s,7s)-9-metil-3-oxa-9-azabiciclo[3.3.1]-nonan-7-il)-1h-indol-3-carboxamida, antagonista del receptor de 5-ht3; composicion farmaceutica; y su uso como medicamento - Google Patents

El compuesto 1-(1-metil-1h-pirazol-4-il)-n-((1r,5s,7s)-9-metil-3-oxa-9-azabiciclo[3.3.1]-nonan-7-il)-1h-indol-3-carboxamida, antagonista del receptor de 5-ht3; composicion farmaceutica; y su uso como medicamento

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Publication number
CL2015000121A1
CL2015000121A1 CL2015000121A CL2015000121A CL2015000121A1 CL 2015000121 A1 CL2015000121 A1 CL 2015000121A1 CL 2015000121 A CL2015000121 A CL 2015000121A CL 2015000121 A CL2015000121 A CL 2015000121A CL 2015000121 A1 CL2015000121 A1 CL 2015000121A1
Authority
CL
Chile
Prior art keywords
methyl
nonan
azabicyclo
pyrazol
oxa
Prior art date
Application number
CL2015000121A
Other languages
English (en)
Inventor
Holger Monenschein
Stephen Hitchcock
Holly Reichard
Huikai Sun
Shota Kikuchi
Todd Macklin
Maria Hopkins
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48877569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000121(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of CL2015000121A1 publication Critical patent/CL2015000121A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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CL2015000121A 2012-07-17 2015-01-16 El compuesto 1-(1-metil-1h-pirazol-4-il)-n-((1r,5s,7s)-9-metil-3-oxa-9-azabiciclo[3.3.1]-nonan-7-il)-1h-indol-3-carboxamida, antagonista del receptor de 5-ht3; composicion farmaceutica; y su uso como medicamento CL2015000121A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672709P 2012-07-17 2012-07-17
US201261708521P 2012-10-01 2012-10-01

Publications (1)

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CL2015000121A1 true CL2015000121A1 (es) 2015-06-12

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CL2015000121A CL2015000121A1 (es) 2012-07-17 2015-01-16 El compuesto 1-(1-metil-1h-pirazol-4-il)-n-((1r,5s,7s)-9-metil-3-oxa-9-azabiciclo[3.3.1]-nonan-7-il)-1h-indol-3-carboxamida, antagonista del receptor de 5-ht3; composicion farmaceutica; y su uso como medicamento

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US (8) US9303045B2 (es)
EP (3) EP2875011B1 (es)
JP (5) JP5816400B2 (es)
KR (1) KR102148969B1 (es)
CN (2) CN104768943B (es)
AP (1) AP2015008240A0 (es)
AR (1) AR091781A1 (es)
AU (1) AU2013290375B2 (es)
BR (1) BR112015001028B1 (es)
CA (1) CA2879115C (es)
CL (1) CL2015000121A1 (es)
CO (1) CO7280468A2 (es)
CR (1) CR20150057A (es)
CY (1) CY1120881T1 (es)
DK (2) DK3312169T3 (es)
DO (1) DOP2015000009A (es)
EA (1) EA025986B1 (es)
EC (1) ECSP15004780A (es)
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GE (1) GEP201606526B (es)
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HR (1) HRP20180523T1 (es)
HU (2) HUE038757T2 (es)
IL (1) IL236702B (es)
IN (1) IN2015DN00957A (es)
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LT (1) LT2875011T (es)
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PH (1) PH12015500085A1 (es)
PL (2) PL3312169T3 (es)
PT (2) PT2875011T (es)
RS (1) RS57096B1 (es)
SG (1) SG11201500302UA (es)
SI (1) SI2875011T1 (es)
TN (1) TN2015000018A1 (es)
TW (1) TWI602821B (es)
UY (1) UY34912A (es)
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JOP20130213B1 (ar) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
SG10201900536TA (en) * 2014-03-06 2019-02-27 Shanghai Haiyan Pharmaceutical Tech Co Ltd Piperidine derivatives as orexin receptor antagonist
EP3201203B1 (en) * 2014-09-29 2021-05-19 Takeda Pharmaceutical Company Limited Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide
EP3233087B1 (en) 2014-12-16 2019-10-02 Axovant Sciences GmbH Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
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