SI2260029T1 - Priprava morfolinskih derivatov - Google Patents

Priprava morfolinskih derivatov

Info

Publication number
SI2260029T1
SI2260029T1 SI200931080T SI200931080T SI2260029T1 SI 2260029 T1 SI2260029 T1 SI 2260029T1 SI 200931080 T SI200931080 T SI 200931080T SI 200931080 T SI200931080 T SI 200931080T SI 2260029 T1 SI2260029 T1 SI 2260029T1
Authority
SI
Slovenia
Prior art keywords
preparation
morpholine derivatives
morpholine
derivatives
Prior art date
Application number
SI200931080T
Other languages
English (en)
Inventor
Martin Albert
Souza Dominic De
Kerstin Knepper
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SI2260029T1 publication Critical patent/SI2260029T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200931080T 2008-02-26 2009-02-20 Priprava morfolinskih derivatov SI2260029T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08151949 2008-02-26
PCT/EP2009/052036 WO2009106486A1 (en) 2008-02-26 2009-02-20 Preparation of morpholine derivatives
EP09715018.9A EP2260029B1 (en) 2008-02-26 2009-02-20 Preparation of morpholine derivatives

Publications (1)

Publication Number Publication Date
SI2260029T1 true SI2260029T1 (sl) 2015-01-30

Family

ID=39712397

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931080T SI2260029T1 (sl) 2008-02-26 2009-02-20 Priprava morfolinskih derivatov

Country Status (10)

Country Link
US (1) US20110009629A1 (sl)
EP (1) EP2260029B1 (sl)
JP (2) JP5587213B2 (sl)
KR (2) KR20160032271A (sl)
CN (1) CN101959870B (sl)
CA (1) CA2715781C (sl)
ES (1) ES2525650T3 (sl)
PL (1) PL2260029T3 (sl)
SI (1) SI2260029T1 (sl)
WO (1) WO2009106486A1 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2343329B1 (en) 2009-12-11 2014-03-19 Shin-Etsu Chemical Co., Ltd. Amino acid group-modified organopolysiloxane and silane, amino acid group-containing compound, and production method thereof
EP2675278B1 (en) 2011-02-18 2016-02-17 Alexion Pharma International SARL Methods for synthesizing molybdopterin precursor z derivatives
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
CZ304770B6 (cs) 2012-03-13 2014-10-08 Zentiva, K.S. Způsob výroby 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluormethyl)fenyl)ethoxy)-3-(4-fluorfenyl)morfolino)methyl)-1H-1,2,4-triazol-5(4H)-onu (Aprepitantu) v polymorfní formě II
CN102675240B (zh) 2012-04-13 2015-01-14 浙江海正药业股份有限公司 4-取代基-2-羟基吗啉-3-酮及其制备方法
CN103214426A (zh) * 2013-04-12 2013-07-24 上海开义医药化工有限公司 阿瑞匹坦吗啉关键中间体或其盐的制法
CN103193725A (zh) * 2013-04-12 2013-07-10 上海医药工业研究院 (2r,3r)-2-[(1r)-1-[3,5-双(三氟甲基)苯基]乙氧基]-3-(4-氟苯基)吗啉盐的制法
CN103275031A (zh) * 2013-05-14 2013-09-04 泰州锦鸿医药科技有限公司 一种制备光学纯的福沙匹坦中间体的方法
CN103288813A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种阿瑞匹坦的制备方法
CN105837526B (zh) * 2016-01-22 2018-02-27 浙江工业大学 一种阿瑞吡坦重要合成中间体(2s,3r)‑4‑苄基‑3‑(4‑氟苯基)吗啉‑2‑醇的制备方法
CN107698574B (zh) * 2017-11-23 2020-12-01 中山奕安泰医药科技有限公司 一种高纯度阿瑞匹坦的精制制备工艺
WO2020067684A1 (ko) * 2018-09-28 2020-04-02 (주)셀트리온 (-)-시벤졸린 숙신산염의 신규한 제조 공정
CN111004190A (zh) * 2019-11-08 2020-04-14 广州曼翔医药有限公司 一种阿瑞匹坦中间体的制备方法
CN111303066A (zh) * 2020-04-09 2020-06-19 江苏海悦康医药科技有限公司 阿瑞匹坦杂质的制备方法
CN113582982B (zh) * 2021-06-15 2023-06-16 山东罗欣药业集团股份有限公司 一种nk1受体拮抗剂的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9511031D0 (en) * 1995-06-01 1995-07-26 Merck Sharp & Dohme Chemical process
GB9819888D0 (en) * 1998-09-11 1998-11-04 Merck Sharp & Dohme Chemical synthesis
AU2001269749A1 (en) * 2000-06-09 2001-12-24 Merck And Co., Inc. Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine
US6403793B2 (en) * 2000-06-12 2002-06-11 Merck & Co., Inc. Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
AR051475A1 (es) * 2004-11-05 2007-01-17 Merck & Co Inc Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico
EP1942734A4 (en) * 2005-10-06 2010-04-07 Reddys Lab Ltd Dr PREPARATION OF THE APREPITANT

Also Published As

Publication number Publication date
EP2260029A1 (en) 2010-12-15
ES2525650T3 (es) 2014-12-26
WO2009106486A1 (en) 2009-09-03
EP2260029B1 (en) 2014-10-01
JP5714153B2 (ja) 2015-05-07
KR101630884B1 (ko) 2016-06-15
PL2260029T3 (pl) 2015-03-31
KR20100122936A (ko) 2010-11-23
CN101959870B (zh) 2013-10-16
JP2011514892A (ja) 2011-05-12
CA2715781A1 (en) 2009-09-03
CA2715781C (en) 2016-06-28
US20110009629A1 (en) 2011-01-13
CN101959870A (zh) 2011-01-26
KR20160032271A (ko) 2016-03-23
JP5587213B2 (ja) 2014-09-10
JP2014159435A (ja) 2014-09-04

Similar Documents

Publication Publication Date Title
SI2260029T1 (sl) Priprava morfolinskih derivatov
ZA201203615B (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
HK1173142A1 (en) N1-sulfonyl-5-fluoropyrimidinone derivatives n1--5-
HK1172893A1 (en) 5-fluoropyrimidinone derivatives 5-
IL219087A0 (en) Benzimidazole-imidazole derivatives
EP2331089A4 (en) USES OF SESQUITERPENE DERIVATIVES
IL216007A0 (en) Isoxazole-pyridine derivatives
EP2242493A4 (en) Gefitinib DERIVATIVES
IL215109A0 (en) Isoxazole-pyridazine derivatives
IL214941A0 (en) Isoxazole-pyrazole derivatives
IL211290A0 (en) New 2-amidothiadiazole derivatives
HK1160847A1 (en) Process for the preparation of piperazine derivatives
EP2231687A4 (en) NEW DERIVATIVES OF ACYL-CYANPYRROLIDINES
IL213927A0 (en) Deoxyactagardine derivatives
HK1172894A1 (en) N1-acyl-5-fluoropyrimidinone derivatives n1--5-
HK1169623A1 (en) Pyrazinooxazepine derivatives
EP2328873A4 (en) PREPARATION OF RANOLAZINE
EP2331490A4 (en) PREPARATION OF DIBUTOXYMETHANE
EP2512482A4 (en) DERIVATIVES OF 2-ALDOXIMINO-5-FLUOROPYRIMIDINE
IL213262A0 (en) Tetrahydronaphthalen-2-ol derivatives
GB0912499D0 (en) Indopyl-pyridone derivatives
GB0821710D0 (en) Derivatives of dihydroindolone
ZA201101583B (en) Novel salt of morpholine derivative
PL386302A1 (pl) Nowa pochodna izotiazolopirydyny
EP2250178A4 (en) IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES