HUP0204229A2 - Orális opioid készítmények, eljárás az előállításukra és alkalmazásuk - Google Patents
Orális opioid készítmények, eljárás az előállításukra és alkalmazásukInfo
- Publication number
- HUP0204229A2 HUP0204229A2 HU0204229A HUP0204229A HUP0204229A2 HU P0204229 A2 HUP0204229 A2 HU P0204229A2 HU 0204229 A HU0204229 A HU 0204229A HU P0204229 A HUP0204229 A HU P0204229A HU P0204229 A2 HUP0204229 A2 HU P0204229A2
- Authority
- HU
- Hungary
- Prior art keywords
- antagonist
- compositions
- dosage form
- preparation
- released
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 3
- 238000009472 formulation Methods 0.000 title 1
- 239000005557 antagonist Substances 0.000 abstract 6
- 239000002552 dosage form Substances 0.000 abstract 5
- 239000002981 blocking agent Substances 0.000 abstract 2
- 239000003402 opiate agonist Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000003401 opiate antagonist Substances 0.000 abstract 1
Classifications
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- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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Abstract
A találmány tárgya olyan orális készítményre vonatkozik, amely(i) egy felszabadítható formájú opioid agonistát és (ii) egy olyanelkülönített opioid antagonistát tartalmaz, amely alapjában véve nemszabadul fel, amikor az adagolási formát épen adják be, ahol amegbolygatás után az adagolási formából felszabadult antagonistamennyiségének az ép adagolási formából felszabadult antagonistamennyiségéhez viszonyított aránya 4:1 vagy nagyobb. Az antagonista egyolyan elzáróanyaggal egyedileg bevont sokszemcsés formájú lehet, amelymegakadályozza az antagonista felszabadulását. Az antagonistát egyolyan mátrixban is diszpergálhatják, amely egy elzáróanyagottartalmaz, amely megakadályozza az antagonista felszabadulását. Atalálmány tárgya továbbá eljárás a készítmény előállítására és azadagolási formában lévő opioid agonistával való visszaéléslehetőségének csökkentésére. A találmány szerinti adagolási forma afájdalom kezelésére alkalmazható. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18136900P | 2000-02-08 | 2000-02-08 | |
PCT/US2001/004346 WO2001058451A1 (en) | 2000-02-08 | 2001-02-08 | Tamper-resistant oral opioid agonist formulations |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0204229A2 true HUP0204229A2 (hu) | 2003-04-28 |
HUP0204229A3 HUP0204229A3 (en) | 2006-01-30 |
HU229705B1 HU229705B1 (en) | 2014-05-28 |
Family
ID=22663996
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204163A HUP0204163A2 (hu) | 2000-02-08 | 2001-02-08 | Opioid agonistát és antagonistát tartalmazó szabályozott leadású készítmény és eljárás az előállítására |
HU0204229A HU229705B1 (en) | 2000-02-08 | 2001-02-08 | Tamper-resistant oral opioid agonist formulations |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204163A HUP0204163A2 (hu) | 2000-02-08 | 2001-02-08 | Opioid agonistát és antagonistát tartalmazó szabályozott leadású készítmény és eljárás az előállítására |
Country Status (35)
Country | Link |
---|---|
US (15) | US6696088B2 (hu) |
EP (6) | EP2517710B1 (hu) |
JP (10) | JP2003522144A (hu) |
KR (2) | KR20020071032A (hu) |
CN (3) | CN100563656C (hu) |
AP (1) | AP1665A (hu) |
AT (1) | ATE431145T1 (hu) |
AU (2) | AU776666B2 (hu) |
BG (1) | BG65828B1 (hu) |
BR (2) | BRPI0108380B8 (hu) |
CA (1) | CA2400567C (hu) |
CY (2) | CY1109270T1 (hu) |
CZ (1) | CZ299991B6 (hu) |
DE (1) | DE60138706D1 (hu) |
DK (5) | DK2092936T3 (hu) |
EA (1) | EA004876B1 (hu) |
EE (1) | EE05171B1 (hu) |
ES (5) | ES2539904T3 (hu) |
GE (1) | GEP20053614B (hu) |
HK (3) | HK1051487A1 (hu) |
HU (2) | HUP0204163A2 (hu) |
IL (5) | IL151057A0 (hu) |
ME (1) | MEP48308A (hu) |
MX (2) | MXPA02007686A (hu) |
NO (2) | NO20023729L (hu) |
NZ (1) | NZ520554A (hu) |
OA (1) | OA12215A (hu) |
PL (1) | PL210845B1 (hu) |
PT (6) | PT2092936E (hu) |
RS (1) | RS50407B (hu) |
SI (5) | SI2517710T1 (hu) |
SK (1) | SK287107B6 (hu) |
TW (1) | TWI292317B (hu) |
UA (1) | UA79069C2 (hu) |
WO (2) | WO2001058447A1 (hu) |
Families Citing this family (329)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
CN1204890C (zh) * | 1997-12-22 | 2005-06-08 | 欧罗赛铁克股份有限公司 | 防止阿片样物质滥用的方法 |
ATE323491T1 (de) | 1997-12-22 | 2006-05-15 | Euro Celtique Sa | Peroral zu verabreichende arzneiform enthaltend eine kombination von einem opioid agonisten und naltrexon |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
AU764453B2 (en) | 1999-10-29 | 2003-08-21 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
ES2539904T3 (es) | 2000-02-08 | 2015-07-07 | Euro-Celtique S.A. | Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas |
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