GB1071304A - Novel substituted morphinans and a process for the manufacture thereof - Google Patents
Novel substituted morphinans and a process for the manufacture thereofInfo
- Publication number
- GB1071304A GB1071304A GB2761/66A GB276166A GB1071304A GB 1071304 A GB1071304 A GB 1071304A GB 2761/66 A GB2761/66 A GB 2761/66A GB 276166 A GB276166 A GB 276166A GB 1071304 A GB1071304 A GB 1071304A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- cyclobutylmethyl
- cyclopropylmethyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Novel racemic and laevorotatory compounds of the formula <FORM:1071304/C2/1> and acid addition salts thereof, wherein R is H, a C1- 5 unsaturated or saturated aliphatic radical, or acyl; and R2 is cyclopropylmethyl or cyclobutylmethyl, are prepared either by reacting a compound of formula <FORM:1071304/C2/2> with an agent which yields the cyclopropylcarbonyl or cyclobutylcarbonyl group, and reducing the carbonyl group in the resulting morphinan of the general formula <FORM:1071304/C2/3> wherein R1 has the above significance and R3 is a cyclopropyl or cyclobutyl group to CH2, e.g. by means of LiAlH4, or by condensing the compound of the second formula given above with a cyclopropylmethyl or cyclobutylmethyl halide and when required converting the product to an ether, ester or acid addition salt. Pharmaceutical compositions comprise a compound of the first formula given above, or a salt thereof with a medicinally acceptable acid, in admixture with a compatible pharmaceutical carrier. They may take the form of a solid or liquid, suitable for oral or injection administration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH95765 | 1965-01-22 | ||
| CH613165 | 1965-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1071304A true GB1071304A (en) | 1967-06-07 |
Family
ID=25686210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2761/66A Expired GB1071304A (en) | 1965-01-22 | 1966-01-21 | Novel substituted morphinans and a process for the manufacture thereof |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE675430A (en) |
| BR (1) | BR6676561D0 (en) |
| ES (1) | ES322095A1 (en) |
| FR (2) | FR1463708A (en) |
| GB (1) | GB1071304A (en) |
| NL (1) | NL6517169A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120122848A1 (en) * | 2009-07-29 | 2012-05-17 | Green Cross Corporation | (+)-3-hydroxymorphinan derivatives as neuroprotectants |
-
1965
- 1965-12-30 NL NL6517169A patent/NL6517169A/xx unknown
-
1966
- 1966-01-18 FR FR46208A patent/FR1463708A/en not_active Expired
- 1966-01-18 FR FR46209A patent/FR4929M/fr not_active Expired
- 1966-01-21 ES ES0322095A patent/ES322095A1/en not_active Expired
- 1966-01-21 BR BR176561/66A patent/BR6676561D0/en unknown
- 1966-01-21 GB GB2761/66A patent/GB1071304A/en not_active Expired
- 1966-01-21 BE BE675430D patent/BE675430A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE675430A (en) | 1966-07-22 |
| FR4929M (en) | 1967-03-20 |
| FR1463708A (en) | 1966-06-03 |
| BR6676561D0 (en) | 1973-09-11 |
| ES322095A1 (en) | 1966-07-16 |
| NL6517169A (en) | 1966-07-25 |
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