HK1175135A1 - Heterocylcic derivatives as inhibiyors of glutaminyl cyclase - Google Patents

Heterocylcic derivatives as inhibiyors of glutaminyl cyclase

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Publication number
HK1175135A1
HK1175135A1 HK13102485.3A HK13102485A HK1175135A1 HK 1175135 A1 HK1175135 A1 HK 1175135A1 HK 13102485 A HK13102485 A HK 13102485A HK 1175135 A1 HK1175135 A1 HK 1175135A1
Authority
HK
Hong Kong
Prior art keywords
inhibiyors
heterocylcic
derivatives
glutaminyl cyclase
glutaminyl
Prior art date
Application number
HK13102485.3A
Other languages
English (en)
Chinese (zh)
Inventor
．海澤
．佐默
．拉姆斯貝克
．邁耶
．赫夫曼
．伯厄勒
．德穆特
Original Assignee
前體生物藥物股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 前體生物藥物股份公司 filed Critical 前體生物藥物股份公司
Publication of HK1175135A1 publication Critical patent/HK1175135A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
HK13102485.3A 2009-09-11 2013-02-27 Heterocylcic derivatives as inhibiyors of glutaminyl cyclase HK1175135A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24143209P 2009-09-11 2009-09-11
PCT/EP2010/063341 WO2011029920A1 (en) 2009-09-11 2010-09-13 Heterocylcic derivatives as inhibitors of glutaminyl cyclase

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HK1175135A1 true HK1175135A1 (en) 2013-06-28

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EP (1) EP2475428B1 (es)
JP (1) JP5934645B2 (es)
KR (1) KR101755737B1 (es)
CN (1) CN102695546B (es)
AU (1) AU2010294214B2 (es)
BR (1) BR112012008346B1 (es)
CA (1) CA2772488C (es)
DK (1) DK2475428T3 (es)
EA (1) EA022007B1 (es)
ES (1) ES2548913T3 (es)
HK (1) HK1175135A1 (es)
IL (1) IL218259A (es)
MX (1) MX2012002993A (es)
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PL (1) PL2475428T3 (es)
SG (1) SG178953A1 (es)
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ZA (1) ZA201201366B (es)

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WO2012123563A1 (en) * 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
BR112013030341A2 (pt) * 2011-05-27 2016-11-29 Probiodrug Ag inibidores de glutaminil ciclase radiomarcados
CA2909510C (en) * 2013-03-15 2024-04-02 Cancer Research Technology, Llc Methods and compositions for gamma-glutamyl cycle modulation
SG11201506609VA (en) * 2013-03-15 2015-09-29 Probiodrug Ag Novel inhibitors
TWI477479B (zh) * 2013-07-18 2015-03-21 Daxin Materials Corp 二胺苯化合物、聚合物、配向膜用組成物、配向膜以及液晶顯示元件
DE102015011780A1 (de) * 2015-09-16 2017-03-16 Hochschule Anhalt Neue Glutaminylcyclase-lnhibitoren
GB201705263D0 (en) * 2017-03-31 2017-05-17 Probiodrug Ag Novel inhibitors
AU2018308191B2 (en) 2017-07-24 2023-12-21 Scenic Immunology B.V. Treating pathological conditions by direct and indirect targeting of SIRPa - CD47 interaction
EP3461819B1 (en) * 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase
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