BR0108379A - Composições de liberação controlada contendo agonista e antagonista opióide, método para a preparação de uma formulação em dosagem de analgésico opióide de liberação controlada com potência analgésica aumentada e sistema de administração através da derme para um analgésico opióide - Google Patents
Composições de liberação controlada contendo agonista e antagonista opióide, método para a preparação de uma formulação em dosagem de analgésico opióide de liberação controlada com potência analgésica aumentada e sistema de administração através da derme para um analgésico opióideInfo
- Publication number
- BR0108379A BR0108379A BR0108379-1A BRPI0108379A BR0108379A BR 0108379 A BR0108379 A BR 0108379A BR PI0108379 A BRPI0108379 A BR PI0108379A BR 0108379 A BR0108379 A BR 0108379A
- Authority
- BR
- Brazil
- Prior art keywords
- opioid
- analgesic
- controlled release
- agonist
- dosage formulation
- Prior art date
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Abstract
"COMPOSIçõES DE LIBERAçãO CONTROLADA CONTENDO AGONISTA E ANTAGONISTA OPIóIDE, MéTODO PARA A PREPARAçãO DE UMA FORMULAçãO EM DOSAGEM DE ANALGéSICO OPIóIDE DE LIBERAçãO CONTROLADA COM POTêNCIA ANALGéSICA AUMENTADA E SISTEMA DE ADMINISTRAçãO ATRAVéS DA DERME PARA UM ANALGéSICO OPIóIDE". Onde as composições compreendem um agonista opióide; um antagonista opióide; e um material de liberação controlada; dita formulação em dosagem liberando durante um intervalo de tempo de dosagem uma quantidade de analgésico ou subanalgésico do agonista opióide juntamente com uma quantidade de dito antagonista opióide eficaz para atenuar um efeito colateral de dito agonista opióide selecionado dentre o grupo consistente de antianalgesia, hiperanalgesia, hiperexcitabilidade, dependência física, tolerância, e uma combinação de quaisquer dos precedentes, dita formulação em dosagem proporcionando analgesia durante pelo menos 8 horas quando administrada a pacientes humanos. O método compreende a preparação de uma formulação em dosagem de liberação controlada contendo um agonista opióide; um antagonista opióide; e um material de liberação controlada de tal maneira que dita formulação em dosagem administra a pacientes humanos durante um intervalo de tempo de dosagem pretendido uma quantidade analgésica ou subanalgésica do agonista opióide juntamente com uma quantidade de dito antagonista opióide, eficaz para aumentar a potência de dita quantidade de agonista opióide liberada da formulação em dosagem, dita formulação em dosagem proporcionando analgesia durante pelo menos 8 horas quando administrada a pacientes humanos. Já o de administração através da derme compreende um agonista opióide e uma antagonista opióide contidos num reservatório ou matriz e capazes de administração a partir do dispositivo de uma maneira controlada, de tal forma que quando o dispositivo é aplicado à pele de um paciente humano, o agonista opióide seja administrado a uma taxa de liberação relativa média eficaz para proporcionar analgesia a dito paciente durante pelo menos 3 dias, e o antagonista opióide seja administrado a uma taxa de liberação relativa média suficiente para reduzir os efeitos colaterais associados ao agonista opióide porém não suficiente para anular a eficácia analgésica do opióide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18136900P | 2000-02-08 | 2000-02-08 | |
PCT/US2001/004347 WO2001058447A1 (en) | 2000-02-08 | 2001-02-08 | Controlled-release compositions containing opioid agonist and antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0108379A true BR0108379A (pt) | 2002-11-05 |
Family
ID=22663996
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0108379-1A BR0108379A (pt) | 2000-02-08 | 2001-02-08 | Composições de liberação controlada contendo agonista e antagonista opióide, método para a preparação de uma formulação em dosagem de analgésico opióide de liberação controlada com potência analgésica aumentada e sistema de administração através da derme para um analgésico opióide |
BRPI0108380-5 BRPI0108380B8 (pt) | 2000-02-08 | 2001-02-08 | fórmulas de opióides agonistas resistentes à adulteração, método para diminuir o abuso de um opióide agonista numa fórmula de dosagem oral, método de preparação de uma fórmula de dosagem oral e método de tratamento da dor |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0108380-5 BRPI0108380B8 (pt) | 2000-02-08 | 2001-02-08 | fórmulas de opióides agonistas resistentes à adulteração, método para diminuir o abuso de um opióide agonista numa fórmula de dosagem oral, método de preparação de uma fórmula de dosagem oral e método de tratamento da dor |
Country Status (35)
Country | Link |
---|---|
US (15) | US6696088B2 (pt) |
EP (6) | EP2277521B1 (pt) |
JP (10) | JP2003522144A (pt) |
KR (2) | KR20020071032A (pt) |
CN (3) | CN101703777B (pt) |
AP (1) | AP1665A (pt) |
AT (1) | ATE431145T1 (pt) |
AU (2) | AU776666B2 (pt) |
BG (1) | BG65828B1 (pt) |
BR (2) | BR0108379A (pt) |
CA (1) | CA2400567C (pt) |
CY (2) | CY1109270T1 (pt) |
CZ (1) | CZ299991B6 (pt) |
DE (1) | DE60138706D1 (pt) |
DK (5) | DK2283842T3 (pt) |
EA (1) | EA004876B1 (pt) |
EE (1) | EE05171B1 (pt) |
ES (5) | ES2539904T3 (pt) |
GE (1) | GEP20053614B (pt) |
HK (3) | HK1051487A1 (pt) |
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