DE3687575T2 - Verwendung von 6-methylen-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphin. - Google Patents
Verwendung von 6-methylen-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphin.Info
- Publication number
- DE3687575T2 DE3687575T2 DE8686906052T DE3687575T DE3687575T2 DE 3687575 T2 DE3687575 T2 DE 3687575T2 DE 8686906052 T DE8686906052 T DE 8686906052T DE 3687575 T DE3687575 T DE 3687575T DE 3687575 T2 DE3687575 T2 DE 3687575T2
- Authority
- DE
- Germany
- Prior art keywords
- hydroxydihydronormorphine
- desoxy
- cyclopropylmethyl
- methylene
- injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- 230000008485 antagonism Effects 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000000246 remedial effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77321385A | 1985-09-06 | 1985-09-06 | |
PCT/US1986/001847 WO1987001282A2 (en) | 1985-09-06 | 1986-09-08 | Method and composition for providing sustained opioid antagonism |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3687575D1 DE3687575D1 (de) | 1993-03-04 |
DE3687575T2 true DE3687575T2 (de) | 1993-07-01 |
Family
ID=25097554
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686906052T Expired - Lifetime DE3687575T2 (de) | 1985-09-06 | 1986-09-08 | Verwendung von 6-methylen-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphin. |
DE19863690457 Withdrawn DE3690457T1 (de) | 1985-09-06 | 1986-09-08 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19863690457 Withdrawn DE3690457T1 (de) | 1985-09-06 | 1986-09-08 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0236477B1 (de) |
JP (1) | JPS63500799A (de) |
AT (1) | ATE84717T1 (de) |
DE (2) | DE3687575T2 (de) |
WO (1) | WO1987001282A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE323491T1 (de) | 1997-12-22 | 2006-05-15 | Euro Celtique Sa | Peroral zu verabreichende arzneiform enthaltend eine kombination von einem opioid agonisten und naltrexon |
ES2539904T3 (es) | 2000-02-08 | 2015-07-07 | Euro-Celtique S.A. | Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas |
DE60238756D1 (de) | 2001-05-11 | 2011-02-10 | Endo Pharmaceuticals Inc | Opioid enthaltende arzneiform gegen missbrauch |
DE60232417D1 (de) | 2001-08-06 | 2009-07-02 | Euro Celtique Sa | Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist |
EP2316428A1 (de) | 2002-04-05 | 2011-05-04 | Euro-Celtique S.A. | Matrix für die modifizierte Freigabe von aktiven Substanzen |
EP2422773A3 (de) | 2002-09-20 | 2012-04-18 | Alpharma, Inc. | Sequestriermitteluntereinheit und zugehörige Zusammensetzungen und Verfahren |
TWI347201B (en) | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
PT2719378T (pt) | 2006-06-19 | 2016-11-02 | Alpharma Pharmaceuticals Llc | Composições farmacêuticas |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
WO2010103039A1 (en) | 2009-03-10 | 2010-09-16 | Euro-Celtique S.A. | Immediate release pharmaceutical compositions comprising oxycodone and naloxone |
CA2918004C (en) | 2013-07-23 | 2018-11-20 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB769517A (en) * | 1953-10-20 | 1957-03-06 | Merck & Co Inc | Analgesic compositions |
US3493657A (en) * | 1961-03-14 | 1970-02-03 | Mozes Juda Lewenstein | Therapeutic compositions of n-allyl-14-hydroxy - dihydronormorphinane and morphine |
US3814768A (en) * | 1971-11-26 | 1974-06-04 | Lewenstein E | 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts |
US4322426A (en) * | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
EP0103636B1 (de) * | 1982-03-16 | 1990-09-12 | Rockefeller University | Verwendung von opium antagonisten zur herstellung von arzneimitteln zur behebung gastro-intestinaler störungen |
US4567185A (en) * | 1983-05-13 | 1986-01-28 | Key Pharmaceuticals, Inc. | Endorphin blockage |
US4535157A (en) * | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
-
1986
- 1986-09-08 JP JP61505302A patent/JPS63500799A/ja active Pending
- 1986-09-08 WO PCT/US1986/001847 patent/WO1987001282A2/en active IP Right Grant
- 1986-09-08 EP EP86906052A patent/EP0236477B1/de not_active Expired - Lifetime
- 1986-09-08 DE DE8686906052T patent/DE3687575T2/de not_active Expired - Lifetime
- 1986-09-08 DE DE19863690457 patent/DE3690457T1/de not_active Withdrawn
- 1986-09-08 AT AT86906052T patent/ATE84717T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS63500799A (ja) | 1988-03-24 |
DE3687575D1 (de) | 1993-03-04 |
EP0236477B1 (de) | 1993-01-20 |
EP0236477A1 (de) | 1987-09-16 |
ATE84717T1 (de) | 1993-02-15 |
WO1987001282A3 (en) | 1987-08-13 |
WO1987001282A2 (en) | 1987-03-12 |
DE3690457T1 (de) | 1987-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8380 | Miscellaneous part iii |
Free format text: DER PATENTINHABER LAUTET RICHTIG: BAKER NORTON PHARMACENTICALS INC., MIAMI, FLA., US |
|
8364 | No opposition during term of opposition |