ES2586231T3 - Inhibidores de glutaminil ciclasa - Google Patents
Inhibidores de glutaminil ciclasa Download PDFInfo
- Publication number
- ES2586231T3 ES2586231T3 ES11707395.7T ES11707395T ES2586231T3 ES 2586231 T3 ES2586231 T3 ES 2586231T3 ES 11707395 T ES11707395 T ES 11707395T ES 2586231 T3 ES2586231 T3 ES 2586231T3
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- ES
- Spain
- Prior art keywords
- benzo
- imidazole
- thiadiazol
- phenyl
- compound
- Prior art date
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- GEDBSTPYAKXKIP-UHFFFAOYSA-N 2-(3h-benzimidazol-5-yl)-5-[(3,4-dimethoxyphenyl)sulfonylmethyl]-1,3,4-thiadiazole Chemical compound C1=C(OC)C(OC)=CC=C1S(=O)(=O)CC1=NN=C(C=2C=C3N=CNC3=CC=2)S1 GEDBSTPYAKXKIP-UHFFFAOYSA-N 0.000 claims description 3
- ODURKURUHXWNHZ-UHFFFAOYSA-N 2-(3h-benzimidazol-5-yl)-5-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,3,4-thiadiazole Chemical compound C1=CC(C(F)(F)F)=CC=C1CCC1=NN=C(C=2C=C3N=CNC3=CC=2)S1 ODURKURUHXWNHZ-UHFFFAOYSA-N 0.000 claims description 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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| US309951P | 2010-03-03 | ||
| PCT/EP2011/053154 WO2011107530A2 (en) | 2010-03-03 | 2011-03-03 | Novel inhibitors |
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| WO (1) | WO2011107530A2 (OSRAM) |
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| EP2822931B1 (en) | 2012-03-09 | 2017-05-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
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| US9676754B2 (en) | 2012-12-20 | 2017-06-13 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| US9040712B2 (en) | 2013-01-23 | 2015-05-26 | Novartis Ag | Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions |
| EP3027600B1 (en) | 2013-07-31 | 2022-04-06 | Novartis AG | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions |
| EA201690230A1 (ru) | 2013-09-06 | 2016-07-29 | Инсепшн 2, Инк. | Соединения триазолона и их применения |
| WO2016097305A1 (en) | 2014-12-19 | 2016-06-23 | Probiodrug Ag | Novel method for the detection of pglu-abeta peptides |
| DE102015011780A1 (de) | 2015-09-16 | 2017-03-16 | Hochschule Anhalt | Neue Glutaminylcyclase-lnhibitoren |
| CN108250196B (zh) * | 2016-12-29 | 2022-12-30 | 上海汇伦医药股份有限公司 | (哌嗪-1-基)-1氢-咪唑并杂芳环化合物的制备方法 |
| JP7189155B2 (ja) | 2017-05-17 | 2022-12-13 | アーカス バイオサイエンシズ インコーポレイティド | 癌関連障害の治療のためのキナゾリン－ピラゾール誘導体 |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| MX2023009059A (es) | 2021-02-02 | 2023-09-15 | Liminal Biosciences Ltd | Antagonistas de gpr84 y usos de estos. |
| KR102750722B1 (ko) * | 2022-03-16 | 2025-01-09 | 재단법인 대구경북첨단의료산업진흥재단 | 싸이아다이아졸 화합물 및 이를 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물 |
| CN116102440A (zh) * | 2023-02-06 | 2023-05-12 | 上海琼燕医药科技有限公司 | 1-(3,4-二氨基苯基)乙酮的制备方法 |
| AU2024260234A1 (en) * | 2023-04-26 | 2025-11-13 | Institució Catalana De Recerca I Estudis Avançats | 1,2,4-triazole-3-thione inhibitors of trex2 for use in the treatment of psoriasis, atopic dermatitis or ichthyosis |
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2011
- 2011-03-03 JP JP2012555421A patent/JP6026284B2/ja active Active
- 2011-03-03 US US13/040,159 patent/US9181233B2/en active Active
- 2011-03-03 WO PCT/EP2011/053154 patent/WO2011107530A2/en not_active Ceased
- 2011-03-03 EP EP11707395.7A patent/EP2542549B1/en active Active
- 2011-03-03 ES ES11707395.7T patent/ES2586231T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011107530A3 (en) | 2011-11-10 |
| EP2542549A2 (en) | 2013-01-09 |
| JP2013521260A (ja) | 2013-06-10 |
| US20110224259A1 (en) | 2011-09-15 |
| WO2011107530A2 (en) | 2011-09-09 |
| EP2542549B1 (en) | 2016-05-11 |
| JP6026284B2 (ja) | 2016-11-16 |
| US9181233B2 (en) | 2015-11-10 |
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