ES2415407T3 - Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas - Google Patents

Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas Download PDF

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Publication number
ES2415407T3
ES2415407T3 ES09006024T ES09006024T ES2415407T3 ES 2415407 T3 ES2415407 T3 ES 2415407T3 ES 09006024 T ES09006024 T ES 09006024T ES 09006024 T ES09006024 T ES 09006024T ES 2415407 T3 ES2415407 T3 ES 2415407T3
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ES
Spain
Prior art keywords
dosage form
opioid
antagonist
naltrexone
oral dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09006024T
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English (en)
Spanish (es)
Inventor
Benjamin Oshlack
Curtis Wright
J. David Haddox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
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Euro Celtique SA
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Filing date
Publication date
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Application filed by Euro Celtique SA filed Critical Euro Celtique SA
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Publication of ES2415407T3 publication Critical patent/ES2415407T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K9/5005—Wall or coating material
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    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES09006024T 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas Expired - Lifetime ES2415407T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18136900P 2000-02-08 2000-02-08
US181369P 2000-02-08

Publications (1)

Publication Number Publication Date
ES2415407T3 true ES2415407T3 (es) 2013-07-25

Family

ID=22663996

Family Applications (5)

Application Number Title Priority Date Filing Date
ES09006024T Expired - Lifetime ES2415407T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas
ES10011789.4T Expired - Lifetime ES2540103T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas
ES01909086T Expired - Lifetime ES2326730T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas.
ES10011790.2T Expired - Lifetime ES2539945T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas
ES12167170.5T Expired - Lifetime ES2539904T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES10011789.4T Expired - Lifetime ES2540103T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas
ES01909086T Expired - Lifetime ES2326730T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas.
ES10011790.2T Expired - Lifetime ES2539945T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas
ES12167170.5T Expired - Lifetime ES2539904T3 (es) 2000-02-08 2001-02-08 Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas

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US (15) US6696088B2 (enExample)
EP (6) EP3130338A1 (enExample)
JP (10) JP2003522144A (enExample)
KR (2) KR100552038B1 (enExample)
CN (3) CN1423559A (enExample)
AP (1) AP1665A (enExample)
AT (1) ATE431145T1 (enExample)
AU (2) AU776904B2 (enExample)
BG (1) BG65828B1 (enExample)
BR (2) BRPI0108380B8 (enExample)
CA (1) CA2400567C (enExample)
CY (2) CY1109270T1 (enExample)
CZ (1) CZ299991B6 (enExample)
DE (1) DE60138706D1 (enExample)
DK (5) DK2517710T3 (enExample)
EA (1) EA004876B1 (enExample)
EE (1) EE05171B1 (enExample)
ES (5) ES2415407T3 (enExample)
GE (1) GEP20053614B (enExample)
HK (1) HK1051487A1 (enExample)
HU (2) HU229705B1 (enExample)
IL (5) IL151057A0 (enExample)
ME (1) MEP48308A (enExample)
MX (2) MXPA02007686A (enExample)
NO (2) NO20023729L (enExample)
NZ (1) NZ520554A (enExample)
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