GB1469745A - Phenylethylamine derivatives - Google Patents

Phenylethylamine derivatives

Info

Publication number
GB1469745A
GB1469745A GB3541975A GB3541975A GB1469745A GB 1469745 A GB1469745 A GB 1469745A GB 3541975 A GB3541975 A GB 3541975A GB 3541975 A GB3541975 A GB 3541975A GB 1469745 A GB1469745 A GB 1469745A
Authority
GB
United Kingdom
Prior art keywords
formula
addition
pharmaceutically acceptable
acid
phenylethylamine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3541975A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of GB1469745A publication Critical patent/GB1469745A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1469745 Phenylethylamine derivatives SYNTHELABO 27 Aug 1975 [6 Sept 1974] 35419/75 Addition to 1415471 Heading C2C The invention comprises compounds of the formula wherein n is 0, 1 or 2 and m is an integer from 1 to 4, and their acid-addition salts with pharmaceutically acceptable organic an inorganic acids. They may be obtained by condensing 1- (3 - trifluoromethylthiophenyl)propan - 2 - one with an amine of the formula and reducing the ethylidene-amino intermediate obtained, and optionally converting the base obtained into an acid-addition salt thereof. Pharmaceutical compositions having powerful anorexigenic properties comprise compounds of Formula II above or a pharmaceutically acceptable salt thereof, and a compatible pharmaceutical carrier, in forms suitable for oral administration.
GB3541975A 1974-09-06 1975-08-27 Phenylethylamine derivatives Expired GB1469745A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7430284A FR2283673A1 (en) 1974-09-06 1974-09-06 NEW M-TRIFLUOROMETHYLTHIO PHENETHYLAMINE DERIVATIVES, THEIR SALTS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING IT

Publications (1)

Publication Number Publication Date
GB1469745A true GB1469745A (en) 1977-04-06

Family

ID=9142841

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3541975A Expired GB1469745A (en) 1974-09-06 1975-08-27 Phenylethylamine derivatives

Country Status (9)

Country Link
JP (1) JPS5163153A (en)
BE (1) BE832999R (en)
DK (1) DK398675A (en)
ES (1) ES440767A2 (en)
FR (1) FR2283673A1 (en)
GB (1) GB1469745A (en)
NL (1) NL7510489A (en)
SE (1) SE7509884L (en)
ZA (1) ZA755417B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447907A1 (en) * 1979-02-05 1980-08-29 Synthelabo Anorexics used to treat obesity - are 1-3-tri:fluoro:methyl-sulphonyl or sulphinyl-phenyl-2-amino-propane(s)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1218135A (en) * 1967-07-28 1971-01-06 Abbott Lab Substituted phenethylamine derivatives
FR2186248B1 (en) * 1972-05-31 1975-11-28 Synthelabo

Also Published As

Publication number Publication date
DE2538593B2 (en) 1977-02-03
DK398675A (en) 1976-03-07
JPS5163153A (en) 1976-06-01
DE2538593A1 (en) 1976-03-25
NL7510489A (en) 1976-03-09
ZA755417B (en) 1976-07-28
SE7509884L (en) 1976-03-08
AU8428375A (en) 1977-03-03
BE832999R (en) 1976-03-02
FR2283673A1 (en) 1976-04-02
FR2283673B1 (en) 1978-08-18
ES440767A2 (en) 1977-04-01

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee