GB769517A - Analgesic compositions - Google Patents

Analgesic compositions

Info

Publication number
GB769517A
GB769517A GB27982/54A GB2798254A GB769517A GB 769517 A GB769517 A GB 769517A GB 27982/54 A GB27982/54 A GB 27982/54A GB 2798254 A GB2798254 A GB 2798254A GB 769517 A GB769517 A GB 769517A
Authority
GB
United Kingdom
Prior art keywords
analgesic
methyl
hydrochloride
phosphate
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27982/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB769517A publication Critical patent/GB769517A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00

Abstract

An analgesic composition comprises a potent analgesic and an antagonist as defined below in amount effective to counteract the side effects (narcosis, nausea, respiratory depresion, addiction, &c.) of the analgesic without impairing its analgesic activity. Potent analgesics specified include codeine, morphine, dihydromorphine, dihydrocodeine, dihydromorphinone, dihydrocodeinone, diacetylmorphine, d, l-isomethadone, l-isomethadone, d, l-methadone, l-methadone, 3-hydroxy-N-methyl-morphinan 6 - methyl - D 6 - desoxymorphine, ethylmorphine, N - methyl - 4 - phenyl - 4 - carbethoxypiperidine hydrochloride and hydroxydihydrocodeinone. Specified antagonists are N - n - propyl, - allyl, - isobutyl and - methallyl substituted normorphines, dihydronormorphines, desoxynormorphines, dihydrodesoxynormorphines, dihydronormorphinones and their acylates; the methyl ether derivatives of these compounds (i.e. the corresponding codeine compounds) with the exception of N - n - propylnorcodeine, N - isobutylnorcodeine, and the N - substituted - dihydronorcodeines; and 3 - hydroxy - N - allylnormorphinan. Both components of the composition may be in the free base or acid addition salt form, especially the sulphate, phosphate, citrate, hydrochloride and hydrobromide. The compositions may be used parenterally as aqueous suspensions or solutions with the addition of a buffer such as trisodium citrate, monosodium phosphate or disodium phosphate, and an antioxidant such as sodium bisulphate. In an example a composition comprising morphine sulphate N - allyl - normorphine hydrochloride, sodium bisulphite, monosodium phosphate monohydrate, anhydrous disodium phosphate and pyrogen free water is described. Specifications 722,571, 769,516, 769,518 and 769,519 [all in Group IV(b)] are referred to.
GB27982/54A 1953-10-20 1954-09-28 Analgesic compositions Expired GB769517A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US769517XA 1953-10-20 1953-10-20

Publications (1)

Publication Number Publication Date
GB769517A true GB769517A (en) 1957-03-06

Family

ID=22135183

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27982/54A Expired GB769517A (en) 1953-10-20 1954-09-28 Analgesic compositions

Country Status (1)

Country Link
GB (1) GB769517A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966940A (en) * 1973-11-09 1976-06-29 Bristol-Myers Company Analgetic compositions
EP0074105A1 (en) * 1981-09-08 1983-03-16 Michael Richard Magruder Nalbuphine-narcotic oral analgesic composition and method of producing analgesia
WO1987001282A2 (en) * 1985-09-06 1987-03-12 Key Pharmaceuticals, Inc. Method and composition for providing sustained opioid antagonism
US7682634B2 (en) 2006-06-19 2010-03-23 Alpharma Pharmaceuticals, Llc Pharmaceutical compositions
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US8685444B2 (en) 2002-09-20 2014-04-01 Alpharma Pharmaceuticals Llc Sequestering subunit and related compositions and methods

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966940A (en) * 1973-11-09 1976-06-29 Bristol-Myers Company Analgetic compositions
EP0074105A1 (en) * 1981-09-08 1983-03-16 Michael Richard Magruder Nalbuphine-narcotic oral analgesic composition and method of producing analgesia
WO1987001282A2 (en) * 1985-09-06 1987-03-12 Key Pharmaceuticals, Inc. Method and composition for providing sustained opioid antagonism
WO1987001282A3 (en) * 1985-09-06 1987-08-13 Key Pharma Method and composition for providing sustained opioid antagonism
US8685444B2 (en) 2002-09-20 2014-04-01 Alpharma Pharmaceuticals Llc Sequestering subunit and related compositions and methods
US8685443B2 (en) 2002-09-20 2014-04-01 Alpharma Pharmaceuticals Llc Sequestering subunit and related compositions and methods
US7682634B2 (en) 2006-06-19 2010-03-23 Alpharma Pharmaceuticals, Llc Pharmaceutical compositions
US7682633B2 (en) 2006-06-19 2010-03-23 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8158156B2 (en) 2006-06-19 2012-04-17 Alpharma Pharmaceuticals, Llc Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist
US8846104B2 (en) 2006-06-19 2014-09-30 Alpharma Pharmaceuticals Llc Pharmaceutical compositions for the deterrence and/or prevention of abuse
US8877247B2 (en) 2006-06-19 2014-11-04 Alpharma Pharmaceuticals Llc Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition

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