AU2002230961A1 - Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one - Google Patents

Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one

Info

Publication number
AU2002230961A1
AU2002230961A1 AU2002230961A AU3096102A AU2002230961A1 AU 2002230961 A1 AU2002230961 A1 AU 2002230961A1 AU 2002230961 A AU2002230961 A AU 2002230961A AU 3096102 A AU3096102 A AU 3096102A AU 2002230961 A1 AU2002230961 A1 AU 2002230961A1
Authority
AU
Australia
Prior art keywords
ethan
trifluoromethyl
bis
phenyl
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002230961A
Inventor
Tomoyuki Asai
Raymond Cvetovich
Yoshiko Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2002230961A1 publication Critical patent/AU2002230961A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2002230961A 2000-12-20 2001-12-18 Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one Abandoned AU2002230961A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25679000P 2000-12-20 2000-12-20
US60256790 2000-12-20
PCT/US2001/048800 WO2002050009A1 (en) 2000-12-20 2001-12-18 Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one

Publications (1)

Publication Number Publication Date
AU2002230961A1 true AU2002230961A1 (en) 2002-07-01

Family

ID=22973590

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002230961A Abandoned AU2002230961A1 (en) 2000-12-20 2001-12-18 Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one

Country Status (5)

Country Link
US (1) US6814895B2 (en)
EP (1) EP1345878A4 (en)
AU (1) AU2002230961A1 (en)
CA (1) CA2431457A1 (en)
WO (1) WO2002050009A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016043079A1 (en) * 2014-09-19 2016-03-24 東レ・ファインケミカル株式会社 Method for producing 2'-trifluoromethyl group-substituted aromatic ketone

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450296A (en) * 1980-09-18 1984-05-22 International Flavors & Fragrances Inc. Process for the production of arylalkanone and intermediate
US5235068A (en) * 1988-04-28 1993-08-10 Sumitomo Chemical Company, Limited Process for producing acylaromatic compounds
DE3836159A1 (en) * 1988-10-24 1990-04-26 Bayer Ag NEW FLUORINE-CONTAINING ACETOPHENONES AND THEIR PRODUCTION FROM NEW FLUORINE-CONTAINING BENZONITRILES, WHICH ORGANIZED IN THE CH (ARROW DOWN) 3 (ARROW DOWN) GROUP
US5481006A (en) * 1994-01-11 1996-01-02 E. I. Du Pont De Nemours And Company Selective asymmetric hydrogenation of dehydroamino acid derivatives using rhodium and iridium diphosphinite carbohydrate catalyst compositions
IL132490A (en) * 1998-10-23 2004-09-27 Nippon Catalytic Chem Ind Method for manufacturing fluoroaryl magnesium halide
US6129863A (en) * 1998-12-18 2000-10-10 Albemarle Corporation Clean generation of a perfluoroaryl grignard reagent
US6255545B1 (en) 1999-06-11 2001-07-03 Merck & Co., Inc. Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
EP1192116A4 (en) 1999-06-11 2002-10-24 Merck & Co Inc Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
EP1192118A4 (en) * 1999-06-11 2002-11-04 Merck & Co Inc Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one
PL352182A1 (en) 1999-07-01 2003-08-11 Merck & Co Inc Process for the synthesis of (r)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation

Also Published As

Publication number Publication date
WO2002050009A1 (en) 2002-06-27
US20040108603A1 (en) 2004-06-10
EP1345878A1 (en) 2003-09-24
CA2431457A1 (en) 2002-06-27
US6814895B2 (en) 2004-11-09
EP1345878A4 (en) 2005-12-14

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