GB1300419A - New morphinone derivatives and their preparation - Google Patents

New morphinone derivatives and their preparation

Info

Publication number
GB1300419A
GB1300419A GB08467/70A GB1846770A GB1300419A GB 1300419 A GB1300419 A GB 1300419A GB 08467/70 A GB08467/70 A GB 08467/70A GB 1846770 A GB1846770 A GB 1846770A GB 1300419 A GB1300419 A GB 1300419A
Authority
GB
United Kingdom
Prior art keywords
formula
acid addition
derivatives
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08467/70A
Inventor
William Roger Buckett
Hans Harold Bosman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Laboratories Ltd
Original Assignee
Organon Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Laboratories Ltd filed Critical Organon Laboratories Ltd
Publication of GB1300419A publication Critical patent/GB1300419A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1300419 Esters of 14-hydroxydihydronormorphinone derivatives ORGANON LABORATORIES Ltd 6 May 1970 [16 May 1969 17 April 1970] 25025/69 Heading C2C Novel 3 - alkoxy - N - substituted - 14 - acyloxy - dihydronormorphinones of the formula in which R is allyl, dimethylallyl, cyclopropylmethyl or cyclobutylmethyl, R 1 is a C 1-8 aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic carboxylic acyl group, and R 2 is a C 1-6 alkyl, or their acid addition salts, may be obtained by reacting the corresponding 14- hydroxy-dihydronormorphinone with a carboxylic acid R 1 OH or a functional derivative thereof, and optionally converting the product to an acid addition salt. Pharmaceutical compositions having analgetic, tranquillizing, cough suppressing and anticonvulsant properties comprise compounds of Formula I together with a pharmaceutical carrier in forms suitable for oral or parenteral administration.
GB08467/70A 1969-05-16 1969-05-16 New morphinone derivatives and their preparation Expired GB1300419A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2502569 1969-05-16

Publications (1)

Publication Number Publication Date
GB1300419A true GB1300419A (en) 1972-12-20

Family

ID=10221004

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08467/70A Expired GB1300419A (en) 1969-05-16 1969-05-16 New morphinone derivatives and their preparation

Country Status (7)

Country Link
CH (1) CH549572A (en)
DE (1) DE2022899A1 (en)
FR (1) FR2051532B1 (en)
GB (1) GB1300419A (en)
NL (1) NL7007167A (en)
SE (1) SE359093B (en)
ZA (1) ZA703011B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005294A2 (en) * 2002-07-03 2004-01-15 Alcasynn Pharmaceuticals Gmbh Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof
WO2004082620A2 (en) * 2003-03-13 2004-09-30 Controlled Chemicals, Inc. Oxycodone conjugates with lower the abuse potential and extended duration of action
EP1782834A2 (en) * 2003-03-13 2007-05-09 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95069B (en) * 1989-08-24 1997-10-31 Searle & Co PROCESS FOR THE PREPARATION OF (+) - ISOMERS OF DERIVATIVES OF ENDOETANO / ENDOETANOEPOXIMOFINANO, UTEIS AS ANTI-TUSTIC AGENTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB981046A (en) * 1962-07-02 1965-01-20 British Drug Houses Ltd Hexahydro-4ah-8,9c-iminoethano phenanthro-[4,5-b,c,d]-furan derivatives

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005294A2 (en) * 2002-07-03 2004-01-15 Alcasynn Pharmaceuticals Gmbh Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof
WO2004005294A3 (en) * 2002-07-03 2004-05-13 Helmut Schmidhammer Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof
US7655671B2 (en) 2002-07-03 2010-02-02 Alcasynn Pharmaceuticals Gmbh Morphinan derivatives, the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof
WO2004082620A2 (en) * 2003-03-13 2004-09-30 Controlled Chemicals, Inc. Oxycodone conjugates with lower the abuse potential and extended duration of action
WO2004082620A3 (en) * 2003-03-13 2005-09-15 Controlled Chemicals Inc Oxycodone conjugates with lower the abuse potential and extended duration of action
EP1782834A2 (en) * 2003-03-13 2007-05-09 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action
US7230005B2 (en) 2003-03-13 2007-06-12 Controlled Chemicals, Inc. Compounds and methods for lowering the abuse potential and extending the duration of action of a drug
EP1782834A3 (en) * 2003-03-13 2007-08-01 Controlled Chemicals, Inc. Oxycodone conjugates with lower abuse potential and extended duration of action

Also Published As

Publication number Publication date
DE2022899A1 (en) 1970-11-19
CH549572A (en) 1974-05-31
FR2051532B1 (en) 1974-04-12
NL7007167A (en) 1970-11-18
ZA703011B (en) 1971-05-27
SE359093B (en) 1973-08-20
FR2051532A1 (en) 1971-04-09

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees