FR2881652B1 - Forme pharmaceutique orale microparticulaire anti-mesuage - Google Patents

Forme pharmaceutique orale microparticulaire anti-mesuage

Info

Publication number
FR2881652B1
FR2881652B1 FR0550364A FR0550364A FR2881652B1 FR 2881652 B1 FR2881652 B1 FR 2881652B1 FR 0550364 A FR0550364 A FR 0550364A FR 0550364 A FR0550364 A FR 0550364A FR 2881652 B1 FR2881652 B1 FR 2881652B1
Authority
FR
France
Prior art keywords
microparticular
measuring
oral pharmaceutical
pharmaceutical form
form anti
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0550364A
Other languages
English (en)
Other versions
FR2881652A1 (fr
Inventor
Gerard Soula
Florence Guimberteau
Remi Meyrueix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Technologies SA
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Priority to FR0550364A priority Critical patent/FR2881652B1/fr
Publication of FR2881652A1 publication Critical patent/FR2881652A1/fr
Application granted granted Critical
Publication of FR2881652B1 publication Critical patent/FR2881652B1/fr
Application status is Expired - Fee Related legal-status Critical
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
FR0550364A 2005-02-08 2005-02-08 Forme pharmaceutique orale microparticulaire anti-mesuage Expired - Fee Related FR2881652B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR0550364A FR2881652B1 (fr) 2005-02-08 2005-02-08 Forme pharmaceutique orale microparticulaire anti-mesuage

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FR0550364A FR2881652B1 (fr) 2005-02-08 2005-02-08 Forme pharmaceutique orale microparticulaire anti-mesuage
CA 2596965 CA2596965A1 (fr) 2005-02-08 2006-02-08 Forme medicamenteuse orale microparticulaire anti-mesusage
JP2007553626A JP2008529990A (ja) 2005-02-08 2006-02-08 誤用防止用の微小粒子状経口薬物形態
PCT/EP2006/050784 WO2006089843A2 (fr) 2005-02-08 2006-02-08 Forme medicamenteuse orale microparticulaire anti-mesusage
CN 200680009975 CN101151022A (zh) 2005-02-08 2006-02-08 抗滥用微粒口服剂型
US11/883,935 US20090041838A1 (en) 2005-02-08 2006-02-08 Anti-Misuse Microparticulate Oral Drug Form
EP20060708128 EP1845958A2 (fr) 2005-02-08 2006-02-08 Forme medicamenteuse orale microparticulaire anti-mesusage
US12/560,044 US20100266701A1 (en) 2005-02-08 2009-09-15 Anti-misuse microparticulate oral drug form

Publications (2)

Publication Number Publication Date
FR2881652A1 FR2881652A1 (fr) 2006-08-11
FR2881652B1 true FR2881652B1 (fr) 2007-05-25

Family

ID=35058447

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0550364A Expired - Fee Related FR2881652B1 (fr) 2005-02-08 2005-02-08 Forme pharmaceutique orale microparticulaire anti-mesuage

Country Status (7)

Country Link
US (2) US20090041838A1 (fr)
EP (1) EP1845958A2 (fr)
JP (1) JP2008529990A (fr)
CN (1) CN101151022A (fr)
CA (1) CA2596965A1 (fr)
FR (1) FR2881652B1 (fr)
WO (1) WO2006089843A2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2957281A1 (fr) 2001-09-21 2015-12-23 Egalet Ltd. Systeme de liberation a base de polymere
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
ES2320438T7 (es) 2002-04-09 2013-02-14 Flamel Technologies Formulación farmaceútica oral de suspensión acuosa de microcápsulas que permiten la liberación modificada de principio(s) activo(s)
WO2004084868A1 (fr) 2003-03-26 2004-10-07 Egalet A/S Systeme de liberation regulee de morphine
WO2006133733A1 (fr) 2005-06-13 2006-12-21 Flamel Technologies Forme posologique orale comportant un systeme anti-abus
FR2892937B1 (fr) * 2005-11-10 2013-04-05 Flamel Tech Sa Forme pharmaceutique orale microparticulaire anti-mesusage
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
US20080069891A1 (en) * 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
AU2008258596B2 (en) 2007-06-04 2013-02-14 Egalet Ltd Controlled release pharmaceutical compositions for prolonged effect
MX2010006694A (es) 2007-12-17 2010-09-07 Labopharm Inc Formulacion de liberacion controlada, preventiva de mal uso.
FR2936709B1 (fr) * 2008-10-02 2012-05-11 Ethypharm Sa Comprimes alcoolo-resistants.
CN102316857A (zh) 2008-12-16 2012-01-11 莱博法姆(巴巴多斯)公司 防止误用的控释配方
US9005660B2 (en) 2009-02-06 2015-04-14 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
EP2403482B1 (fr) 2009-03-04 2017-12-27 Emplicure AB Formulation permettant d'empêcher une consommation abusive
EA027618B1 (ru) 2009-05-08 2017-08-31 Эмпликюре Аб Композиция для непрерывной доставки лекарственного средства, содержащая геополимерное связующее
WO2010149169A2 (fr) 2009-06-24 2010-12-29 Egalet A/S Formulations à libération contrôlée
US20130209560A1 (en) * 2010-02-24 2013-08-15 Cima Labs Inc. Abuse-resistant formulations
FR2959935B1 (fr) * 2010-05-14 2013-02-08 Ethypharm Sa Forme pharmaceutique orale alcoolo-resistante
US9877925B2 (en) 2010-05-14 2018-01-30 Ethypharm Alcohol-resistant oral pharmaceutical form
FR2960775A1 (fr) * 2010-06-07 2011-12-09 Ethypharm Sa Microgranules resistants au detournement
EP2613784B1 (fr) 2010-09-07 2017-12-13 Emplicure AB Dispositif d'administration de médicament transdermique
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
CN103330702B (zh) * 2013-07-02 2016-03-02 江苏长泰药业有限公司 含有拟交感神经胺盐和诱导凝胶体系的医药组合物
AU2014306759B2 (en) 2013-08-12 2018-04-26 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
EP3169315A4 (fr) 2014-07-17 2018-03-21 Pharmaceutical Manufacturing Research Services, Inc. Forme posologique remplie de liquide anti-abus à libération immédiate
US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
CA2969013A1 (fr) * 2015-06-30 2017-01-05 Daiichi Sankyo Company, Limited Composition pharmaceutique offrant des proprietes de prevention de l'abus

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0477135A1 (fr) * 1990-09-07 1992-03-25 Warner-Lambert Company Microcapsules enduites sphéroidales mâchables et méthodes de leur préparation
GB9401894D0 (en) * 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
FR2725623B1 (fr) * 1994-10-18 1997-02-21
US6228863B1 (en) * 1997-12-22 2001-05-08 Euro-Celtique S.A. Method of preventing abuse of opioid dosage forms
AP1665A (en) * 2000-02-08 2006-09-22 Euro Celtique Sa Tamper-resistant oral opioid agonist formulations.
US7842307B2 (en) * 2001-08-06 2010-11-30 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
FR2837100B1 (fr) * 2002-03-18 2004-07-23 Flamel Tech Sa Comprimes a bases de microcapsules a liberation modifiee
EP1492531B3 (fr) * 2002-04-09 2012-04-11 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiée d'amoxicilline
ES2320438T7 (es) * 2002-04-09 2013-02-14 Flamel Technologies Formulación farmaceútica oral de suspensión acuosa de microcápsulas que permiten la liberación modificada de principio(s) activo(s)
AU2003247876B2 (en) * 2002-07-05 2006-10-05 Collegium Pharmaceutical, Inc Abuse-deterrent pharmaceutical compositions of opiods and other drugs
FR2842736B1 (fr) * 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
FR2842735B1 (fr) * 2002-07-26 2006-01-06 Flamel Tech Sa Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
FR2878161B1 (fr) * 2004-11-23 2008-10-31 Flamel Technologies Sa Forme medicamenteuse orale, solide et concue pour eviter le mesusage
FR2878158B1 (fr) * 2004-11-24 2009-01-16 Flamel Technologies Sa Forme pharmaceutique orale, microparticulaire solide concue pour eviter le mesusage

Also Published As

Publication number Publication date
JP2008529990A (ja) 2008-08-07
CA2596965A1 (fr) 2006-08-31
WO2006089843A3 (fr) 2007-03-22
US20090041838A1 (en) 2009-02-12
CN101151022A (zh) 2008-03-26
EP1845958A2 (fr) 2007-10-24
WO2006089843A2 (fr) 2006-08-31
FR2881652A1 (fr) 2006-08-11
US20100266701A1 (en) 2010-10-21

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20141031