GB769517A - Analgesic compositions - Google Patents
Analgesic compositionsInfo
- Publication number
- GB769517A GB769517A GB27982/54A GB2798254A GB769517A GB 769517 A GB769517 A GB 769517A GB 27982/54 A GB27982/54 A GB 27982/54A GB 2798254 A GB2798254 A GB 2798254A GB 769517 A GB769517 A GB 769517A
- Authority
- GB
- United Kingdom
- Prior art keywords
- analgesic
- methyl
- hydrochloride
- phosphate
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
Abstract
An analgesic composition comprises a potent analgesic and an antagonist as defined below in amount effective to counteract the side effects (narcosis, nausea, respiratory depresion, addiction, &c.) of the analgesic without impairing its analgesic activity. Potent analgesics specified include codeine, morphine, dihydromorphine, dihydrocodeine, dihydromorphinone, dihydrocodeinone, diacetylmorphine, d, l-isomethadone, l-isomethadone, d, l-methadone, l-methadone, 3-hydroxy-N-methyl-morphinan 6 - methyl - D 6 - desoxymorphine, ethylmorphine, N - methyl - 4 - phenyl - 4 - carbethoxypiperidine hydrochloride and hydroxydihydrocodeinone. Specified antagonists are N - n - propyl, - allyl, - isobutyl and - methallyl substituted normorphines, dihydronormorphines, desoxynormorphines, dihydrodesoxynormorphines, dihydronormorphinones and their acylates; the methyl ether derivatives of these compounds (i.e. the corresponding codeine compounds) with the exception of N - n - propylnorcodeine, N - isobutylnorcodeine, and the N - substituted - dihydronorcodeines; and 3 - hydroxy - N - allylnormorphinan. Both components of the composition may be in the free base or acid addition salt form, especially the sulphate, phosphate, citrate, hydrochloride and hydrobromide. The compositions may be used parenterally as aqueous suspensions or solutions with the addition of a buffer such as trisodium citrate, monosodium phosphate or disodium phosphate, and an antioxidant such as sodium bisulphate. In an example a composition comprising morphine sulphate N - allyl - normorphine hydrochloride, sodium bisulphite, monosodium phosphate monohydrate, anhydrous disodium phosphate and pyrogen free water is described. Specifications 722,571, 769,516, 769,518 and 769,519 [all in Group IV(b)] are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US769517XA | 1953-10-20 | 1953-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB769517A true GB769517A (en) | 1957-03-06 |
Family
ID=22135183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB27982/54A Expired GB769517A (en) | 1953-10-20 | 1954-09-28 | Analgesic compositions |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB769517A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
EP0074105A1 (en) * | 1981-09-08 | 1983-03-16 | Michael Richard Magruder | Nalbuphine-narcotic oral analgesic composition and method of producing analgesia |
WO1987001282A2 (en) * | 1985-09-06 | 1987-03-12 | Key Pharmaceuticals, Inc. | Method and composition for providing sustained opioid antagonism |
US7682634B2 (en) | 2006-06-19 | 2010-03-23 | Alpharma Pharmaceuticals, Llc | Pharmaceutical compositions |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
US8685444B2 (en) | 2002-09-20 | 2014-04-01 | Alpharma Pharmaceuticals Llc | Sequestering subunit and related compositions and methods |
-
1954
- 1954-09-28 GB GB27982/54A patent/GB769517A/en not_active Expired
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
EP0074105A1 (en) * | 1981-09-08 | 1983-03-16 | Michael Richard Magruder | Nalbuphine-narcotic oral analgesic composition and method of producing analgesia |
WO1987001282A2 (en) * | 1985-09-06 | 1987-03-12 | Key Pharmaceuticals, Inc. | Method and composition for providing sustained opioid antagonism |
WO1987001282A3 (en) * | 1985-09-06 | 1987-08-13 | Key Pharma | Method and composition for providing sustained opioid antagonism |
US8685444B2 (en) | 2002-09-20 | 2014-04-01 | Alpharma Pharmaceuticals Llc | Sequestering subunit and related compositions and methods |
US8685443B2 (en) | 2002-09-20 | 2014-04-01 | Alpharma Pharmaceuticals Llc | Sequestering subunit and related compositions and methods |
US7682634B2 (en) | 2006-06-19 | 2010-03-23 | Alpharma Pharmaceuticals, Llc | Pharmaceutical compositions |
US7682633B2 (en) | 2006-06-19 | 2010-03-23 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
US8158156B2 (en) | 2006-06-19 | 2012-04-17 | Alpharma Pharmaceuticals, Llc | Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist |
US8846104B2 (en) | 2006-06-19 | 2014-09-30 | Alpharma Pharmaceuticals Llc | Pharmaceutical compositions for the deterrence and/or prevention of abuse |
US8877247B2 (en) | 2006-06-19 | 2014-11-04 | Alpharma Pharmaceuticals Llc | Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
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