GB1233194A - - Google Patents

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Publication number
GB1233194A
GB1233194A GB1233194DA GB1233194A GB 1233194 A GB1233194 A GB 1233194A GB 1233194D A GB1233194D A GB 1233194DA GB 1233194 A GB1233194 A GB 1233194A
Authority
GB
United Kingdom
Prior art keywords
formyl
morphinan
derivatives
ccooh
aug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1233194A publication Critical patent/GB1233194A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1,233,194. N-Formyl morphinan derivatives. F. HOFFMANN-LA ROCHE & CO., A.G. 22 Aug., 1968 [25 Aug., 1967], No. 44783/70. Divided out of 1,233,193. Heading C2C. Novel morphinan derivatives of the formula in which R represents a C 1-8 alkyl, C 1-6 alkanoyl or aryl radical, are prepared by treating isoquinoline derivatives of the formulµ with an acidic cyclising agent. Cyclisation may be effected at 0-160‹ C. using, e.g., hydrohalogen acids, H 2 PO 4 , FSO 3 H, polyphosphoric acid or esters thereof, POCl 3 , Lewis acids, HCOOH, CH 3 COOH, Cl 3 CCOOH, F 3 CCOOH or p - toluene - sulphonic acid. The N - formyl morphinans can be obtained in optically active or racemic forms. The optical antipodes may be obtained by resolution of the racemate or by using optically active isoquinoline reactants. Examples relate to the preparation of (Œ) and (+) 3-methoxy-N-formyl morphinan. The N - formyl octa - or deca - hydro - isoquinolines may be prepared by N-formylation, e.g. using methyl formate.
GB1233194D 1967-08-25 1968-08-22 Expired GB1233194A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66321067A 1967-08-25 1967-08-25

Publications (1)

Publication Number Publication Date
GB1233194A true GB1233194A (en) 1971-05-26

Family

ID=24660890

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1233194D Expired GB1233194A (en) 1967-08-25 1968-08-22
GB1233193D Expired GB1233193A (en) 1967-08-25 1968-08-22

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1233193D Expired GB1233193A (en) 1967-08-25 1968-08-22

Country Status (8)

Country Link
BE (1) BE719788A (en)
CH (2) CH560194A5 (en)
DE (1) DE1795193C2 (en)
DK (1) DK129238B (en)
FR (1) FR1584396A (en)
GB (2) GB1233194A (en)
NL (1) NL158791B (en)
SE (1) SE364511B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260286A (en) * 1992-10-16 1993-11-09 Japan Tobacco, Inc. 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2327737A1 (en) * 1972-07-07 1974-01-24 Hoffmann La Roche PROCESS FOR PRODUCING ISOMORPHINANS
US4003903A (en) * 1975-02-12 1977-01-18 Florida Board Of Regents N-acyl-N-norsalutaridines and process for making them
FI773636A (en) * 1976-12-06 1978-06-07 Hoffmann La Roche NYA FENYLDERIVAT
US4194044A (en) 1976-12-06 1980-03-18 Hoffmann-La Roche Inc. Process for preparing 3-phenoxy morphinans
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
CH657007GA3 (en) * 1984-08-23 1986-08-15 Tissot Sa
CH684619B5 (en) * 1992-07-17 1995-05-15 Longines Montres Comp D Timepiece universal time display.
EP0834506B1 (en) * 1996-10-02 2004-01-14 F. Hoffmann-La Roche Ag Process for the preparation of (9alpha, 13alpha, 14alpha)-1-(3-Methoxymorphinan-17-yl)alkanones
US5905153A (en) * 1996-10-02 1999-05-18 Roche Vitamins Inc. Process for preparing (9α,13α,14α)-1-(3-methoxy-morphinan-17-yl)alkanones
EP3712714B1 (en) 2019-03-19 2022-11-30 Omega SA Dial for a universal watch

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260286A (en) * 1992-10-16 1993-11-09 Japan Tobacco, Inc. 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists

Also Published As

Publication number Publication date
DK129238B (en) 1974-09-16
DE1795193A1 (en) 1971-12-30
GB1233193A (en) 1971-05-26
FR1584396A (en) 1969-12-19
DK129238C (en) 1975-02-03
DE1795193C2 (en) 1984-08-23
NL158791B (en) 1978-12-15
CH560194A5 (en) 1975-03-27
NL6811979A (en) 1969-02-27
SE364511B (en) 1974-02-25
BE719788A (en) 1969-02-24
CH543514A (en) 1973-10-31

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years