GB1431712A - Benzomorphan derivatives - Google Patents
Benzomorphan derivativesInfo
- Publication number
- GB1431712A GB1431712A GB3141273A GB3141273A GB1431712A GB 1431712 A GB1431712 A GB 1431712A GB 3141273 A GB3141273 A GB 3141273A GB 3141273 A GB3141273 A GB 3141273A GB 1431712 A GB1431712 A GB 1431712A
- Authority
- GB
- United Kingdom
- Prior art keywords
- denotes
- formula
- benzomorphan
- hydroxy
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Forklifts And Lifting Vehicles (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
1431712 Benzomorphan derivatives SCHERING AG 2 July 1973 [30 June 1972] 31412/73 Heading C2C Novel compounds of the Formula I: in which R 1 denotes H, CH 3 or C 2 H 5 , R 2 denotes CH 3 or C 2 H 5 , and R 3 and R 4 each denotes a C 1-4 alkyl group, and physiologically tolerable acid addition salts thereof, may be obtained by reacting a benzomorphan of Formula II: with an epoxide of the Formula III: or with a halohydrin of the Formula IV: in which one of the symbols X and Y denotes an OH group and the other denotes a halogen atom. (-) : 9 - Ethyl - 2<SP>1 </SP>- hydroxy - 5 - methyl- 6,7-benzomorphan is obtained by resolving (Œ) - 9 - ethyl - 2 - benzyl - 21 - hydroxy - 5- methyl - 6,7 - benzomorphan using (-) - O,O- dibenzoyl-L-tartaric acid to obtain the (+) and (-)ve forms which are isolated as hydrobromides, followed by hydrogenation of the laevo-rotatory form HBr salt with addition of palladium-carbon. Pharmaceutical preparations having high analgesic activity without causing morphinelike tolerance and dependence, and exhibiting morphine - antagonistic, anti - convulsive and muscle-relaxing actions and sedative properties, comprise compounds of Formula I together with a pharmaceutically suitable carrier, in forms suitable for oral or parenteral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2233088A DE2233088A1 (en) | 1972-06-30 | 1972-06-30 | BENZOMORPHAN DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1431712A true GB1431712A (en) | 1976-03-03 |
Family
ID=5849806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3141273A Expired GB1431712A (en) | 1972-06-30 | 1973-07-02 | Benzomorphan derivatives |
| GB3845772A Expired GB1431777A (en) | 1972-06-30 | 1973-08-01 | Tipping assembly for fork trucks |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3845772A Expired GB1431777A (en) | 1972-06-30 | 1973-08-01 | Tipping assembly for fork trucks |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS4942678A (en) |
| AR (1) | AR207743A1 (en) |
| AT (1) | AT327407B (en) |
| AU (1) | AU466223B2 (en) |
| BE (1) | BE801720A (en) |
| CA (1) | CA969940A (en) |
| DD (1) | DD108984A5 (en) |
| DE (1) | DE2233088A1 (en) |
| DK (1) | DK133004C (en) |
| ES (1) | ES416433A1 (en) |
| FR (1) | FR2190457B1 (en) |
| GB (2) | GB1431712A (en) |
| HU (1) | HU166645B (en) |
| NL (1) | NL7309158A (en) |
| ZA (1) | ZA734439B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7804509A (en) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Novel 6,7-benzomorphan derivatives and their acid addition salts. |
| DE2828039A1 (en) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF |
| GB2108925B (en) * | 1981-11-05 | 1985-05-09 | Century Fabrications Ltd | Improvements in or relating to land vehicles |
| CN101780935B (en) * | 2010-03-17 | 2012-05-23 | 张新国 | Hydraulic hoisting machine |
| JP6102227B2 (en) * | 2012-12-05 | 2017-03-29 | Dic株式会社 | Binder for ink, ink, ink for ink jet printing and printed matter |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130089C (en) * | 1963-11-07 | |||
| NL132139C (en) * | 1966-05-20 |
-
1972
- 1972-06-30 DE DE2233088A patent/DE2233088A1/en active Pending
-
1973
- 1973-01-01 AR AR248850A patent/AR207743A1/en active
- 1973-06-25 DK DK350373*A patent/DK133004C/en active
- 1973-06-26 AU AU57369/73A patent/AU466223B2/en not_active Expired
- 1973-06-27 DD DD171866A patent/DD108984A5/xx unknown
- 1973-06-27 AT AT564573A patent/AT327407B/en not_active IP Right Cessation
- 1973-06-28 ES ES416433A patent/ES416433A1/en not_active Expired
- 1973-06-29 JP JP48073543A patent/JPS4942678A/ja active Pending
- 1973-06-29 CA CA175,368A patent/CA969940A/en not_active Expired
- 1973-06-29 BE BE132960A patent/BE801720A/en unknown
- 1973-06-29 FR FR7323934A patent/FR2190457B1/fr not_active Expired
- 1973-06-29 ZA ZA734439A patent/ZA734439B/en unknown
- 1973-06-29 HU HUSC434A patent/HU166645B/hu unknown
- 1973-06-29 NL NL7309158A patent/NL7309158A/xx unknown
- 1973-07-02 GB GB3141273A patent/GB1431712A/en not_active Expired
- 1973-08-01 GB GB3845772A patent/GB1431777A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DD108984A5 (en) | 1974-10-12 |
| GB1431777A (en) | 1976-04-14 |
| DK133004B (en) | 1976-03-08 |
| ZA734439B (en) | 1974-06-26 |
| DK133004C (en) | 1976-08-02 |
| AR207743A1 (en) | 1976-10-29 |
| FR2190457B1 (en) | 1976-07-02 |
| ATA564573A (en) | 1975-04-15 |
| NL7309158A (en) | 1974-01-02 |
| AT327407B (en) | 1976-01-26 |
| HU166645B (en) | 1975-04-28 |
| BE801720A (en) | 1974-01-02 |
| AU5736973A (en) | 1975-01-09 |
| CA969940A (en) | 1975-06-24 |
| AU466223B2 (en) | 1975-10-23 |
| FR2190457A1 (en) | 1974-02-01 |
| ES416433A1 (en) | 1976-03-01 |
| JPS4942678A (en) | 1974-04-22 |
| DE2233088A1 (en) | 1974-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |