PL2260029T3 - Otrzymywanie pochodnych morfoliny - Google Patents

Otrzymywanie pochodnych morfoliny

Info

Publication number
PL2260029T3
PL2260029T3 PL09715018T PL09715018T PL2260029T3 PL 2260029 T3 PL2260029 T3 PL 2260029T3 PL 09715018 T PL09715018 T PL 09715018T PL 09715018 T PL09715018 T PL 09715018T PL 2260029 T3 PL2260029 T3 PL 2260029T3
Authority
PL
Poland
Prior art keywords
preparation
morpholine derivatives
morpholine
derivatives
Prior art date
Application number
PL09715018T
Other languages
English (en)
Inventor
Martin Albert
Souza Dominic De
Kerstin Knepper
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of PL2260029T3 publication Critical patent/PL2260029T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL09715018T 2008-02-26 2009-02-20 Otrzymywanie pochodnych morfoliny PL2260029T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08151949 2008-02-26
PCT/EP2009/052036 WO2009106486A1 (en) 2008-02-26 2009-02-20 Preparation of morpholine derivatives
EP09715018.9A EP2260029B1 (en) 2008-02-26 2009-02-20 Preparation of morpholine derivatives

Publications (1)

Publication Number Publication Date
PL2260029T3 true PL2260029T3 (pl) 2015-03-31

Family

ID=39712397

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09715018T PL2260029T3 (pl) 2008-02-26 2009-02-20 Otrzymywanie pochodnych morfoliny

Country Status (10)

Country Link
US (1) US20110009629A1 (pl)
EP (1) EP2260029B1 (pl)
JP (2) JP5587213B2 (pl)
KR (2) KR101630884B1 (pl)
CN (1) CN101959870B (pl)
CA (1) CA2715781C (pl)
ES (1) ES2525650T3 (pl)
PL (1) PL2260029T3 (pl)
SI (1) SI2260029T1 (pl)
WO (1) WO2009106486A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2343329B1 (en) 2009-12-11 2014-03-19 Shin-Etsu Chemical Co., Ltd. Amino acid group-modified organopolysiloxane and silane, amino acid group-containing compound, and production method thereof
SG192826A1 (en) * 2011-02-18 2013-09-30 Alexion Pharma Internat Sarl Methods for synthesizing molybdopterin precursor z derivatives
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
DK2729147T3 (en) * 2011-07-04 2017-12-18 Irbm - Science Park S P A NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA
CZ304770B6 (cs) 2012-03-13 2014-10-08 Zentiva, K.S. Způsob výroby 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluormethyl)fenyl)ethoxy)-3-(4-fluorfenyl)morfolino)methyl)-1H-1,2,4-triazol-5(4H)-onu (Aprepitantu) v polymorfní formě II
CN102675240B (zh) 2012-04-13 2015-01-14 浙江海正药业股份有限公司 4-取代基-2-羟基吗啉-3-酮及其制备方法
CN103214426A (zh) * 2013-04-12 2013-07-24 上海开义医药化工有限公司 阿瑞匹坦吗啉关键中间体或其盐的制法
CN103193725A (zh) * 2013-04-12 2013-07-10 上海医药工业研究院 (2r,3r)-2-[(1r)-1-[3,5-双(三氟甲基)苯基]乙氧基]-3-(4-氟苯基)吗啉盐的制法
CN103275031A (zh) * 2013-05-14 2013-09-04 泰州锦鸿医药科技有限公司 一种制备光学纯的福沙匹坦中间体的方法
CN103288813A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种阿瑞匹坦的制备方法
CN105837526B (zh) * 2016-01-22 2018-02-27 浙江工业大学 一种阿瑞吡坦重要合成中间体(2s,3r)‑4‑苄基‑3‑(4‑氟苯基)吗啉‑2‑醇的制备方法
CN107698574B (zh) * 2017-11-23 2020-12-01 中山奕安泰医药科技有限公司 一种高纯度阿瑞匹坦的精制制备工艺
CN112739686A (zh) * 2018-09-28 2021-04-30 赛特瑞恩股份有限公司 用于制备(-)-西苯唑啉琥珀酸盐的新方法
CN111004190A (zh) * 2019-11-08 2020-04-14 广州曼翔医药有限公司 一种阿瑞匹坦中间体的制备方法
CN111303066A (zh) * 2020-04-09 2020-06-19 江苏海悦康医药科技有限公司 阿瑞匹坦杂质的制备方法
CN113582982B (zh) * 2021-06-15 2023-06-16 山东罗欣药业集团股份有限公司 一种nk1受体拮抗剂的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9511031D0 (en) * 1995-06-01 1995-07-26 Merck Sharp & Dohme Chemical process
GB9819888D0 (en) * 1998-09-11 1998-11-04 Merck Sharp & Dohme Chemical synthesis
AU2001269749A1 (en) * 2000-06-09 2001-12-24 Merck And Co., Inc. Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine
US6403793B2 (en) * 2000-06-12 2002-06-11 Merck & Co., Inc. Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
AR051475A1 (es) * 2004-11-05 2007-01-17 Merck & Co Inc Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico
WO2007044829A2 (en) * 2005-10-06 2007-04-19 Dr. Reddy's Laboratories Ltd. Preparation of aprepitant

Also Published As

Publication number Publication date
KR101630884B1 (ko) 2016-06-15
CN101959870A (zh) 2011-01-26
CA2715781A1 (en) 2009-09-03
JP5587213B2 (ja) 2014-09-10
JP2011514892A (ja) 2011-05-12
SI2260029T1 (sl) 2015-01-30
KR20100122936A (ko) 2010-11-23
EP2260029B1 (en) 2014-10-01
CN101959870B (zh) 2013-10-16
JP2014159435A (ja) 2014-09-04
US20110009629A1 (en) 2011-01-13
CA2715781C (en) 2016-06-28
ES2525650T3 (es) 2014-12-26
JP5714153B2 (ja) 2015-05-07
EP2260029A1 (en) 2010-12-15
WO2009106486A1 (en) 2009-09-03
KR20160032271A (ko) 2016-03-23

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