AU2001269749A1 - Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine - Google Patents

Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine

Info

Publication number
AU2001269749A1
AU2001269749A1 AU2001269749A AU6974901A AU2001269749A1 AU 2001269749 A1 AU2001269749 A1 AU 2001269749A1 AU 2001269749 A AU2001269749 A AU 2001269749A AU 6974901 A AU6974901 A AU 6974901A AU 2001269749 A1 AU2001269749 A1 AU 2001269749A1
Authority
AU
Australia
Prior art keywords
oxazine
fluorophenyl
trifluoromethyl
ethoxy
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001269749A
Inventor
James M Mcnamara
Matthew M. Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2001269749A1 publication Critical patent/AU2001269749A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2001269749A 2000-06-09 2001-06-05 Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine Abandoned AU2001269749A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21050000P 2000-06-09 2000-06-09
US60210500 2000-06-09
PCT/US2001/018242 WO2001096319A1 (en) 2000-06-09 2001-06-05 Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine

Publications (1)

Publication Number Publication Date
AU2001269749A1 true AU2001269749A1 (en) 2001-12-24

Family

ID=22783150

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001269749A Abandoned AU2001269749A1 (en) 2000-06-09 2001-06-05 Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine

Country Status (3)

Country Link
US (1) US6395898B1 (en)
AU (1) AU2001269749A1 (en)
WO (1) WO2001096319A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985592B2 (en) * 2004-02-13 2011-07-26 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
WO2007044829A2 (en) * 2005-10-06 2007-04-19 Dr. Reddy's Laboratories Ltd. Preparation of aprepitant
KR101630884B1 (en) * 2008-02-26 2016-06-15 산도즈 아게 Preparation of morpholine derivatives
WO2009116081A2 (en) * 2008-03-03 2009-09-24 Msn Laboratories Limited An improved process for the preparation of aprepitant
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
CN102675240B (en) 2012-04-13 2015-01-14 浙江海正药业股份有限公司 4-substitute-2-hydroxy morpholine-3-ketone and preparation method thereof
CN103193725A (en) * 2013-04-12 2013-07-10 上海医药工业研究院 Preparation method of (2R, 3R)-2-((1R)-1-(3, 5-bis (trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl) morpholine
CN103214426A (en) * 2013-04-12 2013-07-24 上海开义医药化工有限公司 Production method of aprepitant morpholine key intermediate body or aprepitant morpholine salt
CN113582982B (en) * 2021-06-15 2023-06-16 山东罗欣药业集团股份有限公司 Preparation method of NK1 receptor antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
NZ277839A (en) * 1993-12-29 1998-01-26 Merck Sharp & Dohme Substituted morpholine derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
WO2001096319A1 (en) 2001-12-20
US20020022725A1 (en) 2002-02-21
US6395898B1 (en) 2002-05-28

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