DE3687575D1 - Verwendung von 6-methylen-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphin. - Google Patents

Verwendung von 6-methylen-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphin.

Info

Publication number
DE3687575D1
DE3687575D1 DE8686906052T DE3687575T DE3687575D1 DE 3687575 D1 DE3687575 D1 DE 3687575D1 DE 8686906052 T DE8686906052 T DE 8686906052T DE 3687575 T DE3687575 T DE 3687575T DE 3687575 D1 DE3687575 D1 DE 3687575D1
Authority
DE
Germany
Prior art keywords
hydroxydihydronormorphine
desoxy
cyclopropylmethyl
methylene
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686906052T
Other languages
English (en)
Other versions
DE3687575T2 (de
Inventor
Ronald R Tuttle
John Howes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Branded Pharmaceutical Products R&D Inc
Original Assignee
Baker Cummins Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baker Cummins Pharmaceuticals Inc filed Critical Baker Cummins Pharmaceuticals Inc
Publication of DE3687575D1 publication Critical patent/DE3687575D1/de
Application granted granted Critical
Publication of DE3687575T2 publication Critical patent/DE3687575T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DE8686906052T 1985-09-06 1986-09-08 Verwendung von 6-methylen-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphin. Expired - Lifetime DE3687575T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77321385A 1985-09-06 1985-09-06
PCT/US1986/001847 WO1987001282A2 (en) 1985-09-06 1986-09-08 Method and composition for providing sustained opioid antagonism

Publications (2)

Publication Number Publication Date
DE3687575D1 true DE3687575D1 (de) 1993-03-04
DE3687575T2 DE3687575T2 (de) 1993-07-01

Family

ID=25097554

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19863690457 Withdrawn DE3690457T1 (de) 1985-09-06 1986-09-08
DE8686906052T Expired - Lifetime DE3687575T2 (de) 1985-09-06 1986-09-08 Verwendung von 6-methylen-6-desoxy-n-cyclopropylmethyl-14-hydroxydihydronormorphin.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19863690457 Withdrawn DE3690457T1 (de) 1985-09-06 1986-09-08

Country Status (5)

Country Link
EP (1) EP0236477B1 (de)
JP (1) JPS63500799A (de)
AT (1) ATE84717T1 (de)
DE (2) DE3690457T1 (de)
WO (1) WO1987001282A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU1500214D0 (hu) 1997-12-22 2002-03-28 Euro Celtique Sa Opioid agonista és antagonista hatóanyagot tartalmazó gyógyszerkészítmény
PT2277521E (pt) 2000-02-08 2015-07-01 Euro Celtique Sa Formulações orais de agonistas de opióides resistentes a adulteração
EP1387673B1 (de) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Opioid enthaltende arzneiform gegen missbrauch
SI1414451T1 (sl) 2001-08-06 2009-10-31 Euro Celtique Sa Formulacije opioidnega agonista s sproščanja sposobnim in sekvestriranim antagonistom
US20050245483A1 (en) 2002-04-05 2005-11-03 Bianca Brogmann Matrix for sustained, invariant and independent release of active compounds
DK1551372T3 (en) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1702558A1 (de) 2005-02-28 2006-09-20 Euro-Celtique S.A. Verfahren und Vorrichtung zur Darmtätigkeitserfassung
ATE552829T1 (de) 2006-06-19 2012-04-15 Alpharma Pharmaceuticals Llc Pharmazeutische zusammensetzungen
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
RU2522212C2 (ru) 2009-03-10 2014-07-10 Еуро-Селтик С.А. Фармацевтические композиции с мгновенным высвобождением, содержащие оксикодон и налоксон
KR20160034352A (ko) 2013-07-23 2016-03-29 유로-셀티큐 에스.에이. 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB769517A (en) * 1953-10-20 1957-03-06 Merck & Co Inc Analgesic compositions
US3493657A (en) * 1961-03-14 1970-02-03 Mozes Juda Lewenstein Therapeutic compositions of n-allyl-14-hydroxy - dihydronormorphinane and morphine
US3814768A (en) * 1971-11-26 1974-06-04 Lewenstein E 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts
US4322426A (en) * 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
DE3381877D1 (de) * 1982-03-16 1990-10-18 Univ Rockefeller Verwendung von opium antagonisten zur herstellung von arzneimitteln zur behebung gastro-intestinaler stoerungen.
US4567185A (en) * 1983-05-13 1986-01-28 Key Pharmaceuticals, Inc. Endorphin blockage
US4535157A (en) * 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
GB8332556D0 (en) * 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions

Also Published As

Publication number Publication date
EP0236477A1 (de) 1987-09-16
WO1987001282A2 (en) 1987-03-12
EP0236477B1 (de) 1993-01-20
ATE84717T1 (de) 1993-02-15
WO1987001282A3 (en) 1987-08-13
JPS63500799A (ja) 1988-03-24
DE3690457T1 (de) 1987-08-06
DE3687575T2 (de) 1993-07-01

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Legal Events

Date Code Title Description
8380 Miscellaneous part iii

Free format text: DER PATENTINHABER LAUTET RICHTIG: BAKER NORTON PHARMACENTICALS INC., MIAMI, FLA., US

8364 No opposition during term of opposition